Involvement of activated caspase-3-like proteases in N-methyl-D- aspartate-induced apoptosis in cerebrocortical neurons

Journal of Neurochemistry

Volumn 74, Issue 1, 2000, Pages 134-142

  Tenneti, Lalitha ^a   Lipton, Stuart A ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BURNHAM INSTITUTE   (United States)

Author keywords

Apoptosis; Caspases; Excitotoxicity; Neurons

Indexed keywords

CASPASE 3; EXCITOTOXIN; GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROPIDIUM IODIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSOL; DEGENERATIVE DISEASE; ENZYME ACTIVATION; IMMUNOCYTOCHEMISTRY; NECROSIS; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELLS, CULTURED; CEREBRAL CORTEX; CHROMATIN; ENDOPEPTIDASES; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; MOLECULAR CONFORMATION; N-METHYLASPARTATE; NEURONS; PROTEASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0033979539     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0740134.x     Document Type: Article

References (49)

1. An S. F., Gray F., and Scaravilli F. (1995) Programmed cell death in brain of HIV-1 positive pre-AIDS patients (Letter). Lancet 346, 911-912.
2. Ankarcrona M., Dypbukt J. M., Bonfoco E., Zhivotovsky B., Orrenius S., Lipton S. A., and Nicotera P. (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15, 961-973.
3. Ayata C., Ayata G., Hara H., Matthews R. T., Beal M. F., Ferrante R. J., Endres M., Kim A., Christie R. H., Waeber C., Huang P. L., Hyman B. T., and Moskowitz M. A. (1997) Mechanisms of reduced striatal NMDA excitotoxicity in type 1 nitric oxide synthase knock-out mice. J. Neurosci. 17, 6908-6917.
4. Bonfoco E., Krainc D., Ankarcrona M., Nicotera P., and Lipton S. A. (1995) Apoptosis and necrosis: two distinct events induced respectively by mild and intense insults with NMDA or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA 92, 7162-7166.
5. Buendia B., Santa-Maria A., and Courvalin J. C. (1999) Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis. J. Cell Sci. 112, 1743-1753.
6. Chen J., Nagayama T., Jin K., Stetler R. A., Zhu R. L., Graham S. H., and Simon R. P. (1998) Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J. Neurosci. 18, 4914-4928.
7. Choi D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
8. Cohen G. M. (1997) Caspases: the executioners of apoptosis. Biochem. J. 15, 1-16.
9. Du Y., Bales K. R., Dodel R. C., Hamilton-Byrd E., Horn J. W., Czilli D. L., Simmons L. K., Ni B., and Paul S. M. (1997) Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons. Proc. Natl. Acad. Sci. USA 94, 11657-11662.
10. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A. and Nagata S. (1998) A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391, 43-50.
11. Friedlander R. M., Gagliárdini V., Hara H., Fink K. B., Li W., MacDonald G., Fishman M. C., Greenberg A. H., Moskowitz M. A., and Yuan J. (1997) Expression of a dominant negative mutant of interleukin-1β converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J. Exp. Med. 185, 933-940.
12. Gelbard H. A., James H., Sharer L., Perry S. W., Saito Y., Kazee A. M., Blumberg B. M., and Epstein L. G. (1995) Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol. Appl. Neurobiol. 21, 208-217.
13. Hara H., Friedlander R. M., Gagliardini V., Ayata C., Fink K., Huang Z., Shimizu-Sasamata M., Yuan J., and Moskowitz M. A. (1997) Inhibition of interleukin1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc. Natl. Acad Sci. USA 94, 2007-2012.
14. Humke E. W., Ni J., and Vishva D. (1998) ERICE, a novel FLICE-activatable caspase. J. Biol. Chem. 273, 15702-15707.
15. Jordan J., Galindo M. F., and Miller R. J. (1997) Role of calpain- and interleukin-1β converting enzyme-like proteases in the β-amyloid-induced death of rat hippocampal neurons in culture. J. Neurochem. 68, 1612-1621.
16. Keane R. W., Srinivasan A., Foster L. M., Testa M., Ord T., Nonner D., Wang H., Reed J. C., Bredesen D. E., and Kayalar C. (1997) Activation of CPP32 during apoptosis of neurons and astrocytes. J. Neurosci. Res. 48, 168-180.
17. Kuida K., Zheng T. S., Na S., Kuan C., Yang D., Karasuyama H., Rakic P., and Flavell R. A. (1996) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384, 368-372.
18. Larm J. A., Cheung N. S., and Beart P. M. (1997) Apoptosis induced via AMPA-selective glutamate receptors in cultured murine cortical neurons. J. Neurochem. 69, 617-622.
19. Lazebnik Y. A., Kaufmann S. H., Desnoyers S., Poirier G. G., and Earnshaw W. C. (1994) Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347.
20. 2+ prevents neurotoxicity. Brain Res. 598, 196-202.
21. Lipton S. A. (1997) Neuropathogenesis of acquired immunodeficiency syndrome dementia. Curr. Opin. Neurol. 10, 247-253.
22. Lipton S. A. and Rosenberg P. A. (1994) Mechanisms of disease: excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613-622.
23. Lipton S. A., Choi Y.-B., Pan Z.-H., Lei S. Z., Chen H.-S. V., Sucher N. J., Loscalzo J., Singel D. J., and Stamler J. S. (1993) A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364, 626-632.
24. Loo D. T., Agata C., Pike C. J., Whittemore E. R., Wulencewicz A. J., and Cotman C. W. (1993) Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. USA 90, 7951-7955.
25. Mattson M. P., Keller J. N., and Begley J. G. (1998) Evidence for synaptic apoptosis. Exp. Neurol. 153, 35-48.
26. Meldrum B. and Garthwaite J. (1990) Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11, 379-387.
27. Mullen R. J., Buck C. R., and Smith A. M. (1992) NeuN, a neuronal specific nuclear protein in vertebrates. Development 116, 201-211.
28. Namura S., Zhu J., Fink K., Endres M., Srinivasan A., Tomaselli K. J., Yuan J., and Moskowitz M. A. (1998) Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J. Neurosci. 18, 3659-3668.
29. Nicholson D. W., Ali A., Thornberry N. A., Vaillancourt J. P., Ding C. K., Gallant M., Gareau Y., Griffin P. R., Labelle M., Lazebnik Y. A., Munday N. A., Raju S. M., Smulson M. E., Yamin T., Yu V. L., and Miller D. K. (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37-43.
30. Ona V. O., Li M., Vonsattel J. P., Andrews L. J., Khan S. Q., Chung W. M., Frey A. S., Menon A. S., Li X. J., Stieg P. E., Yuan J., Penney J. B., Young A. B., Cha J. H., and Friedlander R. M. (1999) Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature 399, 263-267.
31. Petito C. K. and Roberts B. (1995) Evidence of apoptotic cell death in HIV encephalitis. Am. J. Pathol 146, 1121-1130.
32. Portera-Cailliau C., Hedreen J. C., Price D. L., and Koliatsos V. E. (1995) Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models. J. Neurosci. 15, 3775-3787.
33. Rabizadeh S., Gralla E. B., Borchelt D. R., Gwinn R., Valentine J. S., Sisiodia S., Wong P., Lee M., Hahn H., and Bredesen D. E. (1995) Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc. Natl. Acad. Sci. USA 92, 3024-3028.
34. Sakahira H., Enari M., and Nagata S. (1998) Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391, 96-99.
35. Schwartz L. M. and Milligan C. E. (1996) Cold thoughts of death: the role of ICE proteases in neuronal cell death. Trends Neurosci. 19, 555-562.
36. Simonian N. A., Getz R. L., Leveque J. C., Konradi C., and Coyle J. T. (1996) Kainate induces apoptosis in neurons. Neuroscience 74, 675-683.
37. Srinivasan A., Roth K. A., Sayers R. O., Schinders K. S., Wong A. M., Fritz C., and Tomaselli K. J. (1988) In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system. Cell Death Differ. 5, 1004-1016.
38. Talanian R. V., Quinlan C., Trautz S., Hackett M. C., Mankovich J. A., Banach D., Ghayur T., Brady K. D., and Wong W. W. (1997) Substrate specificities of caspase family proteases. J. Biol. Chem. 272, 9677-9682.
39. Tenneti L., D'Emilia D. M., Troy C. M., and Lipton S. A. (1998) Role of caspases in N-methyl-D-aspartate-induced apoptosis of cerebrocortical neurons. J. Neurochem. 71, 946-959.
40. Tewari M., Quan L. T., O'Rourke K., Desnoyers S., Zeng Z., Beidler D. R., Poirier G. G., Salvesen G. S., and Dixit V. M. (1995) Yama/CPP32 beta, a mammalian homologue of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell 81, 801-809.
41. Thornberry N. A., Rano T. A., Peterson E. P., Rasper D. M., Timkey T., Garcia-Calvo M., Houtzager V. M., Nordstrom P. A., Roy S., Vaillancourt J. P., Chapman K. T., and Nicholson D. W. (1997) A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem. 272, 17907-17911.
42. Troy C. M., Derossi D., Prochiantz A., Greene L. A., and Shelanski M. L. (1996a) Downregulation of Cu/Zn SOD1 leads to cell death via the nitric oxide-peroxynitrite pathway. J. Neurosci. 16, 253-261.
43. Troy C. M., Stefanis L., Prochiantz A., Greene L. A., and Shelanski M. L. (1996b) The contrasting roles of ICE family proteases and interleukin-1β in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation. Proc. Natl. Acad. Sci. USA 93, 5635-5640.
44. Troy C. M., Stefanis L., Greene L. A., and Shelanski M. L. (1997) Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells. J. Neurosci. 17, 1911-1918.
45. Xu D., Bureau Y., McIntyre D. C, Nicholson D. W., Liston P., Zhu Y., Fong W. G., Crocker S. J., Komeluk R. G., and Robertson G. S. (1999). Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus. J. Neurosci. 19, 5026-5033.
46. Xue D., Shaham S., and Horvitz H. R. (1996) The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes Dev. 10, 1073-1083.
47. Yakovlev A. G., Knoblach S. M., Fan L., Fox G. B., Goodnight R., and Faden A. I. (1997) Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J. Neurosci. 17, 7415-7424.
48. Yuan J., Shaham S., Ledouz S., Ellis H. M., and Horvitz H. R. (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75, 641-652.
49. Zhivotovsky B., Burgess D. H., Vanags D. M., and Orrenius S. (1997) Involvement of cellular proteolytic machinery in apoptosis. Biochem. Biophys. Res. Commun. 230, 481-488.