Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate

Biochemistry

Volumn 42, Issue 18, 2003, Pages 5438-5452

  Johnson, Joseph L ^a   Cusack, Bernadette ^a   Davies, Matthew P ^a,b   Fauq, Abdul ^a   Rosenberry, Terrone L ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CATALYSIS; ENZYMES; POSITIVE IONS; RATE CONSTANTS; SOLUTIONS; SUBSTRATES;

LIGAND BINDING;

BIOCHEMISTRY;

3 (ACETAMIDO)N,N,N TRIMETHYLANILINIUM; ACETANILIDE; ACETYLCHOLINE DERIVATIVE; ACETYLCHOLINESTERASE; ALCOHOL; CATION; ESTER; LIGAND; PROPIDIUM IODIDE; THIOFLAVINE; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; DEACYLATION; ENZYME SUBSTRATE COMPLEX; FEASIBILITY STUDY; FLUORESCENCE; HUMAN; HYDROLYSIS; MATHEMATICAL ANALYSIS; MOLECULAR DYNAMICS; MUTANT; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TITRIMETRY; WILD TYPE;

ACETANILIDES; ACETOPHENONES; ACETYLCHOLINESTERASE; ACETYLTHIOCHOLINE; ACYLATION; BINDING SITES; CATALYSIS; CHOLINESTERASE INHIBITORS; DRUG INTERACTIONS; FLUORESCENT DYES; HUMANS; HYDROLYSIS; LIGANDS; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; PROPIDIUM; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; THIAZOLES;

EID: 0038219567     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi027065u     Document Type: Article

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