Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression

International Journal of Medical Sciences

Volumn 6, Issue 1, 2009, Pages 51-64

  Lustig, Ana ^a   Carter, Arnell ^a   Bertak, Dorothy ^a   Enika, Divya ^a   Vandanmagsar, Bolormaa ^a   Wood, William ^a   Becker, Kevin G ^a   Weeraratna, Ashani T ^a   Taub, Dennis D ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

AGEMAP; Aging; Caloric restriction; Involution; Microarray; Thymocytes; Thymus

Indexed keywords

AUTOANTIBODY; B LYMPHOCYTE RECEPTOR; CD5 ANTIGEN; CHEMOKINE; COMPLEMENTARY DNA; IMMUNOGLOBULIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LIPOCORTIN 2; PROTEIN S 100; RIBOSOME PROTEIN; SYNDECAN 1; T LYMPHOCYTE RECEPTOR; TRANSCRIPTOME; VAV PROTEIN;

AGING; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SURFACE; DNA MICROARRAY; FLOW CYTOMETRY; GENE EXPRESSION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THYMOCYTE; THYMUS FUNCTION; UPREGULATION;

EID: 60049090034     PISSN: None     EISSN: 14491907     Source Type: Journal    
DOI: 10.7150/ijms.6.51     Document Type: Article

References (64)

1. Targonski P.V, Jacobson R.M, and Poland G.A. Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine 2007;25: 3066-3069
2. Noreddin A.M and Haynes V. Use of pharmacodynamic principles to optimise dosage regimens for antibacterial agents in the elderly. Drugs Aging 2007;24: 275-292
3. Liang S.Y and Mackowiak P.A. Infections in the elderly. Clin Geriatr Med 2007;23: 441-456
4. Vasto S, Candore G, Balistreri C.R, Caruso M, Colonna-Romano G, et al. Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev 2007;128: 83-91
5. High K.P, Prasad R, Marion C.R, Schurig G.G, Boyle S.M, et al. Outcome and immune responses after Brucella abortus infection in young adult and aged mice. Biogerontology 2007;8: 583-593
6. Htwe T.H, Mushtaq A, Robinson S.B, Rosher R.B, and Khardori N. Infection in the elderly. Infect Dis Clin North Am 2007;21: 711-743
7. Hakim F.T and Gress R.E. Immunosenescence: deficits in adaptive immunity in the elderly. Tissue Antigens 2007;70: 179-189
8. Mellanby R.J, Thomas D, Phillips J.M, and Cooke A. Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4+ CD25+ Foxp3+ regulatory T cells. Immunology 2007;121: 15-28
9. Taub D.D and Longo D.L. Insights into thymic aging and regeneration. Immunol Rev 2005;205: 72-93
10. Ribeiro R.M and Perelson A.S. Determining thymic output quantitatively: using models to interpret experimental T-cell receptor excision circle (TREC) data. Immunol Rev 2007;216: 21-34
11. Dixit V.D, Yang H, Sun Y, Weeraratna A.T, Youm Y.H, et al. Ghrelin promotes thymopoiesis during aging. J Clin Invest 2007;117: 2778-2790
12. Mitchell W.A, Meng I, Nicholson S.A, and Aspinall R. Thymic output, ageing and zinc. Biogerontology 2006;7: 461-470
13. Hale J.S, Boursalian T.E, Turk G.L, and Fink P.J. Thymic output in aged mice. Proc Natl Acad Sci U S A 2006;103: 8447-8452
14. Effros R.B. Role of T lymphocyte replicative senescence in vaccine efficacy. Vaccine 2007;25: 599-604
15. Ely K.H, Roberts A.D, Kohlmeier J.E, Blackman M.A, and Woodland D.L. Aging and CD8+ T cell immunity to respiratory virus infections. Exp Gerontol 2007;42: 427-431
16. Clambey E.T, Kappler J.W, and Marrack P. CD8 T cell clonal expansions & aging: a heterogeneous phenomenon with a common outcome. Exp Gerontol 2007;42: 407-411
17. Petrovic-Dergovic D.M, Rakin A.K, Dimitrijevic L.A, Ristovski J.S, Kustrimovic N.Z, et al. Changes in thymus size, cellularity and relation between thymocyte subpopulations in young adult rats induced by Somatostatin-14. Neuropeptides 2007; 41: 485-493
18. Prelog M. Aging of the immune system: a risk factor for autoimmunity? Autoimmun Rev 2006;5: 136-139
19. Jondal M, Pazirandeh A, and Okret S. Different roles for glucocorticoids in thymocyte homeostasis? Trends Immunol 2004;25: 595-600
20. Yajima N, Sakamaki K, and Yonehara S. Age-related thymic involution is mediated by Fas on thymic epithelial cells. Int Immunol 2004;16: 1027-1035
21. Pazirandeh A, Jondal M, and Okret S. Glucocorticoids delay age-associated thymic involution through directly affecting the thymocytes. Endocrinology 2004;145: 2392-2401
22. Dominguez-Gerpe L and Rey-Mendez M. Evolution of the thymus size in response to physiological and random events throughout life. Microsc Res Tech 2003;62: 464-476
23. Li L, Hsu H.C, Grizzle W.E, Stockard C.R, Ho K.J, et al. Cellular mechanism of thymic involution. Scand J Immunol 2003;57: 410-422
24. Mocchegiani E, Santarelli L, Costarelli L, Cipriano C, Muti E, et al. Plasticity of neuroendocrine-thymus interactions during ontogeny and ageing: role of zinc and arginine. Ageing Res Rev 2006;5: 281-309
25. Hannestad J, Monjil D.F, Diaz-Esnal B, Cobo J, and Vega J.A. Age-dependent changes in the nervous and endocrine control of the thymus. Microsc Res Tech 2004;63: 94-101
26. Elcuman E.A and Akay M.T. Age-dependent immunolocalization of fibronectin and histological changes in the thymus of rats. Vet Res Commun 1998;22: 525-532
27. Oksanen A. Multilocular fat in thymuses of rats and mice associated with thymus involution: a light- and electron-microscope and histochemical study. J Pathol 1971;105: 223-226
28. Cheadle C, Vawter M.P, Freed W.J, and Becker K.G. Analysis of microarray data using Z score transformation. J Mol Diagn 2003;5: 73-81
29. Apasov S.G, Blackburn M.R, Kellems R.E, Smith P.T, and Sitkovsky M.V. Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling. J Clin Invest 2001;108: 131-141
30. El-Darahali A, Fawcett H, Mader J.S, Conrad D.M, and Hoskin D.W. Adenosine-induced apoptosis in EL-4 thymoma cells is caspase-independent and mediated through a non-classical adenosine receptor. Exp Mol Pathol 2005;79: 249-258
31. Juntilla M.M, Wofford J.A, Birnbaum M.J, Rathmell J.C, and Koretzky G.A. Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc Natl Acad Sci U S A 2007;104: 12105-12110
32. Swat W, Montgrain V, Doggett T.A, Douangpanya J, Puri K, et al. Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival. Blood 2006;107: 2415-2422
33. Kelso G.F, Porteous C.M, Coulter C.V, Hughes G, Porteous W.K, et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem 2001;276: 4588-4596
34. Aguilaniu H, Durieux J, and Dillin A. Metabolism, ubiquinone synthesis, and longevity. Genes Dev 2005;19: 2399-2406
35. Arkenau H.T, Chua Y.J, and Cunningham D. Current treatment strategies in elderly patients with metastatic colorectal cancer. Clin Colorectal Cancer 2007;6: 508-515
36. Fraga M.F, Agrelo R, and Esteller M. Cross-talk between aging and cancer: the epigenetic language. Ann N Y Acad Sci 2007;1100: 60-74
37. Flores K.G, Li J, and Hale L.P. B cells in epithelial and perivascular compartments of human adult thymus. Hum Pathol 2001;32: 926-934
38. Leprince C, Cohen-Kaminsky S, et al. Thymic B cells from myasthenia gravis patients are activated B cells. Phenotypic and functional analysis. J Immunol 1990;145: 2115-2122
39. Mori S, Inaba M, Sugihara A, Taketani S, Doi H, et al. Presence of B cell progenitors in the thymus. J Immunol 1997;158: 4193-4199
40. Akashi K, Richie L.I, Miyamoto T, Carr W.H, and Weissman I.L. B lymphopoiesis in the thymus. J Immunol 2000;164: 5221-5226
41. MacLennan I and Vinuesa C. Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses. Immunity 2002;17: 235-238
42. Hanada T, Yoshida H, Kato S, Tanaka K, Masutani K, et al. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 2003;19: 437-450
43. Mackay F and Browning J.L. BAFF: a fundamental survival factor for B cells. Nat Rev Immunol 2002;2: 465-475
44. Gruver A.L, Hudson L.L, and Sempowski G.D. Immunosenescence of ageing. J Pathol 2007;211: 144-156
45. Capri M, Monti D, Salvioli S, Lescai F, Pierini M, et al. Complexity of anti-immunosenescence strategies in humans. Artif Organs 2006;30: 730-742
46. Vier J, Gerhard M, Wagner H, and Hacker G. Enhancement of death-receptor induced caspase-8-activation in the death-inducing signalling complex by uncoupling of oxidative phosphorylation. Mol Immunol 2004;40: 661-670
47. Perl A, Nagy G, Gergely P, Puskas F, Qian Y, et al. Apoptosis and mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus. Methods Mol Med 2004;102: 87-114
48. Gramaglia D, Gentile A, Battaglia M, Ranzato L, Petronilli V, et al. Apoptosis to necrosis switching downstream of apoptosome formation requires inhibition of both glycolysis and oxidative phosphorylation in a BCL-X(L)- and PKB/AKT-independent fashion. Cell Death Differ 2004;11: 342-353
49. Bustamante J, Bersier G, Romero M, Badin R.A, and Boveris A. Nitric oxide production and mitochondrial dysfunction during rat thymocyte apoptosis. Arch Biochem Biophys 2000;376: 239-247
50. Wofford J.A, Wieman H.L, Jacobs S.R, Zhao Y, and Rathmell J.C. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood 2008;111: 2101-2111
51. Caravatta L, Sancilio S, di Giacomo V, Rana R, Cataldi A, et al. PI3-K/Akt-dependent activation of cAMP-response element-binding (CREB) protein in Jurkat T leukemia cells treated with TRAIL. J Cell Physiol 2008;214: 192-200
52. Sagan D, Mortl S, Muller I, Eckardt-Schupp F, and Eichholtz-Wirth H. Enhanced CD95-mediated apoptosis contributes to radiation hypersensitivity of NBS lymphoblasts. Apoptosis 2007;12: 753-767
53. Benson R.J, Hostager B.S, and Bishop G.A. Rapid CD40-mediated rescue from CD95-induced apoptosis requires TNFR-associated factor-6 and PI3K. Eur J Immunol 2006;36: 2535-2543
54. Tonomura N, McLaughlin K, Grimm L, Goldsby R.A, and Osborne B.A. Glucocorticoid-induced apoptosis of thymocytes: requirement of proteasome-dependent mitochondrial activity. J Immunol 2003;170: 2469-2478
55. Weksler M.E and Goodhardt M. Do age-associated changes in 'physiologic' auto-antibodies contribute to infection, atherosclerosis, and Alzheimer's disease? Exp Gerontol 2002;37: 971-979
56. Kay M. Immunoregulation of cellular life span. Ann N Y Acad Sci 2005;1057: 85-111
57. Boren E and Gershwin M.E. Inflamm-aging: autoimmunity, and the immune-risk phenotype. Autoimmun Rev 2004;3: 401-406
58. Kerkhoff C, Klempt M, Kaever V, and Sorg C. The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophils. J Biol Chem 1999;274: 32672-32679
59. Ryckman C, Robichaud G.A, Roy J, Cantin R, Tremblay M.J, et al. HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes. J Immunol 2002;169: 3307-3313
60. Greenlee K.J, Corry D.B, Engler D.A, Matsunami R.K, Tessier P, et al. Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation. J Immunol 2006;177: 7312-7321
61. Di Martino C, Basset C, Ogier A, Charpilienne A, Poncet D, et al. Distribution and phenotype of rotavirus-specific B cells induced during the antigen-driven primary response to 2/6 virus-like particles administered by the intrarectal and the intranasal routes. J Leukoc Biol 2007;82: 821-828
62. Dono M, Burgio V.L, Colombo M, Sciacchitano S, Reverberi D, et al. CD5+ B cells with the features of subepithelial B cells found in human tonsils. Eur J Immunol 2007;37: 2138-2147
63. Ferrero I, Anjuere F, Martin P, Martinez del Hoyo G, Fraga M.L, et al. Functional and phenotypic analysis of thymic B cells: role in the induction of T cell negative selection. Eur J Immunol 1999;29: 1598-1609
64. Adkins B and Riley R.L. Auto-antibodies to T-lineage cells in aged mice. Mech Ageing Dev 1998;103: 147-164