Discovery of okilactomycin and congeners from Streptomyces scabrisporus by antisense differential sensitivity assay targeting ribosomal protein S4

Journal of Antibiotics

Volumn 62, Issue 2, 2009, Pages 55-61

  Zhang, Chaowei ^a   Ondeyka, John G ^a   Zink, Deborah L ^a   Basilio, Angela ^b   Vicente, Francisca ^b   Salazar, Oscar ^b   Genilloud, Olga ^b   Dorso, Karen ^a   Motyl, Mary ^a   Byrne, Kevin ^a   Singh, Sheo B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Medical affairs Merck sharp and Dohme ltd   (Spain)

Author keywords

Antisense; Natural products; RNA synthesis inhibitors; rpsD

Indexed keywords

ANTIBIOTIC AGENT; DNA; OKILACTOMYCIN; OKILACTOMYCIN A; OKILACTOMYCIN B; OKILACTOMYCIN C; OKILACTOMYCIN D; PROTEIN S 4; RIBOSOME PROTEIN; RNA; UNCLASSIFIED DRUG;

ANTISENSE DIFFERENTIAL SENSITIVITY ASSAY; ARTICLE; ASSAY; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG ISOLATION; DRUG SCREENING; DRUG TARGETING; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RNA SYNTHESIS; SCREENING; STAPHYLOCOCCUS AUREUS; STREPTOMYCES; STREPTOMYCES SCABRISPORUS;

POSIBACTERIA; STAPHYLOCOCCUS AUREUS; STREPTOMYCES SCABRISPORUS;

EID: 62249126223     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2008.8     Document Type: Article

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