Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells

Anti-Cancer Drugs

Volumn 13, Issue 7, 2002, Pages 725-733

  Meinhardt, Gerold ^a   Eppinger, Elfriede ^a   Schmidmaier, Ralf ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Acute myeloid leukemia; Apoptosis; Chemotherapy; Differentiation; Protein kinase C

Indexed keywords

3 [2 [4 (4,4' DIFLUOROBENZHYDRYLIDENE)PIPERIDINO]ETHYL] 2,3 DIHYDRO 2 THIOXO 4(1H) QUINAZOLINONE; 5 CHLORO N HEPTYL 1 NAPHTHALENESULFONAMIDE; 6 [2 [4 [(4 FLUOROPHENYL)PHENYLMETHYLENE] 1 PIPERIDYL]ETHYL] 7 METHYL 5H THIAZOLO[3,2 A]PYRIMIDIN 5 ONE; BETA2 INTEGRIN; CYTARABINE; DIACYLGLYCEROL; ETOPOSIDE; FARNESYL THIOTRIAZOLE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C INHIBITOR; PROTEIN P21; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CD4 ANTIGEN; DIACYLGLYCEROL KINASE; DRUG DERIVATIVE; ENZYME ACTIVATOR; ENZYME INHIBITOR; FARNESOL; FARNESYLTHIOTRIAZOLE; GLYCOPROTEIN P 15095; ISOENZYME; N (M HEPTYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; N-(M-HEPTYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE; NAPHTHALENE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRIMIDINONE DERIVATIVE; QUINAZOLINE DERIVATIVE; QUINAZOLINONE DERIVATIVE; SULFONAMIDE; THIAZOLE DERIVATIVE; TRIAZOLE DERIVATIVE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL CYCLE; CELL CYCLE G2 PHASE; CELL DIFFERENTIATION; CELL MEMBRANE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; MODULATION; MYELOID LEUKEMIA; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; FLOW CYTOMETRY; IMMUNOBLOTTING; METABOLISM; ONCOGENE; PATHOLOGY;

ANTIGENS, CD11C; ANTIGENS, CD4; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; DIACYLGLYCEROL KINASE; ENZYME ACTIVATORS; ENZYME INHIBITORS; FARNESOL; FLOW CYTOMETRY; GENES, FOS; GENES, JUN; HUMAN; IMMUNOBLOTTING; ISOENZYMES; LEUKEMIA, MYELOID; NAPHTHALENES; ONCOGENE PROTEIN P21(RAS); PIPERIDINES; PROTEIN KINASE C; PYRIMIDINONES; QUINAZOLINES; SULFONAMIDES; THIAZOLES; TRIAZOLES; TUMOR CELLS, CULTURED; HUMANS; QUINAZOLINONES;

EID: 0036667947     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200208000-00007     Document Type: Article

References (37)

1. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
2. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
3. Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells
4. Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
5. Atypical protein kinase C protects human leukemia cells against drug-induced apoptosis
6. Overexpression of protein kinase C isoform epsilon but not delta in human interleukin-3-dependent cells suppresses apoptosis and induces bcl-2 expression
7. Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis
8. Differential regulation of protein kinase C isozymes by Bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts
9. Modulation of resistance to ara-C by Bryostatin in fresh blast cells from patients with AML
10. A phase II trial of Bryostatin 1 in the treatment of metastatic colorectal cancer
11. Phase II study of Bryostatin 1 in patients with relapsed multiple myeloma
12. A phase II trial of Bryostatin-1 for patients with metastatic renal cell carcinoma
13. Treatment of patients with metastatic melanoma with Bryostatin-1 - A phase II study
14. A phase II trial of Bryostatin 1 in patients with non-Hodgkin's lymphoma
15. Phase II trial of Bryostatin 1 in patients with relapsed low-grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia
16. Farnesyl thiotriazole, a potent neutrophil agonist and structurally novel activator of protein kinase C
17. R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet
18. The use of diacylglycerol kinase inhibitors for elucidating the roles of protein kinase C
19. Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a
20. Differential regulations of phosphatidylcholine biosynthesis in U937 cells by inhibitors of protein and tyrosine kinases
21. Activation of protein kinase C relays distinct signaling pathways in the same cell type: Differentiation and caspase-mediated apoptosis
22. Protein kinase C activation modulates pro- and anti-apoptotic signaling pathways
23. TPA-induced differentiation and adhesion of U937 cells: Changes in ultrastructure, cytoskeletal organization and expression of cell surface antigens
24. Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors
25. Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C
26. Signaling defect in the activation of caspase-3 and PKCdelta in human TUR leukemia cells is associated with resistance to apoptosis
27. Selectivity of the diacylglycerol kinase inhibitor 3-[2-(4-[bis-(4-fluorophenyl) methylene]-1-piperidinyl)ethyl]-2, 3-dihydro 2-thioxo-4(1H)quinazolinone (R59949) among diacylglycerol kinase subtypes
28. Molecular cloning and characterization of a novel human diacylglycerol kinase ξ
29. Subcellular localization of diacylglycerol kinase activity in stimulated and unstimulated human peripheral blood lymphocytes and neutrophils
30. Increased adhesion of peripheral blood neutrophils from patients with localized juvenile periodontitis
31. Apoptosis of human leukemic HL-60 cells induced to differentiate by phorbol ester treatment
32. 1 arrest
33. Effects of Bryostatin 1 and calcium ionophore (A23187) on apoptosis and differentiation in human myeloid leukemia cells (HL-60) following 1-beta-d-arabinofuranosylcytosine exposure
34. The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
35. Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells
36. Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: Implications for apoptosis
37. Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector