hERG (KCNH2 or Kv11.1) K+ channels: Screening for cardiac arrhythmia risk

Current Drug Metabolism

Volumn 9, Issue 9, 2008, Pages 965-970

  Bowlby, Mark R ^a   Peri, Ravi ^a   Zhang, Howard ^a   Dunlop, John ^a  

^a PFIZER INC   (United States)

Author keywords

Electrophysiology; In vitro; Ion channel; LQT; Patch clamp; Preclinical toxicology; Safety pharmacology; Torsade de Pointes

Indexed keywords

1' (6 CYANO 1,2,3,4 TETRAHYDRO 2 NAPHTHYL) 3,4 DIHYDRO 6 METHANESULFONAMIDOSPIRO[2H 1 BENZOPYRAN 2,4' PIPERIDIN] 4 OL; ASTEMIZOLE; DOFETILIDE; POTASSIUM CHANNEL HERG; RUBIDIUM ION; TRACER; DRUG; ERG1 POTASSIUM CHANNEL; RUBIDIUM; UNCLASSIFIED DRUG;

BINDING AFFINITY; CARDIOVASCULAR RESPONSE; CARDIOVASCULAR RISK; DRUG BINDING SITE; DRUG DETERMINATION; DRUG POTENCY; HEART ARRHYTHMIA; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HIGH THROUGHPUT SCREENING; HUMAN; ION CURRENT; NONHUMAN; PATCH CLAMP; PHARMACOLOGICAL BLOCKING; QT PROLONGATION; RADIOACTIVITY; RADIOASSAY; REVIEW; RISK ASSESSMENT; SHORT QT SYNDROME; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; DRUG SCREENING; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; GENETICS; METABOLISM; METHODOLOGY; PREDICTION AND FORECASTING;

ANIMALS; ARRHYTHMIAS, CARDIAC; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; PHARMACEUTICAL PREPARATIONS; PREDICTIVE VALUE OF TESTS; RADIOLIGAND ASSAY; RUBIDIUM;

EID: 60749111313     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008786485083     Document Type: Review

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