Cyclo-oxygenase-2 inhibition increases blood pressure in rats

British Journal of Pharmacology

Volumn 136, Issue 8, 2002, Pages 1117-1126

  Höcherl, Klaus ^a   Endemann, Dierk ^a   Kammerl, Martin C ^a   Grobecker, Horst F ^a   Kurtz, Armin ^a  

^a Institut für Pharmakologie   (Germany)

Author keywords

Aldosterone; Blood pressure; Cyclo oxygenase 2; Hypertension; Kidney; Prostaglandin; Renin; SHR

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ALDOSTERONE; BETA ACTIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; MESSENGER RNA; POTASSIUM; PROSTACYCLIN; REFLOTRON; RENIN; ROFECOXIB; SODIUM CHLORIDE; THROMBOXANE B2; ACTIN; LACTONE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; SULFONE;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME INHIBITION; FLUID INTAKE; GENETIC PREDISPOSITION; HEMATOCRIT; HYPERTENSION; MALE; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT; RAT STRAIN; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SALT INTAKE; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; ANIMAL; BLOOD; BLOOD PRESSURE; DOSE RESPONSE; DRINKING; DRUG EFFECT; GENETICS; HEART RATE; KIDNEY CORTEX; METABOLISM; SODIUM INTAKE; WISTAR KYOTO RAT;

6-KETOPROSTAGLANDIN F1 ALPHA; ACTINS; ALDOSTERONE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD PRESSURE; BODY WEIGHT; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; HEART RATE; HEMATOCRIT; KIDNEY CORTEX; LACTONES; MALE; POTASSIUM; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RENIN; RNA, MESSENGER; SODIUM, DIETARY; SULFONES;

EID: 0036687267     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704821     Document Type: Article

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