메뉴 건너뛰기




Volumn 37, Issue 1, 2009, Pages 34-46

Pathophysiology of cyclooxygenase inhibition in animal models

Author keywords

Bone; Cyclooxygenases; Eye; Gastrointestinal tract; Pathophysiology; Renal

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CARPROFEN; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DICLOFENAC; ELECTROLYTE; FIROCOXIB; FLUNIXIN MEGLUMINE; FLURBIPROFEN; IBUPROFEN; INDOMETACIN; KETOROLAC; LUMIRACOXIB; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NAPROXEN; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PARECOXIB; PHENYLBUTAZONE; PROSTAGLANDIN; PROSTAGLANDIN E2; ROFECOXIB; SULINDAC; SUPROFEN; TENOXICAM; UNCLASSIFIED DRUG; VALDECOXIB; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

EID: 62749132930     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623308329474     Document Type: Review
Times cited : (62)

References (172)
  • 1
    • 0028123090 scopus 로고
    • Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
    • Adamis, AP, JW Miller, MT Bernal, DJ D'Amico, J Folkman, TK Yeo, and KT Yeo (1994). Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol, 118, 445-450.
    • (1994) Am J Ophthalmol , vol.118 , pp. 445-450
    • Adamis, A.P.1    Miller, J.W.2    Bernal, M.T.3    D'Amico, D.J.4    Folkman, J.5    Yeo, T.K.6    Yeo, K.T.7
  • 2
    • 0036216417 scopus 로고    scopus 로고
    • Is diabetic retinopathy an inflammatory disease?
    • Adamis, AP (2002). Is diabetic retinopathy an inflammatory disease? Br J Ophthalmol, 86, 363-365.
    • (2002) Br J Ophthalmol , vol.86 , pp. 363-365
    • Adamis, A.P.1
  • 5
    • 0018867802 scopus 로고
    • Indomethacin and aspirin: Effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat
    • Allen, HL, A Wase, and WT Bear (1980). Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat. Acta Orthop Scand, 51, 595-600.
    • (1980) Acta Orthop Scand , vol.51 , pp. 595-600
    • Allen, H.L.1    Wase, A.2    Bear, W.T.3
  • 6
    • 0029445471 scopus 로고
    • Effect of nonsteroidal antiinflammatory drugs on fracture healing: A laboratory study in rats
    • Altman, RD, LL Latta, R Keer, K Renfree, FJ Hornicek, and K Banovac (1995). Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats. J Orthop Trauma, 9, 392-400.
    • (1995) J Orthop Trauma , vol.9 , pp. 392-400
    • Altman, R.D.1    Latta, L.L.2    Keer, R.3    Renfree, K.4    Hornicek, F.J.5    Banovac, K.6
  • 7
    • 0141725412 scopus 로고    scopus 로고
    • Effect of nimesulide, rofecoxib and celecoxib on gastric tissue glutathione level in rats with indomethacin-induced gastric ulcerations
    • Altinkaynak, K, H Suleyman, and F Akcay (2003). Effect of nimesulide, rofecoxib and celecoxib on gastric tissue glutathione level in rats with indomethacin-induced gastric ulcerations. Pol J Pharmacol, 55, 645-648.
    • (2003) Pol J Pharmacol , vol.55 , pp. 645-648
    • Altinkaynak, K.1    Suleyman, H.2    Akcay, F.3
  • 9
    • 4444275738 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas
    • Ayalasomayajula, SP, AC Amrite, and UB Kompella (2004). Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas. Eur J Pharmacol, 498, 275-278.
    • (2004) Eur J Pharmacol , vol.498 , pp. 275-278
    • Ayalasomayajula, S.P.1    Amrite, A.C.2    Kompella, U.B.3
  • 10
    • 0037419532 scopus 로고    scopus 로고
    • Celecoxib, a selective cyclooxygenase-2 inhibitor, inhibits retinal vascular endothelial growth factor expression and vascular leakage in a streptozotocin-induced diabetic rat model
    • Ayalasomayajula, SP, and UB Kompella (2003). Celecoxib, a selective cyclooxygenase-2 inhibitor, inhibits retinal vascular endothelial growth factor expression and vascular leakage in a streptozotocin-induced diabetic rat model. Eur J Pharmacol, 458, 283-289.
    • (2003) Eur J Pharmacol , vol.458 , pp. 283-289
    • Ayalasomayajula, S.P.1    Kompella, U.B.2
  • 11
    • 6344284095 scopus 로고    scopus 로고
    • Retinal delivery of celecoxib is several-fold higher following subconjunctival administration compared to systemic administration
    • Ayalasomayajula, SP, and UB Kompella (2004). Retinal delivery of celecoxib is several-fold higher following subconjunctival administration compared to systemic administration. Pharm Res, 21, 1797-1804.
    • (2004) Pharm Res , vol.21 , pp. 1797-1804
    • Ayalasomayajula, S.P.1    Kompella, U.B.2
  • 13
    • 0031764281 scopus 로고    scopus 로고
    • Differential effect of a selective cyclooxygenase-2 inhibitor versus indomethacin on renal blood flow in conscious volume-depleted dogs
    • Black, SC, C Brideau, M Cirino, M Belley, J Bosquet, CC Chan, and IW Rodger (1998). Differential effect of a selective cyclooxygenase-2 inhibitor versus indomethacin on renal blood flow in conscious volume-depleted dogs. J Cardiovasc Pharmacol, 32, 686-694.
    • (1998) J Cardiovasc Pharmacol , vol.32 , pp. 686-694
    • Black, S.C.1    Brideau, C.2    Cirino, M.3    Belley, M.4    Bosquet, J.5    Chan, C.C.6    Rodger, I.W.7
  • 15
    • 0017375634 scopus 로고
    • Blood vessel-hormone interactions: Angiotensin, bradykinin, and prostaglandins
    • Blumberg, AL, SE Denny, GR Marshall, and P Needleman (1977). Blood vessel-hormone interactions: angiotensin, bradykinin, and prostaglandins. Am J Physiol, 232, H305-310.
    • (1977) Am J Physiol , vol.232 , pp. 305-310
    • Blumberg, A.L.1    Denny, S.E.2    Marshall, G.R.3    Needleman, P.4
  • 16
    • 0023949869 scopus 로고
    • Long term administration of prostaglandin inhibitors in vivo fail to influence cartilage and bone mineral metabolism in the rat
    • Boiskin, I, S Epstein, F Ismail, MD Fallon, and W Levy (1988). Long term administration of prostaglandin inhibitors in vivo fail to influence cartilage and bone mineral metabolism in the rat. Bone Miner, 4, 27-36.
    • (1988) Bone Miner , vol.4 , pp. 27-36
    • Boiskin, I.1    Epstein, S.2    Ismail, F.3    Fallon, M.D.4    Levy, W.5
  • 17
    • 0034723274 scopus 로고    scopus 로고
    • Regulation of cyclooxygenase-2 by hypoxia and peroxisome proliferators in the corneal epithelium
    • Bonazzi, A, V Mastyugin, PA Mieyal, MW Dunn, and M Laniado-Schwartzman (2000). Regulation of cyclooxygenase-2 by hypoxia and peroxisome proliferators in the corneal epithelium. J Biol Chem, 275, 2837-2844.
    • (2000) J Biol Chem , vol.275 , pp. 2837-2844
    • Bonazzi, A.1    Mastyugin, V.2    Mieyal, P.A.3    Dunn, M.W.4    Laniado-Schwartzman, M.5
  • 18
    • 0035092990 scopus 로고    scopus 로고
    • Long-term glucose infusion increases arterial pressure in dogs with cyclooxygenase-2 inhibition
    • Brands, MW, AE Hailman, and SM Fitzgerald (2001). Long-term glucose infusion increases arterial pressure in dogs with cyclooxygenase-2 inhibition. Hypertension, 37, 733-738.
    • (2001) Hypertension , vol.37 , pp. 733-738
    • Brands, M.W.1    Hailman, A.E.2    Fitzgerald, S.M.3
  • 20
    • 4344663889 scopus 로고    scopus 로고
    • Effect of COX inhibitors on VEGF-induced retinal vascular leakage and experimental corneal and choroidal neovascularization
    • Castro, MR, D Lutz, and JL Edelman (2004). Effect of COX inhibitors on VEGF-induced retinal vascular leakage and experimental corneal and choroidal neovascularization. Exp Eye Res, 79, 275-285.
    • (2004) Exp Eye Res , vol.79 , pp. 275-285
    • Castro, M.R.1    Lutz, D.2    Edelman, J.L.3
  • 21
    • 0031594643 scopus 로고    scopus 로고
    • 2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Muller cells
    • Cheng, T, W Cao, R Wen, RH Steinberg, and MM LaVail (1998). Prostaglandin E2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Muller cells. Invest Ophthalmol Vis Sci, 39, 581-591. (Pubitemid 28110692)
    • (1998) Investigative Ophthalmology and Visual Science , vol.39 , Issue.3 , pp. 581-591
    • Cheng, T.1    Cao, W.2    Wen, R.3    Steinberg, R.H.4    LaVail, M.M.5
  • 23
    • 0021870243 scopus 로고
    • Experimentally induced phenylbutazone toxicosis in ponies: Description of the syndrome and its prevention with synthetic prostaglandin E2
    • Collins, LG, and DE Tyler (1985). Experimentally induced phenylbutazone toxicosis in ponies: description of the syndrome and its prevention with synthetic prostaglandin E2. Am J Vet Res, 46, 1605-1165.
    • (1985) Am J Vet Res , vol.46 , pp. 1605-1165
    • Collins, L.G.1    De Tyler2
  • 24
    • 3543054046 scopus 로고    scopus 로고
    • Gastric effects of the selective cyclooxygenase-2 inhibitor, celecoxib, in the rat
    • Coppelli, G, E Guaita, S Spaggiari, and G Coruzzi (2004). Gastric effects of the selective cyclooxygenase-2 inhibitor, celecoxib, in the rat. Digest Liver Dis, 36, 265-270.
    • (2004) Digest Liver Dis , vol.36 , pp. 265-270
    • Coppelli, G.1    Guaita, E.2    Spaggiari, S.3    Coruzzi, G.4
  • 25
    • 0346040849 scopus 로고
    • Drug-induced gastroduodenal ulceration in dogs
    • Cosenza, SF (1984). Drug-induced gastroduodenal ulceration in dogs. Modern Vet Pract, 65, 923-925.
    • (1984) Modern Vet Pract , vol.65 , pp. 923-925
    • Cosenza, S.F.1
  • 26
    • 0031009017 scopus 로고    scopus 로고
    • Molecular basis for deficient acet-aminophen glucuronidation in cats. An interspecies comparison of enzyme kinetics in liver microsomes
    • Court, MH, and DJ Greenblatt (1997). Molecular basis for deficient acet-aminophen glucuronidation in cats. An interspecies comparison of enzyme kinetics in liver microsomes. Biochem Pharmacol, 53, 1041-1047.
    • (1997) Biochem Pharmacol , vol.53 , pp. 1041-1047
    • Court, M.H.1    Greenblatt, D.J.2
  • 27
    • 0033941677 scopus 로고    scopus 로고
    • Immunohistochemical localization of vascular endothelial growth factor, transforming growth factor alpha, and ransforming growth factor beta1 in human corneas with neovascularization
    • Cursiefen, C, C Rummelt, and M Kuchle (2000). Immunohistochemical localization of vascular endothelial growth factor, transforming growth factor alpha, and ransforming growth factor beta1 in human corneas with neovascularization. Cornea, 19, 526-533.
    • (2000) Cornea , vol.19 , pp. 526-533
    • Cursiefen, C.1    Rummelt, C.2    Kuchle, M.3
  • 28
    • 0035834539 scopus 로고    scopus 로고
    • Celecoxib, a selective cyclooxygenase-2 inhibitor reduces the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats
    • Cuzzocrea, S, E Mazzon, I Serraino, L Dugo, T Centorrino, A Ciccolo, L Sautebin, and AP Caputi (2001). Celecoxib, a selective cyclooxygenase-2 inhibitor reduces the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats. Eur J Pharmacol, 431, 91-102.
    • (2001) Eur J Pharmacol , vol.431 , pp. 91-102
    • Cuzzocrea, S.1    Mazzon, E.2    Serraino, I.3    Dugo, L.4    Centorrino, T.5    Ciccolo, A.6    Sautebin, L.7    Caputi, A.P.8
  • 29
    • 0023024629 scopus 로고
    • Transmural pyloric perforation associated with naproxen administration in a dog
    • Daehler, MH (1986). Transmural pyloric perforation associated with naproxen administration in a dog. J Am Vet Med Assoc, 189, 694-695.
    • (1986) J Am Vet Med Assoc , vol.189 , pp. 694-695
    • Daehler, M.H.1
  • 30
    • 0030068309 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and hypertension. the risks in perspective
    • de Leeuw, PW (1996). Nonsteroidal anti-inflammatory drugs and hypertension. The risks in perspective. Drugs, 51, 179-187.
    • (1996) Drugs , vol.51 , pp. 179-187
    • De Leeuw, P.W.1
  • 33
    • 0016711377 scopus 로고
    • Enterohepatic circulation of indomethacin and its role in intestinal irritation
    • Duggan, DE, KF Hooke, RM Noll, and KC Kwan (1975). Enterohepatic circulation of indomethacin and its role in intestinal irritation. Biochem Pharmacol, 24, 1749-1754.
    • (1975) Biochem Pharmacol , vol.24 , pp. 1749-1754
    • Duggan, D.E.1    Hooke, K.F.2    Noll, R.M.3    Kwan, K.C.4
  • 36
    • 0015511637 scopus 로고
    • Indomethacin-associated gastrointestinal hemorrhage in a dog
    • Ewing, GO (1972). Indomethacin-associated gastrointestinal hemorrhage in a dog. J Am Vet Med Assoc, 161, 1665-1668.
    • (1972) J Am Vet Med Assoc , vol.161 , pp. 1665-1668
    • Ewing, G.O.1
  • 37
    • 0021674429 scopus 로고
    • Stimulation of arachidonic acid metabolism in primary cultures of osteoblast-like cells by hormones and drugs
    • Feyen, JH, G van der Wilt, P Moonen, A Di Bon, and PJ Nijweide (1984). Stimulation of arachidonic acid metabolism in primary cultures of osteoblast-like cells by hormones and drugs. Prostaglandins, 28, 769-781.
    • (1984) Prostaglandins , vol.28 , pp. 769-781
    • Feyen, J.H.1    Wilt Der G.Van2    Moonen, P.3    Di Bon, A.4    Nijweide, P.J.5
  • 38
    • 0032160070 scopus 로고    scopus 로고
    • Endoscopy of the gastroduodenal mucosa after carprofen, meloxicam and ketoprofen administration in dogs
    • Forsyth, SF, WG Guilford, SJ Haslett, and J Godfrey (1998). Endoscopy of the gastroduodenal mucosa after carprofen, meloxicam and ketoprofen administration in dogs. J Small Anim Pract, 39, 421-424.
    • (1998) J Small Anim Pract , vol.39 , pp. 421-424
    • Forsyth, S.F.1    Guilford, W.G.2    Haslett, S.J.3    Godfrey, J.4
  • 39
    • 0029998565 scopus 로고    scopus 로고
    • Inducible cyclooxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo
    • Forwood, MR (1996). Inducible cyclooxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo. J Bone Miner Res, 11, 1688-1693.
    • (1996) J Bone Miner Res , vol.11 , pp. 1688-1693
    • Forwood, M.R.1
  • 40
    • 0348048874 scopus 로고    scopus 로고
    • Diabetic retinopathy
    • Frank, RN (2004). Diabetic retinopathy. N Engl J Med, 350, 48-58.
    • (2004) N Engl J Med , vol.350 , pp. 48-58
    • Frank, R.N.1
  • 41
    • 0021677536 scopus 로고
    • Topical indomethacin effect on neovascularisation of the cornea and on prostaglandin E2 levels
    • Frucht, J, and H Zauberman (1984). Topical indomethacin effect on neovascularisation of the cornea and on prostaglandin E2 levels. Br J Ophthalmol, 68, 656-659.
    • (1984) Br J Ophthalmol , vol.68 , pp. 656-659
    • Frucht, J.1    Zauberman, H.2
  • 42
    • 0141639888 scopus 로고    scopus 로고
    • The effect of cyclooxygenase-2 inhibitors on bone healing
    • Gajraj, NM (2003). The effect of cyclooxygenase-2 inhibitors on bone healing. Reg Anesth Pain Med, 28, 456-465.
    • (2003) Reg Anesth Pain Med , vol.28 , pp. 456-465
    • Gajraj, N.M.1
  • 43
    • 0141483046 scopus 로고    scopus 로고
    • Prevention of retinal capillary basement membrane thickening in diabetic dogs by a non-steroidal anti-inflammatory drug
    • Gardiner, TA, HR Anderson, T Degenhardt, SR Thorpe, JW Baynes, DB Archer, and AW Stitt (2003). Prevention of retinal capillary basement membrane thickening in diabetic dogs by a non-steroidal anti-inflammatory drug. Diabetologia, 46, 1269-1275.
    • (2003) Diabetologia , vol.46 , pp. 1269-1275
    • Gardiner, T.A.1    Anderson, H.R.2    Degenhardt, T.3    Thorpe, S.R.4    Baynes, J.W.5    Archer, D.B.6    Stitt, A.W.7
  • 44
    • 0036264563 scopus 로고    scopus 로고
    • Topical nonsteroidal anti-inflammatory drugs for ophthalmic use: A safety review
    • Gaynes, BI, and R Fiscella (2002). Topical nonsteroidal anti-inflammatory drugs for ophthalmic use: a safety review. Drug Saf, 25, 233-250.
    • (2002) Drug Saf , vol.25 , pp. 233-250
    • Gaynes, B.I.1    Fiscella, R.2
  • 46
    • 0037376627 scopus 로고    scopus 로고
    • Fracture healing as a post-natal developmental process: Molecular, spatial, and temporal aspects of its regulation
    • Gerstenfeld, LC, DM Cullinane, GL Barnes, DT Graves, and TA Einhorn (2003). Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem, 88, 873-884.
    • (2003) J Cell Biochem , vol.88 , pp. 873-884
    • Gerstenfeld, L.C.1    Cullinane, D.M.2    Barnes, G.L.3    Graves, D.T.4    Einhorn, T.A.5
  • 48
    • 1942489000 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs in veterinary ophthalmology
    • Giuliano, EA (2004). Nonsteroidal anti-inflammatory drugs in veterinary ophthalmology. Vet Clin North Am Small Anim Pract, 34, 707-723.
    • (2004) Vet Clin North Am Small Anim Pract , vol.34 , pp. 707-723
    • Giuliano, E.A.1
  • 51
    • 33947116489 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition delays the attainment of peak woven bone formation following four-point bending in the rat
    • Gregory, LS, and MR Forwood (2007). Cyclooxygenase-2 inhibition delays the attainment of peak woven bone formation following four-point bending in the rat. Calcif Tissue Int, 80, 176-183.
    • (2007) Calcif Tissue Int , vol.80 , pp. 176-183
    • Gregory, L.S.1    Forwood, M.R.2
  • 52
    • 0032732795 scopus 로고    scopus 로고
    • Natriuretic response to increased pressure is preserved with COX-2 inhibitors
    • Gross, JM, JE Dwyer, and FG Knox (1999). Natriuretic response to increased pressure is preserved with COX-2 inhibitors. Hypertension, 34, 1163-1167.
    • (1999) Hypertension , vol.34 , pp. 1163-1167
    • Gross, J.M.1    Dwyer, J.E.2    Knox, F.G.3
  • 53
  • 54
    • 43549090186 scopus 로고    scopus 로고
    • Physiological regulation of prostaglandins in the kidney
    • Hao, CM, and MD Breyer (2008). Physiological regulation of prostaglandins in the kidney. Annu Rev Physiol, 70, 357-377.
    • (2008) Annu Rev Physiol , vol.70 , pp. 357-377
    • Hao, C.M.1    Breyer, M.D.2
  • 55
    • 0036264157 scopus 로고    scopus 로고
    • Gastrointestinal safety of selective COX-2 inhibitors
    • Hawkey, CJ, and MM Skelly (2002). Gastrointestinal safety of selective COX-2 inhibitors. Curr Pharm Des, 8, 1077-1089.
    • (2002) Curr Pharm des , vol.8 , pp. 1077-1089
    • Hawkey, C.J.1    Skelly, M.M.2
  • 56
    • 0031855192 scopus 로고    scopus 로고
    • Effects of ketorolac on bone repair: A radiographic study in modeled demineralized bone matrix grafted rabbits
    • Ho, ML, JK Chang, and GJ Wang (1998). Effects of ketorolac on bone repair: A radiographic study in modeled demineralized bone matrix grafted rabbits. Pharmacology, 57, 148-159.
    • (1998) Pharmacology , vol.57 , pp. 148-159
    • Ho, M.L.1    Chang, J.K.2    Wang, G.J.3
  • 58
    • 13644275624 scopus 로고
    • Nonsteroidal anti-inflammatory drugs and antihypertensives
    • Houston, MC (1991). Nonsteroidal anti-inflammatory drugs and antihypertensives. Am J Med, 90, 42S-47S.
    • (1991) Am J Med , vol.90
    • Houston, M.C.1
  • 59
    • 0038313094 scopus 로고    scopus 로고
    • Effects of antiinflammatory drugs on arthritic cartilage: A high-frequency quantitative ultrasound study in rats
    • Jaffré, B, A Watrin, D Loeuille, P Gillet, P Netter, P Laugier, and A Saïed (2003). Effects of antiinflammatory drugs on arthritic cartilage: a high-frequency quantitative ultrasound study in rats. Arthritis Rheum, 48, 1594-1601.
    • (2003) Arthritis Rheum , vol.48 , pp. 1594-1601
    • Jaffré, B.1    Watrin, A.2    Loeuille, D.3    Gillet, P.4    Netter, P.5    Laugier, P.6    Saïed, A.7
  • 60
    • 0030696015 scopus 로고    scopus 로고
    • The in vivo anabolic actions of prostaglandins in bone
    • Jee, WS, and YF Ma (1997). The in vivo anabolic actions of prostaglandins in bone. Bone, 21, 297-304.
    • (1997) Bone , vol.21 , pp. 297-304
    • Jee, W.S.1    Ma, Y.F.2
  • 61
    • 0030756864 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and corticosteroids for the management of canine osteoarthritis
    • Johnston, SA, and SC Budsberg (1997). Nonsteroidal anti-inflammatory drugs and corticosteroids for the management of canine osteoarthritis. Vet Clin North Am Small Anim Pract, 27, 841-862.
    • (1997) Vet Clin North Am Small Anim Pract , vol.27 , pp. 841-862
    • Johnston, S.A.1    Budsberg, S.C.2
  • 62
    • 35848931702 scopus 로고    scopus 로고
    • The effects of the short-term administration of low therapeutic doses of anti-COX-2 agents on the healing of fractures. An experimental study in rabbits
    • Karachalios, T, L Boursinos, L Poultsides, L Khaldi, and KN Malizos (2007). The effects of the short-term administration of low therapeutic doses of anti-COX-2 agents on the healing of fractures. An experimental study in rabbits. J Bone Joint Surg Br, 89, 1253-1260.
    • (2007) J Bone Joint Surg Br , vol.89 , pp. 1253-1260
    • Karachalios, T.1    Boursinos, L.2    Poultsides, L.3    Khaldi, L.4    Malizos, K.N.5
  • 63
    • 0024497213 scopus 로고
    • Aspirin-induced gastric mucosal injury: Lessons learned from animal models
    • Kauffman, G (1989). Aspirin-induced gastric mucosal injury: lessons learned from animal models. Gastroenterology, 96, 606-614.
    • (1989) Gastroenterology , vol.96 , pp. 606-614
    • Kauffman, G.1
  • 65
    • 0023627061 scopus 로고
    • Bone repair inhibited by indomethacin. Effects on bone metabolism and strength of rabbit osteotomies
    • Keller, J, C Bunger, TT Andreassen, B Bak, and U Lucht (1987). Bone repair inhibited by indomethacin. Effects on bone metabolism and strength of rabbit osteotomies. Acta Orthop Scand, 58, 379-383.
    • (1987) Acta Orthop Scand , vol.58 , pp. 379-383
    • Keller, J.1    Bunger, C.2    Andreassen, T.T.3    Bak, B.4    Lucht, U.5
  • 66
    • 0026198963 scopus 로고
    • Early hemodynamic response to tibial osteotomy in rabbits: Influence of indomethacin and prostaglandin E2
    • Keller, J, ES Hansen, SZ He, P Kjaersgaard-Andersen, and C Bunger (1991). Early hemodynamic response to tibial osteotomy in rabbits: influence of indomethacin and prostaglandin E2. J Orthop Res, 9, 539-544.
    • (1991) J Orthop Res , vol.9 , pp. 539-544
    • Keller, J.1    Hansen, E.S.2    He, S.Z.3    Kjaersgaard-Andersen, P.4    Bunger, C.5
  • 67
    • 0027466511 scopus 로고
    • Effect of local prostaglandin E2 on fracture callus in rabbits
    • Keller, J, A Klamer, B Bak, and P Suder (1993). Effect of local prostaglandin E2 on fracture callus in rabbits. Acta Orthop Scand, 64, 59-63.
    • (1993) Acta Orthop Scand , vol.64 , pp. 59-63
    • Keller, J.1    Klamer, A.2    Bak, B.3    Suder, P.4
  • 68
    • 0002498916 scopus 로고    scopus 로고
    • Kidney
    • W Haschek, C Rousseux and M Walling (Eds.), San Diego, CA: Academic Press.
    • Khan, N, and C Alden (2002). Kidney. In W Haschek, C Rousseux and M Walling (Eds.), Handbook of Toxicologic Pathology, Vol. 2 (pp. 272-274). San Diego, CA: Academic Press.
    • (2002) Handbook of Toxicologic Pathology , pp. 272-274
    • Khan, N.1    Alden, C.2
  • 69
    • 0004533585 scopus 로고    scopus 로고
    • Gastrointestinal and renal safety of a specific COX-2 inhibitor versus NSAIDs in dogs
    • Khan, KN, S Paulson, and K Seibert (1997). Gastrointestinal and renal safety of a specific COX-2 inhibitor versus NSAIDs in dogs. Vet Pathol, 34, 509.
    • (1997) Vet Pathol , vol.34 , pp. 509
    • Khan, K.N.1    Paulson, S.2    Seibert, K.3
  • 71
    • 0031679914 scopus 로고    scopus 로고
    • Interspecies differences in renal localization of cyclooxygenase isoforms: Implications in nonsteroidal anti-inflammatory drug-related nephrotoxicity
    • Khan, KN, CM Venturini, RT Bunch, JA Brassard, AT Koki, and DL Morris (1998). Interspecies differences in renal localization of cyclooxygenase isoforms: implications in nonsteroidal anti-inflammatory drug-related nephrotoxicity. Toxicol Pathol, 26, 612-620.
    • (1998) Toxicol Pathol , vol.26 , pp. 612-620
    • Khan, K.N.1    Venturini, C.M.2    Bunch, R.T.3    Brassard, J.A.4    Koki, A.T.5    Morris, D.L.6
  • 72
    • 42549166985 scopus 로고    scopus 로고
    • Safety of intravitreal ketorolac and diclofenac: An electroretinographic and histopathologic study
    • Kim, SJ, NA Adams, HS Toma, ML Belair, JE Thorne, WR Green, and DA Jabs (2008). Safety of intravitreal ketorolac and diclofenac: an electroretinographic and histopathologic study. Retina, 28, 595-605.
    • (2008) Retina , vol.28 , pp. 595-605
    • Kim, S.J.1    Adams, N.A.2    Toma, H.S.3    Belair, M.L.4    Thorne, J.E.5    Green, W.R.6    Jabs, D.A.7
  • 73
    • 33846186834 scopus 로고    scopus 로고
    • Low plasma renin and reduced renin secretory responses to acute stimuli in conscious COX-2-deficient mice
    • Kim, SM, L Chen, D Mizel, YG Huang, JP Briggs, and J Schnermann (2007). Low plasma renin and reduced renin secretory responses to acute stimuli in conscious COX-2-deficient mice. Am J Physiol Renal Physiol, 292, F415-F422.
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Kim, S.M.1    Chen, L.2    Mizel, D.3    Huang, Y.G.4    Briggs, J.P.5    Schnermann, J.6
  • 74
    • 0141522427 scopus 로고    scopus 로고
    • Clinical implications of COX-1 and/or COX-2 inhibition for the distal gastrointestinal tract
    • Lanas, A, J Panes, and JM Pique (2003). Clinical implications of COX-1 and/or COX-2 inhibition for the distal gastrointestinal tract. Curr Pharm Des, 9, 2253-2266.
    • (2003) Curr Pharm des , vol.9 , pp. 2253-2266
    • Lanas, A.1    Panes, J.2    Pique, J.M.3
  • 75
    • 0021026481 scopus 로고
    • Effects of fenbufen, indomethacin, naproxen, and placebo on gastric mucosa of normal volunteers. A comparative endoscopic and photographic evaluation
    • Lanza, FL, RS Nelson, and BP Greenberg (1983). Effects of fenbufen, indomethacin, naproxen, and placebo on gastric mucosa of normal volunteers. A comparative endoscopic and photographic evaluation. Am J Med, 75, 75-79.
    • (1983) Am J Med , vol.75 , pp. 75-79
    • Lanza, F.L.1    Nelson, R.S.2    Greenberg, B.P.3
  • 76
    • 0042566233 scopus 로고    scopus 로고
    • Experimental study of the safety of the selective COX-2 inhibitor, celecoxib, for gastric mucosa
    • Li, JT, ZS Li, and XB Zhan (2003). Experimental study of the safety of the selective COX-2 inhibitor, celecoxib, for gastric mucosa. Chin J Dig Dis, 4, 53-56.
    • (2003) Chin J Dig Dis , vol.4 , pp. 53-56
    • Li, J.T.1    Li, Z.S.2    Zhan, X.B.3
  • 78
    • 0036009724 scopus 로고    scopus 로고
    • Effects of prostaglandin E2 on gene expression in primary osteoblastic cells from prostaglandin receptor knockout mice
    • Li, X, CC Pilbeam, L Pan, RM Breyer, and LG Raisz (2002). Effects of prostaglandin E2 on gene expression in primary osteoblastic cells from prostaglandin receptor knockout mice. Bone, 30, 567-573.
    • (2002) Bone , vol.30 , pp. 567-573
    • Li, X.1    Pilbeam, C.C.2    Pan, L.3    Breyer, R.M.4    Raisz, L.G.5
  • 79
    • 0028786766 scopus 로고
    • Early effects of prostaglandin E2 on bone formation and resorption in different bone sites of rats
    • Lin, CH, WS Jee, YF Ma, and RB Setterberg (1995). Early effects of prostaglandin E2 on bone formation and resorption in different bone sites of rats. Bone, 17, 255S-259S.
    • (1995) Bone , vol.17
    • Lin, C.H.1    Jee, W.S.2    Ma, Y.F.3    Setterberg, R.B.4
  • 80
    • 0019491302 scopus 로고
    • Inhibitory effect on bone formation and calcification exerted by the anti-inflammatory drug ibuprofen. An experimental study on adult rat with fracture
    • Lindholm, TS, and H Tornkvist (1981). Inhibitory effect on bone formation and calcification exerted by the anti-inflammatory drug ibuprofen. An experimental study on adult rat with fracture. Scand J Rheumatol, 10, 38-42.
    • (1981) Scand J Rheumatol , vol.10 , pp. 38-42
    • Lindholm, T.S.1    Tornkvist, H.2
  • 81
    • 0029010357 scopus 로고
    • Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors
    • Linz, W, G Wiemer, P Gohlke, T Unger, and BA Scholkens (1995). Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors. Pharmacol Rev, 47, 25-49.
    • (1995) Pharmacol Rev , vol.47 , pp. 25-49
    • Linz, W.1    Wiemer, G.2    Gohlke, P.3    Unger, T.4    Scholkens, B.A.5
  • 82
    • 0029879849 scopus 로고    scopus 로고
    • Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes
    • Lopez, PF, BD Sippy, HM Lambert, AB Thach, and DR Hinton (1996). Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Invest Ophthalmol Vis Sci, 37, 855-868.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 855-868
    • Lopez, P.F.1    Sippy, B.D.2    Lambert, H.M.3    Thach, A.B.4    Hinton, D.R.5
  • 83
    • 0018251544 scopus 로고
    • Effects of indomethacin alone and during diuretic or beta-adrenergic blockade therapy on blood pressure and the renin system in essential hypertension
    • Lopez-Ovejero, JA, MA Weber, JIM Drayer, JE Sealey, and JH Laragh (1978). Effects of indomethacin alone and during diuretic or beta-adrenergic blockade therapy on blood pressure and the renin system in essential hypertension. Clin Sci Mol Med, 55, 203S-205S.
    • (1978) Clin Sci Mol Med , vol.55
    • Lopez-Ovejero, J.A.1    Weber, M.2    Drayer, J.3    Sealey, J.E.4    Laragh, J.H.5
  • 84
    • 33947662010 scopus 로고    scopus 로고
    • Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs
    • Luna, SP, AC Basílio, PV Steagall, LP Machado, FQ Moutinho, and RK Takahira (2007). Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs. Am J Vet Res, 68, 258-264.
    • (2007) Am J Vet Res , vol.68 , pp. 258-264
    • Luna, S.P.1    Basílio, A.C.2    Steagall, P.V.3    MacHado, L.P.4    Moutinho, F.Q.5    Takahira, R.K.6
  • 85
    • 0020961764 scopus 로고
    • Effects of large doses of phenylbutazone administration to horses
    • Mackay, RJ, TW French, HT Nguyen, and IG Mayhew (1983). Effects of large doses of phenylbutazone administration to horses. Am J Vet Res, 44, 774-780.
    • (1983) Am J Vet Res , vol.44 , pp. 774-780
    • MacKay, R.J.1    French, T.W.2    Nguyen, H.T.3    Mayhew, I.G.4
  • 86
    • 0030447091 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation
    • Mahmud, T, SS Rafi, DL Scott, JM Wrigglesworth, and I Bjarnason (1996). Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation. Arthritis Rheum, 39, 1998-2003.
    • (1996) Arthritis Rheum , vol.39 , pp. 1998-2003
    • Mahmud, T.1    Rafi, S.S.2    Scott, D.L.3    Wrigglesworth, J.M.4    Bjarnason, I.5
  • 87
    • 0024235028 scopus 로고
    • Local infusion of prostaglandin E1 stimulates mandibular bone formation in vivo
    • Marks, SC, Jr, and S Miller (1988). Local infusion of prostaglandin E1 stimulates mandibular bone formation in vivo. J Oral Pathol, 17, 500-505.
    • (1988) J Oral Pathol , vol.17 , pp. 500-505
    • Jr M.Sc1    Miller, S.2
  • 88
    • 10744220922 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug reduces neutrophil and macrophage accumulation but does not improve tendon regeneration
    • Marsolais, D, CH Cote, and J Frenette (2003). Nonsteroidal anti-inflammatory drug reduces neutrophil and macrophage accumulation but does not improve tendon regeneration. Lab Invest, 83, 991-999.
    • (2003) Lab Invest , vol.83 , pp. 991-999
    • Marsolais, D.1    Cote, C.2    Frenette, J.3
  • 89
    • 0033451177 scopus 로고    scopus 로고
    • COX-2 inhibitors. A new class of antiangiogenic agents
    • Masferrer, JL, A Koki, and K Seibert (1999). COX-2 inhibitors. A new class of antiangiogenic agents. Ann N Y Acad Sci, 889, 84-86.
    • (1999) Ann N y Acad Sci , vol.889 , pp. 84-86
    • Masferrer, J.L.1    Koki, A.2    Seibert, K.3
  • 91
    • 0029664275 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory analgesics in pain management in dogs and cats
    • Mathews, KA (1996). Nonsteroidal anti-inflammatory analgesics in pain management in dogs and cats. Can Vet J, 37, 539-545.
    • (1996) Can Vet J , vol.37 , pp. 539-545
    • Mathews, K.A.1
  • 92
    • 0024350333 scopus 로고
    • Effects of phenylbutazone and indomethacin on the post-operative course following experimental orthopaedic surgery in dogs
    • Mbugua, SW, LA Skoglund, and P Lokken (1989). Effects of phenylbutazone and indomethacin on the post-operative course following experimental orthopaedic surgery in dogs. Acta Vet Scand, 30, 27-35.
    • (1989) Acta Vet Scand , vol.30 , pp. 27-35
    • Mbugua, S.W.1    Skoglund, L.A.2    Lokken, P.3
  • 93
    • 0027480087 scopus 로고
    • Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs
    • Meade, EA, WL Smith, and DL DeWitt (1993). Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem, 268, 6610-6614.
    • (1993) J Biol Chem , vol.268 , pp. 6610-6614
    • Meade, E.A.1    Smith, W.L.2    Dewitt, D.L.3
  • 94
    • 0025455738 scopus 로고
    • The effects of phenylbutazone on the intestinal mucosa of the horse: A morphological, ultrastructural and biochemical study
    • Meschter, CL, M Gilbert, L Krook, G Maylin, and R Corradino (1990a). The effects of phenylbutazone on the intestinal mucosa of the horse: a morphological, ultrastructural and biochemical study. Equine Vet J, 22, 255-263.
    • (1990) Equine Vet J , vol.22 , pp. 255-263
    • Meschter, C.L.1    Gilbert, M.2    Krook, L.3    Maylin, G.4    Corradino, R.5
  • 95
    • 0024997387 scopus 로고
    • The effects of phenylbutazone on the morphology and prostaglandin concentrations of the pyloric mucosa of the equine stomach
    • Meschter, CL, M Gilbert, L Krook, G Maylin, and R Corradino (1990b). The effects of phenylbutazone on the morphology and prostaglandin concentrations of the pyloric mucosa of the equine stomach. Vet Pathol, 27, 244-253.
    • (1990) Vet Pathol , vol.27 , pp. 244-253
    • Meschter, C.L.1    Gilbert, M.2    Krook, L.3    Maylin, G.4    Corradino, R.5
  • 96
    • 0026209692 scopus 로고
    • Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs
    • Millichamp, NJ, J Dziezyc, BH Rohde, GC Chiou, and WB Smith (1991). Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs. Am J Vet Res, 52, 1279-1284.
    • (1991) Am J Vet Res , vol.52 , pp. 1279-1284
    • Millichamp, N.J.1    Dziezyc, J.2    Rohde, B.H.3    Chiou, G.C.4    Smith, W.B.5
  • 98
    • 0034071374 scopus 로고    scopus 로고
    • Selective cyclooxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence
    • Muscara, MN, N Vergnolle, F Lovren, CR Triggle, SN Elliott, S Asfaha, and JL Wallace (2000). Selective cyclooxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence. Br J Pharmacol, 129, 1423-1430.
    • (2000) Br J Pharmacol , vol.129 , pp. 1423-1430
    • Muscara, M.N.1    Vergnolle, N.2    Lovren, F.3    Triggle, C.R.4    Elliott, S.N.5    Asfaha, S.6    Wallace, J.L.7
  • 99
    • 33747627419 scopus 로고    scopus 로고
    • Safety of reduced-dosage ketoprofen for long-term oral administration in healthy dogs
    • Narita, T, R Sato, N Tomizawa, K Tani, S Komori, and S Hara (2006). Safety of reduced-dosage ketoprofen for long-term oral administration in healthy dogs. Am J Vet Res, 67, 1115-1120.
    • (2006) Am J Vet Res , vol.67 , pp. 1115-1120
    • Narita, T.1    Sato, R.2    Tomizawa, N.3    Tani, K.4    Komori, S.5    Hara, S.6
  • 100
    • 0023935527 scopus 로고
    • Systemic effects of prostaglandin E2 on vertebral trabecular remodeling in beagles used in a healing study
    • Norrdin, RW, and MS Shih (1988). Systemic effects of prostaglandin E2 on vertebral trabecular remodeling in beagles used in a healing study. Calcif Tissue Int, 42, 363-368.
    • (1988) Calcif Tissue Int , vol.42 , pp. 363-368
    • Norrdin, R.W.1    Shih, M.S.2
  • 102
    • 0038307436 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 in bone resorption
    • Okada, Y, C Pilbeam, L Raisz, and Y Tanaka (2003). Role of cyclooxygenase-2 in bone resorption. J UOEH, 25, 185-195.
    • (2003) J UOEH , vol.25 , pp. 185-195
    • Okada, Y.1    Pilbeam, C.2    Raisz, L.3    Tanaka, Y.4
  • 103
    • 0242708804 scopus 로고    scopus 로고
    • The effect of deletion of cyclooxygenase-2, prostaglandin receptor EP2, or EP4 in bone marrow cells on osteoclasts induced by mouse mammary cancer cell lines
    • Ono, K, T Akatsu, N Kugai, CC Pilbeam, and LG Raisz (2003). The effect of deletion of cyclooxygenase-2, prostaglandin receptor EP2, or EP4 in bone marrow cells on osteoclasts induced by mouse mammary cancer cell lines. Bone, 33, 798-804.
    • (2003) Bone , vol.33 , pp. 798-804
    • Ono, K.1    Akatsu, T.2    Kugai, N.3    Pilbeam, C.C.4    Raisz, L.G.5
  • 104
    • 33748436682 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension
    • Opay, AL, CR Mouton, JJ Mullins, and KD Mitchell (2006). Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension. Am J Physiol Renal Physiol, 29, F612-8.
    • (2006) Am J Physiol Renal Physiol , vol.29 , pp. 612-8
    • Opay, A.L.1    Mouton, C.R.2    Mullins, J.J.3    Mitchell, K.D.4
  • 107
    • 33750581315 scopus 로고    scopus 로고
    • Clinical evaluation of firocoxib and carprofen for the treatment of dogs with osteoarthritis
    • Pollmeier, M, C Toulemonde, C Fleishman, and PD Hanson (2006). Clinical evaluation of firocoxib and carprofen for the treatment of dogs with osteoarthritis. Vet Rec, 159, 547-551.
    • (2006) Vet Rec , vol.159 , pp. 547-551
    • Pollmeier, M.1    Toulemonde, C.2    Fleishman, C.3    Hanson, P.D.4
  • 108
    • 32944478395 scopus 로고    scopus 로고
    • Effects of cyclooxygenases on bone, tendon, and ligament healing
    • Radi, ZA, and NK Khan (2005). Effects of cyclooxygenases on bone, tendon, and ligament healing. Inflamm Res, 54, 358-366.
    • (2005) Inflamm Res , vol.54 , pp. 358-366
    • Radi, Z.A.1    Khan, N.K.2
  • 109
    • 33750321297 scopus 로고    scopus 로고
    • Effects of cyclooxygenase inhibition on the gastrointestinal tract
    • Radi, ZA, and NK Khan (2006). Effects of cyclooxygenase inhibition on the gastrointestinal tract. Exp Tox Pathol, 58, 163-173.
    • (2006) Exp Tox Pathol , vol.58 , pp. 163-173
    • Radi, Z.A.1    Khan, N.K.2
  • 110
    • 34250850213 scopus 로고    scopus 로고
    • Pulmonary and cardiorenal cyclooxygenase-1 (COX-1), -2 (COX-2), and microsomal prostaglandin e synthase- 1 (mPGES-1) and -2 (mPGES-2) expression in a hypertension model
    • Radi, ZA, and R Ostroski (2007). Pulmonary and cardiorenal cyclooxygenase-1 (COX-1), -2 (COX-2), and microsomal prostaglandin E synthase- 1 (mPGES-1) and -2 (mPGES-2) expression in a hypertension model. Mediators Inflamm, 2007, 85091.
    • (2007) Mediators Inflamm , vol.2007 , pp. 85091
    • Radi, Z.A.1    Ostroski, R.2
  • 111
    • 60249098863 scopus 로고    scopus 로고
    • Expression of COX-1, COX-2, iNOS and p38 in human brain with stroke lesions
    • Radi, ZA, and NK Khan (2008). Expression of COX-1, COX-2, iNOS and p38 in human brain with stroke lesions. Int J Pharmacol, 4, 108-113.
    • (2008) Int J Pharmacol , vol.4 , pp. 108-113
    • Radi, Z.A.1    Khan, N.K.2
  • 112
    • 41349096517 scopus 로고    scopus 로고
    • The pathophysiologic role of cycooxygenases in the eye
    • Radi, ZA, and JA Render (2008). The pathophysiologic role of cycooxygenases in the eye. J Ocular Pharmacol Ther, 24, 141-151.
    • (2008) J Ocular Pharmacol Ther , vol.24 , pp. 141-151
    • Radi, Z.A.1    Render, J.A.2
  • 114
    • 0020325135 scopus 로고
    • An analysis of the gastro-intestinal side-effects of non-steroidal anti-inflammatory drugs, with particular reference to comparative studies in man and laboratory species
    • Rainsford, KD (1982). An analysis of the gastro-intestinal side-effects of non-steroidal anti-inflammatory drugs, with particular reference to comparative studies in man and laboratory species. Rheumatol Int, 2, 1-10.
    • (1982) Rheumatol Int , vol.2 , pp. 1-10
    • Rainsford, K.D.1
  • 115
    • 0033166189 scopus 로고    scopus 로고
    • Prostaglandins and bone: Physiology and pathophysiology
    • Raisz, LG (1999). Prostaglandins and bone: physiology and pathophysiology. Osteoarthritis Cartilage, 7, 419-421.
    • (1999) Osteoarthritis Cartilage , vol.7 , pp. 419-421
    • Raisz, L.G.1
  • 116
    • 0035911004 scopus 로고    scopus 로고
    • Potential impact of selective cyclooxygenase-2 inhibitors on bone metabolism in health and disease
    • Raisz, LG (2001). Potential impact of selective cyclooxygenase-2 inhibitors on bone metabolism in health and disease. Am J Med, 110 (Suppl 3A). 43S-45S.
    • (2001) Am J Med , vol.110 , Issue.SUPPL 3A
    • Raisz, L.G.1
  • 117
    • 0037003171 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug-induced duodenal ulceration and perforation in a mature rottweiler
    • Reed, S (2002). Nonsteroidal anti-inflammatory drug-induced duodenal ulceration and perforation in a mature rottweiler. Can Vet J, 43, 971-972.
    • (2002) Can Vet J , vol.43 , pp. 971-972
    • Reed, S.1
  • 118
    • 0031014088 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug enteropathy in rats: Role of permeability, bacteria, and enterohepatic circulation
    • Reuter, BK, NM Davies, and JL Wallace (1997). Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation. Gastroenterology, 112, 109-117.
    • (1997) Gastroenterology , vol.112 , pp. 109-117
    • Reuter, B.K.1    Davies, N.M.2    Wallace, J.L.3
  • 120
    • 0031740348 scopus 로고    scopus 로고
    • Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other non-steroidal anti-inflammatory drugs
    • Ricketts, AP, KM Lundy, and SB Seibel (1998). Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other non-steroidal anti-inflammatory drugs. Am J Vet Res, 59, 1441-1446.
    • (1998) Am J Vet Res , vol.59 , pp. 1441-1446
    • Ricketts, A.P.1    Lundy, K.M.2    Seibel, S.B.3
  • 121
    • 0034954674 scopus 로고    scopus 로고
    • Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro
    • Riley, GP, M Cox, RL Harrall, S Clements, and BL Hazleman (2001). Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro. J Hand Surg [Br], 26, 224-228.
    • (2001) J Hand Surg [Br] , vol.26 , pp. 224-228
    • Riley, G.P.1    Cox, M.2    Harrall, R.L.3    Clements, S.4    Hazleman, B.L.5
  • 122
    • 0020077614 scopus 로고
    • Prostaglandin-induced periostitis: A complication of long-term PGE1 infusion in an infant with congenital heart disease
    • Ringel, RE, JI Brenner, PJ Haney, JE Burns, AL Moulton, and MA Berman (1982). Prostaglandin-induced periostitis: a complication of long-term PGE1 infusion in an infant with congenital heart disease. Radiology, 142, 657-658.
    • (1982) Radiology , vol.142 , pp. 657-658
    • Ringel, R.E.1    Brenner, J.I.2    Haney, P.J.3    Burns, J.E.4    Moulton, A.L.5    Berman, M.6
  • 123
  • 124
    • 0033894982 scopus 로고    scopus 로고
    • Renal changes induced by a cyclooxygenase-2 inhibitor during normal and low sodium intake
    • Rodriguez, F, MT Llinas, JD Gonzalez, J Rivera, and FJ Salazar (2000). Renal changes induced by a cyclooxygenase-2 inhibitor during normal and low sodium intake. Hypertension, 36, 276-281.
    • (2000) Hypertension , vol.36 , pp. 276-281
    • Rodriguez, F.1    Llinas, M.T.2    Gonzalez, J.D.3    Rivera, J.4    Salazar, F.J.5
  • 125
    • 33748210192 scopus 로고    scopus 로고
    • Clinical effectiveness and safety of a new NSAID, firocoxib: A 1,000 dog study
    • Ryan, WG, K Moldave, and D Carithers (2006). Clinical effectiveness and safety of a new NSAID, firocoxib: a 1,000 dog study. Vet Ther, 7, 119-126.
    • (2006) Vet Ther , vol.7 , pp. 119-126
    • Ryan, W.G.1    Moldave, K.2    Carithers, D.3
  • 126
    • 0025053009 scopus 로고
    • Nonsteroidal anti-inflammatory drugs and antihypertensives. Cooperative malfeasance
    • Sahloul, MZ, R al-Kiek, P Ivanovich, and SK Mujais (1990). Nonsteroidal anti-inflammatory drugs and antihypertensives. Cooperative malfeasance. Nephron, 56, 345-352.
    • (1990) Nephron , vol.56 , pp. 345-352
    • Sahloul, M.Z.1    Al-Kiek, R.2    Ivanovich, P.3    Mujais, S.K.4
  • 127
    • 0028913563 scopus 로고
    • Effect of intravitreal administration of indomethacin on experimental subretinal neovascularization in the subhuman primate
    • Sakamoto, T, D Soriano, J Nassaralla, TL Murphy, A Oganesian, C Spee, DR Hinton, and SJ Ryan (1995). Effect of intravitreal administration of indomethacin on experimental subretinal neovascularization in the subhuman primate. Arch Ophthalmol, 113, 222-226.
    • (1995) Arch Ophthalmol , vol.113 , pp. 222-226
    • Sakamoto, T.1    Soriano, D.2    Nassaralla, J.3    Murphy, T.L.4    Oganesian, A.5    Spee, C.6    Hinton, D.R.7    Ryan, S.J.8
  • 128
    • 0037280734 scopus 로고    scopus 로고
    • Topical nonsteroidal anti-inflammatory therapy in ophthalmology
    • Schalnus, R (2003). Topical nonsteroidal anti-inflammatory therapy in ophthalmology. Ophthalmologica, 217, 89-98.
    • (2003) Ophthalmologica , vol.217 , pp. 89-98
    • Schalnus, R.1
  • 129
    • 0030013358 scopus 로고    scopus 로고
    • NSAIDs, gastrointestinal injury, and cytoprotection
    • Scheiman, JM (1996). NSAIDs, gastrointestinal injury, and cytoprotection. Gastroenterol Clin North Am, 25, 279-298.
    • (1996) Gastroenterol Clin North Am , vol.25 , pp. 279-298
    • Scheiman, J.M.1
  • 130
    • 0023414610 scopus 로고
    • Pharmacokinetics of ibuprofen in the dog
    • Scherkl, R, and HH Frey (1987). Pharmacokinetics of ibuprofen in the dog. J Vet Pharmacol Ther, 10, 261-265.
    • (1987) J Vet Pharmacol Ther , vol.10 , pp. 261-265
    • Scherkl, R.1    Frey, H.H.2
  • 131
    • 2542488121 scopus 로고    scopus 로고
    • Interspecies differences in the nephrotoxic response to cyclooxygenase inhibition
    • Sellers, RS, PB Senese, and KN Khan (2004). Interspecies differences in the nephrotoxic response to cyclooxygenase inhibition. Drug Chem Toxicol, 27, 111-122.
    • (2004) Drug Chem Toxicol , vol.27 , pp. 111-122
    • Sellers, R.S.1    Senese, P.B.2    Khan, K.N.3
  • 133
    • 0022555707 scopus 로고
    • Effect of prostaglandin E2 on rib fracture healing in beagles: Histomorphometric study on periosteum adjacent to the fracture site
    • Shih, MS, and RW Norrdin (1986). Effect of prostaglandin E2 on rib fracture healing in beagles: histomorphometric study on periosteum adjacent to the fracture site. Am J Vet Res, 47, 1561-1564.
    • (1986) Am J Vet Res , vol.47 , pp. 1561-1564
    • Shih, M.S.1    Norrdin, R.W.2
  • 135
    • 33847665704 scopus 로고    scopus 로고
    • Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing
    • Simon, AM, and JP O'Connor (2007). Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. J Bone Joint Surg Am, 89, 500-511.
    • (2007) J Bone Joint Surg Am , vol.89 , pp. 500-511
    • Simon, A.M.1    O'Connor, J.P.2
  • 136
    • 0035999429 scopus 로고    scopus 로고
    • Cyclooxygenase 2 function is essential for bone fracture healing
    • Simon, AM, MB Manigrasso, and JP O'Connor (2002). Cyclooxygenase 2 function is essential for bone fracture healing. J Bone Miner Res, 17, 963-976.
    • (2002) J Bone Miner Res , vol.17 , pp. 963-976
    • Simon, A.M.1    Manigrasso, M.B.2    O'Connor, J.P.3
  • 139
    • 0033052563 scopus 로고    scopus 로고
    • Bone defect healing enhanced by ultrasound stimulation: An in vitro tissue culture model
    • Sun, JS, YH Tsuang, FH Lin, HC Liu, CZ Tsai, and WH Chang (1999). Bone defect healing enhanced by ultrasound stimulation: an in vitro tissue culture model. J Biomed Mater Res, 46, 253-261.
    • (1999) J Biomed Mater Res , vol.46 , pp. 253-261
    • Sun, J.S.1    Tsuang, Y.H.2    Lin, F.H.3    Liu, H.C.4    Tsai, C.Z.5    Chang, W.H.6
  • 140
    • 0031975973 scopus 로고    scopus 로고
    • Differential effects of systemic prostaglandin E2 on bone mass in rat long bones and calvariae
    • Suponitzky, I, and M Weinreb (1998). Differential effects of systemic prostaglandin E2 on bone mass in rat long bones and calvariae. J Endocrinol, 156, 51-57.
    • (1998) J Endocrinol , vol.156 , pp. 51-57
    • Suponitzky, I.1    Weinreb, M.2
  • 141
    • 0034455647 scopus 로고    scopus 로고
    • The role of prostaglandin e receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: An analysis using specific agonists for the respective EPs
    • Suzawa, T, C Miyaura, M Inada, T Maruyama, Y Sugimoto, F Ushikubi, A Ichikawa, S Narumiya, and T Suda (2000). The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology, 141, 1554-1559.
    • (2000) Endocrinology , vol.141 , pp. 1554-1559
    • Suzawa, T.1    Miyaura, C.2    Inada, M.3    Maruyama, T.4    Sugimoto, Y.5    Ushikubi, F.6    Ichikawa, A.7    Narumiya, S.8    Suda, T.9
  • 143
    • 7644236908 scopus 로고    scopus 로고
    • COX-2-selective inhibitor, etodolac, suppresses choroidal neovascularization in a mice model
    • Takahashi, H, Y Yanagi, Y Tamaki, S Uchida, and K Muranaka (2004). COX-2-selective inhibitor, etodolac, suppresses choroidal neovascularization in a mice model. Biochem Biophys Res Commun, 325, 461-466.
    • (2004) Biochem Biophys Res Commun , vol.325 , pp. 461-466
    • Takahashi, H.1    Yanagi, Y.2    Tamaki, Y.3    Uchida, S.4    Muranaka, K.5
  • 144
    • 1642304336 scopus 로고    scopus 로고
    • Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: Importance of gastric hypermotility
    • Takeuchi, K, A Tanaka, Y Hayashi, and Y Kubo (2004). Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility. Dig Dis Sci, 49, 180-187.
    • (2004) Dig Dis Sci , vol.49 , pp. 180-187
    • Takeuchi, K.1    Tanaka, A.2    Hayashi, Y.3    Kubo, Y.4
  • 146
    • 0034747922 scopus 로고    scopus 로고
    • Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs
    • Tanaka, A, H Araki, Y Komoike, S Hase, and K Takeuchi (2001). Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs. J Physiol Paris, 95, 21-27.
    • (2001) J Physiol Paris , vol.95 , pp. 21-27
    • Tanaka, A.1    Araki, H.2    Komoike, Y.3    Hase, S.4    Takeuchi, K.5
  • 147
    • 0036551298 scopus 로고    scopus 로고
    • Up-regulation of COX-2 by inhibition of COX-1 in the rat: A key to NSAID-induced gastric injury
    • Tanaka, A, H Araki, S Hase, Y Komoike, and K Takeuchi (2002). Up-regulation of COX-2 by inhibition of COX-1 in the rat: a key to NSAID-induced gastric injury. Aliment Pharmacol Ther, 16 (Suppl 2). 90-101.
    • (2002) Aliment Pharmacol Ther , vol.16 , Issue.SUPPL 2 , pp. 90-101
    • Tanaka, A.1    Araki, H.2    Hase, S.3    Komoike, Y.4    Takeuchi, K.5
  • 148
    • 0036895998 scopus 로고    scopus 로고
    • Role of cyclooxygenase (COX)-1 and COX-2 inhibition in nonsteroidal anti-inflammatory drug-induced intestinal damage in rats: Relation to various pathogenic events
    • Tanaka, A, S Hase, T Miyazawa, R Ohno, and K Takeuchi (2002). Role of cyclooxygenase (COX)-1 and COX-2 inhibition in nonsteroidal anti-inflammatory drug-induced intestinal damage in rats: relation to various pathogenic events. J Pharmacol Exp Ther, 303, 1248-1254.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 1248-1254
    • Tanaka, A.1    Hase, S.2    Miyazawa, T.3    Ohno, R.4    Takeuchi, K.5
  • 149
    • 41949109359 scopus 로고    scopus 로고
    • Continuous PGE2 leads to net bone loss while intermittent PGE2 leads to net bone gain in lumbar vertebral bodies of adult female rats
    • Tian, XY, Q Zhang, R Zhao, RB Setterberg, QQ Zeng, SJ Iturria, YF Ma, and WS Jee (2008). Continuous PGE2 leads to net bone loss while intermittent PGE2 leads to net bone gain in lumbar vertebral bodies of adult female rats. Bone., 42, 914-920.
    • (2008) Bone. , vol.42 , pp. 914-920
    • Tian, X.Y.1    Zhang, Q.2    Zhao, R.3    Setterberg, R.B.4    Zeng, Q.Q.5    Iturria, S.J.6    Ma, Y.F.7    Jee, W.S.8
  • 150
    • 0037358022 scopus 로고    scopus 로고
    • Inhibition of COX-2 prevents hypertension and proteinuria associated with a decrease of 8-iso-PGF2alpha formation in L-NAME-treated rats
    • Tomida, T, Y Numaguchi, Y Nishimoto, M Tsuzuki, Y Hayashi, H Imai, H Matsui, and K Okumura (2003). Inhibition of COX-2 prevents hypertension and proteinuria associated with a decrease of 8-iso-PGF2alpha formation in L-NAME-treated rats. J Hypertens, 21, 601-609.
    • (2003) J Hypertens , vol.21 , pp. 601-609
    • Tomida, T.1    Numaguchi, Y.2    Nishimoto, Y.3    Tsuzuki, M.4    Hayashi, Y.5    Imai, H.6    Matsui, H.7    Okumura, K.8
  • 152
  • 153
    • 0023092135 scopus 로고
    • Comparison of the effects of corticosteroids and indomethacin on the response of the blood-aqueous barrier to injury
    • van Delft, JL, NJ van Haeringen, E Glasius, ER Barthen, and JA Oosterhuis (1987). Comparison of the effects of corticosteroids and indomethacin on the response of the blood-aqueous barrier to injury. Curr Eye Res, 6, 419-425.
    • (1987) Curr Eye Res , vol.6 , pp. 419-425
    • Van Delft, J.L.1    Van Haeringen, N.J.2    Glasius, E.3    Barthen, E.R.4    Oosterhuis, J.A.5
  • 154
    • 0033517718 scopus 로고    scopus 로고
    • Transcriptional regulation of the cyclooxygenase-2 gene by diverse ligands in murine osteoblasts
    • Wadleigh, DJ, and HR Herschman (1999). Transcriptional regulation of the cyclooxygenase-2 gene by diverse ligands in murine osteoblasts. Biochem Biophys Res Commun, 264, 865-870.
    • (1999) Biochem Biophys Res Commun , vol.264 , pp. 865-870
    • Wadleigh, D.J.1    Herschman, H.R.2
  • 155
    • 0025078185 scopus 로고
    • Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process
    • Wallace, JL, CM Keenan, and DN Granger (1990). Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol, 259, G462-467.
    • (1990) Am J Physiol , vol.259 , pp. 462-467
    • Wallace, J.L.1    Keenan, C.M.2    Granger, D.N.3
  • 156
    • 0033851568 scopus 로고    scopus 로고
    • NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2
    • Wallace, JL, W Mcknight, BK Reuter, and N Vergnolle (2000). NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology, 119, 706-714.
    • (2000) Gastroenterology , vol.119 , pp. 706-714
    • Wallace, J.L.1    McKnight, W.2    Reuter, B.K.3    Vergnolle, N.4
  • 157
    • 0032793945 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension
    • Wang, JL, HF Cheng, and RC Harris (1999). Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension. Hypertension, 34, 96-101.
    • (1999) Hypertension , vol.34 , pp. 96-101
    • Wang, J.L.1    Cheng, H.F.2    Harris, R.C.3
  • 158
    • 0034128995 scopus 로고    scopus 로고
    • A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats
    • Wang, JL, HF Cheng, S Shappell, and RC Harris (2000). A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats. Kidney Int, 57, 2334-2342.
    • (2000) Kidney Int , vol.57 , pp. 2334-2342
    • Wang, J.L.1    Cheng, H.F.2    Shappell, S.3    Harris, R.C.4
  • 160
    • 0035126685 scopus 로고    scopus 로고
    • Expression of the prostaglandin E(2) (PGE(2)) receptor subtype EP(4) and its regulation by PGE(2) in osteoblastic cell lines and adult rat bone tissue
    • Weinreb, M, M Machwate, N Shir, M Abramovitz, GA Rodan, and S Harada (2001). Expression of the prostaglandin E(2) (PGE(2)) receptor subtype EP(4) and its regulation by PGE(2) in osteoblastic cell lines and adult rat bone tissue. Bone, 28, 275-281.
    • (2001) Bone , vol.28 , pp. 275-281
    • Weinreb, M.1    MacHwate, M.2    Shir, N.3    Abramovitz, M.4    Rodan, G.A.5    Harada, S.6
  • 161
    • 0030899145 scopus 로고    scopus 로고
    • Nephrotoxicities of nonsteroidal anti-inflammatory drugs
    • Wen, SF (1997). Nephrotoxicities of nonsteroidal anti-inflammatory drugs. J Formos Med Assoc, 96, 157-171.
    • (1997) J Formos Med Assoc , vol.96 , pp. 157-171
    • Wen, S.F.1
  • 162
    • 4644243612 scopus 로고    scopus 로고
    • Vasoactive factors and diabetic retinopathy: Vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide
    • Wilkinson-Berka, JL (2004). Vasoactive factors and diabetic retinopathy: vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide. Curr Pharm Des, 10, 3331-3348.
    • (2004) Curr Pharm des , vol.10 , pp. 3331-3348
    • Wilkinson-Berka, J.L.1
  • 164
    • 0032719928 scopus 로고    scopus 로고
    • The effect of selective cyclooxygenase-2 inhibitor on corneal angiogenesis in the rat
    • Yamada, M, M Kawai, Y Kawai, and Y Mashima (1999). The effect of selective cyclooxygenase-2 inhibitor on corneal angiogenesis in the rat. Curr Eye Res, 19, 300-304.
    • (1999) Curr Eye Res , vol.19 , pp. 300-304
    • Yamada, M.1    Kawai, M.2    Kawai, Y.3    Mashima, Y.4
  • 165
    • 0018701335 scopus 로고
    • The role of prostaglandins in experimental ocular inflammations
    • Yamauchi, H, T Iso, J Iwao, and H Iwata (1979). The role of prostaglandins in experimental ocular inflammations. Agents Actions, 9, 280-283.
    • (1979) Agents Actions , vol.9 , pp. 280-283
    • Yamauchi, H.1    Iso, T.2    Iwao, J.3    Iwata, H.4
  • 166
    • 0027399419 scopus 로고
    • Increased bone growth by local prostaglandin E2 in rats
    • Yang, RS, TK Liu, and SY Lin-Shiau (1993). Increased bone growth by local prostaglandin E2 in rats. Calcif Tissue Int, 52, 57-61.
    • (1993) Calcif Tissue Int , vol.52 , pp. 57-61
    • Yang, R.S.1    Liu, T.K.2    Lin-Shiau, S.Y.3
  • 169
    • 4644240323 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2 in the rat renal medulla leads to sodium-sensitive hypertension
    • Zewde, T, and DL Mattson (2004). Inhibition of cyclooxygenase-2 in the rat renal medulla leads to sodium-sensitive hypertension. Hypertension, 44, 424-428.
    • (2004) Hypertension , vol.44 , pp. 424-428
    • Zewde, T.1    Mattson, D.L.2
  • 170
    • 4444271267 scopus 로고    scopus 로고
    • Effects and mechanism of the selective COX-2 inhibitor, celecoxib, on rat colitis induced by trini-trobenzene sulfonic acid
    • Zhang, L, YM Lu, and XY Dong (2004). Effects and mechanism of the selective COX-2 inhibitor, celecoxib, on rat colitis induced by trini-trobenzene sulfonic acid. Chin J Dig Dis, 5, 110-114.
    • (2004) Chin J Dig Dis , vol.5 , pp. 110-114
    • Zhang, L.1    Lu, Y.M.2    Dong, X.Y.3
  • 172
    • 0036259278 scopus 로고    scopus 로고
    • Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
    • Zhang, X, EM Schwarz, DA Young, JE Puzas, RN Rosier, and RJ OKeefe (2002). Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest, 109, 1405-1415.
    • (2002) J Clin Invest , vol.109 , pp. 1405-1415
    • Zhang, X.1    Schwarz, E.M.2    Young, D.A.3    Puzas, J.E.4    Rosier, R.N.5    Okeefe, R.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.