Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 2, 1997, Pages 136-146

  Wang, Liang ^a   Kittaka, Mamoru ^a   Sun, Ning ^a   Schreiber, Steven S ^a   Zlokovic, Berislav V ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NONE   (United States)

Author keywords

Brain capillaries; Cerebral ischemia; Nicotine; Rats; Tissue plasminogen activator

Indexed keywords

NICOTINE; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN LEVEL; DRUG EFFECT; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME;

EID: 0031045339     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199702000-00002     Document Type: Article

References (61)

1. Allen RA, Kluft C, Brommer EJ (1985) Effect of chronic smoking on fibrinolysis. Arteriosclerosis 5:443-450
2. Barron E, Lipovac MN, Zlokovic BV, Johnson LV, Perlmutter LS (1992) Morphologic alterations in neurohypophyseal endothelial cells of nicotine-treated guinea pigs [Abstract]. Soc Neurosci Abstr 18:1,492
3. Biemond BJ, Levi M, Ten Cate H, Van Der Poll T, Buller HR, Hack CE, Ten Cate JW (1995) Plasminogen activator and plasminogen activator inhibitor 1 release during experimental endotoxaemia in chimpanzees: effect of interventions in the cytokine and coagulation cascades. Clin Sci 88:587-594
4. Booyse FM, Osikowicz G, Quarfoot AJ (1981) Effects of chronic oral consumption of nicotine on the rabbit aortic endothelium. Am J Pathol 102:229-238
5. Chomoczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
6. Colleen D (1980) On the regulation and control of fibrinolysis. Thromb Haemostas 43:77-89
7. Diamond SL, Eskin SG, McIntire LV (1989) Fluid flow stimulates tissue plasminogen activator secretion by cultured human endothelial cells. Science 243:1,483-1,485
8. Emeis JJ, Hoekzema R, de Vos AF (1995) Inhibiting interleukin-1 and tumor necrosis factor-α does not reduce induction of plasminogen activator inhibitor type-1 by endotoxin in rats in vivo. Blood 85:115-120
9. Emeis JJ, Kooistra, T. (1986) Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells. J Exp Med 163:1,260-1,266
10. Fisher M, Francis R (1990) Altered coagulation in cerebral ischemia: platelet, thrombin, and plasmin activity. Arch Neurol 47:1,075-1,079
11. Folts JD (1988) Cigarette smoking and thrombus formation. Am Heart J 116:1,657-1,658
12. Gill JS, Shipley MJ, Tsementzis SA, Hornby R, Gill SK, Hitchcock ER, Beevers DG (1989) Cigarette smoking: A risk factor for hemorrhagic and nonhemorrhagic stroke. Arch Inter Med 149:2,053-2,057
13. Gross CE, Raymond AS, Howard DB, Bednar MM (1995) Delayed tissue-plasminogen activator therapy in a rabbit model of thromboembolic stroke. Neurosurgery 36:1,172-1,177
14. Haire WD, Goldsmith JC, Rasmussen J (1989) Abnormal fibrinolysis in healthy male cigarette smokers: role of plasminogen activator inhibitors. Am J Hematol 31:36-40
15. Haley NJ, Axelard CM, Tilton KA (1983) Validation of self-reported smoking behavior: biochemical analyses of cotinine and thiocyanate. Am J Pub Health 73:1,204-1,207
16. Hanss M, Collen D (1987) Secretion of tissue-type plasminogen activator and plasminogen activator inhibitor by cultured human endothelial cells: Modulation by thrombin, endotoxin, and histamine. J Lab Clin Med 109:97-104
17. Hashimoto Y, Kobayashi A, Yamazaki N, Takada Y, Takada A (1988) Relationship between smoking and fibrinolytic system with special reference to and PA inhibitor. Thromb Res 51:303-311
18. Kipl accumulation during the cell cycle. Science 271:1,861-1,864
19. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265:1,883-1,885
20. Iba T, Shin T, Sonoda T, Rosales O, Sumpio BE (1991) Stimulation of endothelial secretion of tissues-type plasminogen activator by repetitive stretch. J Surg Res 50:457-460
21. Jackson M (1993) Cerebral artery narrowing with nicotine patch. Lancet 342:236-237
22. Joo F (1993) The blood-brain barrier in vitro: recent progress. Neurochem Int 23:499-521
23. Kittaka M, Wang L, Sun N, Schreiber SS, Seeds NW, Fisher M, Zlokovic BV (1996) Brain capillary tissue plasminogen activator in a diabetes stroke model. Stroke 27:712-719
24. Kjaeldgaard A, Larsson B (1986) Long-term treatment with combined oral contraceptives and cigarette smoking associated with impaired activity of tissue plasminogen activator. Acta Obstet Gynecol Scand 65:219-222
25. Kollros PR, Konkle BA, Ambarian AP, Henrikson P (1994) Plasminogen activator inhibitor-1 expression by brain microvessel endothelial cells is inhibited by elevated glucose. J Neurochem 63:903-909
26. Kuo B, Dryjski M, Bjornsson TB (1989) Influence of nicotine and cotinine on the expression of plasminogen activator activity in bovine aortic endothelial cells. Thromb Haemostas 61:70-76
27. Lasarsere CA, Pitts D, Nelson DR, Faulk PW (1995) Vascular tissue plasminogen activator and the development of coronary artery disease in heart-transplant recipients. N Engl J Med 333: 1,111-1,116
28. Levin EG, Santell L (1988) Stimulation and desensitization of tissue plasminogen activator release from human endothelial cells. J Biol Chem 263:9,360-9,365
29. Levin EG, de Zoppo GJ (1994) Localization of tissue plasminogen activator in the endothelium of a limited number of vessels. Am J Pathol 144:855-861
30. Levin EG, Santell L, Saljooque F (1993) Hyperosmotic stress stimulates tissue plasminogen activator expression by a PCK-independent pathway. Am J Physiol 265:C387-C396
31. Loskutoff DJ, Sawdey M, Keeton M, Scheiderman J (1993) Regulation of PAI-1 gene expression in vivo. Thromb Haemostas 70:135-137
32. Murrin LC, Ferrer JR, Zeng WY, Haley NJ (1987) Nicotine administration to rats: methodological considerations. Life Sci 40:1,699-1,708
33. Nakajima S, Yoshimine T, Kato A, Kumura E, Takemoto O, Hayakawa T (1993) The effect of t-PA on the microcirculatory disturbance in experimental cerebral ischemia. J Cereb Blood Flow Metab 13:S183-S184
34. Ny T, Leonardsson G, Hsueh AJW (1988) Cloning and characterization of a cDNA for rat tissue-type plasminogen activator. DNA 7:671-677
35. Ozdemir O, Karaaslan Y, Ozcebe O, Dundar S, Kirazli S (1992) The acute effect of smoking on platelet and endothelial release reaction is suppressed in chronic smokers. Thromb Res 65: 263-274
36. Padro T, Quax PHA, van den Hoogen C, Roholl P, Verheijen JH, Emeis JJ (1994) Tissue plasminogen activator and its inhibitor in rat aorta: effect of endotoxin. Arterioscler Thromb 14:1,459-1,465
37. Pierce JR Jr. (1994) Stroke following application of a nicotine patch. Ann Pharmacother 28:402-403
38. Qian Z, Gilbert ME, Colicos MA, Kandel ER, Kuhl D (1994) Tissue plasminogen activator is induced as an immediate early gene during seizure, kindling and long term potentiation. Nature 361:453-457
39. Sakata Y, Curriden S, Lawrence D, Griffin JH, Loskutoff DJ (1985) Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity. Proc Natl Acad Sci U S A 82:1,121-1,125
40. Saksela O, Moscatelli D, Rifkin DB (1987) The opposing effect of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells. J Cell Biol 105:957-963
41. Sawdey M, Podor TJ, Loskutoff DJ (1989) Regulation of type 1 plasminogen activator inhibitor gene expression in cultured bovine aortic endothelial cells. J Biol Chem 264:10,396-10,401
42. Schleef RR, Bevilacqua MP, Sawdey M, Gimbrone, Jr., MA, Loskutoff DJ (1988) Cytokine activation of vascular endothelium: Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor. J Biol Chem 263:5,797-5,803
43. Seeds NW, Williams BL, Bickford PC (1995) Tissue plasminogen activator induction in purkinje neurons after cerebellar motor learning. Science 270:1,992-1,994
44. Shatos MA, Orfeo T, Doherty JM, Penar PL, Collen D, Mann KG (1996) α-Thrombin stimulates urokinase production and DNA synthesis in cultured human cerebral microvascular endothelial cells. Artherioscler Thromb Vasc Biol 15:901-911
45. Siesjo BK (1992) Pathophysiology and treatment of focal cerebral ischemia. Part II: mechanisms of damage and treatment. J Neurosurg 77:337-354
46. Sun N, Wang L, Kittaka M, Fisher MJ, Schreiber SS, Zlokovic BV (1995) Depletion of tissue plasminogen activator in cerebral microvessels correlates with enhanced focal cerebral injury in rats chronically treated with nicotine [Abstract]. Soc Neurosci Abstr 21:221
47. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR (1990) A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 10:290-295
48. Talloss JH, Booyse FM (1978) Effects of various agents and physical damage on giant cell formation in bovine aortic endothelial cell cultures. Microvasc Res 16:51-58
49. Tsirka SE, Gualandris A, Amaral DG, Strickland S (1996) Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator. Nature 377:340-344
50. van Hinsbergh VW, Kooistra T, Emeis JJ, Koolwijk P (1991) Regulation of plasminogen activator production by endothelial cells: role in fibrinolysis and local proteolysis. Int J Radiat Biol 60:261-272
51. 2 isoform of NA,K-ATPase at the blood-brain barrier and brain in rats. Biochem Biophys Res Commun 199:1,422-1,427
52. Wetscher GJ, Bagchi M, Bagchi D, Perdikis G, Hinder PR, Glaser K, and Hinder RA (1995a) Free radical production in nicotine treated pancreatic tissue. Free Radical Biol Med 18:877-882
53. Wetscher GJ, Bagchi D, Perdikis G, Bagchi M, Redmond EJ, Hinder PR, Glaser K, and Hinder RA (1995b) In vitro free radical production in rat esophageal mucosa induced by nicotine. Digest Dis Sci 40:853-858
54. Yang GY, Chen SF, Kinouchi H, Chan PH, Weinstein PR (1992) Edema, cation content and ATPase activity after middle cerebral artery occlusion i rats. Stroke 23:1,331-1,336
55. Zea Longa E, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91
56. Zimmerman M, McGeachie J (1987) The effect of nicotine on aortic endothelium: a quantitative ultrastructural study. Atherosclerosis 63:33-41
57. Zlokovic BV (1993) Critique of the blood-brain barrier in vitro: recent progress. Neurochem Int 23:523-524
58. Zlokovic BV, Macki BV, Wang L, McComb JG, McDonough A (1993) Differential expression of Na,K-ATPase α and β subunit isoforms at the blood-brain barrier and the choroid plexus. J Biol Chem 268:8,019-8,025
59. Zlokovic BV, Wang L, Schreiber SS, Fisher MJ (1995a) Hemostatic functions of the blood-brain barrier: possible implications in the pathogenesis of stroke. In: New Concepts of the Blood-Brain Barrier (Greenwood J, Begley DJ, Segal MB, eds), New York, Plenum Press, pp 141-145
60. Zlokovic BV, Wang L, Sun N, Haffke S, Verrall S, Seeds NW, Fisher MJ, Schreiber SS (1995b) Expression of tissue plasminogen activator in cerebral capillaries: possible fibrinolytic function of the blood-brain barrier. Neurosurgery 37:955-961
61. Zlokovic BV, Wang L, Kittaka M, Schreiber SS, Fisher MJ, Sun L (1996) Nicotine enhances focal ischemic stroke in rats. Stroke 27:166