Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation

Journal of Biological Chemistry

Volumn 281, Issue 10, 2006, Pages 6253-6260

  Teer, Jamie K ^a,b   Machida, Yuichi J ^b   Labit, Helene ^c   Novac, Olivia ^d   Hyrien, Olivier ^c   Marheineke, Kathrin ^c   Zannis Hadjopoulos, Maria ^d   Dutta, Anindya ^a,b,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c ECOLE NORMALE SUPÉRIEURE   (France)

^d MCGILL UNIVERSITY   (Canada)

^e UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYME KINETICS; GENES; MUTAGENESIS; PHASE TRANSITIONS; TUMORS;

BROMODEOXYURIDINE; KINASE; ORIGIN RECOGNITION COMPLEX (ORC);

CELLS;

BROXURIDINE; CYCLIN DEPENDENT KINASE 2; CYCLIN E; ORIGIN RECOGNITION COMPLEX; PROTEIN P53; TUMOR PROTEIN;

ARTICLE; CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIVISION; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENT ANTIBODY TECHNIQUE; FRACTIONATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; BIOSYNTHESIS; CELL CYCLE; CELL ENLARGEMENT; CELL PROLIFERATION; CELL STRAIN HCT116; DNA REPLICATION; GENETICS; HETEROZYGOTE DETECTION; METABOLISM; MUTATION; PHOSPHORYLATION;

CELL CYCLE; CELL ENLARGEMENT; CELL PROLIFERATION; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; DNA REPLICATION; ENZYME ACTIVATION; HCT116 CELLS; HETEROZYGOTE DETECTION; HUMANS; MUTATION; NEOPLASM PROTEINS; ORIGIN RECOGNITION COMPLEX; PHOSPHORYLATION; S PHASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33646588731     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M507150200     Document Type: Article

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