Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRγ

European Journal of Immunology

Volumn 38, Issue 1, 2008, Pages 166-173

  Chu, Ching Liang ^a   Yu, Yen Ling ^a   Shen, Kuan Yin ^a   Lowell, Clifford A ^b   Lanier, Lewis L ^b   Hamerman, Jessica A ^c  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

Antigen presentation; Dendritic cell; TLR

Indexed keywords

ADAPTOR PROTEIN; B7 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 12P40; INTERLEUKIN 6; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN FCRGAMMA; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; BONE MARROW CELL; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGEN PRESENTATION; CYTOKINES; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, IGG; TOLL-LIKE RECEPTORS;

EID: 38349057561     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737600     Document Type: Article

References (39)

1. Granucci, F., Foti, M. and Ricciardi-Castagnoli, P., Dendritic cell biology. Adv. Immunol. 2005. 88: 193-233.
2. Reis e Sousa, C., Dendritic cells in a mature age. Nat. Rev. Immunol. 2006. 6: 476-483.
3. Lee, M. S. and Kim, Y. J., Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu. Rev. Biochem. 2007. 76: 447-480.
4. Kawai, T. and Akira, S., TLR signaling. Semin. Immunol. 2007. 19: 24-32.
5. Tomasello, E. and Vivier, E., KARAP/DAP12/TYROBP: Three names and a multiplicity of biological functions. Eur. J. Immunol. 2005. 35: 1670-1677.
6. Humphrey, M. B., Lanier, L. L. and Nakamura, M. C., Role of ITAM-containing adapter proteins and their receptors in the immune system and bone. Immunol. Rev. 2005. 208: 50-65.
7. Abram, C. L. and Lowell, C. A., The expanding role for ITAM-based signaling pathways in immune cells. Sci. STKE 2007. 2007: re2.
8. Hamerman, J. A., Tchao, N. K., Lowell, C. A. and Lanier, L. L., Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat. Immunol. 2005. 6: 579-586.
9. Hamerman, J. A., Jarjoura, J. R., Humphrey, M. B., Nakamura, M. C., Seaman, W. E. and Lanier, L. L., Cutting edge: Inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J. Immunol. 2006. 177: 2051-2055.
10. Turnbull, I. R., Gilfillan, S., Cella, M., Aoshi, T., Miller, M., Piccio, L., Hernandez, M. and Colonna, M., Cutting edge: TREM-2 attenuates macrophage activation. J. Immunol. 2006. 177: 3520-3524.
11. Fuchs, A., Cella, M., Kondo, T. and Colonna, M., Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44. Blood 2005. 106: 2076-2082.
12. Blasius, A. L., Cella, M., Maldonado, J., Takai, T. and Colonna, M., Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12. Blood 2006. 107: 2474-2476.
13. Sjolin, H., Robbins, S. H., Bessou, G., Hidmark, A., Tomasello, E., Johansson, M., Hall, H. et al., DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection. J. Immunol. 2006. 177: 2908-2916.
14. Hamerman, J. A. and Lanier, L. L., Inhibition of immune responses by ITAM-bearing receptors. Sci. STKE 2006. 2006: Re1.
15. Takaki, R., Watson, S. R. and Lanier, L. L., DAP12: An adapter protein with dual functionality. Immunol. Rev. 2006. 214: 118-129.
16. Barrow, A. D. and Trowsdale, J., You say ITAM and I say ITIM, let's call the whole thing off: The ambiguity of immunoreceptor signalling. Eur. J. Immunol. 2006. 36: 1646-1653.
17. Turnbull, I. R. and Colonna, M., Activating and inhibitory functions of DAP12. Nat. Rev. Immunol. 2007. 7: 155-161.
18. Brown, G. D., Dectin-1: A signalling non-TLR pattern-recognition receptor. Nat. Rev. Immunol. 2006. 6: 33-43.
19. Pasquier, B., Launay, P., Kanamaru, Y., Moura, I. C., Pfirsch, S., Ruffie, C., Henin, D. et al., Identification of FcαRI as an inhibitory receptor that controls inflammation: Dual role of FcRγ ITAM. Immunity 2005. 22: 31-42.
20. Cao, W., Rosen, D. B., Ito, T., Bover, L., Bao, M., Watanabe, G., Yao, Z. et al., Plasmacytoid dendritic cell-specific receptor ILT7-Fc εRI γ inhibits Toll-like receptor-induced interferon production. J. Exp. Med. 2006. 203: 1399-1405.
21. Boekhoudt, G. H., Frazier-Jessen, M. R. and Feldman, G. M., Immune complexes suppress IFN-γ signaling by activation of the FcγRI pathway. J. Leukoc. Biol. 2007. 81: 1086-1092.
22. Dietrich, J., Cella, M., Seiffert, M., Buhring, H. J. and Colonna, M., Cutting edge: Signal-regulatory protein β 1 is a DAP12-associated activating receptor expressed in myeloid cells. J. Immunol. 2000. 164: 9-12.
23. Tomasello, E., Desmoulins, P. O., Chemin, K., Guia, S., Cremer, H., Ortakldo, J., Love, P. et al., Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Immunity 2000. 13: 355-364.
24. Bouchon, A., Hernandez-Munain, C., Cella, M. and Colonna, M., A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. J. Exp. Med. 2001. 194: 1111-1122.
25. Kanazawa, N., Tashiro, K., Inaba, K. and Miyachi, Y., Dendritic cell immunoactivating receptor, a novel C-type lectin immunoreceptor, acts as an activating receptor through association with Fc receptor γ chain. J. Biol. Chem. 2003. 278: 32645-32652.
26. Merck, E., de Saint-Vis, B., Scuiller, M., Gaillard, C., Caux, C., Trinchieri, G. and Bates, E. E., Fc receptor γ-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses. Blood 2005. 105: 3623-3632.
27. Hara, H., Ishihara, C., Takeuchi, A., Imanishi, T., Xue, L., Morris, S. W., Inui, M. et al., The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat. Immunol. 2007. 8: 619-629.
28. Orabona, C., Tomasello, E., Fallarino, F., Bianchi, R., Volpi, C., Bellocchio, S., Romani, L. et al., Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12. Eur. J. Immunol. 2005. 35: 3111-3118.
29. Nakahashi, C., Tahara-Hanaoka, S., Totsuka, N., Okoshi, Y., Takai, T., Ohkohchi, N., Honda, S. et al., Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRγ chain on peritoneal macrophages. J. Immunol. 2007. 178: 765-770.
30. Klesney-Tait, J., Turnbull, I. R. and Colonna, M., The TREM receptor family and signal integration. Nat. Immunol. 2006. 7: 1266-1273.
31. Ishii, K. J. and Akira, S., Toll or Toll-free adjuvant path toward the optimal vaccine development. J. Clin. Immunol. 2007. 27: 363-371.
32. Gilboa, E., DC-based cancer vaccines. J. Clin. Invest. 2007. 117: 1195-1203.
33. Goldman, M., Translational mini-review series on Toll-like receptors: Toll-like receptor ligands as novel pharmaceuticals for allergic disorders. Clin. Exp. Immunol. 2007. 147: 208-216.
34. Kanzler, H., Barrat, F. J., Hessel, E. M. and Coffman, R. L., Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat. Med. 2007. 13: 552-559.
35. Chu, C. L. and Lowell, C. A., The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J. Immunol. 2005. 175: 2880-2889.
36. Bakker, A. B., Hoek, R. M., Cerwenka, A., Blom, B., Lucian, L., McNeil, T., Murray, R. et al., DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming. Immunity 2000. 13: 345-353.
37. Takai, T., Li, M., Sylvestre, D., Clynes, R. and Ravetch, J. V., FcRγ chain deletion results in pleiotrophic effector cell defects. Cell 1994. 76: 519-529.
38. Mocsai, A., Humphrey, M. B., Van Ziffle, J. A., Hu, Y., Burghardt, A., Spusta, S. C., Majumdar, S. et al., The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc. Natl. Acad. Sci. USA 2004. 101: 6158-6163.
39. Mocsai, A., Zhou, M., Meng, F., Tybulewicz, V. L. and Lowell, C. A., Syk is required for integrin signaling in neutrophils. Immunity 2002. 16: 547-558.