-
1
-
-
0036069958
-
Genetic approaches to the study of Toll-like receptor function
-
Takeuchi, O., Akira, S. (2002) Genetic approaches to the study of Toll-like receptor function. Microbes Infect. 4, 887-895.
-
(2002)
Microbes Infect.
, vol.4
, pp. 887-895
-
-
Takeuchi, O.1
Akira, S.2
-
2
-
-
0037083638
-
Cutting edge: Immune stimulation by neisserial porins is Toll-like receptor 2 and MyD88 dependent
-
Massari, P., Henneke, P., Ho, Y., Latz, E., Golenbock, D. T., Wetzler, L. M. (2002) Cutting edge: immune stimulation by neisserial porins is Toll-like receptor 2 and MyD88 dependent. J. Immunol. 168, 1533-1537.
-
(2002)
J. Immunol.
, vol.168
, pp. 1533-1537
-
-
Massari, P.1
Henneke, P.2
Ho, Y.3
Latz, E.4
Golenbock, D.T.5
Wetzler, L.M.6
-
3
-
-
0033580949
-
Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2
-
Schwandner, R., Dziarski, R., Wesche, H., Rothe, M., Kirschning, C. J. (1999) Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2. J. Biol. Chem. 274, 17406-17409.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17406-17409
-
-
Schwandner, R.1
Dziarski, R.2
Wesche, H.3
Rothe, M.4
Kirschning, C.J.5
-
4
-
-
0032716031
-
The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors
-
Means, T. K., Lien, E., Yoshimura, A., Wang, S., Golenbock, D. T., Fenton, M. J. (1999) The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors. J. Immunol. 163, 6748-6755.
-
(1999)
J. Immunol.
, vol.163
, pp. 6748-6755
-
-
Means, T.K.1
Lien, E.2
Yoshimura, A.3
Wang, S.4
Golenbock, D.T.5
Fenton, M.J.6
-
5
-
-
0035115080
-
Signaling by TLR2 versus TLR4 agonists results in differential gene expression in murine macrophages
-
Hirschfeld, M., Weis, J. J., Toshchakov, V., Salkowski, C. A., Cody, M. J., Ward, D. C., Qureshi, N., Michalek, S. M., Vogel, S. N. (2001) Signaling by TLR2 versus TLR4 agonists results in differential gene expression in murine macrophages. Infect. Immun. 69, 1477-1482.
-
(2001)
Infect. Immun.
, vol.69
, pp. 1477-1482
-
-
Hirschfeld, M.1
Weis, J.J.2
Toshchakov, V.3
Salkowski, C.A.4
Cody, M.J.5
Ward, D.C.6
Qureshi, N.7
Michalek, S.M.8
Vogel, S.N.9
-
6
-
-
0035979192
-
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
-
Bauer, S., Kirschning, C. J., Hacker, H., Redecke, V., Hausmann, S., Akira, S., Wagner, H., Lipford, G. B. (2001) Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 98, 9237-9242.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9237-9242
-
-
Bauer, S.1
Kirschning, C.J.2
Hacker, H.3
Redecke, V.4
Hausmann, S.5
Akira, S.6
Wagner, H.7
Lipford, G.B.8
-
7
-
-
0036076593
-
Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling
-
Matsumoto, M., Kikkawa, S., Kohase, M., Miyake, K., Seya, T. (2002) Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem. Biophys. Res. Commun. 293, 1364-1369.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.293
, pp. 1364-1369
-
-
Matsumoto, M.1
Kikkawa, S.2
Kohase, M.3
Miyake, K.4
Seya, T.5
-
8
-
-
0034650427
-
Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex
-
Ohashi, K., Burkart, V., Flohe, S., Kolb, H. (2000) Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex. J. Immunol. 164, 558-561.
-
(2000)
J. Immunol.
, vol.164
, pp. 558-561
-
-
Ohashi, K.1
Burkart, V.2
Flohe, S.3
Kolb, H.4
-
9
-
-
0037094116
-
The role of Toll-like receptor (TLR)2 and TLR4 in the host defense against disseminated candidiasis
-
Netea, M. G., Van Der Graaf, C. A., Vonk, A. G., Verschueren, I., Van Der Meer, J. W., Kullberg, B. J. (2002) The role of Toll-like receptor (TLR)2 and TLR4 in the host defense against disseminated candidiasis. J. Infect. Dis. 185, 1483-1489.
-
(2002)
J. Infect. Dis.
, vol.185
, pp. 1483-1489
-
-
Netea, M.G.1
Van Der Graaf, C.A.2
Vonk, A.G.3
Verschueren, I.4
Van Der Meer, J.W.5
Kullberg, B.J.6
-
10
-
-
0034669910
-
TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
-
Takeuchi, O., Hoshino, K., Akira, S. (2000) TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165, 5392-5396.
-
(2000)
J. Immunol.
, vol.165
, pp. 5392-5396
-
-
Takeuchi, O.1
Hoshino, K.2
Akira, S.3
-
11
-
-
0034976848
-
Different Toll-like receptor agonists induce distinct macrophage responses
-
Jones, B., Means, T., Heldwein, K., Keen, M., Hill, P., Belisle, J., Fenton, M. (2001) Different Toll-like receptor agonists induce distinct macrophage responses. J. Leukoc. Biol. 69, 1036-1044.
-
(2001)
J. Leukoc. Biol.
, vol.69
, pp. 1036-1044
-
-
Jones, B.1
Means, T.2
Heldwein, K.3
Keen, M.4
Hill, P.5
Belisle, J.6
Fenton, M.7
-
12
-
-
0036222241
-
TLR4, but not TLR2, mediates IFN-β-induced STAT1α/β -dependent gene expression in macrophages
-
Toshchakov, V., Jones, B. W., Perera, P. Y., Thomas, K., Cody, M. J., Zhang, S., Williams, B. R., Major, J., Hamilton, T. A., Fenton, M. J., Vogel, S. N. (2002) TLR4, but not TLR2, mediates IFN-β-induced STAT1α/β -dependent gene expression in macrophages. Nat. Immunol. 3, 392-398.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 392-398
-
-
Toshchakov, V.1
Jones, B.W.2
Perera, P.Y.3
Thomas, K.4
Cody, M.J.5
Zhang, S.6
Williams, B.R.7
Major, J.8
Hamilton, T.A.9
Fenton, M.J.10
Vogel, S.N.11
-
13
-
-
0033618562
-
Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors
-
Brightbill, H. D., Libraty, D. H., Krutzik, S. R., Yang, R. B., Belisle, J. T., Bleharski, J. R., Maitland, M., Norgard, M. V., Plevy, S. E., Smale, S. T., Brennan, P. J., Bloom, B. R., Godowski, P. J., Modlin, R. L. (1999) Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors. Science 285, 732-736.
-
(1999)
Science
, vol.285
, pp. 732-736
-
-
Brightbill, H.D.1
Libraty, D.H.2
Krutzik, S.R.3
Yang, R.B.4
Belisle, J.T.5
Bleharski, J.R.6
Maitland, M.7
Norgard, M.V.8
Plevy, S.E.9
Smale, S.T.10
Brennan, P.J.11
Bloom, B.R.12
Godowski, P.J.13
Modlin, R.L.14
-
14
-
-
0035869553
-
Differential effects of a Toll-like receptor antagonist on macrophage responses to M. tuberculosis
-
Means, T. K., Jones, B. W., Schromm, A. B., Shurtleff, E., Keane, J., Smith, J., Golenbock, D. T., Vogel, S. N., Fenton, M. J. (2001) Differential effects of a Toll-like receptor antagonist on macrophage responses to M. tuberculosis. J. Immunol. 166, 4074-4082.
-
(2001)
J. Immunol.
, vol.166
, pp. 4074-4082
-
-
Means, T.K.1
Jones, B.W.2
Schromm, A.B.3
Shurtleff, E.4
Keane, J.5
Smith, J.6
Golenbock, D.T.7
Vogel, S.N.8
Fenton, M.J.9
-
15
-
-
0037105425
-
Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice
-
Abel, B., Thieblemont, N., Quesniaux, V. J. F., Brown, N., Mpagi, J., Miyake, K., Bihl, F., Ryffel, B. (2002) Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J. Immunol. 169, 3155-3162.
-
(2002)
J. Immunol.
, vol.169
, pp. 3155-3162
-
-
Abel, B.1
Thieblemont, N.2
Quesniaux, V.J.F.3
Brown, N.4
Mpagi, J.5
Miyake, K.6
Bihl, F.7
Ryffel, B.8
-
16
-
-
0034443265
-
Maturation of human dendritic cells by cell wall skeleton of M. bovis bacillus Calmette-Guerin: Involvement of Toll-like receptors
-
Tsuji, S., Matsumoto, M., Takeuchi, O., Akira, S., Azuma, I., Hayashi, A., Toyoshima, K., Seya, T. (2000) Maturation of human dendritic cells by cell wall skeleton of M. bovis bacillus Calmette-Guerin: involvement of Toll-like receptors. Infect. Immun. 68, 6883-6890.
-
(2000)
Infect. Immun.
, vol.68
, pp. 6883-6890
-
-
Tsuji, S.1
Matsumoto, M.2
Takeuchi, O.3
Akira, S.4
Azuma, I.5
Hayashi, A.6
Toyoshima, K.7
Seya, T.8
-
17
-
-
0033585011
-
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
-
Lien, E., Sellati, T. J., Yoshimura, A., Flo, T. H., Rawadi, G., Finberg, R. W., Carroll, J. D., Espevik, T., Ingalls, R. R., Radolf, J. D., Golenbock, D. T. (1999) Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 274, 33419-33425.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33419-33425
-
-
Lien, E.1
Sellati, T.J.2
Yoshimura, A.3
Flo, T.H.4
Rawadi, G.5
Finberg, R.W.6
Carroll, J.D.7
Espevik, T.8
Ingalls, R.R.9
Radolf, J.D.10
Golenbock, D.T.11
-
18
-
-
0033213590
-
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
-
Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., Akira, S. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443-451.
-
(1999)
Immunity
, vol.11
, pp. 443-451
-
-
Takeuchi, O.1
Hoshino, K.2
Kawai, T.3
Sanjo, H.4
Takada, H.5
Ogawa, T.6
Takeda, K.7
Akira, S.8
-
19
-
-
0033120081
-
Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
-
Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., Akira, S. (1999) Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162, 3749-3752.
-
(1999)
J. Immunol.
, vol.162
, pp. 3749-3752
-
-
Hoshino, K.1
Takeuchi, O.2
Kawai, T.3
Sanjo, H.4
Ogawa, T.5
Takeda, Y.6
Takeda, K.7
Akira, S.8
-
20
-
-
0028168798
-
Three NF-κB binding sites in the human E-selectin gene required for maximal tumor necrosis factor α-induced expression
-
Schindler, U., Baichwal, V. R. (1994) Three NF-κB binding sites in the human E-selectin gene required for maximal tumor necrosis factor α-induced expression. Mol. Cell. Biol. 14, 5820-5831.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 5820-5831
-
-
Schindler, U.1
Baichwal, V.R.2
-
21
-
-
0034623141
-
Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways
-
Paik, J. H., Ju, J. H., Lee, J. Y., Boudreau, M. D., Hwang, D. H. (2000) Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. J. Biol. Chem. 275, 28173-28179.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 28173-28179
-
-
Paik, J.H.1
Ju, J.H.2
Lee, J.Y.3
Boudreau, M.D.4
Hwang, D.H.5
-
22
-
-
0028981285
-
CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition
-
Delude, R. L., Savedra, R., Zhao, H., Thieringer, R., Yamamoto, S., Fenton, M. J., Golenbock, D. T. (1995) CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition. Proc. Natl. Acad. Sci. USA 92, 9288-9292.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9288-9292
-
-
Delude, R.L.1
Savedra, R.2
Zhao, H.3
Thieringer, R.4
Yamamoto, S.5
Fenton, M.J.6
Golenbock, D.T.7
-
23
-
-
0033532629
-
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
-
Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., Kimoto, M. (1999) MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189, 1777-1782.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1777-1782
-
-
Shimazu, R.1
Akashi, S.2
Ogata, H.3
Nagai, Y.4
Fukudome, K.5
Miyake, K.6
Kimoto, M.7
-
24
-
-
0035165287
-
Cutting edge: Functional interactions between Toll-like receptor (TLR)2 and TLR1 or TLR6 in response to phenol-soluble modulin
-
Hajjar, A. M., O'Mahony, D. S., Ozinsky, A., Underhill, D. M., Aderem, A., Klebanoff, S. J., Wilson, C. B. (2001) Cutting edge: functional interactions between Toll-like receptor (TLR)2 and TLR1 or TLR6 in response to phenol-soluble modulin. J. Immunol. 166, 15-19.
-
(2001)
J. Immunol.
, vol.166
, pp. 15-19
-
-
Hajjar, A.M.1
O'Mahony, D.S.2
Ozinsky, A.3
Underhill, D.M.4
Aderem, A.5
Klebanoff, S.J.6
Wilson, C.B.7
-
26
-
-
0033215123
-
Human Toll-like receptors mediate cellular activation by M. tuberculosis
-
Means, T. K., Wang, S., Lien, E., Yoshimura, A., Golenbock, D. T., Fenton, M. J. (1999) Human Toll-like receptors mediate cellular activation by M. tuberculosis. J. Immunol. 163, 3920-3927.
-
(1999)
J. Immunol.
, vol.163
, pp. 3920-3927
-
-
Means, T.K.1
Wang, S.2
Lien, E.3
Yoshimura, A.4
Golenbock, D.T.5
Fenton, M.J.6
-
27
-
-
0032770008
-
Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin
-
Nau, G. J., Liaw, L., Chupp, G. L., Berman, J. S., Hogan, B. L., Young, R. A. (1999) Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin. Infect. Immun. 67, 4223-4230.
-
(1999)
Infect. Immun.
, vol.67
, pp. 4223-4230
-
-
Nau, G.J.1
Liaw, L.2
Chupp, G.L.3
Berman, J.S.4
Hogan, B.L.5
Young, R.A.6
-
29
-
-
0027360333
-
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection
-
Flynn, J. L., Chan, J., Triebold, K. J., Dalton, D. K., Stewart, T. A., Bloom, B. R. (1993) An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178, 2249-2254.
-
(1993)
J. Exp. Med.
, vol.178
, pp. 2249-2254
-
-
Flynn, J.L.1
Chan, J.2
Triebold, K.J.3
Dalton, D.K.4
Stewart, T.A.5
Bloom, B.R.6
-
30
-
-
0027482327
-
Disseminated tuberculosis in interferon gamma gene-disrupted mice
-
Cooper, A. M., Dalton, D. K., Stewart, T. A., Griffin, J. P., Russell, D. G., Orme, I. M. (1993) Disseminated tuberculosis in interferon gamma gene-disrupted mice. J. Exp. Med. 178, 2243-2247.
-
(1993)
J. Exp. Med.
, vol.178
, pp. 2243-2247
-
-
Cooper, A.M.1
Dalton, D.K.2
Stewart, T.A.3
Griffin, J.P.4
Russell, D.G.5
Orme, I.M.6
-
31
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
-
Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B., Beutler, B. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088.
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.Y.4
Van Huffel, C.5
Du, X.6
Birdwell, D.7
Alejos, E.8
Silva, M.9
Galanos, C.10
Freudenberg, M.11
Ricciardi-Castagnoli, P.12
Layton, B.13
Beutler, B.14
-
32
-
-
0036312668
-
Endotoxin can induce MyD88-deficient dendritic cells to support Th2 cell differentiation
-
Kaisho, T., Hoshino, K., lwabe, T., Takeuchi, O., Yasui, T., Akira, S. (2002) Endotoxin can induce MyD88-deficient dendritic cells to support Th2 cell differentiation. Int. Immunol. 14, 695-700.
-
(2002)
Int. Immunol.
, vol.14
, pp. 695-700
-
-
Kaisho, T.1
Hoshino, K.2
Lwabe, T.3
Takeuchi, O.4
Yasui, T.5
Akira, S.6
-
33
-
-
0035082863
-
Gamma interferon-producing CD4+ T lymphocytes in the lung correlate with resistance to infection with Mycobacterium tuberculosis
-
Chackerian, A. A., Perera, T. V., Behar, S. M. (2001) Gamma interferon-producing CD4+ T lymphocytes in the lung correlate with resistance to infection with Mycobacterium tuberculosis. Infect. Immun. 69, 2666-2674.
-
(2001)
Infect. Immun.
, vol.69
, pp. 2666-2674
-
-
Chackerian, A.A.1
Perera, T.V.2
Behar, S.M.3
-
34
-
-
0036784614
-
Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis
-
Reiling, N., Holscher, C., Fehrenbach, A., Kroger, S., Kirschning, C. J., Goyert, S., Ehlers, S. (2002) Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J. Immunol. 169, 3480-3484.
-
(2002)
J. Immunol.
, vol.169
, pp. 3480-3484
-
-
Reiling, N.1
Holscher, C.2
Fehrenbach, A.3
Kroger, S.4
Kirschning, C.J.5
Goyert, S.6
Ehlers, S.7
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