Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect

Biochemistry

Volumn 38, Issue 1, 1999, Pages 122-133

  Szegletes, Tivadar ^a   Mallender, William D ^a   Thomas, Patrick J ^b   Rosenberry, Terrone L ^a  

^a MAYO CLINIC   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; FASCICULIN;

ARTICLE; CATALYSIS; DISSOCIATION CONSTANT; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HUMAN; PRIORITY JOURNAL;

ACETYLCHOLINESTERASE; ACETYLTHIOCHOLINE; BINDING, COMPETITIVE; CATALYSIS; CHOLINESTERASE INHIBITORS; ELAPID VENOMS; HUMANS; HYDROLYSIS; LIGANDS; MODELS, CHEMICAL; PROTEIN BINDING; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 0033524414     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9813577     Document Type: Article

References (45)

1. Rosenberry, T. L. (1975) Acetylcholinesterase, in Advances in Enzymology (Meister, A., Ed.) Vol. 43, pp 103-218, John Wiley & Sons, New York.
2. Sussman, J. L., Harel, M., Frolow, F., Oefner, C., Goldman, A., Toker, L., and Silman, I. (1991) Science 253, 872-879.
3. Weise, C., Kreienkamp, H.-J., Raba, R., Pedak, A., Aaviksaar, A., and Hucho, F. (1990) EMBO J. 9, 3885-3888.
4. Schalk, I., Ehret-Sabatier, L., Bouet, F., Goeldner, M., and Hirth, C. (1992) in Multidisciplinary Approaches to Cholinesterase Functions (Shafferman, A., and Velan, B., Eds.) pp 117-120, Plenum Press, New York.
5. Radie, Z., Pickering, N. A., Vellom, D. C., Camp, S., and Taylor, P. (1993) Biochemistry 32, 12074-12084.
6. Barak, D., Kronman, C., Ordentlich, A., Ariel, N., Bromberg, A., Marcus, D., Lazar, A., Velan, B., and Shafferman, A. (1994) J. Biol. Chem. 269, 6296-6305.
7. Harel, M., Kleywegt, G. J., Ravelli, R. B. G., Silman, I., and Sussman, J. L. (1995) Structure 3, 1355-1366.
8. Bourne, Y., Taylor, P., and Marchot, P. (1995) Cell 83, 503-512.
9. Taylor, P., and Lappi, S. (1975) Biochemistry 14, 1989-1997.
10. Karlsson, E., Mbugua, P. M., and Rodriguez-Ithurralde, D. (1984) J. Physiol. (Paris) 79, 232-240.
11. Marchot, P., Khelif, A., Ji, Y.-H., Masnuelle, P., and Bourgis, P. E. (1993) J. Biol. Chem. 268, 12458-12467.
12. Nolte, H. J., Rosenberry, T. L., and Neumann, E. (1980) Biochemistry 19, 3705-3711.
13. Ripoll, D. R., Faerman, C. H., Axelsen, P. H., Silman, I., and Sussman, J. L. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 5128-5132.
14. Antosiewicz, J., McCammon, J. A., Wlodek, S. T., and Gilson, M. K. (1995) Biochemistry 34, 4211-4219.
15. Radic, Z., Kirchhoff, P. D., Quinn, D. M., McCammon, J. A., and Taylor, P. (1997) J. Biol. Chem. 272, 23265-23277.
16. Shafferman, A., Ordentlich, A., Barak, D., Kronman, C., Ber, R., Bino, T., Ariel, N., Osman, R., and Velan, B. (1994) EMBO J. 13, 3448-3455.
17. Barak, D., Ordentlich, A., Bromberg, A., Kronman, C., Marcus, D., Lazar, A., Ariel, N., Velan, B., and Shafferman, A. (1995) Biochemistry 34, 15444-15452.
18. Szegletes, T., Mallender, W. D., and Rosenberry, T. L. (1998) Biochemistry 37, 4206-4216.
19. Masson, P., Legrand, P., Bartels, C. F., Froment, M.-T., Schopfer, L. M., and Lockridge, O. (1997) Biochemists 36, 2266-2277.
20. Rosenberry, T. L., and Scoggin, D. M. (1984) J. Biol. Chem. 259, 5643-5652.
21. Roberts, W. L., Kim., B. H., and Rosenberry, T. L. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 7817-7821.
22. Eastman, J., Wilson, E. J., Cervenansky, C., and Rosenberry, T. L. (1995) J. Biol. Chem. 270, 19694-19701.
23. Riddles, P. W., Blakeley, R. L., and Zerner, B. (1979) Anal. Biochem. 94, 75-81.
24. Ellman, G. L., Courtney, K. D., Andres, J. V., and Featherstone, R. M. (1961) Biochem. Pharmacol. 7, 88-95.
25. Rosenberry, T. L., and Bernhard, S. A. (1971) Biochemistry 10, 4114-4120.
26. Rosenberry, T. L., and Bernhard, S. A. (1972) Biochemistry 11, 4308-4321.
27. Haldane, J. B. S. (1930) Enzymes, p 84, Longmans, Green, New York.
28. Stuchbury, T., Shipton, M., Morris, R., Malthouse, J. P. G., and Brocklehurst, K. (1975) Biochem. J. 151, 417-432.
29. Hodge, A. S., Humphrey, D. R., and Rosenberry, T. L. (1992) Mol. Pharmacol. 41, 937-942.
30. Bazelyansky, M., Robey, E., and Kirsch, J. F. (1986) Biochemistry 25, 125-130.
31. Kasianowicz, J. J., and Bezrukov, S. M. (1995) Biophys. J. 69, 94-105.
32. Nachmansohn, D., and Wilson, I. B. (1951) Adv. Enzymol. 12, 259-339.
33. Prince, A. K. (1966) Arch. Biochem. Biophys. 113, 195-204.
34. Kitz, R. J., Ginsburg, S., and Wilson, I. B. (1967) Biochem. Pharmacol. 16, 2201-2209.
35. Krupka, R. M., and Laidler, K. J. (1961) J. Am. Chem. Soc. 83, 1445-1447.
36. Krupka, R. M., and Laidler, K. J. (1961) J. Am. Chem. Soc. 83, 1448-1454.
37. Froede, H. C., and Wilson, I. B. (1971) in The Enzymes (Boyer, P. D., Ed.) 3rd ed., Vol. V, pp 87-114, Academic Press, New York.
38. Zeller, E. A., and Bissegger, A. (1943) Helv. Chim. Acta 26, 1619-1630.
39. Aldridge, W. N., and Reiner, E. (1969) Biochem. J. 115, 147-162.
40. Radic, Z., Reiner, E., and Taylor, P. (1991) Mol. Pharmacol. 39, 98-104.
41. Hosea, N. A., Radic, Z., Tsigelny, I., Berman, H. A., Quinn, D. M., and Taylor, P. (1996) Biochemistry 35, 10995-11004.
42. Rosenberry, T. L. (1979) Biophys. J. 26, 263-290.
43. Mallender, W. D., Szegletes, T., and Rosenberry, T. L. (1999) J. Biol. Chem. (in press).
44. Barnett, P., and Rosenberry, T. L. (1977) J. Biol. Chem. 252, 7200-7206.
45. Rosenberry, T. L., Mallender, W. D., Thomas, P. J., and Szegletes, T. (1999) Chem.-Biol. Interact. (in press).