Coniothyrione, a chlorocyclopentandienylbenzopyrone as a bacterial protein synthesis inhibitor discovered by antisense technology

Journal of Natural Products

Volumn 70, Issue 4, 2007, Pages 668-670

  Ondeyka, John G ^a   Zink, Deborah ^a   Basilio, Angela ^b   Vicente, Francisca ^b   Bills, Gerald ^b   Diez, Maria Teresa ^b   Motyl, Mary ^a   Dezeny, Gabe ^a   Byrne, Kevin ^a   Singh, Sheo B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Medical affairs Merck sharp and Dohme ltd   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CHLOROCYCLOPENTANDIENYLBENZOPYRONE; CONIOTHYRIONE; PROTEIN S 4; PROTEIN SYNTHESIS INHIBITOR; RIBOSOME PROTEIN; RIBOSOME PROTEIN SUBUNIT D; RIBOSOME RNA; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CARBON NUCLEAR MAGNETIC RESONANCE; CHLORINATION; CONIOTHYRIUM CEREALIS; DRUG ISOLATION; DRUG STRUCTURE; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; LEPTOSPIRA; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN INTERACTION; PROTEIN TARGETING; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BACTERIA; CHROMONES; DNA, ANTISENSE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PROTEIN SYNTHESIS INHIBITORS; RIBOSOMAL PROTEINS; RNA, ANTISENSE; SPAIN; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); CONIOTHYRIUM CEREALE; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

EID: 34249084617     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np060557d     Document Type: Article

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