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Volumn 1, Issue 10, 2006, Pages 1073-1080

6-Alkylthio-4-[1-(2,6-difluorophenyl)alkyl]-1H-[1,3,5]triazin-2-ones (ADATs): Novel regulators of cell differentiation and proliferation

Author keywords

Antitumor agents; Cytodifferentiation; Endogenous reverse transcriptase; Epigenetics; Gene expression

Indexed keywords

TRIAZINE DERIVATIVE;

EID: 33750284393     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200600139     Document Type: Article
Times cited : (14)

References (48)
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    • note
    • Most derivatives (apart from the achiral 3 a-3 c and 6 a) contain one or two (in the case of 3 f) stereogenic centers. To avoid the resolution of all the compounds, we decided to perform an initial screening of 3 d, 3 e, 3 g-n, and 6 b-d as enantiomeric mixtures, and of 3 f as a diastereomeric mixture. Chiral resolution of derivatives 3 f and 6 c, which exhibit the most interesting antiproliferative and cytodifferentiating activities, respectively, are in progress.
  • 32
    • 33750295195 scopus 로고    scopus 로고
    • note
    • 2,6-Difluorophenyl)acetic acid 4 a was purchased from Lancaster Synthesis Milan (Italy). Non-commercially available 2-(2,6-difluorophenyl)alkanoic acids 4 b-d were prepared following a procedure previously reported by us (see references [13] and [20]). Characterization data are reported in the Supporting Information.
  • 35
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    • Purdue University Cytometry Laboratories, West Lafayette (USA)
    • A comprehensive review of experimental methods in cell death analysis can be found in J. P. Robinson, The Purdue Cytometry CD-ROM, Vol. 5, 2000, Purdue University Cytometry Laboratories, West Lafayette (USA). http://flowcvt.cyto. purdue.edu/flowcyt/cdseries.htm.
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    • Robinson, J.P.1
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    • The set of human housekeeping genes is publicly available at
    • E. Eisenberg, E. Y. Levanon, Trends Genet. 2003, 19, 362-365. The set of human housekeeping genes is publicly available at http://www.compugen.co.il/ supp_info/Housekeeping_genes.html.
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    • Eisenberg, E.1    Levanon, E.Y.2
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    • note
    • Characterization data are available in the Supporting Information.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.