메뉴 건너뛰기




Volumn 14, Issue 7, 1999, Pages 642-651

A selective cyclo-oxygenase-2 inhibitor, NS-398, may improve portal hypertension without inducing gastric mucosal injury

Author keywords

Cyclo oxygenase 2; Portal hypertensive gastropathy; Prostaglandin

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ALCOHOL; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTACYCLIN; THROMBOXANE B2;

EID: 0032777750     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.1999.01930.x     Document Type: Article
Times cited : (27)

References (43)
  • 1
    • 0002942706 scopus 로고
    • Portal hypertension
    • Schiff L (ed.). Philadelphia: JB Lippincott
    • 1 Genecin P, Groszmann RJ. Portal hypertension. In: Schiff L (ed.). Diseases of the Liver, 7th edn. Philadelphia: JB Lippincott, 1993; 935-73.
    • (1993) Diseases of the Liver, 7th Edn. , pp. 935-973
    • Genecin, P.1    Groszmann, R.J.2
  • 2
    • 0002388394 scopus 로고
    • Biology of portal hypertension
    • Arias T, Boyer JL, Fausto N et al. (eds). New York: Raven Press
    • 2 Genecin P, Groszmann RJ. Biology of portal hypertension. In: Arias T, Boyer JL, Fausto N et al. (eds). The Liver: Biology and Pathophysiology. New York: Raven Press, 1994; 1327-42.
    • (1994) The Liver: Biology and Pathophysiology , pp. 1327-1342
    • Genecin, P.1    Groszmann, R.J.2
  • 3
    • 0020677377 scopus 로고
    • Hyperdynamic circulation in portal-hypertensive rat model: A primary factor maintenance of chronic portal hypertension
    • 3 Vorobioff J, Bredfeldt JE, Groszmann RJ et al. Hyperdynamic circulation in portal-hypertensive rat model: A primary factor maintenance of chronic portal hypertension. Am. J. Physiol. 1983; 244: G52.
    • (1983) Am. J. Physiol. , vol.244
    • Vorobioff, J.1    Bredfeldt, J.E.2    Groszmann, R.J.3
  • 4
    • 0022518362 scopus 로고
    • Hemodynamic studies in long and short term portal hypertensive rats: The relation to systemic glucagon levels
    • 4 Sikuler E, Groszmann RJ. Hemodynamic studies in long and short term portal hypertensive rats: The relation to systemic glucagon levels. Hepatology 1988; 6: 414-18.
    • (1988) Hepatology , vol.6 , pp. 414-418
    • Sikuler, E.1    Groszmann, R.J.2
  • 5
    • 0024523451 scopus 로고
    • Role of prostacyclin in the splanchnic hyperemia contributing to portal hypertension
    • 5 Sitzmann JV, Bulkley GB, Mitchell MC et al. Role of prostacyclin in the splanchnic hyperemia contributing to portal hypertension. Ann. Surg. 1989; 209: 322-7.
    • (1989) Ann. Surg. , vol.209 , pp. 322-327
    • Sitzmann, J.V.1    Bulkley, G.B.2    Mitchell, M.C.3
  • 6
    • 0026021496 scopus 로고
    • Evidence for role of prostacyclin as a systemic hormone in portal hypertension
    • 6 Sitzmann JV, Li SS, Adkinson NF et al. Evidence for role of prostacyclin as a systemic hormone in portal hypertension. Surgery 1991; 109: 149-53.
    • (1991) Surgery , vol.109 , pp. 149-153
    • Sitzmann, J.V.1    Li, S.S.2    Adkinson, N.F.3
  • 7
    • 0021881118 scopus 로고
    • The role of prostacyclin in patients with portal hypertension
    • 7 Hashizume M, Inokuchi K, Tanaka K. The role of prostacyclin in patients with portal hypertension. Liver 1985; 5: 89-93.
    • (1985) Liver , vol.5 , pp. 89-93
    • Hashizume, M.1    Inokuchi, K.2    Tanaka, K.3
  • 8
    • 0030045689 scopus 로고    scopus 로고
    • Prostaglandin modulates the responsiveness of the gastric microcirculation to sodium nitroprusside in cirrhotic rats
    • 8 Ferraz JGP, Wallace JL. Prostaglandin modulates the responsiveness of the gastric microcirculation to sodium nitroprusside in cirrhotic rats. Hepatology 1996; 23: 123-9.
    • (1996) Hepatology , vol.23 , pp. 123-129
    • Ferraz, J.G.P.1    Wallace, J.L.2
  • 9
    • 0029920878 scopus 로고    scopus 로고
    • Acute and chronic cyclooxygenase blockade in portal-hypertensive rats: Influence on nitric oxide biosynthesis
    • 9 Fernández M, Garcia-Pagán JC, Casadevall M et al. Acute and chronic cyclooxygenase blockade in portal-hypertensive rats: Influence on nitric oxide biosynthesis. Gastroenterology 1996; 110: 1529-35.
    • (1996) Gastroenterology , vol.110 , pp. 1529-1535
    • Fernández, M.1    Garcia-Pagán, J.C.2    Casadevall, M.3
  • 10
    • 0025754779 scopus 로고
    • Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
    • 10 Xie W, Chipman JG, Robertson DL et al. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Natl Acad. Sci. USA 1991; 88: 2692-6.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 2692-2696
    • Xie, W.1    Chipman, J.G.2    Robertson, D.L.3
  • 11
    • 0025871150 scopus 로고
    • TIS10, a pholbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase
    • 11 Kujubu DA, Fletcher BS, Varnum BC et al. TIS10, a pholbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase. J. Biol. Chem. 1991; 266: 12866-72.
    • (1991) J. Biol. Chem. , vol.266 , pp. 12866-12872
    • Kujubu, D.A.1    Fletcher, B.S.2    Varnum, B.C.3
  • 12
    • 0029928405 scopus 로고    scopus 로고
    • Mechanism of action of anti-inflammatory drugs
    • 12 Vane JR, Botting RM. Mechanism of action of anti-inflammatory drugs. Scand. J. Rheumatol. 1996; 25 (Suppl. 102): 9-21.
    • (1996) Scand. J. Rheumatol. , vol.25 , Issue.SUPPL. 102 , pp. 9-21
    • Vane, J.R.1    Botting, R.M.2
  • 13
    • 0028089109 scopus 로고
    • NS-398, a new anti-inflammatory agent, selectivity inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
    • 13 Futaki N, Takahashi S, Yokoyama M et al. NS-398, a new anti-inflammatory agent, selectivity inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 1994; 47: 55-9.
    • (1994) Prostaglandins , vol.47 , pp. 55-59
    • Futaki, N.1    Takahashi, S.2    Yokoyama, M.3
  • 14
    • 0027516402 scopus 로고
    • NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions
    • 14 Futaki N, Yoshikawa K, Hamasaki Y et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen. Pharmacol. 1993; 24: 105-10.
    • (1993) Gen. Pharmacol. , vol.24 , pp. 105-110
    • Futaki, N.1    Yoshikawa, K.2    Hamasaki, Y.3
  • 15
    • 0027201818 scopus 로고
    • Selective inhibition of NS-398 on prostanoid production in inflamed tissues in rat carrageenan-air-pouch inflammation
    • 15 Futaki N, Arai I, Hamasaki Y et al. Selective inhibition of NS-398 on prostanoid production in inflamed tissues in rat carrageenan-air-pouch inflammation. J. Pharm. Pharmacol. 1993; 45: 753-5.
    • (1993) J. Pharm. Pharmacol. , vol.45 , pp. 753-755
    • Futaki, N.1    Arai, I.2    Hamasaki, Y.3
  • 16
    • 0027423709 scopus 로고
    • Effect of NS-398, a new nonsteroidal anti-inflammatory agent, on gastric ulceration and acid secretion in rats
    • 16 Arai I, Hamasaki Y, Futaki N et al. Effect of NS-398, a new nonsteroidal anti-inflammatory agent, on gastric ulceration and acid secretion in rats. Res. Commun. Chem. Pathol. Pharmacol. 1993; 81: 259-70.
    • (1993) Res. Commun. Chem. Pathol. Pharmacol. , vol.81 , pp. 259-270
    • Arai, I.1    Hamasaki, Y.2    Futaki, N.3
  • 18
    • 0029935083 scopus 로고    scopus 로고
    • Activity of gastric mucosal nitric oxide synthase in portal hypertensive gastropathy
    • 18 El Newihi HM, Kanji VK, Mihas AA. Activity of gastric mucosal nitric oxide synthase in portal hypertensive gastropathy. Am. J. Gastroenterol. 1996; 91: 535-8.
    • (1996) Am. J. Gastroenterol. , vol.91 , pp. 535-538
    • El Newihi, H.M.1    Kanji, V.K.2    Mihas, A.A.3
  • 19
    • 0030048814 scopus 로고    scopus 로고
    • Effect of teprenone on portal hypertensive gastric mucosa
    • 19 Tanoue K, Tarnawski AS, Kishihara F et al. Effect of teprenone on portal hypertensive gastric mucosa. Digestion 1996; 57: 35-40.
    • (1996) Digestion , vol.57 , pp. 35-40
    • Tanoue, K.1    Tarnawski, A.S.2    Kishihara, F.3
  • 20
    • 0029863444 scopus 로고    scopus 로고
    • Increased blood hemoglobin attenuates splanchnic vasodilatation in portal-hypertensive rats by nitric oxide inactivation
    • 20 Casadevall M, Pique JM, Cirera I et al. Increased blood hemoglobin attenuates splanchnic vasodilatation in portal-hypertensive rats by nitric oxide inactivation. Gastroenterology 1996; 110: 1156-65.
    • (1996) Gastroenterology , vol.110 , pp. 1156-1165
    • Casadevall, M.1    Pique, J.M.2    Cirera, I.3
  • 21
    • 0021041385 scopus 로고
    • Morphology of gastric microcirculation in cirrhosis
    • 21 Hashizume M, Tanaka K, Inokuchi K. Morphology of gastric microcirculation in cirrhosis. Hepatology 1983; 3: 1008-12.
    • (1983) Hepatology , vol.3 , pp. 1008-1012
    • Hashizume, M.1    Tanaka, K.2    Inokuchi, K.3
  • 22
    • 0025972590 scopus 로고
    • Hyperdynamic circulation in cirrhosis: A role for nitric oxide?
    • 22 Vallence P, Moncade S. Hyperdynamic circulation in cirrhosis: A role for nitric oxide? Lancet 1991; 377: 776-8.
    • (1991) Lancet , vol.377 , pp. 776-778
    • Vallence, P.1    Moncade, S.2
  • 23
    • 0024241539 scopus 로고
    • Microvascular abnormalities of the portal hypertensive gastric mucosa
    • 23 Tarnawski AS, Sarfeh IJ, Stachura J et al. Microvascular abnormalities of the portal hypertensive gastric mucosa. Hepatology 1988; 8: 1288-494.
    • (1988) Hepatology , vol.8 , pp. 1288-1494
    • Tarnawski, A.S.1    Sarfeh, I.J.2    Stachura, J.3
  • 24
    • 0026036413 scopus 로고
    • A rat model of esophageal varices
    • 24 Tanoue K, Kitano S, Hashizume M et al. A rat model of esophageal varices. Hepatology 1991; 13: 353-8.
    • (1991) Hepatology , vol.13 , pp. 353-358
    • Tanoue, K.1    Kitano, S.2    Hashizume, M.3
  • 25
    • 0018637521 scopus 로고
    • Cytoprotection by prostaglandins in rats: Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury
    • 25 Robert A, Nezamis JE, Lancaster C et al. Cytoprotection by prostaglandins in rats: Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 1979; 77: 433-43.
    • (1979) Gastroenterology , vol.77 , pp. 433-443
    • Robert, A.1    Nezamis, J.E.2    Lancaster, C.3
  • 27
    • 0022360519 scopus 로고
    • Gastric lesions in portal hypertension: Inflammatory gastritis or congestive gastropathy?
    • 27 McCormack TT, Sims J, Eyre-Brook I et al. Gastric lesions in portal hypertension: Inflammatory gastritis or congestive gastropathy? Gut 1985; 26: 1226-32.
    • (1985) Gut , vol.26 , pp. 1226-1232
    • McCormack, T.T.1    Sims, J.2    Eyre-Brook, I.3
  • 28
    • 0025242833 scopus 로고
    • Natural history of congestive gastropathy in cirrhosis
    • 28 D'Amico G, Montalbano L, Traina M et al. Natural history of congestive gastropathy in cirrhosis. Gastroenterology 1990; 99: 1558-64.
    • (1990) Gastroenterology , vol.99 , pp. 1558-1564
    • D'Amico, G.1    Montalbano, L.2    Traina, M.3
  • 29
    • 0023514336 scopus 로고
    • Gastric mucosal vascular ectasia causing bleeding in cirrhosis: A distinct entity associated with hypergastrinaemia and low levels of pepsinogen I
    • 29 Quintero E, Pique JM, Bombi JA et al. Gastric mucosal vascular ectasia causing bleeding in cirrhosis: A distinct entity associated with hypergastrinaemia and low levels of pepsinogen I. Gastroenterology 1987; 93: 1054-61.
    • (1987) Gastroenterology , vol.93 , pp. 1054-1061
    • Quintero, E.1    Pique, J.M.2    Bombi, J.A.3
  • 30
    • 0029028590 scopus 로고
    • Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach
    • 30 Iseki S. Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach. Histochem. J. 1995; 25: 323-8.
    • (1995) Histochem. J. , vol.25 , pp. 323-328
    • Iseki, S.1
  • 31
    • 0030017042 scopus 로고    scopus 로고
    • Characterization of prostaglandin G/H synthase 1 and 2 in rats, monkey, and human gastrointestinal tracts
    • 31 Kargman S, Charleson S, Cartwright M et al. Characterization of prostaglandin G/H synthase 1 and 2 in rats, monkey, and human gastrointestinal tracts. Gastroenterology 1996; 111: 445-54.
    • (1996) Gastroenterology , vol.111 , pp. 445-454
    • Kargman, S.1    Charleson, S.2    Cartwright, M.3
  • 32
    • 0016748441 scopus 로고
    • Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides
    • 32 Hamberg M, Svensson J, Samuelsson B. Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. Natl Acad. Sci. USA 1975; 72: 2994-8.
    • (1975) Proc. Natl Acad. Sci. USA , vol.72 , pp. 2994-2998
    • Hamberg, M.1    Svensson, J.2    Samuelsson, B.3
  • 34
    • 0018771263 scopus 로고
    • Prostaglandin and thromboxane production by human and guinea-pig macrophages and leucocytes
    • 34 Morley J, Bray MA, Jones RW et al. Prostaglandin and thromboxane production by human and guinea-pig macrophages and leucocytes. Prostaglandins 1979; 17: 730-6.
    • (1979) Prostaglandins , vol.17 , pp. 730-736
    • Morley, J.1    Bray, MA.2    Jones, R.W.3
  • 35
    • 0026489476 scopus 로고
    • Increased gastric mucosal perfusion in cirrhotic patients with portal hypertensive gastropathy
    • 35 Panes J, Bordas JM, Pique JM et al. Increased gastric mucosal perfusion in cirrhotic patients with portal hypertensive gastropathy. Gastroenterology 1992; 103; 1875-82.
    • (1992) Gastroenterology , vol.103 , pp. 1875-1882
    • Panes, J.1    Bordas, J.M.2    Pique, J.M.3
  • 36
    • 0028075851 scopus 로고
    • Portal and gastric mucosal hemodynamics in cirrhotic patients with portal-hypertensive gastropathy
    • 36 Ohta M, Hashizume M, Higashi H et al. Portal and gastric mucosal hemodynamics in cirrhotic patients with portal-hypertensive gastropathy. Hepatology 1994; 20: 1432-6.
    • (1994) Hepatology , vol.20 , pp. 1432-1436
    • Ohta, M.1    Hashizume, M.2    Higashi, H.3
  • 37
    • 0026594336 scopus 로고
    • Gastric mucosal blood flow in portal hypertension patients: A laser Doppler flowmetry study
    • 37 Kotzampassi K, Eleftheriadis E, Aletras H. Gastric mucosal blood flow in portal hypertension patients: A laser Doppler flowmetry study. Hepatogastroenterology 1992; 39: 39-42.
    • (1992) Hepatogastroenterology , vol.39 , pp. 39-42
    • Kotzampassi, K.1    Eleftheriadis, E.2    Aletras, H.3
  • 38
    • 0027181688 scopus 로고
    • Congestive gastropathy versus chronic gastritis: A comparison of some pathophysiological aspects
    • 38 Guslandi M, Sorghi M, Foppa L et al. Congestive gastropathy versus chronic gastritis: A comparison of some pathophysiological aspects. Digestion 1993; 54: 160-2.
    • (1993) Digestion , vol.54 , pp. 160-162
    • Guslandi, M.1    Sorghi, M.2    Foppa, L.3
  • 39
    • 0027294660 scopus 로고
    • Reduced gastric mucosal blood flow in patients with portal-hypertensive gastropathy
    • 39 Iwao T, Toyonaga A, Ikegami M et al. Reduced gastric mucosal blood flow in patients with portal-hypertensive gastropathy. Hepatology 1993; 18: 36-40.
    • (1993) Hepatology , vol.18 , pp. 36-40
    • Iwao, T.1    Toyonaga, A.2    Ikegami, M.3
  • 40
    • 0028557184 scopus 로고
    • Measurement of gastric intramucosal pH in patients with cirrhosis and portal hypertensive gastropathy
    • 40 Lamarque D, Levoir D, Duvoux C et al. Measurement of gastric intramucosal pH in patients with cirrhosis and portal hypertensive gastropathy. Gastroenterol. Clin. Biol. 1994; 18: 969-74.
    • (1994) Gastroenterol. Clin. Biol. , vol.18 , pp. 969-974
    • Lamarque, D.1    Levoir, D.2    Duvoux, C.3
  • 41
    • 0026532798 scopus 로고
    • A study of regional gastric mucosal blood flow in a rat model of hepatic cirrhosis
    • 41 Geraghty JG, Angerson WJ, Carter DC. A study of regional gastric mucosal blood flow in a rat model of hepatic cirrhosis. Am. J. Physiol. 1992; 262: G727-31.
    • (1992) Am. J. Physiol. , vol.262
    • Geraghty, J.G.1    Angerson, W.J.2    Carter, D.C.3
  • 42
    • 0020580513 scopus 로고
    • Portal hypertension and gastric mucosal injury in rats
    • 42 Sarfeh IJ, Tarnawski A, Malki A. Portal hypertension and gastric mucosal injury in rats. Gastroenterology 1983; 34: 987-93.
    • (1983) Gastroenterology , vol.34 , pp. 987-993
    • Sarfeh, I.J.1    Tarnawski, A.2    Malki, A.3
  • 43
    • 0028969527 scopus 로고
    • Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2
    • 43 Morita I et al. Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J. Biol. Chem. 1995; 270: 24019-23.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24019-24023
    • Morita, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.