Chapter Twenty‐Nine Monitoring the Role of Autophagy in C. elegans Aging

Methods in Enzymology

Volumn 451, Issue C, 2008, Pages 493-520

  Meléndez, Alicia ^a   Hall, David H ^b   Hansen, Malene ^c  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 61949432569     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/S0076-6879(08)03229-1     Document Type: Review

References (80)

1. J. Apfeld C. Kenyon Cell nonautonomy of C. elegans daf‐2 function in the regulation of diapause and life span Cell 95 1998 199 210
2. B.A. Bamber A.M. Rowland Shaping cellular form and function by autophagy Autophagy 2 2006 247 249
3. N.A. Bishop L. Guarente Two neurons mediate diet‐restriction‐induced longevity in C. elegans Nature 447 2007 545 549
4. M. Bluher B.B. Kahn C.R. Kahn Extended longevity in mice lacking the insulin receptor in adipose tissue Science 299 2003 572 574
5. Chen Aging Cell 2007
6. G.V. Clokey L.A. Jacobson The autofluorescent “lipofuscin granules” in the intestinal cells of Caenorhabditis elegans are secondary lysosomes Mech. Ageing Dev. 35 1986 79 94
7. D. Crawford N. Libina C. Kenyon Caenorhabditis elegans integrates food and reproductive signals in lifespan determination Aging Cell 6 2007 715 721
8. Curran Ruvkun PLOS G 2007
9. A. Dillin D.K. Crawford C. Kenyon Timing requirements for insulin/IGF‐1 signaling in C. elegans Science 298 2002 830 834
10. A. Dillin A.L. Hsu N. Arantes‐Oliveira J. Lehrer‐Graiwer H. Hsin A.G. Fraser R.S. Kamath J. Ahringer C. Kenyon Rates of behavior and aging specified by mitochondrial function during development Science 298 2002 2398 2401
11. J. Feng F. Bussiere S. Hekimi Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans Dev. Cell 1 2001 663–644
12. M.L. Florez‐McClure L.A. Hohsfield G. Fonte M.T. Bealor C.D. Link Decreased insulin‐receptor signaling promotes the autophagic degradation of beta‐amyloid peptide in C. elegans Autophagy 3 2007
13. B. Gerstbrein G. Stamatas N. Kollias M. Driscoll In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans Aging Cell 4 2005 127 137
14. M.E. Giannakou L. Partridge Role of insulin‐like signalling in Drosophila lifespan Trends Biochem. Sci. 32 2007 180 188
15. L. Guarente F. Picard Calorie restriction: The SIR2 connection Cell 120 2005 473 482
16. D.H. Hall Electron microscopy and three‐dimensional image reconstruction Methods Cell Biol. 48 1995 395 436
17. B. Hamilton Y. Dong M. Shindo W. Liu I. Odell G. Ruvkun S.S. Lee A systematic RNAi screen for longevity genes in C. elegans Genes Dev. 19 2005 1544 1555
18. M. Hansen A. Chandra L.L. Mitic B. Onken M. Driscoll C. Kenyon A role for autophagy in the extension of lifespan by dietary restriction in C. elegans PLoS Genet. 4 2008 e24
19. M. Hansen A.L. Hsu A. Dillin C. Kenyon New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen PLoS Genet. 1 2005 119 128
20. M. Hansen S. Taubert D. Crawford N. Libina S.J. Lee C. Kenyon Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans Aging Cell 6 2007 95 110
21. E.S. Hars H. Qi A.G. Ryazanov S. Jin L. Cai C. Hu L.F. Liu Autophagy regulates ageing in C. elegans Autophagy 3 2007 93 95
22. S.T. Henderson M. Bonafe T.E. Johnson daf‐16 protects the nematode Caenorhabditis elegans during food deprivation J. Gerontol. A Biol. Sci. Med. Sci. 61 2006 444 460
23. M. Holzenberger J. Dupont B. Ducos P. Leneuve A. Geloen P.C. Even P. Cervera Y. Le Bouc IGF‐1 receptor regulates lifespan and resistance to oxidative stress in mice Nature 421 2003 182 187
24. Y. Honda S. Honda The daf‐2 gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression in Caenorhabditis elegans Faseb J. 13 1999 1385 1393
25. K. Houthoofd B.P. Braeckman T.E. Johnson J.R. Vanfleteren Life extension via dietary restriction is independent of the Ins/IGF‐1 signalling pathway in Caenorhabditis elegans Exp. Gerontol. 38 2003 947 954
26. H. Hsin C. Kenyon Signals from the reproductive system regulate the lifespan of C. elegans [see comments] Nature 399 1999 362 366
27. A.L. Hsu C.T. Murphy C. Kenyon Regulation of aging and age‐related disease by DAF‐16 and heat‐shock factor Science 300 2003 1142 1145
28. K. Jia D. Chen D.L. Riddle The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span Development 131 2004 3897 3906
29. K. Jia B. Levine Autophagy is required for dietary restriction‐mediated life span extension in C. elegans Autophagy 3 2007
30. M. Kaeberlein R.W. Powers III K.K. Steffen E.A. Westman D. Hu N. Dang E.O. Kerr K.T. Kirkland S. Fields B.K. Kennedy Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients Science 310 2005 1193 1196
31. T.L. Kaeberlein E.D. Smith M. Tsuchiya K.L. Welton J.H. Thomas S. Fields B.K. Kennedy M. Kaeberlein Lifespan extension in Caenorhabditis elegans by complete removal of food Aging Cell 2006
32. C. Kang Y.J. You L. Avery Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation Genes Dev. 21 2007 2161 2171
33. P. Kapahi B.M. Zid T. Harper D. Koslover V. Sapin S. Benzer Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway Curr. Biol. 14 2004 885 890
34. C. Kenyon The plasticity of aging: Insights from long‐lived mutants Cell 120 2005 449 460
35. C. Kenyon J. Chang E. Gensch A. Rudner R. Tabtiang A C. elegans mutant that lives twice as long as wild type [see comments] Nature 366 1993 461 464
36. M.R. Klass Aging in the nematode Caenorhabditis elegans : major biological and environmental factors influencing life span Mech. Ageing Dev. 6 1977 413 429
37. M.R. Klass A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results Mech. Ageing Dev. 22 1983 279 286
38. D.J. Klionsky A.M. Cuervo P.O. Seglen Methods for monitoring autophagy from yeast to human Autophagy 3 2007 181 206
39. B. Lakowski S. Hekimi Determination of life‐span in Caenorhabditis elegans by four clock genes Science 272 1996 1010 1013
40. B. Lakowski S. Hekimi The genetics of caloric restriction in Caenorhabditis elegans Proc. Natl. Acad. Sci. USA 95 1998 13091 13096
41. D.W. Lamming M. Latorre‐Esteves O. Medvedik S.N. Wong F.A. Tsang C. Wang S.J. Lin D.A. Sinclair HST2 mediates SIR2‐independent life‐span extension by calorie restriction Science 309 2005 1861 1864
42. G.D. Lee M.A. Wilson M. Zhu C.A. Wolkow R. de Cabo D.K. Ingram S. Zou Dietary deprivation extends lifespan in Caenorhabditis elegans Aging Cell 5 2006 515 524
43. S.S. Lee S. Kennedy A.C. Tolonen G. Ruvkun DAF‐16 target genes that control C. elegans life‐span and metabolism Science 300 2003 644 647
44. S.S. Lee R.Y. Lee A.G. Fraser R.S. Kamath J. Ahringer G. Ruvkun A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity Nat. Genet. 33 2003 40 48
45. B. Levine D.J. Klionsky Development by self‐digestion: Molecular mechanisms and biological functions of autophagy Dev. Cell 6 2004 463 477
46. N. Libina J.R. Berman C. Kenyon Tissue‐specific activities of C. elegans DAF‐16 in the regulation of lifespan Cell 115 2003 489 502
47. K. Lin J.B. Dorman A. Rodan C. Kenyon daf‐16: An HNF‐3/forkhead family member that can function to double the life‐span of Caenorhabditis elegans [see comments] Science 278 1997 1319 1322
48. X. Liu N. Jiang B. Hughes E. Bigras E. Shoubridge S. Hekimi Evolutionary conservation of the clk‐1 ‐dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice Genes Dev. 19 2005 2424 2434
49. K.L. McDonald Electron microcopy and EM immunocytochrmistry Met. Cell Biol. 44 1994 411 444
50. J. McElwee K. Bubb J.H. Thomas Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF‐16 Aging Cell 2 2003 111 121
51. B. Meissner M. Boll H. Daniel R. Baumeister Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans J. Biol. Chem. 279 2004 36739 36745
52. A. Meléndez Z. Talloczy M. Seaman E.L. Eskelinen D.H. Hall B. Levine Autophagy genes are essential for dauer development and life‐span extension in C. elegans Science 301 2003 1387 1391
53. N. Mizushima A. Yamamoto M. Matsui T. Yoshimori Y. Ohsumi In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker Mol. Biol. Cell 15 2004 1101 1111
54. C. Morck M. Pilon C. elegans feeding defective mutants have shorter body lengths and increased autophagy BMC Dev. Biol. 6 2006 39
55. T. Muller‐Reichert M. Srayko A. Hyman E.T. O'Toole K. McDonald Correlative light and electron microscopy of early Caenorhabditis elegans embryos in mitosis Methods Cell Biol. 79 2007 101 119
56. C.T. Murphy S.A. McCarroll C.I. Bargmann A. Fraser R.S. Kamath J. Ahringer H. Li C. Kenyon Genes that act downstream of DAF‐16 to influence the lifespan of Caenorhabditis elegans Nature 424 2003 277 283
57. A.S. Nicot H. Fares B. Payrastre A.D. Chisholm M. Labouesse J. Laporte The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans Mol. Biol. Cell 17 2006 3062 3074
58. S. Ogg S. Paradis S. Gottlieb G.I. Patterson L. Lee H.A. Tissenbaum G. Ruvkun The fork head transcription factor DAF‐16 transduces insulin‐like metabolic and longevity signals in C. elegans Nature 389 1997 994 999
59. S.W. Oh A. Mukhopadhyay B.L. Dixit T. Raha M.R. Green H.A. Tissenbaum Identification of direct DAF‐16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation Nat. Genet. 38 2006 251 257
60. S.W. Oh A. Mukhopadhyay N. Svrzikapa F. Jiang R.J. Davis H.A. Tissenbaum JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF‐16 Proc. Natl. Acad. Sci. USA 102 2005 4494 4499
61. K.Z. Pan J.E. Palter A.N. Rogers A. Olsen D. Chen G.J. Lithgow P. Kapahi Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans Aging Cell 6 2007 111 119
62. S.H. Panowski S. Wolff H. Aguilaniu J. Durieux A. Dillin PHA‐4/Foxa mediates diet‐restriction‐induced longevity of C. elegans Nature 447 2007 550 555
63. D.M. Raizen R.Y. Lee L. Avery Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans Genetics 141 1995 1365 1382
64. S.L. Rea N. Ventura T.E. Johnson Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans PLoS Biol. 5 2007 e259
65. D.L. Riddle D.L. Riddle T. Blumenthal B.J. Meyer J.R. Priess C. elegans II 1997 Cold Spring Harbor Laboratory Cold Spring Harbor, NY 739 768
66. A.M. Rowland J.E. Richmond J.G. Olsen D.H. Hall B.A. Bamber Presynaptic terminals independently regulate synaptic clustering and autophagy of GABAA receptors in Caenorhabditis elegans J. Neurosci. 26 2006 1711 1720
67. A.V. Samuelson C.E. Carr G. Ruvkun Gene activities that mediate increased life span of C. elegans insulin‐like signaling mutants Genes Dev. 21 2007 2976 2994
68. W.M. Shaw S. Luo J. Landis J. Ashraf C.T. Murphy The C. elegans TGF‐beta Dauer pathway regulates longevity via insulin signaling Curr. Biol. 17 2007 1635 1645
69. P. Syntichaki K. Troulinaki N. Tavernarakis eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans Nature 445 2007 922 926
70. K. Takeshige M. Baba S. Tsuboi T. Noda Y. Ohsumi Autophagy in yeast demonstrated with proteinase‐deficient mutants and conditions for its induction J. Cell Biol. 119 1992 301 311
71. H.A. Tissenbaum L. Guarente Increased dosage of a sir‐2 gene extends lifespan in Caenorhabditis elegans Nature 410 2001 227 230
72. M.L. Toth T. Sigmond E. Borsos J. Barna P. Erdelyi K. Takacs‐Vellai L. Orosz A.L. Kovacs G. Csikos M. Sass T. Vellai Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans Autophagy 4 2008 330 338
73. M.L. Toth P. Simon A.L. Kovacs T. Vellai Influence of autophagy genes on ion‐channel‐dependent neuronal degeneration in Caenorhabditis elegans J. Cell Sci. 120 2007 1134 1141
74. J.M. Tullet M. Hertweck J.H. An J. Baker J.Y. Hwang S. Liu R.P. Oliveira R. Baumeister T.K. Blackwell Direct inhibition of the longevity‐promoting factor SKN‐1 by insulin‐like signaling in C. elegans Cell 132 2008 1025 1038
75. T. Vellai K. Takacs‐Vellai Y. Zhang A.L. Kovacs L. Orosz F. Muller Genetics: Influence of TOR kinase on lifespan in C. elegans Nature 426 2003 620
76. J. Wang M.M. Barr RNA interference in Caenorhabditis elegans Methods Enzymol. 392 2005 36 55
77. Y. Wang H.A. Tissenbaum Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF‐16/FOXO Mech. Ageing Dev. 127 2006 48 56
78. R.M. Weimer Preservation of C. elegans tissue via high‐pressure freezing and freeze‐substitution for ultrastructural analysis and immunocytochemistry Methods Mol. Biol. 351 2006 203 221
79. C.A. Wolkow K.D. Kimura M.S. Lee G. Ruvkun Regulation of C. elegans life‐span by insulinlike signaling in the nervous system Science 290 2000 147 150
80. D. Yin Biochemical basis of lipofuscin, ceroid, and age pigment‐like fluorophores Free Radic. Biol. Med. 21 1996 871 888