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Volumn 46, Issue 1, 2009, Pages 65-71

Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis

Author keywords

Apoptosis; CNTF; Pancreatic islets; SOCS3; STAT3

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CILIARY NEUROTROPHIC FACTOR; COLLAGENASE; CURCUMIN; GLUCOSE; INSULIN; JANUS KINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; WORTMANNIN;

EID: 62749178498     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2008.12.014     Document Type: Article
Times cited : (36)

References (47)
  • 1
    • 0035947044 scopus 로고    scopus 로고
    • Role of insulin and insulin receptor in learning and memory
    • Zhao W.Q., and Alkon D.L. Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol 177 (2001) 125-134
    • (2001) Mol Cell Endocrinol , vol.177 , pp. 125-134
    • Zhao, W.Q.1    Alkon, D.L.2
  • 2
    • 1842633872 scopus 로고    scopus 로고
    • Insulin and the insulin receptor in experimental models of learning and memory
    • Zhao W.Q., Chen H., Quon M.J., and Alkon D.L. Insulin and the insulin receptor in experimental models of learning and memory. Eur J Pharmacol 490 (2004) 71-81
    • (2004) Eur J Pharmacol , vol.490 , pp. 71-81
    • Zhao, W.Q.1    Chen, H.2    Quon, M.J.3    Alkon, D.L.4
  • 3
  • 5
    • 0027163502 scopus 로고
    • Temporal and spatial expression of ciliary neurotrophic factor after peripheral nerve injury
    • Smith G.M., Eric D., Rabinovsky J.L., McManaman J.L., and Shine D.H. Temporal and spatial expression of ciliary neurotrophic factor after peripheral nerve injury. Exp Neurol 121 (1993) 239-247
    • (1993) Exp Neurol , vol.121 , pp. 239-247
    • Smith, G.M.1    Eric, D.2    Rabinovsky, J.L.3    McManaman, J.L.4    Shine, D.H.5
  • 7
    • 0942266055 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor: a role in obesity?
    • Duff E., and Baile C.A. Ciliary neurotrophic factor: a role in obesity?. Nutr Rev 61 (2003) 423-426
    • (2003) Nutr Rev , vol.61 , pp. 423-426
    • Duff, E.1    Baile, C.A.2
  • 8
    • 0025983810 scopus 로고
    • Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain
    • Stöckli K.A., Lillien L.E., Näher-Noé M., Breitfeld G., Hughes R.A., Raff M.C., et al. Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain. J Cell Biol 115 (1991) 447-459
    • (1991) J Cell Biol , vol.115 , pp. 447-459
    • Stöckli, K.A.1    Lillien, L.E.2    Näher-Noé, M.3    Breitfeld, G.4    Hughes, R.A.5    Raff, M.C.6
  • 9
    • 0029058922 scopus 로고
    • A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury
    • Winter C.G., Saotome Y., Levison S.W., and Hirsh D. A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury. Proc Natl Acad Sci USA 20 92 (1995) 5865-5869
    • (1995) Proc Natl Acad Sci USA , vol.20 , Issue.92 , pp. 5865-5869
    • Winter, C.G.1    Saotome, Y.2    Levison, S.W.3    Hirsh, D.4
  • 10
    • 0030948031 scopus 로고    scopus 로고
    • Transient up-regulation of ciliary neurotrophic factor receptor-alpha mRNA in axotomized rat septal neurons
    • Lee M.Y., Naumann T., Kirsch M., Frotscher M., and Hofmann H.D. Transient up-regulation of ciliary neurotrophic factor receptor-alpha mRNA in axotomized rat septal neurons. Eur J Neurosci 9 g1033 (1997) 622-626
    • (1997) Eur J Neurosci , vol.9 , Issue.g1033 , pp. 622-626
    • Lee, M.Y.1    Naumann, T.2    Kirsch, M.3    Frotscher, M.4    Hofmann, H.D.5
  • 11
    • 0037085721 scopus 로고    scopus 로고
    • CNTF and CNTF receptor alpha are constitutively expressed by astrocytes in the mouse brain
    • Dallner C., Woods A.G., Deller T., Kirsch M., and Hofmann H.D. CNTF and CNTF receptor alpha are constitutively expressed by astrocytes in the mouse brain. Glia 15 (2002) 374-378
    • (2002) Glia , vol.15 , pp. 374-378
    • Dallner, C.1    Woods, A.G.2    Deller, T.3    Kirsch, M.4    Hofmann, H.D.5
  • 12
    • 0029813807 scopus 로고    scopus 로고
    • Differential expression of ciliary neurotrophic factor receptor in skeletal muscle of chick and rat after nerve injury
    • Ip F.C., Fu A.K., Tsim K.W., and Ip N.Y. Differential expression of ciliary neurotrophic factor receptor in skeletal muscle of chick and rat after nerve injury. J Neurochem 67 1033 (1996) 1607-1612
    • (1996) J Neurochem , vol.67 , Issue.1033 , pp. 1607-1612
    • Ip, F.C.1    Fu, A.K.2    Tsim, K.W.3    Ip, N.Y.4
  • 13
    • 0034979217 scopus 로고    scopus 로고
    • Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease
    • de Almeida L.P., Zala D., Aebischer P., and Déglon N. Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease. Neurobiol Dis 8 (2001) 433-446
    • (2001) Neurobiol Dis , vol.8 , pp. 433-446
    • de Almeida, L.P.1    Zala, D.2    Aebischer, P.3    Déglon, N.4
  • 14
    • 0034212562 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia
    • Peterson W.M., Wang Q., Tzekova R., and Wiegand S.J. Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia. J Neurosci 20 1033 (2000) 4081-4090
    • (2000) J Neurosci , vol.20 , Issue.1033 , pp. 4081-4090
    • Peterson, W.M.1    Wang, Q.2    Tzekova, R.3    Wiegand, S.J.4
  • 15
    • 0027484249 scopus 로고
    • Disruption of the CNTF gene results in motor neuron degeneration
    • Masu Y., Wolf E., Holtmann B., Sendtner M., Brem G., and Thoenen H. Disruption of the CNTF gene results in motor neuron degeneration. Nature 365 27-32 (1993) 1033
    • (1993) Nature , vol.365 , Issue.27-32 , pp. 1033
    • Masu, Y.1    Wolf, E.2    Holtmann, B.3    Sendtner, M.4    Brem, G.5    Thoenen, H.6
  • 16
    • 0031037661 scopus 로고    scopus 로고
    • Evidence for multiple, local functions of ciliary neurotrophic factor (CNTF) in retinal development: expression of CNTF and its receptors and in vitro effects on target cells
    • Kirsch M., Lee M., Meyer V., Wiese A., and Hofmann H.D. Evidence for multiple, local functions of ciliary neurotrophic factor (CNTF) in retinal development: expression of CNTF and its receptors and in vitro effects on target cells. J Neurochem 68 (1997) 979-990
    • (1997) J Neurochem , vol.68 , pp. 979-990
    • Kirsch, M.1    Lee, M.2    Meyer, V.3    Wiese, A.4    Hofmann, H.D.5
  • 17
    • 0031710647 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase
    • Wadt K.A., Larsen C.M., Andersen H.U., Nielsen K., Karlsen A.E., and Mandrup-Poulsen T. Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase. Diabetes 47 (1998) 1602-1608
    • (1998) Diabetes , vol.47 , pp. 1602-1608
    • Wadt, K.A.1    Larsen, C.M.2    Andersen, H.U.3    Nielsen, K.4    Karlsen, A.E.5    Mandrup-Poulsen, T.6
  • 18
    • 35848933266 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor promotes survival of neonatal rat islets via the BCL-2 anti-apoptotic pathway
    • Rezende L.F., Stoppiglia L.F., Souza K.L., Negro A., Langone F., and Boschero A.C. Ciliary neurotrophic factor promotes survival of neonatal rat islets via the BCL-2 anti-apoptotic pathway. J Endocrinol 195 (2007) 157-165
    • (2007) J Endocrinol , vol.195 , pp. 157-165
    • Rezende, L.F.1    Stoppiglia, L.F.2    Souza, K.L.3    Negro, A.4    Langone, F.5    Boschero, A.C.6
  • 19
    • 0345121142 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance
    • Gloaguen I., Costa P., Demartis A., Lazzaro D., Di Marco A., Graziani R., et al. Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci USA 10 94 (1997) 6456-6461
    • (1997) Proc Natl Acad Sci USA , vol.10 , Issue.94 , pp. 6456-6461
    • Gloaguen, I.1    Costa, P.2    Demartis, A.3    Lazzaro, D.4    Di Marco, A.5    Graziani, R.6
  • 20
    • 0035836760 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity
    • Lambert P.D., Anderson K.D., Sleeman M.W., Wong V., Tan J., Hijarunguru A., et al. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci USA 10 98 (2001) 4652-4657
    • (2001) Proc Natl Acad Sci USA , vol.10 , Issue.98 , pp. 4652-4657
    • Lambert, P.D.1    Anderson, K.D.2    Sleeman, M.W.3    Wong, V.4    Tan, J.5    Hijarunguru, A.6
  • 21
    • 0345060844 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice
    • Sleeman M.W., Garcia K., Liu R., Murray J.D., Malinova L., Moncrieffe M., et al. Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice. Proc Natl Acad Sci USA 100 (2003) 14297-14302
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14297-14302
    • Sleeman, M.W.1    Garcia, K.2    Liu, R.3    Murray, J.D.4    Malinova, L.5    Moncrieffe, M.6
  • 22
    • 7044272602 scopus 로고    scopus 로고
    • Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice
    • Erratum in: Diabetes 54:296. Sleemann, Mark W [corrected to Sleeman, Mark W]
    • Blüher S., Moschos S., Bullen Jr. J., Kokkotou E., Maratos-Flier E., Wiegand S.J., et al. Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice. Diabetes 1 (2004) 2787-2796 Erratum in: Diabetes 54:296. Sleemann, Mark W [corrected to Sleeman, Mark W]
    • (2004) Diabetes , vol.1 , pp. 2787-2796
    • Blüher, S.1    Moschos, S.2    Bullen Jr., J.3    Kokkotou, E.4    Maratos-Flier, E.5    Wiegand, S.J.6
  • 23
    • 12144287927 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain
    • Kelly J.F., Elias C.F., Lee C.E., Ahima R.S., Seeley R.J., Bjørbaek C., et al. Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain. Diabetes 53 (2004) 911-920
    • (2004) Diabetes , vol.53 , pp. 911-920
    • Kelly, J.F.1    Elias, C.F.2    Lee, C.E.3    Ahima, R.S.4    Seeley, R.J.5    Bjørbaek, C.6
  • 24
    • 4444236708 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor influences endocrine adipocyte function: inhibition of leptin via PI 3-kinase
    • Ott V., Fasshauer M., Meier B., Dalski A., Kraus D., Gettys T.W., et al. Ciliary neurotrophic factor influences endocrine adipocyte function: inhibition of leptin via PI 3-kinase. Mol Cell Endocrinol 224 (2004) 21-27
    • (2004) Mol Cell Endocrinol , vol.224 , pp. 21-27
    • Ott, V.1    Fasshauer, M.2    Meier, B.3    Dalski, A.4    Kraus, D.5    Gettys, T.W.6
  • 25
    • 33646576549 scopus 로고    scopus 로고
    • Overcoming insulin resistance with CNTF
    • Ahima R.S. Overcoming insulin resistance with CNTF. Nat Med 12 (2006) 511-512
    • (2006) Nat Med , vol.12 , pp. 511-512
    • Ahima, R.S.1
  • 27
    • 0029986152 scopus 로고    scopus 로고
    • STAT proteins are activated by ciliary neurotrophic factor in cells of central nervous system origin
    • Rajan P., Symes A.J., and Fink J.S. STAT proteins are activated by ciliary neurotrophic factor in cells of central nervous system origin. J Neurosci Res 43 4 (1996) 403-411
    • (1996) J Neurosci Res , vol.43 , Issue.4 , pp. 403-411
    • Rajan, P.1    Symes, A.J.2    Fink, J.S.3
  • 28
    • 0030890718 scopus 로고    scopus 로고
    • Gp130 and the interleukin-6 family of cytokines
    • Review
    • Taga T., and Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 15 (1997) 797-819 Review
    • (1997) Annu Rev Immunol , vol.15 , pp. 797-819
    • Taga, T.1    Kishimoto, T.2
  • 29
    • 11844304348 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor protects rat retina cells in vitro and in vivo via PI3 kinase
    • Ikeda K., Tatsuno T., Noguchi H., and Nakayama C. Ciliary neurotrophic factor protects rat retina cells in vitro and in vivo via PI3 kinase. Curr Eye Res 29 (2004) 349-355
    • (2004) Curr Eye Res , vol.29 , pp. 349-355
    • Ikeda, K.1    Tatsuno, T.2    Noguchi, H.3    Nakayama, C.4
  • 30
    • 7744233466 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor promotes muller glia differentiation from the postnatal retinal progenitor pool
    • Goureau O., Rhee K.D., and Yang X.J. Ciliary neurotrophic factor promotes muller glia differentiation from the postnatal retinal progenitor pool. Dev Neurosci 26 (2004) 359-370
    • (2004) Dev Neurosci , vol.26 , pp. 359-370
    • Goureau, O.1    Rhee, K.D.2    Yang, X.J.3
  • 31
    • 0036731485 scopus 로고    scopus 로고
    • Stats. Transcriptional control and biological impact
    • Levy D.E., and Darnell Jr. J.E. Stats. Transcriptional control and biological impact. Nat Rev Mol Cell Biol 1-2 (2002) 651-662
    • (2002) Nat Rev Mol Cell Biol , vol.1-2 , pp. 651-662
    • Levy, D.E.1    Darnell Jr., J.E.2
  • 32
    • 0037138370 scopus 로고    scopus 로고
    • Signaling through the JAK/STAT pathway, recent advances and future challenges
    • Kisseleva T., Bhattacharya S., Braunstein J., and Schindler C.W. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 20 285 (2002) 1-24
    • (2002) Gene , vol.20 , Issue.285 , pp. 1-24
    • Kisseleva, T.1    Bhattacharya, S.2    Braunstein, J.3    Schindler, C.W.4
  • 33
    • 0035941135 scopus 로고    scopus 로고
    • STAM/EAST/Hbp adapter proteins--integrators of signaling pathways
    • Review
    • Lohi O., and Lehto V.P. STAM/EAST/Hbp adapter proteins--integrators of signaling pathways. FEBS Lett 508 (2001) 287-290 Review
    • (2001) FEBS Lett , vol.508 , pp. 287-290
    • Lohi, O.1    Lehto, V.P.2
  • 35
    • 0034872381 scopus 로고    scopus 로고
    • Functional effects of APS and SH2-B on insulin receptor signaling
    • Review
    • Ahmed Z., and Pillay T.S. Functional effects of APS and SH2-B on insulin receptor signaling. Biochem Soc Trans Pt 4 (2001) 529-534 Review
    • (2001) Biochem Soc Trans , vol.PART 4 , pp. 529-534
    • Ahmed, Z.1    Pillay, T.S.2
  • 36
    • 0347093460 scopus 로고    scopus 로고
    • Inhibitors of cytokine signal transduction
    • Review
    • Wormald S., and Hilton D.J. Inhibitors of cytokine signal transduction. J Biol Chem 279 (2004) 821-884 Review
    • (2004) J Biol Chem , vol.279 , pp. 821-884
    • Wormald, S.1    Hilton, D.J.2
  • 37
    • 0035834171 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 (SOCS-3) protects beta-cells against interleukin-1beta and interferon-gamma-mediated toxicity
    • Karlsen A.E., Rønn S.G., Lindberg K., Johannesen J., Galsgaard E.D., Pociot F., et al. Suppressor of cytokine signaling 3 (SOCS-3) protects beta-cells against interleukin-1beta and interferon-gamma-mediated toxicity. Proc Natl Acad Sci USA 98 (2001) 2191-2196
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2191-2196
    • Karlsen, A.E.1    Rønn, S.G.2    Lindberg, K.3    Johannesen, J.4    Galsgaard, E.D.5    Pociot, F.6
  • 38
    • 19944429062 scopus 로고    scopus 로고
    • Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways
    • Karlsen A.E., Heding P.E., Frobøse H., Rønn S.G., Kruhøffer M., Orntoft T.F., et al. Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways. Diabetologia 11 (2004) 1998-2011
    • (2004) Diabetologia , vol.11 , pp. 1998-2011
    • Karlsen, A.E.1    Heding, P.E.2    Frobøse, H.3    Rønn, S.G.4    Kruhøffer, M.5    Orntoft, T.F.6
  • 39
    • 34250675270 scopus 로고    scopus 로고
    • Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes
    • Mori H., Shichita T., Yu Q., Yoshida R., Hashimoto M., Okamoto F., et al. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Biochem Biophys Res Commun 359 (2007) 952-958
    • (2007) Biochem Biophys Res Commun , vol.359 , pp. 952-958
    • Mori, H.1    Shichita, T.2    Yu, Q.3    Yoshida, R.4    Hashimoto, M.5    Okamoto, F.6
  • 41
    • 33644684253 scopus 로고    scopus 로고
    • Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta cells
    • Laubner K., Kieffer T.J., Lam N.T., Niu X., Jakob F., and Seufert J. Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta cells. Diabetes 54 (2005) 3407-3410
    • (2005) Diabetes , vol.54 , pp. 3407-3410
    • Laubner, K.1    Kieffer, T.J.2    Lam, N.T.3    Niu, X.4    Jakob, F.5    Seufert, J.6
  • 42
    • 33846134010 scopus 로고    scopus 로고
    • Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release
    • Nakata M., Okada T., Ozawa K., and Yada T. Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release. Biochem Biophys Res Commun 353 (2007) 1046-1051
    • (2007) Biochem Biophys Res Commun , vol.353 , pp. 1046-1051
    • Nakata, M.1    Okada, T.2    Ozawa, K.3    Yada, T.4
  • 43
    • 0033324777 scopus 로고    scopus 로고
    • Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor
    • Bjørbaek C., Elmquist J.K., El-Haschimi K., Kelly J., Ahima R.S., Hileman S., et al. Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor. Endocrinology 140 (1999) 2035-2043
    • (1999) Endocrinology , vol.140 , pp. 2035-2043
    • Bjørbaek, C.1    Elmquist, J.K.2    El-Haschimi, K.3    Kelly, J.4    Ahima, R.S.5    Hileman, S.6
  • 44
    • 0034612271 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
    • Nicholson S.E., De Souza D., Fabri L.J., Corbin J., Willson T.A., Zhang J.G., et al. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc Natl Acad Sci USA 97 (2000) 6493-6498
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6493-6498
    • Nicholson, S.E.1    De Souza, D.2    Fabri, L.J.3    Corbin, J.4    Willson, T.A.5    Zhang, J.G.6
  • 45
    • 0034724677 scopus 로고    scopus 로고
    • SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
    • Schmitz J., Weissenbach M., Haan S., Heinrich P.C., and Schaper F. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J Biol Chem 275 (2000) 12848-12856
    • (2000) J Biol Chem , vol.275 , pp. 12848-12856
    • Schmitz, J.1    Weissenbach, M.2    Haan, S.3    Heinrich, P.C.4    Schaper, F.5
  • 46
    • 38949207497 scopus 로고    scopus 로고
    • Prolactin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: involvement of p-38 MAP kinase, STAT3 and NF-kappaB
    • Epub 2008
    • Sodhi A., and Tripathi A. Prolactin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: involvement of p-38 MAP kinase, STAT3 and NF-kappaB. Cytokine 41 2 (2008) 162-173 Epub 2008
    • (2008) Cytokine , vol.41 , Issue.2 , pp. 162-173
    • Sodhi, A.1    Tripathi, A.2
  • 47
    • 42649116579 scopus 로고    scopus 로고
    • Regulation of IL-6 induced hepatic insulin resistance by mtor through the STAT3-SOCS3 pathway
    • Nov 10 [Epub ahead of print
    • Kim JH, Kim JE, Liu HY, Cao W, Chen J. Regulation of IL-6 induced hepatic insulin resistance by mtor through the STAT3-SOCS3 pathway. J Biol Chem 2007;Nov 10 [Epub ahead of print].
    • (2007) J Biol Chem
    • Kim, J.H.1    Kim, J.E.2    Liu, H.Y.3    Cao, W.4    Chen, J.5


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