Evidence for multiple, local functions of ciliary neurotrophic factor (CNTF) in retinal development: Expression of CNTF and its receptor and in vitro effects on target cells

Journal of Neurochemistry

Volumn 68, Issue 3, 1997, Pages 979-990

  Kirsch, Matthias ^a   Lee, Mun Yong ^a   Meyer, Verena ^b   Wiese, Annette ^a   Hofmann, Hans Dieter ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Ciliary neurotrophic factor; Ciliary neurotrophic factor receptor; Development; Neurotrophic factor; Rat; Retina

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; CELL SURVIVAL; CHICK EMBRYO; CILIARY GANGLION; CONTROLLED STUDY; EMBRYO; MUELLER CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA CELL; RETINA DEVELOPMENT;

ANIMALIA;

EID: 0031037661     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68030979.x     Document Type: Article

References (59)

1. Altshuler D. and Cepko C. (1992) A temporally regulated, diffusible activity is required for rod photoreceptor development in vitro. Development 114, 947-957.
2. Arakawa Y., Sendtner M., and Thoenen H. (1990) Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines. J. Neurosci. 10, 3507-3515.
3. Bazan J. F. (1991) Neuropoietic cytokines in the hematopoietic fold. Neuron 7, 197-208.
4. Bottenstein J. E. and Sato G. H. (1979) Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc. Natl. Acad. Sci. USA 76, 514-517.
5. Celi F. S., Zenilman M. E., and Shuldiner A. R. (1993) A rapid and versatile method to synthesize internal standards for competitive PCR. Nucleic Acids Res. 21, 1047.
6. Cepko C. L., Austin C. P., Yang X. J., Alexiades M., and Ezzeddine D. (1996) Cell fate determination in the vertebrate retina. Proc. Natl. Acad. Sci. USA 93, 589-595.
7. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
8. Davis S., Aldrich T. H., Valenzuela D. M., Wong V. V., Furth M. E., Squinto S. P., and Yancopoulos G. D. (1991) The receptor for ciliary neurotrophic factor. Science 253, 59-63.
9. Davis S., Aldrich T. H., Ip N. Y., Stahl N., Scherer S., Farruggella T., DiStefano P. S., Curtis R., Panayotatos N., Gascan H., Chevalier S., and Yancopoulos G. D. (1993) Released form of CNTF receptor a component as a soluble mediator of CNTF responses. Science 259, 1736-1739.
10. DeChiara T. M., Vejsada R., Poueymirou W. T., Acheson A., Suri C., Conover J. C., Friedman B., McClain J., Pan L., Stahl N., Ip N. Y., Kato A., and Yancopoulos G. D. (1995) Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell 83, 313-322.
11. Dobrea G. M., Unnerstall J. R., and Rao M. S. (1992) The expression of CNTF message and immunoreactivity in the central and peripheral nervous system of the rat. Dev. Brain Res. 66, 209-219.
12. Ernsberger U., Sendtner M., and Rohrer H. (1989) Proliferation and differentiation of embryonic chick sympathetic neurons: effects of ciliary neurotrophic factor. Neuron 2, 1275-1284.
13. Fonnum F. (1975) A rapid radiochemical method for the determination of choline acetyltransferase. J. Neurochem. 24, 407-409.
14. Förster E., Otten U., and Frotscher M. (1993) Developmental neurotrophin expression in slice cultures of rat hippocampus. Neurosci. Lett. 155, 216-219.
15. Friedman B., Scherer S. S., Rudge J. S., Helgren M., Morrisey D., Wang X. X., Wiegand S. J., Furth M. E., Lindsay R. M., and Ip N. Y. (1992) Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo. Neuron 9, 295-305.
16. Fuhrmann S., Kirsch M., and Hofmann H.-D. (1995) Ciliary neurotrophic factor promotes chick photoreceptor development in vitro. Development 121, 2695-2706.
17. Heller S., Finn T. P., Huber J., Nishi R., Geiben M., Püschel A. W., and Rohrer H. (1995) Analysis of function and expression of chick GPA receptor (GPARa) suggests multiple roles in neuronal development. Development 121, 2681-2706.
18. Hofmann H.-D. (1988) Ciliary neuronotrophic factor stimulates choline acetyltransterase activity in cultured chicken retina neurons. J. Neurochem. 51, 109-113.
19. 3H]-butyric acid from cultured amacrine-like neurons mediated by different excitatory amino acid receptors. J. Neurochem. 56, 923-932.
20. Ip N. Y., Li Y., van de Stadt I., Panayotatos N., Alderson R. F., and Lindsay R. M. (1991) Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures. J. Neurosci. 11, 3124-3134.
21. Ip N. Y., McClain J., Barrezueta N. X., Aldrich T. H., Pan L., Li Y., Wiegand S. J., Friedman B., Davis S., and Yancopoulos G. D. (1993a) The a component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development. Neuron 10, 89-102.
22. Ip N. Y., Wiegand S. J., Morse J., and Rudge J. S. (1993b) Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain. Eur. J. Neurosci. 5, 25-33.
23. Kamiguchi H., Yoshida K., Sagoh M., Sasaki H., Inaba M., Wakamoto H., Otani M., and Toya S. (1995) Release of ciliary neurotrophic factor from cultured astrocytes and its modulation by cytokines. Neurochem. Res. 20, 1187-1193.
24. Kirsch M. and Hofmann H.-D. (1994) Expression of ciliary neurotrophic factor receptor mRNA and protein in the early postnatal and adult rat nervous system. Neurosci. Lett. 180, 163-167.
25. Kirsch M., Fuhrmann S., Wiese A., and Hofmann H.-D. (1996) CNTF exerts opposite effects on in vitro development of rat and chick photoreceptors. Neuroreport 7, 697-700.
26. Kondo H., Yamamoto M., Yamakuni T., and Takahashi Y. (1988) An immunohistochemical study of the ontogeny of the horizontal cell in the rat retina using an antiserum against spot 35 protein, a novel Purkinje cell-specific protein, as a marker. Anat. Rec. 222, 103-109.
27. Korsching S. (1993) The neurotrophic factor concept: a reexamination. J. Neurosci. 13, 2739-2748.
28. Lamballe F., Klein R., and Barbacid M. (1991) trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66, 967-979.
29. LaVail M. M., Unoki K., Yasumura D., Matthes M. T., Yancopoulos G. D., and Steinberg R. H. (1992) Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from damaging effects of constant light. Proc. Natl. Acad. Sci. USA 89, 11249-11253.
30. Lillien L. E. and Raff M. C. (1990) Differentiation signals in the CNS: type-2 astrocyte development in vitro as a model system. Neuron 5, 111-119.
31. Lin A., Chan Y.-L., Jones R., and Wool I. G. (1987) The primary structure of rat ribosomal protein S12. J. Biol. Chem. 262, 14343-14351.
32. Lin L.-F. H., Mismer D., Lile J. D., Armes L. G., Butler E. T., Vannice J. L., and Collins F. (1989) Purification, cloning, and expression of ciliary neurotrophic factor (CNTF). Science 246, 1023-1025.
33. Löhrke S., Möckel V., and Hofmann H.-D. (1994) Expression of horizontal cell phenotypes in monolayer cultures from immature rabbit retina. Dev. Brain Res. 77, 97-110.
34. Louis J.-C., Magal E., Takayama S., and Varon S. (1993) CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced cell death. Science 259, 689-692.
35. Lowry O. H., Rosebrough N. J., Farr A. L., and Randall R. J. (1951) Protein measurements with the Folin phenol reagent. J. Biol Chem. 193, 265-275.
36. MacLennan A. J., Vinson E. N., Marks L., McLaurin D., Pfeifer M., and Lee N. (1996) Immunohistochemical localization of ciliary neurotrophic factor receptor a expression in the rat nervous system. J. Neurosci. 16, 621-630.
37. Magal E., Louis J.-C., Oudega M., and Varon S. (1993) CNTF promotes the survival of neonatal rat corticospinal neurons in vitro. Neuroreport 4, 779-782.
38. Manthorpe M., Skaper S. D., Williams R. L., and Varon S. (1986) Purification of adult rat sciatic nerve ciliary neuronotrophic factor. Brain Res. 367, 282-286.
39. Manthorpe M., Louis J.-L., Hagg T., and Varon S. (1993) Ciliary neuronotrophic factor, in Neurotrophic Factors (Loughlin S. E. and Fallon J. H., eds), pp. 443-473. Academic Press, San Diego.
40. Masu Y., Wolf E., Holtmann B., Sendtner M., Brem G., and Thoenen H. (1993) Disruption of the CNTF gene results in motor neuron degeneration. Nature 365, 27-32.
41. Mayer M., Bhakoo K., and Noble M. (1994) Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro. Development 120, 143-153.
42. Mey J. and Thanos S. (1993) Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo. Brain Res. 602, 304-317.
43. Meyer V. and Unsicker K. (1994) Cell density and exogenous CNTF affect CNTF mRNA levels in glial cell cultures. Neuroreport 5, 1946-1948.
44. Meyer-Franke A., Kaplan M. R., Pfrieger F. W., and Barres B. A. (1995) Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron 15, 805-819.
45. Möckel V., Löhrke S., and Hofmann H.-D. (1994) Diversity of neuronal phenotypes expressed in monolayer cultures from immature rabbit retina. Vis. Neurosci. 11, 629-642.
46. Molday R. S. (1989) Monoclonal antibodies to rhodopsin and other proteins of rod outer segments. Prog. Retinal Res. 8, 173-209.
47. Moscona A. A. and Linser P. (1983) Developmental and experimental changes in retinal glia cells: cell interactions and control of phenotype expression and stability. Curr. Top. Dev. Biol. 18, 115-183.
48. Reh T. A. (1992) Generation of neuronal diversity in the vertebrate retina, in Determinants of Neuronal Identity (Shankland M. and Macagno E. R., eds), pp. 433-467. Academic Press, San Diego.
49. Rudge J. S., Li Y., Pasnikowski E. M., Mattsson K., Pan L., Yancopoulos G. D., Wiegand S. J., Lindsay R. M., and Ip N. Y. (1994) Neurotrophic factor receptors and their signal transduction in rat astrocytes. Eur. J. Neurosci. 6, 693-705.
50. Saadat S., Sendtner M., and Rohrer H. (1989) Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in culture. J. Cell Biol. 108, 1807-1816.
51. Sendtner M., Carroll P., Holtmann B., Hughes R. A., and Thoenen H. (1994) Ciliary neurotrophic factor. J. Neurobiol. 25, 1436-1453.
52. Stöckli K. A., Lottspeich F., Sendtner M., Masiakowski P., Carroll P., Götz R., Lindholm D., and Thoenen H. (1989) Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor. Nature 342, 920-923.
53. Stöckli K. A., Lillien L. E., Näher-Noé M., Breitfeld G., Hughes R. A., Raff M. C., Thoenen H., and Sendtner M. (1991) Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain. J. Cell Biol. 115, 447-459.
54. Takahashi R., Yokoji H., Misawa H., Hayashi M., Hu J., and Deguchi T. (1994) A null mutation in the human CNTF gene is not causally related to neurological diseases. Nat. Genet. 7, 79-84.
55. Vaney D. I. (1990) The mosaic of amacrine cells in the mammalian retina. Prog. Retinal Res. 9, 1-45.
56. Versaux-Botteri C., Pochet R., and Nguyen-Legros J. (1989) Immunocytochemical localization of GABA-containing neurons during postnatal development of the rat retina. Invest. Ophthalmol. Vis. Sci. 30, 652-659.
57. Watanabe T. and Raff M. C. (1990) Rod photoreceptor development in vitro: intrinsic properties of proliferating neuroepithelial cells change as development proceeds in the rat retina. Neuron 4, 461-467.
58. Watanabe T. and Raff M. C. (1992) Diffusible rod-promoting signals in the developing rat retina. Development 114, 899-906.
59. Zimmermann K. and Mannhalter J. W. (1996) Technical aspects of quantitative competitive PCR. Biotechniques 21, 268-279.