The rapid activation of N-Ras by α-thrombin in fibroblasts is mediated by the specific G-protein Gαi2-Gβ1-Gγ5 and occurs in lipid rafts

Cellular Signalling

Volumn 21, Issue 6, 2009, Pages 1007-1014

  Lents, Nathan H ^b   Irintcheva, Virginia ^a   Goel, Reema ^a   Wheeler, Leroy W ^a   Baldassare, Joseph J ^a  

^a SAINT LOUIS UNIVERSITY   (United States)

^b JOHN JAY COLLEGE OF CRIMINAL JUSTICE   (United States)

Author keywords

thrombin; Caveolae; G protein; GPCR; Lipid rafts; PAR1; Ras

Indexed keywords

DIMER; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA I2 SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA1 SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA5 SUBUNIT; ISOPROTEIN; PROTEINASE ACTIVATED RECEPTOR 1; RAS PROTEIN; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CAVEOLA; CELL MEMBRANE; CELL SPECIFICITY; CELL TYPE; CONTROLLED STUDY; FIBROBLAST; LIPID COMPOSITION; LIPID RAFT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ANIMALS; CHO CELLS; CHOLESTEROL; CRICETINAE; CRICETULUS; FIBROBLASTS; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; GUANINE NUCLEOTIDE-RELEASING FACTOR 2; HUMANS; MEMBRANE MICRODOMAINS; PROTEIN BINDING; PROTEIN TRANSPORT; RAS PROTEINS; SIGNAL TRANSDUCTION; THROMBIN;

EID: 62749198071     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2009.02.016     Document Type: Article

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