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The reported binding results (±SEM) were an average of 2-4 independent determinations, which were normally within 50% of the average value based on a standard sample. For the assay conditions for both the binding and functional assays, see: C.C. Felder, K.E. Joyce, E.M. Briley, J. Mansouri, K. Mackie, O. Blond, Y. Lai, A.L. Ma, and R.L. Mitchell Mol. Pharmacol. 48 1995 443
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12444325938
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WO Patent 03/082191 A2, 2003;
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1H NMR and/or LC-MS data were in agreement with the assigned structures. For full experimental and spectral details, see: Finke, P. E.; Meurer, L. C.; Debenham, J. S.; Toupence, R. B.; Walsh, T. F. WO Patent 03/082191 A2, 2003; Chem. Abstr. 2003, 139, 307686f
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12444270799
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WO Patent 03/084930 A1, 2003
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An EPO patent from Sanofi-Synthelabo related to this same 2-amido pyridine structure has recently been published, see: Barth, F.; Martinez, S.; Rinaldi-Carmona, M. WO Patent 03/084930 A1, 2003; Chem. Abstr. 2003, 139, 307689j
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12444330071
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note
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50 ratios were observed for the more active benzyloxy compounds of Tables 1 and 2 (50-500) than for the less active amides of Table 3 (0.2-10) and Table 4 (5-30)
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