Evaluation of adverse effects of long-term orally administered carprofen in dogs

Journal of the American Veterinary Medical Association

Volumn 228, Issue 6, 2006, Pages 876-880

  Raekallio, Marja R ^a   Hielm Björkman, Anna K ^a   Kejonen, Johanna ^a   Salonen, Hanna M ^a   Sankari, Satu M ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; CARPROFEN; CORTICOSTEROID; CREATININE; GAMMA GLUTAMYLTRANSFERASE; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; UREA;

APPETITE; ARTICLE; BODY WEIGHT; CREATININE BLOOD LEVEL; DIARRHEA; DISEASE SEVERITY; DRUG TOLERABILITY; ELBOW DISEASE; ENZYME ACTIVITY; HIP OSTEOARTHRITIS; INTESTINE MUCOSA PERMEABILITY; LIVER TOXICITY; NEPHROTOXICITY; NONHUMAN; OSTEOARTHRITIS; SKIN MANIFESTATION; UREA BLOOD LEVEL; VOMITING;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD PROTEINS; CARBAZOLES; DOG DISEASES; DOGS; FEMALE; KIDNEY; KIDNEY FUNCTION TESTS; LIVER; LIVER FUNCTION TESTS; MALE; OSTEOARTHRITIS; PROSPECTIVE STUDIES; SERUM ALBUMIN; TREATMENT OUTCOME; URINALYSIS;

ANIMALIA; CANIS FAMILIARIS;

EID: 33645083458     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.228.6.876     Document Type: Article

References (30)

1. Holtsinger SA, Parker RB, Beale BS, et al. The therapeutic efficacy of carprofen (Rimadyl-V™) in 209 clinical cases of canine degenerative joint disease. Vet Comp Orthop Traumatol 1992;5:140-144.
2. Vasseur PB, Johnston AL, Budsberg SC, et al. Randomized, controlled trial of the efficacy of carprofen, a non-steroidal anti-inflammatory drug, in treatment of osteoarthritis in dogs. J Am Vet Med Assoc 1995;206:807-811.
3. Lønaas L, Nyman G, Palmér E. Anti-inflammatory and analgesic treatment of osteoarthritis in the dog-experiences from continuous treatment with carprofen [Swedish]. Svensk Veterinärtidning 1999;51:707-711.
4. McKellar QA, Pearson T, Bogan JA, et al. Pharmacokinetics, tolerance and serum thromboxane inhibition of carprofen in the dog. J Small Anim Pract 1990;31:443-448.
5. EMEA/MRL/528/98-FINAL, Committee for Veterinary Medicinal Products, Carprofen, Summary report (2), 1999. Available at: www.emea.eu.int/pdfs/vet/ mrls/052899en.pdf. Accessed Jan 1999.
6. Forsyth SF, Guilford WG, Haslett SJ, et al. Endoscopy of the gastroduodenal mucosa after carprofen, meloxicam and ketoprofen administration in dogs. J Small Anim Pract 1998;39:421-424.
7. Reimer ME, Johnston SA, Leib MS, et al. The gastroduodenal effects of buffered aspirin, carprofen, and etodolac in healthy dogs. J Vet Intern Med 1999;13:472-477.
8. Sessions JK, Reynolds LR, Budsberg SC. In vivo effects of carprofen, deracoxib, and etodolac on prostanoid production in blood, gastric mucosa, and synovial fluid in dogs with chronic osteoarthritis. Am J Vet Res 2005;66:812-817.
9. Ko JC, Miyabiyashi T, Mandsager RE, et al. Renal effects of carprofen administered to healthy dogs anesthetized with propofol and isoflurane. J Am Vet Med Assoc 2000;217:346-349.
10. Lobetti RG, Joubert KE. Effect of administration of non-steroidal anti-inflammatory drugs before surgery on renal function in clinically normal dogs. Am J Vet Res 2000;61:1501-1507.
11. Boström IM, Nyman GC, Lord PE, et al. Effects of carprofen on renal function and results of serum biochemical and hematologic analyses in anesthetized dogs that had low blood pressure during anesthesia. Am J Vet Res 2002;63:712-721.
12. Crandell DE, Mathews KA, Dyson DH. Effect of meloxicam and carprofen on renal function when administered to healthy dogs prior to anesthesia and painful stimulation. Am J Vet Res 2004;65:1384-1390.
13. Forsyth SF, Guilford WG, Pfeiffer DU. Effect of NSAID administration on creatinine clearance in healthy dogs undergoing anaesthesia and surgery. J Small Anim Pract 2000;41:547-550.
14. MacPhail CM, Lappin MR, Meyer DJ, et al. Hepatocellular toxicosis associated with administration of carprofen in 21 dogs. J Am Vet Med Assoc 1998;212:1895-1901.
15. Mellor PJ, Roulois AJ, Day MJ, et al. Neutrophilic dermatitis and immune-mediated haematological disorders in a dog: suspected adverse reaction to carprofen. J Small Anim Pract 2005;46:237-242.
16. Weichselbaum TE. An accurate and rapid method for the determination of proteins in small amounts of blood serum and plasma. Am J Clin Pathol 1946;16:40-49.
17. Doumas BT, Watson WA, Biggs H. Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta 1971;31:87-96.
18. Fabiny DL, Ertigshausen G. Automated reaction rate method for determination of serum creatinine with Centrifichem. Clin Chem 1971;17:696-700.
19. Watanabe N, Kamei S, Ohkubo A, et al. Urinary protein as measured with a pyrogallol red-molybdate complex, manually and in a Hitachi 726 automated analyzer. Clin Chem 1986;32:1551-1554.
20. Gutmann I, Bergmeyer HU. Determination of urea with glutamate dehydrogenase as indicator enzyme. In: Bergmeyer HU, ed. Methods of enzymatic analysis. Vol 4. 2nd ed. New York: Academic Press Inc, 1974;1794-1798
21. European Committee for Clinical Laboratory Standards ECCLS Document 3-4, 1988;34-69.
22. Scandinavian Society for Clinical Chemistry and Clinical Physiology. Recommended methods for the determination of four enzymes in blood. Scand J Clin Lab Invest 1974;33:291-306.
23. IFCC 2002/7: IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37°C. International Federation of Clinical Chemistry and Laboratory Medicine. Part 6. Reference procedure for the measurement of catalytic concentrations of γ-glutamyltransferase. Clin Chem Lab Med 2002;40:734-738.
24. Heiene R, Moe L, Mølmen G. Calculation of urinary enzyme excretion, with renal structure and function in dogs with pyometra. Res Vet Sci 2001;70:129-137.
25. Stockham SL, Scott MA. Urinary system. In: Stockham SL, Scott MA, eds. Fundamentals of veterinary clinical pathologym. Ames, Iowa: Iowa State Press, 2002;277-335.
26. Clive DM, Stoff JS. Renal syndromes associated with non-steroidal antiinflammatory drugs. N Engl J Med 1984;310:563-572.
27. Stillman MT, Napier J, Blackshear JL. Adverse effects of nonsteroidal anti-inflammatory drugs on the kidney. Med Clin North Am 1984;68:371-385.
28. Laredo FG, Belda E, Murciano J, et al. Comparison of the analgesic effects of meloxicam and carprofen administered preoperatively to dogs undergoing orthopaedic surgery Vet Rec 2004;155:667-671.
29. Clemo FA. Urinary enzyme evaluation of nephrotoxicity in the dog. Toxicol Pathol 1998;26:29-32.
30. Cook AK, Gilson SD, Fischer WD, et al. Effect of diet on results obtained by use of two commercial test kits for detection of occult blood in feces of dogs. Am J Vet Res 1992;53:1749-1751.