In vivo measurements of brain trapping of 11C-labelled α-methyl-L-tryptophan during acute changes in mood states

Journal of Psychiatry and Neuroscience

Volumn 32, Issue 6, 2007, Pages 430-434

  Perreau Linck, Elisabeth ^a   Beauregard, Mario ^a   Gravel, Paul ^b   Paquette, Vincent ^a   Soucy, Jean Paul ^c   Diksic, Mirko ^c   Benkelfat, Chawki ^b,d  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d Research and Training Building ^*  (Canada)

Author keywords

Brain; Depression; Emotions; Gyrus, cingulate; Positron emission tomography; Serotonin; Tryphophan

Indexed keywords

ADULT; ARTICLE; AUTOBIOGRAPHICAL MEMORY; AUTOREGULATION; BRAIN FUNCTION; CINGULATE GYRUS; CLINICAL ARTICLE; CORRELATION ANALYSIS; EMOTION; HUMAN; MALE; MOOD CHANGE; POSITRON EMISSION TOMOGRAPHY;

EID: 37049035591     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Davidson RJ. Affective style, psychopathology, and resilience: brain mechanisms and plasticity. Am Psychol 2000;55:1196-214.
2. Benkelfat C, Ellenbogen MA, Dean P, et al. Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective-disorders. Arch Gen Psychiatry 1994;51:687-97.
3. Young SN, Leyton M. The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels [review]. Pharmacol Biochem Behav 2002;71:857-65.
4. Blier P, DeMontigny C. Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders. Neuropsychopharmacology 1999;21(2 Suppl):91S-8S.
5. Lucki I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry 1998;44:151-62.
6. Rosa-Neto P, Diksic M, Okazawa H, et al. Measurement of brain regional alpha-[11C]methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression. Arch Gen Psychiatry 2004;61:556-63.
7. Nishizawa S, Leyton M, Okazawa H, et al. Validation of a less-invasive method for measurement of serotonin synthesis rate with alpha-[11C]methyl- tryptophan. J Cereb Blood Flow Metab 1998;18:1121-9.
8. Chugani DC, Muzik O. Alpha[C-11]methyl-L-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism. J Cereb Blood Flow Metab 2000;20:2-9.
9. Lundquist P, Hartvig P, Blomquist G, et al. 5-Hydroxy-L-[beta-11C] tryptophan versus alpha-[11C]methyl-L-tryptophan for positron emission tomography imaging of serotonin synthesis capacity in the rhesus monkey brain. J Cereb Blood Flow Metab 2007;27:821-30.
10. Diksic M, Tohyama Y, Takada A. Brain net unidirectional uptake of alpha-[(14)C]methyl-L-tryptophan (alpha-MTrp) and its correlation with regional serotonin synthesis, tryptophan incorporation into proteins, and permeability surface area products of tryptophan and alpha-MTrp. Neurochem Res 2000;25:1537-46.
11. American Psychiatric Association. Diagnostic and statistical manual of mental disorders-IV-TR. 4th ed. Text revision. Washington: The Association; 2000.
12. First MB, Spitzer RL, Gibbon M. Axis I disorders. New York: New York State Psychiatric Institute; 2002.
13. Sakai Y, Nishikawa M, Leyton M, et al. Cortical trapping of alpha-[(11)C]methyl-L-tryptophan, an index of serotonin synthesis, is lower in females than males. Neuroimage 2006;33:815-24.
14. Mzengeza S, Venkatachalam TK, Diksic M. Asymmetric radiosynthesis of alpha-[11C]methyl-L-tryptophan for PET studies. Nucl Med Biol 1995;22:303-7.
15. Diksic M, Young SN. Study of the brain serotonergic system with labeled alpha-methyl-L-tryptophan. J Neurochem 2001;78:1185-200.
16. Worsley KJ, Cao J, Paus T, et al. Applications of random field theory to functional connectivity. Hum Brain Mapp 1998;6:364-7.
17. Friston KJ, Frith CD, Liddle PF, et al. Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab 1991;11:690-9.
18. Friston KJ, Tononi G, Reeke GN Jr, et al. Value-dependent selection in the brain: simulation in a synthetic neural model. Neuroscience 1994;59:229-43.
19. Beauregard M, Lévesque J, Paquette V. Neural basis of conscious and voluntary self-regulation of emotion. In: Beauregard M, editor. Consciousness, emotional self-regulation and the brain. Amsterdam (NL): John Benjamins Publishing; 2004. p. 163-94.
20. Rosa-Neto P, Diksic M, Leyton M, et al. Stability of alpha-[(11)C]methyl- L-tryptophan brain trapping in healthy male volunteers. Eur J Nucl Med Mol Imaging 2005;32:1199-204.
21. Hildebrand J, Bourgeois F, Buyse M, et al. Reproducibility of monoamine metabolite measurements in human cerebrospinal fluid. Acta Neurol Scand 1990;81:427-30.
22. Haller J, Toth M, Halasz J. The activation of raphe serotonergic neurons in normal and hypoarousal-driven aggression: a double labeling study in rats. Behav Brain Res 2005;161:88-94.
23. Yokoyama M, Suzuki E, Sato T, et al. Amygdalic levels of dopamine and serotonin rise upon exposure to conditioned fear stress without elevation of glutamate. Neurosci Lett 2005;379:37-41.
24. Jaffe EH, De Frias V, Ibarra C. Changes in basal and stimulated release of endogenous serotonin from different nuclei of rats subjected to two models of depression. Neurosci Lett 1993;162:157-60.
25. Hasegawa S, Nishi K, Watanabe A, et al. Brain 5-HT synthesis in the Flinders Sensitive Line rat model of depression: an autoradiographic study. Neurochem Int 2006;48:358-66.
26. Flory JD, Manuck SB, Matthews KA, et al. Serotonergic function in the central nervous system is associated with daily ratings of positive mood. Psychiatry Res 2004;129:11-9.
27. Williams, E, Stewart-Knox B, Helander A, et al. Associations between whole-blood serotonin and subjective mood in healthy male volunteers. Biol Psychol 2006;71:171-4.
28. Mayberg HS, Liotti M, Brannan SK, et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry 1999;156:675-82.
29. Shoaf SE, Carson R, Hommer D, et al. Brain serotonin synthesis rates in rhesus monkeys determined by [11C]alpha-methyl-L-tryptophan and positron emission tomography compared to CSF 5-hydroxyindole-3-acetic acid concentrations. Neuropsychopharmacology 1998;19:345-53.
30. Muzik O, Chugani DC, Chakraborty P, et al. Analysis of [C-11] alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in vivo. J Cereb Blood Flow Metab 1997;17:659-69.
31. Fenstermacher JD, Blasberg RG, Patlak CS. Methods for quantifying the transport of drugs across brain barrier systems. Pharmacol Ther 1981;14:217-48.