Cystatin incorporated in poly(lactide-co-glycolide) nanoparticles: Development and fundamental studies on preservation of its activity

European Journal of Pharmaceutical Sciences

Volumn 22, Issue 5, 2004, Pages 357-364

  Cegnar, Mateja ^a   Kos, Janko ^a,b   Kristl, Julijana ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b Krka   (Slovenia)

Author keywords

Biopharmaceutics; Cystatin; Lyoprotection; Nanoparticles; PLGA; Stability

Indexed keywords

BOVINE SERUM ALBUMIN; CYSTATIN; FUNCTIONAL GROUP; NANOPARTICLE; OIL; POLYGLACTIN; POLYMER; SOLVENT; WATER;

ARTICLE; CANCER CHEMOTHERAPY; CHEMICAL MODIFICATION; DENATURATION; DIFFUSION; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; DRUG SYNTHESIS; EMULSION; ENERGY; MECHANICS; PARTICLE SIZE; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TECHNIQUE; ULTRASOUND;

ANIMALS; CATTLE; CHICKENS; CYSTATINS; GLYCOLATES; NANOSTRUCTURES; PARTICLE SIZE;

EID: 3242716580     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.04.003     Document Type: Article

References (34)

1. Alonso, M.J., 1996. Nanoparticulate drug carrier technology. In: Cohen, S. and Bernstein, H. (Eds.), Microparticulate systems for the delivery of proteins and vaccines. Marcel Dekker, New York, pp. 2030-242.
2. Bilati U., Allemann E., Doelker E. Sonication parameters for the preparation of biodegradable nanocapsules of controlled size by the double emulsion method. Pharm. Dev. Technol. 8:2003;1-9
3. Blanco M.D., Alonso M.J. Development and characterisation of protein-loaded poly(lactide-co-glycolide) nanospheres. Eur. J. Pharm. Biopharm. 43:1997;287-294
4. Bode W., Engh R., Musil D., Thiele U., Huber R., Karshikov A., Brzin J., Kos J., Turk V. The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases. EMBOS. 7:1988;2593-2959
5. Cohen S., Yoshioka T., Lucarelli M., Hwang L.H., Langer R. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharm. Res. 8(6):1991;713-720
6. Coppola, M.L., 2000. Freeze-drying concepts: The basics. In: McNally, E.J. (Ed.), Protein formulation and delivery. Marcel Dekker, New York-Basel, pp. 159-199.
7. Dorkoosh F.A., Verhoef J.C., Rafiee-Tehrani M., Borchard G., Junginger H.E. Peroral drug delivery systems for peptides and proteins. STP Pharm. Sci. 12:2002;205-211
8. Florence T. The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual. Pharm. Res. 14:1997;259-266
9. Gaspar M.M., Blanco D., Cruz M.E.M., Alonso M.J. Formulation of L-asparaginase-loaded poly(lactide-co-glycolide) nanoparticles: Influence of polymer properties on enzyme loading, activity and in vitro release. J. Control. Rel. 52:1998;53-62
10. Govender T., Stolnik S., Garnett M.C., Illum L., Davis S.S. PLGA nanoparticles prepared by nanoprecipitation: drug loading and relese studies of water soluble drug. J. Control. Rel. 57:1999;171-185
11. Herrmann J., Bodmeier R. Biodegradable, somatostatin acetate containing microspheres prepared by various aqueous and non-aqueous solvent evaporation methods. Eur. J. Pharm. Biopharm. 45:1998;75-82
12. Jaeghere F., Allémann E., Kubel F., Galli B., Cozens R., Doelker E., Gurny R. Oral bioavailability of a poorly water soluble HIV-1 protease inhibitor incorporated into pH-sensitive particles: Effect of the particle size and nutritional state. J. Control. Rel. 68:2000;291-298
13. Jung T., Kamm W., Breitenbach A., Kaiserling E., Xiao J.X., Kissel T. Biodegradible nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? Eur. J. Pharm. Biopharm. 50:2000;147-160
14. Kos J., Dolinar M., Turk V. Isolation and characterisation of chicken L- and H-kininogens and their interaction with chicken cysteine proteinases and papain. Agents Action. Suppl. 38:1992;331-339
15. Kos J., Werle B., Lah T., Brunner N. Cysteine proteinases and their inhibitors in extracellular fluids: Markers for diagnosis and prognosis in cancer. Int. J. Bio. Marker. 15:2000;84-89
16. Kristl J., Alemmann E., Gurny R. Formulation and evaluation of zinc-phthalocyanine loaded poly(D, L-lactic acid) nanoparticles. Acta Pharm. 46:1996;1-12
17. Lee W., Park J., Yang E.H., Suh H., Kim S.H., Chung D.S., Choi K., Yang C.W., Park J. Investigation of the factors influencing the release rates of cyclosporin A-loaded micro- and nanoparticles prepared by high-pressure homogenizer. J. Control. Rel. 84:2002;115-123
18. Lowry O.H., Rosebrough N.F., Farr A.L., Rohdoll R.I. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275
19. Maa Y.F., Hsu C.C. Performance of sonication and microfluidization for liquid-liquid emulsification. Pharm. Dev. Technol. 4:1999;233-240
20. McClean S., Prosser E., Meehan E., O'Malley D., Clarke N., Ramtoola Z., Brayden D. Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia. Eur. J. Pharm. Sci. 6:1998;153-163
21. Meng F.T., Ma G.H., Qui W., Su Z.G. W/O/W double emulsion technique using ethyl acetate as organic solvent: effects of its diffusion rate on the characteristics of microparticles. J. Control. Rel. 91:2003;407-416
22. Murakami H., Kobayashi M., Takeuchi H., Kawashima Y. Further application of modified spontaneous emulsification solvent diffusion method to various types of PLGA-PLA polymers for preparation of nanoparticles. Powder Tech. 107:2000;137-143
23. Norris D.A., Puri N., Sinko P.J. The effect of physical barriers and properties on the oral absorption of particles. Adv. Drug Del. Rev. 34:1998;135-154
24. Premzl A., Kos J. Cysteine and aspartic proteases cathepsins B and D determine the invasiveness of MCF10A neoT cells. Radiol. Oncol. 37:2003;241-248
25. Quintanar-Guerrero D., Allemann E., Fessi H., Doelker E. Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers. Drug. Devel. Ind. Pharm. 24:1998;1113-1128
26. Raghuvanshi R.S., Goyal S., Singh O., Panda A.K. Stabilisation of dichloromethane-induced protein denaturation during microencapsulation. Pharm. Dev. Technol. 3:1998;269-276
27. Sah H. Stabilization of proteins against methylene chloride/water interface-induced denaturation and aggregation. J. Control. Rel. 58:1999;143-151
28. Sanchez A., Tobio M., Gonzalez L., Fabra A., Alonso M.J. Biodegradable micro- and nanoparticles as long-term delivery vehicles for interferon-alpha. Eur. J. Pharm. Sci. 18:2003;221-229
29. Song C.X., Labhasetwar V., Murphy H., Qu X., Humphrey W.R., Shebuski R.J., Levy R.J. Formulation and characterization of biodegradable nanoparticles for intravaskular local drug delivery. J. Control. Rel. 43:1997;197-212
30. Sturesson C., Carlfors J. Incorporation of protein in PLG-microspheres with retention of bioactivity. J. Control. Rel. 67:2000;171-178
31. Tobio M., Alonso M.J. Study of the inactivation process of the tetanus toxoid in contact with poly(lactic/glycolic acid) degrading microspheres. STP Pharm. Sci. 8:1998;302-310
32. Vila A., Sánchez A., Tobío M., Calvo P., Alonso M.J. Design of biodegradable particles for protein delivery. J. Control. Rel. 78:2000;15-24
33. Wang W. Lyophilisation and development of solid protein pharmaceuticals (review). Int. J. Pharm. 203:2000;1-60
34. Yeo Y., Basaran O.A., Park K. A new process for making reservoir-type microcapsules using ink-jet technology and interfacial phase separation. J. Control. Rel. 93:2003;161-173