Expression of MicroRNA processing machinery genes in rhesus monkey oocytes and embryos of different developmental potentials

Molecular Reproduction and Development

Volumn 76, Issue 3, 2009, Pages 255-269

  Mtango, Namdori R ^a   Potireddy, Santhi ^a   Latham, Keith E ^a,b  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMANITIN; MESSENGER RNA; MICRORNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; FEMALE; GENE EXPRESSION; GENE SILENCING; GERMINAL VESICLE; HORMONAL REGULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; OOCYTE DEVELOPMENT; OOCYTE MATURATION; PRIORITY JOURNAL; RHESUS MONKEY; RNA PROCESSING; RNA SPLICING; RNA TRANSLATION; SPECIES DIFFERENCE; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; UNTRANSLATED REGION;

ANIMALIA; MACACA MULATTA; PRIMATES;

EID: 61449195129     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.20950     Document Type: Article

References (121)

1. Allemand E, Hastings ML, Murray MV, Myers MP, Krainer AR. 2007. Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid binding protein YB-1. Nat Struct Mol Biol 7:630-638.
2. Artley JK, Braude PR, Johnson MH. 1992. Gene activity and cleavage arrest in human pre-embryos. Hum Reprod 7:1014-1021.
3. Bachvarova R, Cohen EM, De Leon V, Tokunaga K, Sakiyama S, Paynton BV. 1989. Amounts and modulation of actin mRNAs in mouse oocytes and embryos. Development 106:561-565.
4. Bagga S, Bracht J, Hunter S, Massirer K, Holtz J, Eachus R, Pasquinelli AE. 2005. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122:553-563.
5. Bamba C, Bobinnec Y, Fukuda M, Nishida E. 2002. The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo. Curr Biol 12:503-507.
6. Bardoni B, Sittler A, Shen Y, Mandel JL. 1997. Analysis of domains affecting intracellular localization of the FMRP protein. Neurobiol Dis 4:329-336.
7. Bartel DP. 2004. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116:281-297.
8. Bass BL. 2002. RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem 71:817-846.
9. Bernstein E, Caudy AA, Hammond SM, Hannon GJ. 2001. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409:363-366.
10. Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ. 2003. Dicer is essential for mouse development. Nat Genet 35:215-217.
11. Bohnsack MT, Czaplinski K, Girlish D. 2004. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 10:185-191.
12. Brady G, Iscove NN. 1993. Construction of cDNA libraries from single cells. Meth Enzymol 225:611-623.
13. Brady G, Billia F, Knox J, Hoang T, Kirsch IR, Voura EB, Hawley RG, Cumming R, Buchwald M, Siminovitch K. 1995. Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells. Curr Biol 5:909-922.
14. Brower-Toland B, Findley SD, Jiang L, Liu L, Yin H, Dus M, Zhou P, Elgin SCR, Lin H. 2007. Drosophila PIWI associates with chromatin and interacts directly with Hp1a. Genes Dev 21:2300-2311.
15. Cano-Gauci DF, Lualdi JC, Ouellette AJ, Brady G, Iscove NN, Buick RN. 1993. In vitro cDNA amplification from individual intestinal crypts: A novel approach to the study of differential gene expression along the crypt-villus axis. Exp Cell Res 20:344-349.
16. Carmell MA, Hannon GJ. 2004. RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol 11:214-218.
17. Carmell MA, Xuan Z, Zhang MQ, Hannon GJ. 2002. The Argonaute family: Tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev 16:2733-2742.
18. Carmell MA, Girard A, van de Kant HJ, Bourc'his D, Bestor TH, de Rooij DG, Hannon GJ. 2007. MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germ-line. Dev Cell 12:503-514.
19. Cerutti L, Mian N, Bateman A. 2000. Domains in gene silencing and cell differentiation proteins: The novel PAZ domain and redefinition of the Piwi domain. Trends Biochem Sci 25:481-482.
20. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G. 1999. Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems. J Cell Biol 147:1181-1194.
21. Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G. 2000. Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. J Cell Biol 148:1177-1186.
22. Cox DN, Chao A, Baker J, Chang L, Qiao D, Lin H. 1998. A novel class of evolutionarily conserved genes defined by Piwi are essential for stem cell self-renewal. Genes Dev 12:3715-3727.
23. Cuia X, Shena X, Kim N. 2007. Dicer1 expression in preimplantation mouse embryos: Involvement of Oct3/4 transcription at the blastocyst stage. Biochem Biophys Res Commun 352:231-236.
24. DeGregori J, Russ A, von Melchner H, Rayburn H, Priyaranjan P, Jenkins NA, Copeland NG, Ruley HE. 1994. A murine homolog of the yeast RNA1 gene is required for postimplantation development. Genes Dev 8:265-276.
25. Deng W, Lin H. 2002. miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Dev Cell 6:819-830.
26. Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ. 2004. Processing of primary microRNAs by the Microprocessor complex. Nature 32:231-235.
27. Desterro JM, Keegan LP, Lafarga M, Berciano MT, O'Connell M, Carmo-Fonseca M. 2003. Dynamic association of RNA-editing enzymes with the nucleolus. J Cell Sci 116:1805-1818.
28. Ding L, Spencer A, Morita K, Han M. 2005. The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans. Mol Cell 19:437-447.
29. Domachenko A, Latham KE, Hatton KS. 1997. Expression of myc-family, myc-interacting, and myc target genes during preimplantation mouse development. Mol Reprod Dev 47:57-65.
30. Eberhart DE, Malter HE, Feng Y, Warren ST. 1996. The Fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals. Hum Mol Genet 5:1083-1091.
31. Feinberg AP, Vogelstein B, Addendum A. 1983. A technique for radiolabeling DNA restriction fragmetns to high specific activity. Anal Biochem 137:266-267.
32. Fischer U, Liu Q, Dreyfuss G. 1997. The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis. Cell 90:1023-1029.
33. Fridell RA, Benson RE, Hua J, Bogerd HP, Cullen BR. 1996. A nuclear role for the Fragile X mental retardation protein. EMBO J 15:5408-5414.
34. Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R. 2004. The Microprocessor complex mediates the genesis of microRNAs. Nature 432:235-240.
35. Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. 2001. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106:23-34.
36. Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G. 2002. Gemin5: A novel WD repeat protein component of the SMN complex that binds Sm proteins. J Biol Chem 277:5631-5636.
37. Hammond S. 2005. Dicing and slicing: The core machinery of the RNA interference pathway. FEBS Lett 579:5822-5829.
38. Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN. 2004. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 18:3016-3027.
39. Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, Sohn SY, Cho Y, Zhang BT, Kim VN. 2006. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 125:887-901.
40. Hartshorn C, Rice JE, Wangh LJ. 2002. Developmentally-regulated changes of Xist RNA levels in single preimplantation mouse embryos, as revealed by quantitative real-time PCR. Mol Reprod Dev 61:425-436.
41. He L, Hannon GJ. 2004. MicroRNAs: Small RNAs with a big role in gene regulation. Nat Rev Genet 5:522-531.
42. Ho Sui SJ, Mortimer JR, Arenillas DJ, Brumm J, Walsh CJ, Kennedy BP, Wasserman WW. 2005. oPOSSUM: Identification of over-represented transcription factor binding sites in co-expressed genes. Nucleic Acids Res 33:3154-3164.
43. Hutvágner G, McLachlan J, Pasquinelli AE, Bálint E, Tuschl T, Zamore PD. 2001. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293:834-838.
44. Iscove NN, Barbara M, Gu M, Gibson M, Modi C, Winegarden N. 2002. Representation is faithfully preserved in global cDNA amplified exponentially from sub-picogram quantities of mRNA. Nat Biotechnol 20:940-943.
45. Jablonka S, Holtmann B, Meisterdagger G, Bandilladagger M, Rossoll W, Fischerdagger U, Sendtner M. 2002. Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death. Proc Natl Acad Sci 99:10126-10131.
46. Jones KW, Gorzynski K, Hales CM, Fischer U, Badbanchi F, Terns RM, Terns MP. 2001. Direct interaction of the spinal muscular atrophy disease protein SMN with the small nucleolar RNA-associated protein fibrillarin. J Biol Chem 276:38645-38651.
47. Ketting RF, Fischer SE, Bernstein E, Sijen T, Hannon GJ, Plasterk RH. 2001. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev 15:2654-2659.
48. Khvorova A, Reynolds A, Jayasena SD. 2003. Functional siRNAs and miRNAs exhibit strand bias. Cell 115:209-216.
49. Kim VN. 2005. MicroRNA biogenesis: Coordinated cropping and dicing. Nat Rev Mol Cell Biol 6:376-385.
50. Knight SW, Bass BL. 2001. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science 293:2269-2271.
51. Knight SW, Bass BL. 2002. The role of RNA editing by ADARs in RNAi. Mol Cell 10:809-817.
52. Kusano A, Staber C, Ganetzky B. 2002. Segregation distortion induced by wild-type RanGAP in Drosophila. Proc Natl Acad Sci USA 99:6866-6870.
53. Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. 2001. Identification of novel genes coding for small expressed RNAs. Science 294:853-858.
54. Landthaler M, Yalcin A, Tuschl T. 2004. The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis. Curr Biol 14:2162-2167.
55. Latham KE, Rambhatla L. 1995. Expression of X-linked genes in androgenetic, gynogenetic, and normal mouse preimplantation embryos. Dev Genet 17:212-222.
56. Latham KE, Solter D, Schultz RM. 1991. Activation of a two-cell stage-specific gene following transfer of heterologous nuclei into enucleated mouse embryos. Mol Reprod Dev 30:182-186.
57. Latham KE, Rambhatla L, Hayashizaki Y, Chapman VM. 1995. Stage-specific induction and regulation by genomic imprinting of the mouse U2afbp-rs gene during preimplantation development.
58. Dev Biol 168:670-676. Latham KE, De La Casa E, Schultz R. 1999. Analysis of mRNA expression during preimplantation development. In: Tuan RS, Lo CW, editors. Methods in molecular biology: Developmental biology protocols. New York: Springer. Vol. II. pp. 315-331.
59. Lau NC, Lim LP, Weinstein EG, Bartel DP. 2001. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294:858-862.
60. Lee RC, Ambros V. 2001. An extensive class of small RNAs in Caenorhabditis elegans. Science 294:862-864.
61. Lee RC, Feinbaum RL, Ambros V. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843-854.
62. Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Rådmark O, Kim S, Kim VN. 2003. The nuclear RNase III Drosha initiates microRNA processing. Nature 425:415-419.
63. Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH, Kim VN. 2004. MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23:4051-4060.
64. Lin H. 2007. piRNAs in the germ line. Science 316:397.
65. Lingel A, Simon B, Izaurralde E, Sattler M. 2004. Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat Struct Mol Biol 11:576-577.
66. Liu Q, Fischer U, Wang F, Dreyfuss G. 1997. The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell 90:1013-1021.
67. Lund E, Guttinger S, Calado A, Dahlberg JE, Kutay U. 2004. Nuclear export of microRNA precursors. Science 303:95-98.
68. Mann M, Latham KE, Varmuza S. 1995. Identification of genes showing altered expression in preimplantation and early postimplantation parthenogenetic embryos. Dev Genet 17:223-232.
69. Meister G, Bühler D, Pillai R, Lottspeich F, Fischer U. 2001. A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs. Nat Cell Biol 3:945-949.
70. Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Luhrmann R, Tuschl T. 2005. Identification of novel argonaute-associated proteins. Curr Biol 15:2149-2155. Merrill C, Bayraktaroglu L, Kusano A, Ganetzky B. 1999. Truncated RanGAP encoded by the segregation distorter locus of drosophila. Science 283:1742-1745.
71. Morita S, Horiia T, Kimuraa M, Gotoc Y, Ochiyad T, Hatada I. 2007. One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation. Genomics 89:687-696.
72. Mourelatos Z, Abel L, Yong J, Kataoka N, Dreyfuss G. 2001. SMN interacts with a novel family of hnRNP and spliceosomal proteins. EMBO J 20:5443-5452.
73. Mtango NR, Latham KE. 2008. Differential expression of cell cycle genes in rhesus monkey oocytes and embryos of different developmental potentials. Biol Reprod 78:254-266.
74. Murchison EP, Stein P, Xuan Z, Pan H, Zhang MQ, Schultz RM, Hannon GJ. 2007. Critical roles for Dicer in the female germline. Genes Dev 21:682-693.
75. Nacerddine K, Lehembre F, Bhaumik M, Artus J, Cohen-Tannoudji M, Babinet C, Pandolfi PP, Dejean A. 2005. The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. Dev Cell 9:769-779.
76. Pellizzoni L, Kataoka N, Charroux B, Dreyfuss G. 1998. A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing. Cell 95:615-624.
77. Pellizzoni L, Baccon J, Charroux B, Dreyfuss G. 2001a. The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1. Curr Biol 11:1079-1088.
78. Pellizzoni L, Charroux B, Rappsilber J, Mann M, Dreyfuss G. 2001b. A functional interaction between the survival motor neuron complex and RNA polymerase II. J Cell Biol 152:75-85.
79. Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G. 2002. Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. J Biol Chem 277:7540-7545.
80. Rambhatla L, Patel B, Dhanasekaran N, Latham KE. 1995. Analysis of G protein a subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT-PCR approach. Mol Reprod Dev 41:314-324.
81. Rehwinkel J, Behm-Ansmant I, Gatfield D, Izaurralde E. 2005. A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. RNA 11:1640-1647.
82. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. 2000. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403:901-906.
83. Rossant J, Guillemot F, Tanaka M, Latham K, Gertenstein M, Nagy A. 1998. Mash2 is expressed in oogenesis and preimplantation development but is not required for blastocyst formation. Mech Dev 73:183-191.
84. Sansam CL, Wells KS, Emeson RB. 2003. Modulation of RNA editing by functional nucleolar sequestration of ADAR2. Proc Natl Acad Sci USA 100:14018-14023.
85. Schramm RD, Tennier MT, Boatman DE, Bavister BD. 1993. Chromatin configurations and meiotic competence of oocytes are related to follicular diameter in nonstimulated rhesus monkeys. Biol Reprod 48:349-356.
86. Schramm RD, Bavister BD. 1994. Follicle-stimulating hormone priming of rhesus monkeys enhances meiotic and developmental competence of oocytes matured in vitro. Biol Reprod 51:904-912.
87. Schramm RD, Bavister BD. 1995. Effects of granulosa cells and gonadotrophins on meiotic and developmental competence of oocytes in vitro in non-stimulated rhesus monkeys. Hum Reprod 10:887-895.
88. Schramm RD, Bavister BD. 1996. Granulosa cells from follicle stimulating hormone-primed monkeys enhance the development competence of in-vitro-matured oocytes from non-stimulated rhesus monkeys. Hum Reprod 11:1698-1702.
89. Schramm RD, Bavister BD. 1999. A macaque model for studying mechanisms controlling oocyte development and maturation in human and non-human primates. Hum Reprod 14:2544-2555.
90. Schramm RD, Paprocki AM, VandeVoort CA. 2003. Causes of developmental failure of in-vitro matured rhesus monkey oocytes: Impairments in embryonic genome activation. Hum Reprod 18:826-833.
91. Schultz RM. 1993. Regulation of zygotic gene activation in the mouse. Bioessays 15:531-538.
92. Schultz RM. 1999. The regulation and reprogramming of gene expression in the preimplantation embryo. Adv Dev Biochem 5:127-162.
93. Schwarz DS, Hutvágner G, Du T, Xu Z, Aronin N, Zamore PD. 2003. Asymmetry in the assembly of the RNAi enzyme complex. Cell 115:199-208.
94. Sommerville J. 1999. Activities of cold-shock domain proteins in translation control. Bioessays 21:319-325.
95. Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L. 2003. The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motifin RNAi effector complexes. Nat Struct Biol 10:1026-1032.
96. Stickeler E, Fraser SD, Honig A, Chen AL, Berget SM, Cooper TA. 2001. The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4. EMBO J 20:3821-3830.
97. Tahbaz N, Kolb FA, Zhang F, Jaronczyk K, Filipowicz W, Hobman TC. 2004. Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. EMBO Rep 5: 189-194.
98. Tam OH, Aravin AA, Stein P, Girard A, Murchison EP, Cheloufi S, Hodges E, Anger M, Sachidanandam R, Schultz RM, Hannon GJ. 2008. Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature 453:534-538.
99. Tamanini F, Bontekoe C, Bakker CE, van Unen L, Anar B, Willemsen R, Yoshida M, Galjaard H, Oostra BA, Hoogeveen AT. 1999. Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations. Hum Mol Genet 8:863-869.
100. Tang F, Hajkova P, Barton SC, O'Carroll D, Lee C, Lao K, Surani MA. 2006. 220-plex microRNA expression profile of a single cell. Nat Protoc 1:1154-1159.
101. Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA. 2007. Maternal microRNAs are essential for mouse zygotic development. Genes Dev 21:644-648.
102. TesarikJ, KopecnyV, PlachotM, Mandelbaum J. 1986a. Activation of nucleolar and extranucleolar RNA synthesis and changes in the ribosomal content of human embryos developing in vitro. J Reprod Fertil 78:463-470.
103. Tesarik J, Kopecny V, Plachot M, Mandelbaum J, DaLage C, Flechon JE. 1986b. Nucleologenesis in the human embryo developing in vitro: Ultrastructural and autoradiographic analysis. Dev Biol 115:193-203.
104. Tesarik J, Kopecny V, Plachot M, Mandelbaum J. 1987. High-resolution autoradiographic localization of DNA-containing sites and RNA synthesis in developing nucleoli of human preimplantation embryos: A new concept of embryonic nucleologenesis. Development 101:777-791.
105. Tesarik J, Kopecny V, Plachot M, Mandelbaum J. 1988. Early morphological signs of embryonic genome expression in human preimplantation development as revealed by quantitative electron microscopy. Dev Biol 128:15-20.
106. Tomari Y, Zamore PD. 2005. Perspective: Machines for RNAi. Genes Dev 19:517-529.
107. Tonkin LA, Bass BL. 2003. Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants. Science 302:1725.
108. Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. 2006. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 20:515-5524.
109. Wang Q, Latham KE. 2000. Translation of maternal mRNAs encoding transcription factors during genome activation in early mouse embryos. Biol Reprod 62:969-978.
110. Wang Q, Chung YG, DeVries WN, Struwe M, Latham KE. 2001. Role of protein synthesis in the development of a transcriptionally permissive state in one-cell stage mouse embryos. Biol Reprod 65:748-754.
111. Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R. 2007. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet 39:380-385.
112. Watanabe T, Totoki Y, Toyoda A, Kaneda M, Kuramochi-Miyagawa S, Obata Y, Chiba H, Kohara Y, Kono T, Nakano T, Surani A, Sakaki Y, Sasaki H. 2008. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 453:539-543.
113. Weaver DL, Nu?ñez C, Brunet C, Bostock V, Brady G. 1999. Single-cell RT-PCR cDNA subtraction. Methods Mol Biol 97:601-609.
114. Weston AM, Wolf DP. 1994. Timing of the maternal to embryonic transition in rhesus monkey embryos. Biol Reprod 50(Abstract).
115. Wilkinson MF, Shyu AB. 2001. Multifunctional regulatory proteins that control gene expression in both the nucleus and the cytoplasm. Bioessays 23:775-787.
116. Yang W, Wang Q, Howell KL, Lee JT, Cho DS, Murray JM, Nishikura K. 2005. ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells. J Biol Chem 280:3946-3953.
117. Yi R, Qin Y, Macara IG, Cullen BR. 2003. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 17:3011-3016.
118. Zeng F, Baldwin DA, Schultz RM. 2004. Transcript profiling during preimplantation development. Dev Biol 272:483-496.
119. Zheng P, Patel B, McMenamin M, Reddy SE, Paprocki AM, Schramm RD, Latham KE. 2004. The primate embryo gene expression resource: A novel resource to facilitate rapid analysis of gene expression patterns in non-human primate oocytes and preimplantation stage embryos. Biol Reprod 70:1411-1418.
120. Zheng P, Patel B, McMenamin M, Moran E, Paprocki AM, Kihara M, Schramm RD, Latham KE. 2005. Effects of follicle size and oocyte maturation conditions on maternal messenger RNA regulation and gene expression in rhesus monkey oocytes and embryos. Biol Reprod 72:890-897.
121. Zuccotti M, Boiani M, Ponce R, Guizzardi S, Scandroglio R, Garagna S, Redi CA. 2002. Mouse Xist expression begins at zygotic genome activation and is timed by a zygotic clock. Mol Reprod Dev 61:14-20.