메뉴 건너뛰기




Volumn 272, Issue 5270, 1996, Pages 1950-1953

Nonselective and G(βγ)-insensitive weaver K+ channels

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; POTASSIUM CHANNEL; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL;

EID: 0029666231     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.272.5270.1950     Document Type: Article
Times cited : (147)

References (21)
  • 6
    • 0023132940 scopus 로고    scopus 로고
    • D. E. Logothetis, Y. Kurachi, J. Galper, E. J. Neer, D. E. Clapham, Nature 325, 321 (1987); K. D. Wickman et al., ibid. 368, 255 (1994); E. Reuveny et al., ibid. 370, 143 (1994); C.-H. Huang, P. A. Slesinger, P. J. Casey, Y. N. Jan, L. Y. Jan, Neuron 15, 1133 (1995); P. A. Slesinger, E. Reuveny, Y. N. Jan, L. Y. Jan, ibid., p. 1145; G. Krapivinsky et al., J. Biol. Chem. 270, 29059 (1995).
    • (1987) Nature , vol.325 , pp. 321
    • Logothetis, D.E.1    Kurachi, Y.2    Galper, J.3    Neer, E.J.4    Clapham, D.E.5
  • 7
    • 0028180952 scopus 로고
    • D. E. Logothetis, Y. Kurachi, J. Galper, E. J. Neer, D. E. Clapham, Nature 325, 321 (1987); K. D. Wickman et al., ibid. 368, 255 (1994); E. Reuveny et al., ibid. 370, 143 (1994); C.-H. Huang, P. A. Slesinger, P. J. Casey, Y. N. Jan, L. Y. Jan, Neuron 15, 1133 (1995); P. A. Slesinger, E. Reuveny, Y. N. Jan, L. Y. Jan, ibid., p. 1145; G. Krapivinsky et al., J. Biol. Chem. 270, 29059 (1995).
    • (1994) Nature , vol.368 , pp. 255
    • Wickman, K.D.1
  • 8
    • 0028322077 scopus 로고
    • D. E. Logothetis, Y. Kurachi, J. Galper, E. J. Neer, D. E. Clapham, Nature 325, 321 (1987); K. D. Wickman et al., ibid. 368, 255 (1994); E. Reuveny et al., ibid. 370, 143 (1994); C.-H. Huang, P. A. Slesinger, P. J. Casey, Y. N. Jan, L. Y. Jan, Neuron 15, 1133 (1995); P. A. Slesinger, E. Reuveny, Y. N. Jan, L. Y. Jan, ibid., p. 1145; G. Krapivinsky et al., J. Biol. Chem. 270, 29059 (1995).
    • (1994) Nature , vol.370 , pp. 143
    • Reuveny, E.1
  • 9
    • 0028792375 scopus 로고
    • D. E. Logothetis, Y. Kurachi, J. Galper, E. J. Neer, D. E. Clapham, Nature 325, 321 (1987); K. D. Wickman et al., ibid. 368, 255 (1994); E. Reuveny et al., ibid. 370, 143 (1994); C.-H. Huang, P. A. Slesinger, P. J. Casey, Y. N. Jan, L. Y. Jan, Neuron 15, 1133 (1995); P. A. Slesinger, E. Reuveny, Y. N. Jan, L. Y. Jan, ibid., p. 1145; G. Krapivinsky et al., J. Biol. Chem. 270, 29059 (1995).
    • (1995) Neuron , vol.15 , pp. 1133
    • Huang, C.-H.1    Slesinger, P.A.2    Casey, P.J.3    Jan, Y.N.4    Jan, L.Y.5
  • 10
    • 0023132940 scopus 로고    scopus 로고
    • D. E. Logothetis, Y. Kurachi, J. Galper, E. J. Neer, D. E. Clapham, Nature 325, 321 (1987); K. D. Wickman et al., ibid. 368, 255 (1994); E. Reuveny et al., ibid. 370, 143 (1994); C.-H. Huang, P. A. Slesinger, P. J. Casey, Y. N. Jan, L. Y. Jan, Neuron 15, 1133 (1995); P. A. Slesinger, E. Reuveny, Y. N. Jan, L. Y. Jan, ibid., p. 1145; G. Krapivinsky et al., J. Biol. Chem. 270, 29059 (1995).
    • Neuron , pp. 1145
    • Slesinger, P.A.1    Reuveny, E.2    Jan, Y.N.3    Jan, L.Y.4
  • 11
    • 0028971463 scopus 로고
    • D. E. Logothetis, Y. Kurachi, J. Galper, E. J. Neer, D. E. Clapham, Nature 325, 321 (1987); K. D. Wickman et al., ibid. 368, 255 (1994); E. Reuveny et al., ibid. 370, 143 (1994); C.-H. Huang, P. A. Slesinger, P. J. Casey, Y. N. Jan, L. Y. Jan, Neuron 15, 1133 (1995); P. A. Slesinger, E. Reuveny, Y. N. Jan, L. Y. Jan, ibid., p. 1145; G. Krapivinsky et al., J. Biol. Chem. 270, 29059 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 29059
    • Krapivinsky, G.1
  • 14
    • 8944239513 scopus 로고    scopus 로고
    • For in situ hybridization, brains from 6-day-old B6CBA mice were dissected free of the skull and immediately frozen. Sagittal sections were cut, transferred to coated slides, and fixed in paraformaldehyde. Sections were hybridized with digoxigenin-labeled RNA probes with the use of reagents from Boehringer Mannheim according to the manufacturer's protocol. After hybridization at 59°C, sections were washed and incubated with an alkaline phosphatase-labeled antibody to digoxigenin (Boehringer Mannheim) and developed in substrate buffer for 2 to 6 hours in a volume of ≃ 100 μl per slide. Each 100 μl of hybridization buffer contained 100 ng of probe and 50% formamide, 5x standard saline citrate, yeast RNA (1 mg/ml), 1x Denhardt's, 0.1% Tween-20, 0.1% CHAPS detergent, and 5 mM EDTA. Additional information about the expression of GIRK1 and GIRK2 is available at http:// peterson02.mc.duke.edu.
  • 15
    • 8944221296 scopus 로고    scopus 로고
    • note
    • +] increased the number of cells transfected with wvGIRK2 or wvGIRK2-GIRK1 that survived. NMDG-containing media did not change the expression of wild-type GIRK2 or GIRK1.
  • 16
    • 8944251708 scopus 로고    scopus 로고
    • note
    • +, filtered at 5 kHz (8-pole Bessel filter), and digitized at 25 kHz (pCLAMP6).
  • 17
    • 0028267224 scopus 로고
    • L. Heginbotham, Z. Lu, T. Abramson, R. MacKinnon, Biophys. J. 66, 1061 (1994); L. Heginbotham, T. Abramson, R. MacKinnon, Science 258, 1152 (1992). P. A. Slesinger et al. [Neuron 16, 321 (1996)] have reported a loss of selectivity of truncated wvGIRK2 and wvGIRK2-containing channels.
    • (1994) Biophys. J. , vol.66 , pp. 1061
    • Heginbotham, L.1    Lu, Z.2    Abramson, T.3    MacKinnon, R.4
  • 18
    • 0026446347 scopus 로고
    • L. Heginbotham, Z. Lu, T. Abramson, R. MacKinnon, Biophys. J. 66, 1061 (1994); L. Heginbotham, T. Abramson, R. MacKinnon, Science 258, 1152 (1992). P. A. Slesinger et al. [Neuron 16, 321 (1996)] have reported a loss of selectivity of truncated wvGIRK2 and wvGIRK2-containing channels.
    • (1992) Science , vol.258 , pp. 1152
    • Heginbotham, L.1    Abramson, T.2    MacKinnon, R.3
  • 19
    • 0030045830 scopus 로고    scopus 로고
    • L. Heginbotham, Z. Lu, T. Abramson, R. MacKinnon, Biophys. J. 66, 1061 (1994); L. Heginbotham, T. Abramson, R. MacKinnon, Science 258, 1152 (1992). P. A. Slesinger et al. [Neuron 16, 321 (1996)] have reported a loss of selectivity of truncated wvGIRK2 and wvGIRK2-containing channels.
    • (1996) Neuron , vol.16 , pp. 321
    • Slesinger, P.A.1
  • 21
    • 8944262933 scopus 로고    scopus 로고
    • note
    • βγ, and S. Manahan for assistance with cell culture. Supported by a Colciencias award to B.N., a National Research Service Award award to M.E.K., a Minnesota American Heart Association award to B.V., and an NIH grant to D.E.C. A.S.P. is a Sandoz scholar and is supported by a grant from the National Down Syndrome Society.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.