메뉴 건너뛰기




Volumn 6, Issue SUPPL. 3, 2009, Pages 269-278

Reversal of voltage-dependent erectile responses in the zucker obese-diabetic rat by rosuvastatin-altered rhoa/rho-kinase signaling

Author keywords

Metabolic syndrome x; Nitric oxide synthase; Rosuvastatin

Indexed keywords

H 1152; MESSENGER RNA; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; ROSUVASTATIN; UNCLASSIFIED DRUG;

EID: 61849104506     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2008.01184.x     Document Type: Conference Paper
Times cited : (28)

References (61)
  • 2
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 3
    • 0141730248 scopus 로고    scopus 로고
    • The metabolic syndrome: More than the sum of its parts?
    • Reilly MP, Rader DJ. The metabolic syndrome: More than the sum of its parts? Circulation 2003; 108: 1546-51.
    • (2003) Circulation , vol.108 , pp. 1546-1551
    • Reilly, M.P.1    Rader, D.J.2
  • 4
    • 4243176029 scopus 로고    scopus 로고
    • Causes of erectile dysfunction
    • Heaton JP, Adams MA. Causes of erectile dysfunction. Endocrine 2004; 23: 119-23.
    • (2004) Endocrine , vol.23 , pp. 119-123
    • Heaton, J.P.1    Adams, M.A.2
  • 5
    • 2442476233 scopus 로고    scopus 로고
    • The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction
    • Seftel AD, Sun P, Swindle R. The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction. J Urol 2004; 171: 2341-5.
    • (2004) J Urol , vol.171 , pp. 2341-2345
    • Seftel, A.D.1    Sun, P.2    Swindle, R.3
  • 6
    • 2542480675 scopus 로고    scopus 로고
    • Erectile dysfunction: An underdiagnosed condition associated with multiple risk factors
    • Shabbir M, Mikhailidis DM, Morgan RJ. Erectile dysfunction: An underdiagnosed condition associated with multiple risk factors. Curr Med Res Opin 2004; 20: 603-6.
    • (2004) Curr Med Res Opin , vol.20 , pp. 603-606
    • Shabbir, M.1    Mikhailidis, D.M.2    Morgan, R.J.3
  • 8
    • 34249036769 scopus 로고    scopus 로고
    • A comparison of NCEP-ATPIII and IDF metabolic syndrome definitions with relation to metabolic syndrome-associated sexual dysfunction
    • Corona G, Mannucci E, Petrone L, Schulman C, Balercia G, Fisher AD, Chiarini V, Forti G, Maggi M. A comparison of NCEP-ATPIII and IDF metabolic syndrome definitions with relation to metabolic syndrome-associated sexual dysfunction. J Sex Med 2007; 4: 789-96.
    • (2007) J Sex Med , vol.4 , pp. 789-796
    • Corona, G.1    Mannucci, E.2    Petrone, L.3    Schulman, C.4    Balercia, G.5    Fisher, A.D.6    Chiarini, V.7    Forti, G.8    Maggi, M.9
  • 10
    • 32644433204 scopus 로고    scopus 로고
    • Metabolic syndrome, endothelial dysfunction, and erectile dysfunction: Association and management
    • Burnett AL. Metabolic syndrome, endothelial dysfunction, and erectile dysfunction: Association and management. Curr Urol Rep 2005; 6: 470-5.
    • (2005) Curr Urol Rep , vol.6 , pp. 470-475
    • Burnett, A.L.1
  • 11
    • 14044258671 scopus 로고    scopus 로고
    • Erectile dysfunction: Interrelationship with the metabolic syndrome
    • Matfin G, Jawa A, Fonseca VA. Erectile dysfunction: Interrelationship with the metabolic syndrome. Curr Diab Rep 2005; 5: 64-9.
    • (2005) Curr Diab Rep , vol.5 , pp. 64-69
    • Matfin, G.1    Jawa, A.2    Fonseca, V.A.3
  • 12
    • 29544435525 scopus 로고    scopus 로고
    • Endothelial and erectile dysfunction, diabetes mellitus, and the metabolic syndrome: Common pathways and treatments?
    • Fonseca V, Jawa A. Endothelial and erectile dysfunction, diabetes mellitus, and the metabolic syndrome: Common pathways and treatments? Am J Cardiol 2005; 96: 13M-18M.
    • (2005) Am J Cardiol , vol.96
    • Fonseca, V.1    Jawa, A.2
  • 15
    • 42949159918 scopus 로고    scopus 로고
    • Erectile dysfunction and dyslipidemia: Relevance and role of phosphodiesterase type-5 inhibitors and statins
    • Miner M, Billups KL. Erectile dysfunction and dyslipidemia: Relevance and role of phosphodiesterase type-5 inhibitors and statins. J Sex Med 2008; 5: 1066-78.
    • (2008) J Sex Med , vol.5 , pp. 1066-1078
    • Miner, M.1    Billups, K.L.2
  • 16
    • 33744535721 scopus 로고    scopus 로고
    • Erectile dysfunction as a predictor of the metabolic syndrome in aging men: Results from the Massachusetts male aging study
    • Kupelian V, Shabsigh R, Araujo AB, O'Donnell AB, McKinlay JB. Erectile dysfunction as a predictor of the metabolic syndrome in aging men: Results from the Massachusetts male aging study. J Urol 2006; 176: 222-6.
    • (2006) J Urol , vol.176 , pp. 222-226
    • Kupelian, V.1    Shabsigh, R.2    Araujo, A.B.3    O'Donnell, A.B.4    McKinlay, J.B.5
  • 17
    • 33744784890 scopus 로고    scopus 로고
    • Prevalence of erectile dysfunction in patients with metabolic syndrome
    • Demir T, Demir O, Kefi A, Comlekci A, Yesil S, Esen A. Prevalence of erectile dysfunction in patients with metabolic syndrome. Int J Urol 2006; 13: 385-8.
    • (2006) Int J Urol , vol.13 , pp. 385-388
    • Demir, T.1    Demir, O.2    Kefi, A.3    Comlekci, A.4    Yesil, S.5    Esen, A.6
  • 18
    • 42949161182 scopus 로고    scopus 로고
    • Erectile dysfunction and men's health: Developing a comorbidity risk calculator
    • Shabsigh R, Shah M, Sand M. Erectile dysfunction and men's health: Developing a comorbidity risk calculator. J Sex Med 2008; 5: 1237-43.
    • (2008) J Sex Med , vol.5 , pp. 1237-1243
    • Shabsigh, R.1    Shah, M.2    Sand, M.3
  • 19
    • 0042093517 scopus 로고    scopus 로고
    • Statin therapy for the treatment of diabetic dyslipidemia
    • Haffner SM. Statin therapy for the treatment of diabetic dyslipidemia. Diabetes Metab Res Rev 2003; 19: 280-7.
    • (2003) Diabetes Metab Res Rev , vol.19 , pp. 280-287
    • Haffner, S.M.1
  • 21
    • 7644242146 scopus 로고    scopus 로고
    • Effects of statins on endothelium and signaling mechanisms
    • Endres M, Laufs U. Effects of statins on endothelium and signaling mechanisms. Stroke 2004; 35 (11 suppl): 2708-11.
    • (2004) Stroke , vol.35 , Issue.11 SUPPL. , pp. 2708-2711
    • Endres, M.1    Laufs, U.2
  • 22
    • 0034838627 scopus 로고    scopus 로고
    • Can modulation of endothelial nitric oxide synthase explain the vasculoprotective actions of statins?
    • Sessa WC. Can modulation of endothelial nitric oxide synthase explain the vasculoprotective actions of statins? Trends Mol Med 2001; 7: 189-91.
    • (2001) Trends Mol Med , vol.7 , pp. 189-191
    • Sessa, W.C.1
  • 24
    • 3242766006 scopus 로고    scopus 로고
    • Statin blocks Rho/Rho-kinase signalling and disrupts the actin cytoskeleton: Relationship to enhancement of LPS-mediated nitric oxide synthesis in vascular smooth muscle cells
    • Kato T, Hashikabe H, Iwata C, Akimoto K, Hattori Y. Statin blocks Rho/ Rho-kinase signalling and disrupts the actin cytoskeleton: Relationship to enhancement of LPS-mediated nitric oxide synthesis in vascular smooth muscle cells. Biochim Biophys Acta 2004; 1689: 267-72.
    • (2004) Biochim Biophys Acta , vol.1689 , pp. 267-272
    • Kato, T.1    Hashikabe, H.2    Iwata, C.3    Akimoto, K.4    Hattori, Y.5
  • 25
    • 0034687606 scopus 로고    scopus 로고
    • Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription
    • Laufs U, Endres M, Custodis F, Gertz K, Nickenig G, Liao JK, Bohm M. Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription. Circulation 2000; 102: 3104-10.
    • (2000) Circulation , vol.102 , pp. 3104-3110
    • Laufs, U.1    Endres, M.2    Custodis, F.3    Gertz, K.4    Nickenig, G.5    Liao, J.K.6    Bohm, M.7
  • 26
    • 0013198310 scopus 로고    scopus 로고
    • Improved erectile function following Rho-kinase inhibition in a rat castrate model of erectile dysfunction
    • Wingard CJ, Johnson JA, Holmes A, Prikosh A. Improved erectile function following Rho-kinase inhibition in a rat castrate model of erectile dysfunction. Am J Physiol Regul Integr Comp Physiol 2003; 284: R1572-9.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.284
    • Wingard, C.J.1    Johnson, J.A.2    Holmes, A.3    Prikosh, A.4
  • 27
    • 33947129737 scopus 로고    scopus 로고
    • Altered penile vascular reactivity and erection in the Zucker obese-diabetic rat
    • Wingard C, Fulton D, Husain S. Altered penile vascular reactivity and erection in the Zucker obese-diabetic rat. J Sex Med 2007; 4: 348-62.
    • (2007) J Sex Med , vol.4 , pp. 348-362
    • Wingard, C.1    Fulton, D.2    Husain, S.3
  • 28
    • 4644253670 scopus 로고    scopus 로고
    • Role of PKCalpha and PKC iota in phenylephrine-induced contraction of rat corpora cavernosa
    • Husain S, Young D, Wingard CJ. Role of PKCalpha and PKC iota in phenylephrine-induced contraction of rat corpora cavernosa. Int J Impot Res 2004; 16: 325-33.
    • (2004) Int J Impot Res , vol.16 , pp. 325-333
    • Husain, S.1    Young, D.2    Wingard, C.J.3
  • 29
    • 0034863248 scopus 로고    scopus 로고
    • Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation
    • Mills TM, Chitaley K, Wingard CJ, Lewis RW, Webb RC. Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation. J Appl Physiol 2001; 91: 1269-73.
    • (2001) J Appl Physiol , vol.91 , pp. 1269-1273
    • Mills, T.M.1    Chitaley, K.2    Wingard, C.J.3    Lewis, R.W.4    Webb, R.C.5
  • 32
    • 0141751697 scopus 로고    scopus 로고
    • Ca2+ sensitivity of smooth muscle and nonmuscle myosin II. Modulated by G proteins, kinases, and myosin phosphatase
    • Somlyo AP, Somlyo AV. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II. Modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003; 83: 1325-58.
    • (2003) Physiol Rev , vol.83 , pp. 1325-1358
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 33
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414: 813-20.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 34
    • 0141615707 scopus 로고    scopus 로고
    • Pase regulation: Getting aRnd rock and rho inhibition
    • Chardin PGT. Pase regulation: Getting aRnd rock and rho inhibition. Curr Biol 2003; 13: R702-4.
    • (2003) Curr Biol , vol.13
    • Chardin, P.G.T.1
  • 35
    • 0038338728 scopus 로고    scopus 로고
    • Remodeling of the skeletal muscle microcirculation increases resistance to perfusion in obese Zucker rats
    • Frisbee JC. Remodeling of the skeletal muscle microcirculation increases resistance to perfusion in obese Zucker rats. Am J Physiol Heart Circ Physiol 2003; 285: H104-11.
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Frisbee, J.C.1
  • 36
    • 3242734728 scopus 로고    scopus 로고
    • Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats
    • Frisbee JC. Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats. J Appl Physiol 2004; 97: 764-72.
    • (2004) J Appl Physiol , vol.97 , pp. 764-772
    • Frisbee, J.C.1
  • 39
    • 44949135000 scopus 로고    scopus 로고
    • Erectile dysfunction in the type II diabetic db/db mouse: Impaired venoocclusion with altered cavernosal vasoreactivity and matrix
    • Luttrell IP, Swee M, Starcher B, Parks WC, Chitaley K. Erectile dysfunction in the type II diabetic db/db mouse: Impaired venoocclusion with altered cavernosal vasoreactivity and matrix. Am J Physiol Heart Circ Physiol 2008; 294: H2204-11.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Luttrell, I.P.1    Swee, M.2    Starcher, B.3    Parks, W.C.4    Chitaley, K.5
  • 40
    • 32644449489 scopus 로고    scopus 로고
    • RhoA/Rho-kinase in erectile tissue: Mechanisms of disease and therapeutic insights
    • Jin L, Burnett AL. RhoA/Rho-kinase in erectile tissue: Mechanisms of disease and therapeutic insights. Clin Sci (Lond) 2006; 110: 153-65.
    • (2006) Clin Sci (Lond) , vol.110 , pp. 153-165
    • Jin, L.1    Burnett, A.L.2
  • 41
    • 24644445979 scopus 로고    scopus 로고
    • Calcium sensitization as a pharmacological target in vascular smooth-muscle regulation
    • Christ G, Wingard C. Calcium sensitization as a pharmacological target in vascular smooth-muscle regulation. Curr Opin Investig Drugs 2005; 6: 920-33.
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 920-933
    • Christ, G.1    Wingard, C.2
  • 42
    • 4243094095 scopus 로고    scopus 로고
    • Therapy of erectile dysfunction: Potential future treatments
    • Gonzalez-Cadavid NF, Rajfer J. Therapy of erectile dysfunction: Potential future treatments. Endocrine 2004; 23: 167-76.
    • (2004) Endocrine , vol.23 , pp. 167-176
    • Gonzalez-Cadavid, N.F.1    Rajfer, J.2
  • 43
    • 0042376168 scopus 로고    scopus 로고
    • Statins and their role in vascular protection
    • Mason JC. Statins and their role in vascular protection. Clin Sci (Lond) 2003; 105: 251-66.
    • (2003) Clin Sci (Lond) , vol.105 , pp. 251-266
    • Mason, J.C.1
  • 44
    • 33751183978 scopus 로고    scopus 로고
    • Molecular basis of differences among statins and a comparison with antioxidant vitamins
    • Mason RP. Molecular basis of differences among statins and a comparison with antioxidant vitamins. Am J Cardiol 2006; 98: 4P-41P.
    • (2006) Am J Cardiol , vol.98
    • Mason, R.P.1
  • 45
    • 23944466455 scopus 로고    scopus 로고
    • Intermolecular differences of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors contribute to distinct pharmacologic and pleiotropic actions
    • Mason RP, Walter MF, Day CA, Jacob RF. Intermolecular differences of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors contribute to distinct pharmacologic and pleiotropic actions. Am J Cardiol 2005; 96: 11F-23F.
    • (2005) Am J Cardiol , vol.96
    • Mason, R.P.1    Walter, M.F.2    Day, C.A.3    Jacob, R.F.4
  • 46
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 1990; 343: 425-30.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 47
    • 0028935780 scopus 로고
    • Protein lipidation in cell signaling
    • Casey PJ. Protein lipidation in cell signaling. Science 1995; 268: 221-5.
    • (1995) Science , vol.268 , pp. 221-225
    • Casey, P.J.1
  • 49
    • 0028859180 scopus 로고
    • Role of nitric oxide in the physiology of erection
    • Burnett AL. Role of nitric oxide in the physiology of erection. Biol Reprod 1995; 52: 485-9.
    • (1995) Biol Reprod , vol.52 , pp. 485-489
    • Burnett, A.L.1
  • 50
    • 3342887762 scopus 로고    scopus 로고
    • Novel nitric oxide signaling mechanisms regulate the erectile response
    • Burnett AL. Novel nitric oxide signaling mechanisms regulate the erectile response. Int J Impot Res 2004; 16 (1 suppl): S15-9.
    • (2004) Int J Impot Res , vol.16 , Issue.1 SUPPL.
    • Burnett, A.L.1
  • 51
    • 18844393441 scopus 로고    scopus 로고
    • ROCKs as therapeutic targets in cardiovascular diseases
    • Rikitake Y, Liao JK. ROCKs as therapeutic targets in cardiovascular diseases. Expert Rev Cardiovasc Ther 2005; 3: 441-51.
    • (2005) Expert Rev Cardiovasc Ther , vol.3 , pp. 441-451
    • Rikitake, Y.1    Liao, J.K.2
  • 52
    • 0041820000 scopus 로고    scopus 로고
    • Effects of rosuvastatin on nitric oxide-dependent function in aorta and corpus cavernosum of diabetic mice: Relationship to cholesterol biosynthesis pathway inhibition and lipid lowering
    • Nangle MR, Cotter MA, Cameron NE. Effects of rosuvastatin on nitric oxide-dependent function in aorta and corpus cavernosum of diabetic mice: Relationship to cholesterol biosynthesis pathway inhibition and lipid lowering. Diabetes 2003; 52: 2396-402.
    • (2003) Diabetes , vol.52 , pp. 2396-2402
    • Nangle, M.R.1    Cotter, M.A.2    Cameron, N.E.3
  • 53
    • 0037130769 scopus 로고    scopus 로고
    • Direct vascular and cardioprotective effects of rosuvastatin, a new HMG-CoA reductase inhibitor
    • Jones SP, Gibson MF, Rimmer DM, III, Gibson TM, Sharp BR, Lefer DJ. Direct vascular and cardioprotective effects of rosuvastatin, a new HMG-CoA reductase inhibitor. J Am Coll Cardiol 2002; 40: 1172-8.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 1172-1178
    • Jones, S.P.1    Gibson, M.F.2    Rimmer, D.M.3    Gibson, T.M.4    Sharp, B.R.5    Lefer, D.J.6
  • 54
    • 0032555154 scopus 로고    scopus 로고
    • Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
    • Endres M, Laufs U, Huang Z, Nakamura T, Huang P, Moskowitz MA, Liao JK. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci USA 1998; 95: 8880-5.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8880-8885
    • Endres, M.1    Laufs, U.2    Huang, Z.3    Nakamura, T.4    Huang, P.5    Moskowitz, M.A.6    Liao, J.K.7
  • 55
    • 34547469050 scopus 로고    scopus 로고
    • Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
    • Trebicka J, Hennenberg M, Laleman W, Shelest N, Biecker E, Schepke M, Nevens F, Sauerbruch T, Heller J. Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase. Hepatology 2007; 46: 242-53.
    • (2007) Hepatology , vol.46 , pp. 242-253
    • Trebicka, J.1    Hennenberg, M.2    Laleman, W.3    Shelest, N.4    Biecker, E.5    Schepke, M.6    Nevens, F.7    Sauerbruch, T.8    Heller, J.9
  • 56
    • 33645732870 scopus 로고    scopus 로고
    • Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production
    • Erdos B, Snipes JA, Tulbert CD, Katakam P, Miller AW, Busija DW. Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production. Am J Physiol Heart Circ Physiol 2006; 290: H1264-70.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Erdos, B.1    Snipes, J.A.2    Tulbert, C.D.3    Katakam, P.4    Miller, A.W.5    Busija, D.W.6
  • 57
    • 34147203072 scopus 로고    scopus 로고
    • Pitavastatin restores vascular dysfunction in insulin-resistant state by inhibiting NAD(P)H oxidase activity and uncoupled endothelial nitric oxide synthase-dependent superoxide production
    • Shinozaki K, Nishio Y, Ayajiki K, Yoshida Y, Masada M, Kashiwagi A, Okamura T. Pitavastatin restores vascular dysfunction in insulin-resistant state by inhibiting NAD(P)H oxidase activity and uncoupled endothelial nitric oxide synthase-dependent superoxide production. J Cardiovasc Pharmacol 2007; 49: 122-30.
    • (2007) J Cardiovasc Pharmacol , vol.49 , pp. 122-130
    • Shinozaki, K.1    Nishio, Y.2    Ayajiki, K.3    Yoshida, Y.4    Masada, M.5    Kashiwagi, A.6    Okamura, T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.