Erectile dysfunction in the type II diabetic db/db mouse: Impaired venoocclusion with altered cavernosal vasoreactivity and matrix

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 5, 2008, Pages

  Luttrell, Ian P ^a   Swee, Mei ^b   Starcher, Barry ^c   Parks, William C ^b   Chitaley, Kanchan ^a,d  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^d NONE   (United States)

Author keywords

Collagen; Elastin; Matrix; Penis

Indexed keywords

ACETYLCHOLINE; COLLAGEN; DESMOSINE; ELASTIN; FIBRILLIN 1; HYDROXYPROLINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LEPTIN RECEPTOR; PHENYLEPHRINE; TROPOELASTIN; LEPTIN RECEPTOR, MOUSE; MESSENGER RNA; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; BODY WEIGHT; CONTROLLED STUDY; CORPUS CAVERNOSUM; ERECTILE DYSFUNCTION; GENE EXPRESSION; GENE MUTATION; GLUCOSE BLOOD LEVEL; HISTOLOGY; MALE; MEAN ARTERIAL PRESSURE; MOUSE; MYOGRAPHY; NERVE STIMULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VASOCONSTRICTION; ANIMAL; BLOOD FLOW; BLOOD PRESSURE; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; ELECTROSTIMULATION; EXTRACELLULAR MATRIX; GENETICS; INNERVATION; METABOLISM; MOUSE MUTANT; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PENIS; VASCULARIZATION; VASODILATATION; VEIN;

ACETYLCHOLINE; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; BODY WEIGHT; COLLAGEN; DESMOSINE; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; ELASTIN; ELECTRIC STIMULATION; ERECTILE DYSFUNCTION; EXTRACELLULAR MATRIX; HYDROXYPROLINE; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MYOGRAPHY; ORGAN SIZE; PENIS; PHENYLEPHRINE; POLYMERASE CHAIN REACTION; RECEPTORS, LEPTIN; REGIONAL BLOOD FLOW; RNA, MESSENGER; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS; VEINS;

EID: 44949135000     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00027.2008     Document Type: Article

References (22)

1. Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB. Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med 139: 161-168, 2003.
2. Basu A, Ryder RE. New treatment options for erectile dysfunction in patients with diabetes mellitus. Drugs 64: 2667-2688, 2004.
3. Burnett AL. Novel nitric oxide signaling mechanisms regulate the erectile response. Int J Impot Res 16, Suppl 1: S15-S19, 2004.
4. Burnett AL, Nelson RJ, Calvin DC, Liu JX, Demas GE, Klein SL, Kriegsfeld LJ, Dawson VL, Dawson TM, Snyder SH. Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase. Mol Med 2: 288-296, 1996.
5. Carneiro FS, Giachini FR, Lima VV, Carneiro ZN, Leite R, Inscho EW, Tostes RC, Webb RC. Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse. J Sex Med In press.
6. Costa WS, Carrerete FB, Horta WG, Sampaio FJ. Comparative analysis of the penis corpora cavernosa in controls and patients with erectile dysfunction. BJU Int 97: 567-569, 2006.
7. Du XL, Edelstein D, Dimmeler S, Ju Q, Sui C, Brownlee M. Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J Clin Invest 108: 1341-1348, 2001.
8. Heaton JP, Adams MA. Causes of erectile dysfunction. Endocrine 23: 119-123, 2004.
9. Kielty CM. Elastic fibres in health and disease. Expert Rev Mol Med 8: 1-23, 2006.
10. Kielty CM, Sherratt MJ, Marson A, Baldock C. Fibrillin microfibrils. Adv Protein Chem 70: 405-436, 2005.
11. Kovanecz I, Ferrini MG, Vernet D, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Pioglitazone prevents corporal veno-occlusive dysfunction in a rat model of type 2 diabetes mellitus. BJU Int 98: 116-124, 2006.
12. Lazar MH, Christensen PJ, Du M, Yu B, Subbotina NM, Hanson KE, Hansen JM, White ES, Simon RH, Sisson TH. Plasminogen activator inhibitor-1 impairs alveolar epithelial repair by binding to vitronectin. Am J Respir Cell Mol Biol 31: 672-678, 2004.
13. Li DY, Faury G, Taylor DG, Davis EC, Boyle WA, Mecham RP, Stenzel P, Boak B, Keating MT. Novel arterial pathology in mice and humans hemizygous for elastin. J Clin Invest 102: 1783-1787, 1998.
14. Ludwig A, Berkhout T, Moores K, Groot P, Chapman G. Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity. J Immunol 168: 604-612, 2002.
15. Musicki B, Kramer MF, Becker RE, Burnett AL. Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction. Proc Natl Acad Sci USA 102: 11870-11875, 2005.
16. Nangle MR, Cotter MA, Cameron NE. Protein kinase C beta inhibition and aorta and corpus cavernosum function in streptozotocin-diabetic mice. Eur J Pharmacol 475: 99-106, 2003.
17. Patel BN, Dunn RJ, Jeong SY, Zhu Q, Julien JP, David S. Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci 22: 6578-6586, 2002.
18. Pereira L, Andrikopoulos K, Tian J, Lee SY, Keene DR, Ono R, Reinhardt DP, Sakai LY, Biery NJ, Bunton T, Dietz HC, Ramirez F. Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome. Nat Genet 17: 218-222, 1997.
19. Sato F, Wachi H, Ishida M, Nonaka R, Onoue S, Urban Z, Starcher BC, Seyama Y. Distinct steps of cross-linking, self-association, and maturation of tropoelastin are necessary for elastic fiber formation. J Mol Biol 369: 841-851, 2007.
20. Shafik A, Shafik I, El Sibai O, Shafik AA. On the pathogenesis of penile venous leakage: role of the tunica albuginea (Abstract). BMC Urol 7: 14, 2007.
21. Sharma K, McCue P, Dunn SR. Diabetic kidney disease in the db/db mouse. Am J Physiol Renal Physiol 284: F1138-F1144, 2003.
22. Susic D. Cross-link breakers as a new therapeutic approach to cardiovascular disease. Biochem Soc Trans 35: 853-856, 2007.