Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 7, 2009, Pages 2842-2851

  Behrenswerth, Andrea ^a   Volz, Nicole ^b   Toräng, Jakob ^b   Hinz, Sonja ^a   Bräse, Stefan ^b   Müller, Christa E ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Antagonists; Cannabinoid receptors; Coumarins; Inverse agonists

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; 2 (2 METHOXYBENZYL) 3H BENZO[F]CHROMEN 3 ONE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 2H CHROMENE DERIVATIVE; 3 (2 CHLOROBENZYL) 5 METHOXY 7 METHYL 2H CHROMEN 2 ONE; 3 (2 HYDROXYBENZYL) 5 METHOXY 7 METHYL 2H CHROMEN 2 ONE; 3 (2,4 DIMETHOXYBENZYL) 5 METHOXY 7 METHYL 2H CHROMEN 2 ONE; 3 (4 CHLOROBENZYL) 5 METHOXY 7 METHYL 2H CHROMEN 2 ONE; 3 BENZYL 6 IODOCHROMEN 2 ONE; 3 BENZYL 6 NITROCHROMEN 2 ONE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 ISOPROPYL 3 (2 METHOXYBENZYL) 7 METHYL 2H CHROMEN 2 ONE; 5 METHOXY 3 (2 METHOXYBENZYL) 2H CHROMEN 2 ONE; 5 METHOXY 3 (2 METHOXYBENZYL) 8 METHYL 2H CHROMEN 2 ONE; 5 METHOXY 3 (3 METHOXYBENZYL) 7 METHYL 2H CHROMEN 2 ONE; 5 METHOXY 7 METHYL 3 (2 METHYLBENZYL) 2H CHROMEN 2 ONE; 5 METHOXY 7 METHYL 3 (4 METHYLBENZYL) 2H CHROMEN 2 ONE; 8 BROMO 6 CHLORO 3 METHYLCHROMEN 2 ONE; ALDEHYDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CHROMENE DERIVATIVE; COUMARIN DERIVATIVE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); SALICYLALDEHYDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RADIOASSAY; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; COUMARINS; DRUG INVERSE AGONISM; HUMANS; RATS; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62949184168     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.027     Document Type: Article

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