Toll-like receptors TLR1, TLR2 and TLR4 gene mutations and natural resistance to Mycobacterium avium subsp. paratuberculosis infection in cattle

Veterinary Immunology and Immunopathology

Volumn 128, Issue 4, 2009, Pages 381-388

  Mucha, R ^a   Bhide, M R ^a,b   Chakurkar, E B ^c   Novak, M ^b   Mikula Sr , I ^a,b  

^a UNIVERSITY OF VETERINARY MEDICINE   (Slovakia)

^b INSTITUTE OF NEUROIMMUNOLOGY   (Slovakia)

^c INDIAN COUNCIL OF AGRICULTURAL RESEARCH   (India)

Author keywords

MAP; Mutation; Mycobacterium avium subsp. paratuberculosis; Natural resistance; Toll like receptor

Indexed keywords

TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ARTICLE; CATTLE; CONTROLLED STUDY; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; INFECTION SENSITIVITY; MISSENSE MUTATION; MYCOBACTERIUM PARATUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PARATUBERCULOSIS; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN DOMAIN; PROTEIN MOTIF;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATTLE; CATTLE DISEASES; DNA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; MOLECULAR SEQUENCE DATA; MUTATION; MUTATION, MISSENSE; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS; PARATUBERCULOSIS; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE; SEQUENCE ALIGNMENT; SLOVAKIA; TOLL-LIKE RECEPTORS;

BOS; BOVINAE; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS;

EID: 61549134538     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2008.12.007     Document Type: Article

References (61)

1. Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
2. Ayele W.Y., Svastova P., Roubal P., Bartos M., and Pavlik I. Mycobacterium avium subspecies paratuberculosis cultured from locally and commercially pasteurized cow's milk in the Czech Republic. Appl. Environ. Microbiol. 71 (2005) 1210-1214
3. Bell J.K., Mullen G.E., Leifer C.A., Mazzoni A., Davies D.R., and Segal D.M. Leucine-rich repeats and pathogen recognition in toll-like receptors. Trends Immunol. 24 (2003) 528-533
4. Ben-Ali M., Barbouche M.R., Bousnina S., Chabbou A., and Dellagi K. Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients. Clin. Diagn. Lab. Immunol. 11 (2004) 625-626
5. Berdeli A., Celik H.A., Ozyurek R., Dogrusoz B., and Aydin H.H. TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. J. Mol. Med. 83 (2005) 535-541
6. Bhide M., Chakurkar E., Tkacikova L., Barbuddhe S., Novak M., and Mikula I. IS900-PCR-based detection and characterization of Mycobacterium avium subsp. paratuberculosis from buffy coat of cattle and sheep. Vet. Microbiol. 112 (2006) 33-41
7. Bochud P.Y., Hawn T.R., and Aderem A. Cutting edge: a toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. J. Immunol. 170 (2003) 3451-3454
8. Bochud P.Y., Hawn T.R., Siddiqui M.R., Saunderson P., Britton S., Abraham I., Argaw A.T., Janer M., Zhao L.P., Kaplan G., and Aderem A. Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy. J. Infect. Dis. 197 (2008) 253-261
9. Brightbill H.D., Libraty D.H., Krutzik S.R., Yang R.B., Belisle J.T., Bleharski J.R., Maitland M., Norgard M.V., Plevy S.E., Smale S.T., Brennan P.J., Bloom B.R., Godowski P.J., and Modlin R.L. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285 (1999) 732-736
10. Bull T.J., McMinn E.J., Sidi-Boumedine K., Skull A., Durkin D., Neild P., Rhodes G., Pickup R., and Hermon-Taylor J. Detection and verification of Mycobacterium avium subsp. paratuberculosis in fresh ileocolonic mucosal biopsy specimens from individuals with and without Crohn's disease. J. Clin. Microbiol. 41 (2003) 2915-2923
11. Buwitt-Beckmann U., Heine H., Wiesmuller K.H., Jung G., Brock R., Akira S., and Ulmer A.J. TLR1- and TLR6-independent recognition of bacterial lipopeptides. J. Biol. Chem. 281 (2006) 9049-9057
12. Chang J.S., Huggett J.F., Dheda K., Kim L.U., Zumla A., and Rook G.A. Myobacterium tuberculosis induces selective up-regulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis. J. Immunol. 176 (2006) 3010-3018
13. Cheng J., Randall A.Z., Sweredoski M.J., and Baldi P. SCRATCH: a protein structure and structural feature prediction server. Nucleic Acids Res. 33 (2005) W72-76
14. Cristofaro P., and Opal S.M. Role of toll-like receptors in infection and immunity: clinical implications. Drugs 66 (2006) 15-29
15. Drennan M.B., Nicolle D., Quesniaux V.J., Jacobs M., Allie N., Mpagi J., Fremond C., Wagner H., Kirschning C., and Ryffel B. Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infection. Am. J. Pathol. 164 (2004) 49-57
16. Franchimont D., Vermeire S., El Housni H., Pierik M., Van Steen K., Gustot T., Quertinmont E., Abramowicz M., Van Gossum A., Deviere J., and Rutgeerts P. Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut 53 (2004) 987-992
17. Fukusaki T., Ohara N., Hara Y., Yoshimura A., and Yoshiura K. Evidence for association between a toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population. J. Periodontal. Res. 42 (2007) 541-545
18. Furrie E., Macfarlane S., Thomson G., and Macfarlane G.T. Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria. Immunology 115 (2005) 565-574
19. Garza-Gonzalez E., Bosques-Padilla F.J., Mendoza-Ibarra S.I., Flores-Gutierrez J.P., Maldonado-Garza H.J., and Perez-Perez G.I. Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8-251 polymorphisms in the risk for the development of distal gastric cancer. BMC Cancer 7 (2007) 70
20. Grant I.R., Ball H.J., and Rowe M.T. Incidence of Mycobacterium paratuberculosis in bulk raw and commercially pasteurized cows' milk from approved dairy processing establishments in the United Kingdom. Appl. Environ. Microbiol. 68 (2002) 2428-2435
21. Hamann L., Kumpf O., Muller M., Visintin A., Eckert J., Schlag P.M., and Schumann R.R. A coding mutation within the first exon of the human MD-2 gene results in decreased lipopolysaccharide-induced signaling. Genes Immun. 5 (2004) 283-288
22. Hawn T.R., Misch E.A., Dunstan S.J., Thwaites G.E., Lan N.T., Quy H.T., Chau T.T., Rodrigues S., Nachman A., Janer M., Hien T.T., Farrar J.J., and Aderem A. A common human TLR1 polymorphism regulates the innate immune response to lipopeptides. Eur. J. Immunol. 37 (2007) 2280-2289
23. Heldwein K.A., Liang M.D., Andresen T.K., Thomas K.E., Marty A.M., Cuesta N., Vogel S.N., and Fenton M.J. TLR2 and TLR4 serve distinct roles in the host immune response against Mycobacterium bovis BCG. J. Leukoc. Biol. 74 (2003) 277-286
24. Henckaerts L., Pierik M., Joossens M., Ferrante M., Rutgeerts P., and Vermeire S. Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease. Gut 56 (2007) 1536-1542
25. Hong J., Leung E., Fraser A.G., Merriman T.R., Vishnu P., and Krissansen G.W. TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort. J. Gastroenterol. Hepatol. 22 (2007) 1760-1766
26. Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., and Akira S. Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162 (1999) 3749-3752
27. Ikonomopoulos J., Gazouli M., Pavlik I., Bartos M., Zacharatos P., Xylouri E., Papalambros E., and Gorgoulis V. Comparative evaluation of PCR assays for the robust molecular detection of Mycobacterium avium subsp. paratuberculosis. J. Microbiol. Methods 56 (2004) 315-321
28. Janeway Jr. C.A., and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 20 (2002) 197-216
29. Johnson C.M., Lyle E.A., Omueti K.O., Stepensky V.A., Yegin O., Alpsoy E., Hamann L., Schumann R.R., and Tapping R.I. Cutting edge: a common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. J. Immunol. 178 (2007) 7520-7524
30. Kesh S., Mensah N.Y., Peterlongo P., Jaffe D., Hsu K., Van den Brink M., O'Reilly R., Pamer E., Satagopan J., and Papanicolaou G.A. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Ann. N.Y. Acad. Sci. 1062 (2005) 95-103
31. Khor C.C., Chapman S.J., Vannberg F.O., Dunne A., Murphy C., Ling E.Y., Frodsham A.J., Walley A.J., Kyrieleis O., Khan A., Aucan C., Segal S., Moore C.E., Knox K., Campbell S.J., Lienhardt C., Scott A., Aaby P., Sow O.Y., Grignani R.T., Sillah J., Sirugo G., Peshu N., Williams T.N., Maitland K., Davies R.J., Kwiatkowski D.P., Day N.P., Yala D., Crook D.W., Marsh K., Berkley J.A., O'Neill L.A., and Hill A.V. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat. Genet. 39 (2007) 523-528
32. Kirschning C.J., and Schumann R.R. TLR2: cellular sensor for microbial and endogenous molecular patterns. Curr. Top. Microbiol. Immunol. 270 (2002) 121-144
33. Kohler H., Burkert B., Pavlik I., Diller R., Geue L., Conraths F., and Martin G. Evaluation of five ELISA test kits for the measurement of antibodies against Mycobacterium avium subspecies paratuberculosis in bovine serum. Berl. Munch. Tierarztl. Wochenschr. 121 (2008) 203-210
34. Lakatos P.L., Lakatos L., Szalay F., Willheim-Polli C., Osterreicher C., Tulassay Z., Molnar T., Reinisch W., Papp J., Mozsik G., and Ferenci P. Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: phenotype-genotype correlations. World J. Gastroenterol. 11 (2005) 1489-1495
35. Lien E., Sellati T.J., Yoshimura A., Flo T.H., Rawadi G., Finberg R.W., Carroll J.D., Espevik T., Ingalls R.R., Radolf J.D., and Golenbock D.T. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 274 (1999) 33419-33425
36. Ma X., Liu Y., Gowen B.B., Graviss E.A., Clark A.G., and Musser J.M. Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. PLoS ONE 2 (2007) e1318
37. Malley R., Henneke P., Morse S.C., Cieslewicz M.J., Lipsitch M., Thompson C.M., Kurt-Jones E., Paton J.C., Wessels M.R., and Golenbock D.T. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 1966-1971
38. Matsushima N., Tachi N., Kuroki Y., Enkhbayar P., Osaki M., Kamiya M., and Kretsinger R.H. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases. Cell Mol. Life Sci. 62 (2005) 2771-2791
39. Matsushima N., Tanaka T., Enkhbayar P., Mikami T., Taga M., Yamada K., and Kuroki Y. Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics 8 (2007) 124
40. Means T.K., Wang S., Lien E., Yoshimura A., Golenbock D.T., and Fenton M.J. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J. Immunol. 163 (1999) 3920-3927
41. Moravkova M., Hlozek P., Beran V., Pavlik I., Preziuso S., Cuteri V., and Bartos M. Strategy for the detection and differentiation of Mycobacterium avium species in isolates and heavily infected tissues. Res. Vet. Sci. (2007)
42. Morre S.A., Murillo L.S., Bruggeman C.A., and Pena A.S. The role that the functional Asp299Gly polymorphism in the toll-like receptor-4 gene plays in susceptibility to Chlamydia trachomatis-associated tubal infertility. J. Infect. Dis. 187 (2003) 341-342 author reply 342-343
43. Ohara T., Morishita T., Suzuki H., and Hibi T. Heterozygous Thr 135 Ala polymorphism at leucine-rich repeat (LRR) in genomic DNA of toll-like receptor 4 in patients with poorly differentiated gastric adenocarcinomas. Int. J. Mol. Med. 18 (2006) 59-63
44. Omueti K.O., Mazur D.J., Thompson K.S., Lyle E.A., and Tapping R.I. The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components. J. Immunol. 178 (2007) 6387-6394
45. Oshiumi H., Matsumoto M., Funami K., Akazawa T., and Seya T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat. Immunol. 4 (2003) 161-167
46. Ozinsky A., Underhill D.M., Fontenot J.D., Hajjar A.M., Smith K.D., Wilson C.B., Schroeder L., and Aderem A. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 13766-13771
47. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., and Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2085-2088
48. Roura-Mir C., Wang L., Cheng T.Y., Matsunaga I., Dascher C.C., Peng S.L., Fenton M.J., Kirschning C., and Moody D.B. Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2. J. Immunol. 175 (2005) 1758-1766
49. Schroder N.W., and Schumann R.R. Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect. Dis. 5 (2005) 156-164
50. Schumann R.R., and Tapping R.I. Genomic variants of TLR1-it takes (TLR-)two to tango. Eur. J. Immunol. 37 (2007) 2059-2062
51. Schwandner R., Dziarski R., Wesche H., Rothe M., and Kirschning C.J. Peptidoglycan and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274 (1999) 17406-17409
52. Schwartz D.A. The genetics of innate immunity. Chest 121 (2002) 62S-68S
53. Tabel Y., Berdeli A., and Mir S. Association of TLR2 gene Arg753Gln polymorphism with urinary tract infection in children. Int. J. Immunogenet. 34 (2007) 399-405
54. Tabeta K., Georgel P., Janssen E., Du X., Hoebe K., Crozat K., Mudd S., Shamel L., Sovath S., Goode J., Alexopoulou L., Flavell R.A., and Beutler B. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 3516-3521
55. Takeda K., Kaisho T., and Akira S. Toll-like receptors. Annu. Rev. Immunol. 21 (2003) 335-376
56. Thuong N.T., Hawn T.R., Thwaites G.E., Chau T.T., Lan N.T., Quy H.T., Hieu N.T., Aderem A., Hien T.T., Farrar J.J., and Dunstan S.J. A polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis. Genes Immun. 8 (2007) 422-428
57. Uehori J., Fukase K., Akazawa T., Uematsu S., Akira S., Funami K., Shingai M., Matsumoto M., Azuma I., Toyoshima K., Kusumoto S., and Seya T. Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation. J. Immunol. 174 (2005) 7096-7103
58. Underhill D.M., and Ozinsky A. Toll-like receptors: key mediators of microbe detection. Curr. Opin. Immunol. 14 (2002) 103-110
59. Underhill D.M., Ozinsky A., Smith K.D., and Aderem A. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 14459-14463
60. Vansnick E., De Rijk P., Vercammen F., Geysen D., Rigouts L., and Portaels F. Newly developed primers for the detection of Mycobacterium avium subspecies paratuberculosis. Vet. Microbiol. 100 (2004) 197-204
61. Xu Y., Tao X., Shen B., Horng T., Medzhitov R., Manley J.L., and Tong L. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408 (2000) 111-115