Can modulation of endothelial nitric oxide synthase explain the vasculoprotective actions of statins?

Trends in Molecular Medicine

Volumn 7, Issue 5, 2001, Pages 189-191

  Sessa, William C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITRIC OXIDE SYNTHASE; PROTECTIVE AGENT; STATIN;

BLOOD VESSEL CAPACITANCE; CHOLESTEROL BLOOD LEVEL; CORONARY ARTERY DISEASE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME RELEASE; HEART PROTECTION; HUMAN; PROTEIN EXPRESSION; SHORT SURVEY;

EID: 0034838627     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(01)01985-2     Document Type: Review

References (22)

1. Statins do more than just lower cholesterol
2. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
3. Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment
4. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
5. Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance
6. Caveolins, liquid-ordered domains, and signal transduction
7. Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae
8. Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation
9. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: Implications for nitric oxide signaling
10. Caveolin-1 detergent solubility and association with endothelial nitric oxide synthase is modulated by tyrosine phosphorylation
11. Receptor-regulated translocation of endothelial nitric-oxide synthase
12. Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells
13. The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide
14. Nonuniformity of endothelial constitutive nitric oxide synthase distribution in cardiac endothelium
15. Histochemical demonstration of membranous localization of endothelial nitric oxide synthase in endothelial cells of the rat brain
16. Nitric oxide synthase is localized predominantly in the Golgi apparatus and cytoplasmic vesicles of vascular endothelial cells
17. Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies
18. In situ flow activates endothelial nitric oxide synthase in luminal caveolae of endothelium with rapid caveolin dissociation and calmodulin association
19. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
20. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
21. Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo
22. Dynamic activation of endothelial nitric oxide synthase by HSP90