Heterozygous Thr 135 Ala polymorphism at leucine-rich repeat (LRR) in genomic DNA of toll-like receptor 4 in patients with poorly-differentiated gastric adenocarcinomas

International Journal of Molecular Medicine

Volumn 18, Issue 1, 2006, Pages 59-63

  Ohara, Tadashi ^a   Morishita, Tetsuo ^a   Suzuki, Hidekazu ^b   Hibi, Toshifumi ^b  

^a TOKYO DENTAL COLLEGE   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

Gastric adenocarcinoma; Leucine rich repeat; Toll like receptor

Indexed keywords

DNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 9;

ADENOCARCINOMA; AGED; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CHEMISTRY; COMPARATIVE STUDY; GENETIC POLYMORPHISM; GENETICS; HETEROZYGOTE; HUMAN; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; POLYMERASE CHAIN REACTION; STOMACH TUMOR;

ADENOCARCINOMA; AGED; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; HETEROZYGOTE; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; REPETITIVE SEQUENCES, AMINO ACID; STOMACH NEOPLASMS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 6; TOLL-LIKE RECEPTOR 9; TOLL-LIKE RECEPTORS;

EID: 33748136551     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.18.1.59     Document Type: Article

References (21)

1. Takeda K and Akira S: Toll-like receptors in innate immunity. Int Immunol 17: 1-14, 2005.
2. Goldstein DR: Toll-like receptors and other links between innate and acquired alloimmunity. Curr Opin Immunol 16: 538-544, 2004. (Pubitemid 39165878)
3. Kobe B and Deisenhofer J: Proteins with leucine-rich repeats. Curr Opin Struct Biol 5: 409-416, 1995.
4. Akira S, Takeda K and Kaisho T: Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2: 675-680, 2001. (Pubitemid 32747155)
5. Berdeli A, Celik HA, Ozyurek R, et al: TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. J Mol Med 83: 535-541, 2005. (Pubitemid 41126069)
6. Schroder NW, Meister D, Wolff V, et al: Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene. Genes Immun 6: 448-451, 2005. (Pubitemid 43090522)
7. Schroder NW and Schumann RR: Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis 5: 156-164, 2005. (Pubitemid 40568671)
8. Nagai Y, Shimazu R, Ogata H, et al: Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. Blood 99: 1699-1705, 2002. (Pubitemid 34533044)
9. Nagai Y, Akashi S, Nagafuku M, et al: Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol 3: 667-672, 2002. (Pubitemid 34752476)
10. Vinderola G, Mastar C and Perdigon G: Role of intestinal epithelial cells in immune effects mediated by gram-positive probiotic bacteria: involvement of toll-like receptors. Clin Diagn Lab Immunol 12: 1075-1084, 2005. (Pubitemid 41324539)
11. Clarke JH, Cha JY, Walsh MD, et al: Melanoma inhibits macrophage activation by suppressing toll-like receptor 4 signaling. J Am Coll Surg 201: 418-425, 2005.
12. Munz C, Steinman RM and Fujii S: Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity. J Exp Med 18: 203-207, 2005.
13. Talreja J, Kabir MH, B Filla M, et al: Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components. Immunology 113: 224-233, 2004.
14. Hasan UA, Trinchieri G and Viach J: Toll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts. J Biol Chem 27: 20620-20627, 2005.
15. Peng G, Guo Z, Kiniwa Y, et al: Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 26: 1380-1384, 2005.
16. Borsutzky S, Kretschmer K, Becker PD, et al: The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells. J Immunol 15: 6308-6313, 2005.
17. Okamura Y, Watari M, Jerud ES, et al: The extra domain A of fibronectin activators Toll-like receptor 4. J Biol Chem 276: 10229-10233, 2001.
18. Termeer C, Benedix F, Sleeman J, et al: Oligosaccharides of Hyaluronan activate dendritic cells via Toll-like receptor 4. J Exp Med 195: 99-111, 2002.
19. Johnson GB, Brunn GJ, Kodaira Y, et al: Receptor-mediated monitoring of tissue well-being via detection of soluble heparin sulfate by Toll-like receptor 4. J Immunol 168: 5233-5239, 2002.
20. Ohashi K, Burkart V, Flohe S, et al: Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164: 558-561, 2000.
21. Vabulas RM, Ahmad-Nejad P, Ghose S, et al: HSP70 as endogenous stimulus of toll/interleukin-1 receptor signal pathway. J Biol Chem 277: 15107-15112, 2002.