Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1 H-indole-3-carboxaldehyde (oncrasin-1)

Molecular Cancer Therapeutics

Volumn 8, Issue 2, 2009, Pages 441-448

  Guo, Wei ^a   Wu, Shuhong ^a   Wang, Li ^a   Wang, Rui Yu ^a   Wei, Xiaoli ^a   Liu, Jinsong ^a   Fang, Bingliang ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA ACTIN; CYCLIN DEPENDENT KINASE 9; CYCLIN T1; ONCRASIN 1; PROTEIN KINASE C IOTA; RAD51 PROTEIN; RECOMBINANT PROTEIN; RNA POLYMERASE II; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DNA REPAIR; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRON; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN AGGREGATION; REPORTER GENE; RNA PROCESSING; RNA TRANSCRIPTION;

CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 9; CYCLINS; DRUG SCREENING ASSAYS, ANTITUMOR; GENES, REPORTER; HUMANS; INDOLES; ISOENZYMES; LUCIFERASES; NUCLEAR PROTEINS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C; PROTEIN STRUCTURE, QUATERNARY; PROTEIN TRANSPORT; RAD51 RECOMBINASE; RIBONUCLEOPROTEINS; RNA POLYMERASE II; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA-BINDING PROTEINS; TRANSCRIPTION, GENETIC;

EID: 60849135119     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0839     Document Type: Article

References (38)

1. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992;258:607-14.
2. Fedorov YV, Jones NC, Olwin BB. Atypical protein kinase Cs are the Ras effectors that mediate repression of myogenic satellite cell differentiation. Mol Cell Biol 2002;22:1140- 9.
3. Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ. Protein kinase Cisotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 1998;281:2042-5.
4. Cornford P, Evans J, Dodson A, et al. Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer. Am J Pathol 1999;154:137 - 44.
5. Eder AM, Sui X, Rosen DG, et al. Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci U S A 2005;102:12519 - 24.
6. Regala RP, Weems C, Jamieson L, et al. Atypical protein kinase Cι is an oncogene in human non-small cell lung cancer. Cancer Res 2005;65:8905-11.
7. Murray NR, Jamieson L, Yu W, et al. Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo. J Cell Biol 2004;164:797 - 802.
8. Terasawa H, Noda Y, Ito T, et al. Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PCmotif. EMBO J 2001;20:3947 - 56.
9. Diaz-Meco MT, Moscat J. MEK5, a new target of the atypical protein kinase Cisoforms in mitogenic signaling. Mol Cell Biol 2001;21:1218 - 27.
10. Lin D, Edwards AS, Fawcett JP, Mbamalu G, Scott JD, Pawson T. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol 2000;2:540- 7.
11. Puls A, Schmidt S, Grawe F, Stabel S. Interaction of protein kinase Cæ with ZIP, a novel protein kinase C-binding protein. Proc Natl Acad Sci U S A 1997;94:6191 - 6.
12. Zhou G, Seibenhener ML, Wooten MW. Nucleolin is a protein kinase Cæ substrate. Connection between cell surface signaling and nucleus in PC12 cells. J Biol Chem 1997;272:31130- 7.
13. Leitges M, Sanz L, Martin P, et al. Targeted disruption of the ζPKC gene results in the impairment of the NF-κB pathway. Mol Cell 2001;8:771 - 80.
14. Soloff RS, Katayama C, Lin MY, Feramisco JR, Hedrick SM. Targeted deletion of protein kinase Cλ reveals a distribution of functions between the two atypical protein kinase Cisoforms. J Immunol 2004;173:3250- 60.
15. Guo W, Wu S, Liu J, Fang B. Identification of a small molecule with synthetic lethality for K-ras and protein kinase Cι. Cancer Res 2008;68:7403 - 8.
16. Teraishi F, Wu S, Sasaki J, et al. JNK1-dependent antimitotic activity of thiazolidin compounds in human non-small-cell lung and colon cancer cells. Cell Mol Life Sci 2005;62:2382 - 9.
17. Baumann P, Benson FE, West SC. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell 1996;87:757 - 66.
18. Fu XD, Maniatis T. Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. Science 1992;256:535 - 8.
19. Misteli T, Caceres JF, Spector DL. The dynamics of a pre-mRNA splicing factor in living cells. Nature 1997;387:523 - 7.
20. Fakan S, Bernhard W. Localisation of rapidly and slowly labelled nuclear RNA as visualized by high resolution autoradiography. Exp Cell Res 1971;67:129 - 41.
21. Fakan S, Nobis P. Ultrastructural localization of transcription sites and of RNA distribution during the cell cycle of synchronized CHO cells. Exp Cell Res 1978;113:327 - 37.
22. Spector DL. Macromolecular domains within the cell nucleus. Annu Rev Cell Biol 1993;9:265 - 315.
23. Spector DL. Nuclear organization and gene expression. Exp Cell Res 1996;229:189 - 97.
24. Carmo-Fonseca M, Pepperkok R, Carvalho MT, Lamond AI. Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies. J Cell Biol 1992;117:1 - 14.
25. Zeng C, Kim E, Warren SL, Berget SM. Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity. EMBO J 1997;16:1401 - 12.
26. O'Keefe RT, Mayeda A, Sadowski CL, Krainer AR, Spector DL. Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. J Cell Biol 1994;124:249 - 60.
27. Blaydes JP, Craig AL, Wallace M, et al. Synergistic activation of p53- dependent transcription by two cooperating damage recognition pathways. Oncogene 2000;19:3829 - 39.
28. Koumenis C, Giaccia A. Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis. Mol Cell Biol 1997;17:7306 - 16.
29. McCracken S, Fong N, Yankulov K, et al. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature 1997;385:357 - 61.
30. Misteli T, Spector DL. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. Mol Cell 1999;3:697 - 705.
31. Mortillaro MJ, Blencowe BJ, Wei X, et al. A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix. Proc Natl Acad Sci U S A 1996;93:8253-57.
32. Graveley BR. Sorting out the complexity of SR protein functions. RNA 2000;6:1197 - 211.
33. Hirose Y, Tacke R, Manley JL. Phosphorylated RNA polymerase II stimulates pre-mRNA splicing. Genes Dev 1999;13:1234-9.
34. Acevedo-Duncan M, Patel R, Whelan S, Bicaku E. Human glioma PKC-ι and PKC-βII phosphorylate cyclin-dependent kinase activating kinase during the cell cycle. Cell Prolif 2002;35:23-36.
35. Bicaku E, Patel R, Acevedo-Duncan M. Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-ι in human glioma cells. Tissue Cell 2005;37:53-8.
36. Abdellatif M, Packer SE, Michael LH, Zhang D, Charng MJ, Schneider MD. A Ras-dependent pathway regulates RNA polymerase II phosphorylation in cardiac myocytes: implications for cardiac hypertrophy. Mol Cell Biol 1998;18:6729-36.
37. Chang YW, Howard SC, Herman PK. The Ras/PKA signaling pathway directly targets the Srb9 protein, a component of the general RNA polymerase II transcription apparatus. Mol Cell 2004;15:107 - 16.
38. Howard SC, Budovskaya YV, Chang YW, Herman PK. The C- terminal domain of the largest subunit of RNA polymerase II is required for stationary phase entry and functionally interacts with the Ras/PKA signaling pathway. J Biol Chem 2002;277:19488-97.