-
1
-
-
3242892589
-
Nijmegen breakage syndrome: Clinical manifestation of defective response to DNA double-strand breaks
-
Digweed M, Sperling K (2004) Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks. DNA Repair (Amst) 3:1207-1217
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 1207-1217
-
-
Digweed, M.1
Sperling, K.2
-
2
-
-
0031466618
-
Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
-
Shiloh Y (1997) Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Ann Rev Genet 31:635-662
-
(1997)
Ann Rev Genet
, vol.31
, pp. 635-662
-
-
Shiloh, Y.1
-
3
-
-
0037115935
-
Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability
-
Tauchi H, Matsuura S, Kobayashi J, Sakamoto S, Komatsu K (2002) Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability. Oncogene 21:8967-8980
-
(2002)
Oncogene
, vol.21
, pp. 8967-8980
-
-
Tauchi, H.1
Matsuura, S.2
Kobayashi, J.3
Sakamoto, S.4
Komatsu, K.5
-
4
-
-
0034953719
-
Chk2 activation dependence on Nbs1 after DNA damage
-
Buscemi G, Savio C, Zannini L et al (2001) Chk2 activation dependence on Nbs1 after DNA damage. Mol Cell Biol 21:5214-5222
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5214-5222
-
-
Buscemi, G.1
Savio, C.2
Zannini, L.3
-
5
-
-
0036500690
-
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
-
Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J (2002) SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev 16:571-582
-
(2002)
Genes Dev
, vol.16
, pp. 571-582
-
-
Yazdi, P.T.1
Wang, Y.2
Zhao, S.3
Patel, N.4
Lee, E.Y.5
Qin, J.6
-
6
-
-
0030786912
-
Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation
-
Jongmans W, Vuillaume M, Chrzanowska K, Smeets D, Sperling K, Hall J (1997) Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation. Mol Cell Biol 17:5016-5022
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5016-5022
-
-
Jongmans, W.1
Vuillaume, M.2
Chrzanowska, K.3
Smeets, D.4
Sperling, K.5
Hall, J.6
-
7
-
-
0036464515
-
Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction
-
Huang J, Dynan WS (2002) Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction. Nucleic Acids Res 30:667-674
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 667-674
-
-
Huang, J.1
Dynan, W.S.2
-
8
-
-
0033008552
-
Immortalization and characterization of Nijmegen Breakage syndrome fibroblasts
-
Kraakman-van der Zwet M, Overkamp WJ, Friedl AA et al (1999) Immortalization and characterization of Nijmegen Breakage syndrome fibroblasts. Mutat Res 434:17-27
-
(1999)
Mutat Res
, vol.434
, pp. 17-27
-
-
Kraakman-van der Zwet, M.1
Overkamp, W.J.2
Friedl, A.A.3
-
9
-
-
9744220428
-
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
-
Riballo E, Kuhne M, Rief N et al (2004) A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell 16:715-724
-
(2004)
Mol Cell
, vol.16
, pp. 715-724
-
-
Riballo, E.1
Kuhne, M.2
Rief, N.3
-
10
-
-
30344432122
-
Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients
-
Howlett NG, Scuric Z, D'Andrea AD, Schiestl RH (2006) Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients. DNA Repair (Amst) 5:251-257
-
(2006)
DNA Repair (Amst)
, vol.5
, pp. 251-257
-
-
Howlett, N.G.1
Scuric, Z.2
D'Andrea, A.D.3
Schiestl, R.H.4
-
11
-
-
0037038362
-
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells
-
Tauchi H, Kobayashi J, Morishima K et al (2002) Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature 420:93-98
-
(2002)
Nature
, vol.420
, pp. 93-98
-
-
Tauchi, H.1
Kobayashi, J.2
Morishima, K.3
-
12
-
-
0025006831
-
DNA repair in radiation sensitive mutants of mammalian cells: Possible involvement of DNA topoisomerases
-
Hickson ID, Davies SL, Davies SM, Robson CN (1990) DNA repair in radiation sensitive mutants of mammalian cells: possible involvement of DNA topoisomerases. Int J Radiat Biol 58:561-568
-
(1990)
Int J Radiat Biol
, vol.58
, pp. 561-568
-
-
Hickson, I.D.1
Davies, S.L.2
Davies, S.M.3
Robson, C.N.4
-
13
-
-
0038978266
-
Positional cloning and functional analysis of the gene responsible for Nijmegen breakage syndrome, NBS1
-
Tauchi H (2000) Positional cloning and functional analysis of the gene responsible for Nijmegen breakage syndrome, NBS1. J Radiat Res (Tokyo) 41:9-17
-
(2000)
J Radiat Res (Tokyo)
, vol.41
, pp. 9-17
-
-
Tauchi, H.1
-
14
-
-
0036270993
-
DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: Fail-safe protection against carcinogenesis
-
Bernstein C, Bernstein H, Payne CM, Garewal H (2002) DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat Res 511:145-178
-
(2002)
Mutat Res
, vol.511
, pp. 145-178
-
-
Bernstein, C.1
Bernstein, H.2
Payne, C.M.3
Garewal, H.4
-
15
-
-
18844394291
-
An essential function for NBS1 in the prevention of ataxia and cerebellar defects
-
Frappart PO, Tong WM, Demuth I et al (2005) An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat Med 11:538-544
-
(2005)
Nat Med
, vol.11
, pp. 538-544
-
-
Frappart, P.O.1
Tong, W.M.2
Demuth, I.3
-
16
-
-
1642270611
-
Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2
-
Rogoff HA, Pickering MT, Frame FM et al (2004) Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol Cell Biol 24:2968-2977
-
(2004)
Mol Cell Biol
, vol.24
, pp. 2968-2977
-
-
Rogoff, H.A.1
Pickering, M.T.2
Frame, F.M.3
-
17
-
-
21344452093
-
NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells
-
Zhang Y, Lim CU, Williams ES et al (2005) NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells. Cancer Res 65:5544-5553
-
(2005)
Cancer Res
, vol.65
, pp. 5544-5553
-
-
Zhang, Y.1
Lim, C.U.2
Williams, E.S.3
-
18
-
-
0034163385
-
CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types
-
O'Connor L, Harris AW, Strasser A (2000) CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types. Cancer Res 60:1217-1220
-
(2000)
Cancer Res
, vol.60
, pp. 1217-1220
-
-
O'Connor, L.1
Harris, A.W.2
Strasser, A.3
-
19
-
-
0242526126
-
Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells
-
Sheard MA, Uldrijan S, Vojtesek B (2003) Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells. Cancer Res 63:7176-7184
-
(2003)
Cancer Res
, vol.63
, pp. 7176-7184
-
-
Sheard, M.A.1
Uldrijan, S.2
Vojtesek, B.3
-
20
-
-
0029003501
-
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
-
Owen-Schaub LB, Zhang W, Cusack JC et al (1995) Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol 15:3032-3040
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3032-3040
-
-
Owen-Schaub, L.B.1
Zhang, W.2
Cusack, J.C.3
-
21
-
-
3342935962
-
The Fas signalling pathway and its role in the pathogenesis of cancer
-
Houston A, O'Connell J (2004) The Fas signalling pathway and its role in the pathogenesis of cancer. Curr Opin Pharmacol 4:321-326
-
(2004)
Curr Opin Pharmacol
, vol.4
, pp. 321-326
-
-
Houston, A.1
O'Connell, J.2
-
22
-
-
0344825072
-
DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation
-
Huang HL, Fang LW, Lu SP, Chou CK, Luh TY, Lai MZ (2003) DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation. Oncogene 22:8168-8177
-
(2003)
Oncogene
, vol.22
, pp. 8168-8177
-
-
Huang, H.L.1
Fang, L.W.2
Lu, S.P.3
Chou, C.K.4
Luh, T.Y.5
Lai, M.Z.6
-
23
-
-
0032076190
-
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
-
Varon R, Vissinga C, Platzer M et al (1998) Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 93:467-476
-
(1998)
Cell
, vol.93
, pp. 467-476
-
-
Varon, R.1
Vissinga, C.2
Platzer, M.3
-
24
-
-
19544389992
-
An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability
-
Demuth I, Frappart PO, Hildebrand G et al (2004) An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability. Hum Mol Genet 13:2385-2397
-
(2004)
Hum Mol Genet
, vol.13
, pp. 2385-2397
-
-
Demuth, I.1
Frappart, P.O.2
Hildebrand, G.3
-
25
-
-
0033780412
-
Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit
-
Ueki K, Algenstaedt P, Mauvais-Jarvis F, Kahn CR (2000) Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit. Mol Cell Biol 20:8035-8046
-
(2000)
Mol Cell Biol
, vol.20
, pp. 8035-8046
-
-
Ueki, K.1
Algenstaedt, P.2
Mauvais-Jarvis, F.3
Kahn, C.R.4
-
26
-
-
0034066847
-
Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation
-
Cerosaletti KM, Desai-Mehta A, Yeo TC, Kraakman-Van Der Zwet M, Zdzienicka MZ, Concannon P (2000) Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation. Mutagenesis 15:281-286
-
(2000)
Mutagenesis
, vol.15
, pp. 281-286
-
-
Cerosaletti, K.M.1
Desai-Mehta, A.2
Yeo, T.C.3
Kraakman-Van Der Zwet, M.4
Zdzienicka, M.Z.5
Concannon, P.6
-
27
-
-
0033377979
-
Control of the cell cycle and apoptosis
-
Lundberg AS, Weinberg RA (1999) Control of the cell cycle and apoptosis. Eur J Cancer 35:1886-1894
-
(1999)
Eur J Cancer
, vol.35
, pp. 1886-1894
-
-
Lundberg, A.S.1
Weinberg, R.A.2
-
28
-
-
28244443670
-
Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo
-
Al Rashid ST, Dellaire G, Cuddihy A et al (2005) Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo. Cancer Res 65:10810-10821
-
(2005)
Cancer Res
, vol.65
, pp. 10810-10821
-
-
Al Rashid, S.T.1
Dellaire, G.2
Cuddihy, A.3
-
29
-
-
28844448182
-
Oncogenic PI3K deregulates transcription and translation
-
Bader AG, Kang S, Zhao L, Vogt PK (2005) Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 5:921-929
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 921-929
-
-
Bader, A.G.1
Kang, S.2
Zhao, L.3
Vogt, P.K.4
-
30
-
-
13844273087
-
PI3K-Akt pathway: Its functions and alterations in human cancer
-
Osaki M, Oshimura M, Ito H (2004) PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 9:667-676
-
(2004)
Apoptosis
, vol.9
, pp. 667-676
-
-
Osaki, M.1
Oshimura, M.2
Ito, H.3
-
31
-
-
25444455323
-
Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt
-
Chen YC, Su YN, Chou PC et al (2005) Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt. J Biol Chem 280:32505-32511
-
(2005)
J Biol Chem
, vol.280
, pp. 32505-32511
-
-
Chen, Y.C.1
Su, Y.N.2
Chou, P.C.3
-
32
-
-
0035093880
-
Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways
-
Bilderback TR, Gazula VR, Dobrowsky RT (2001) Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways. J Neurochem 76:1540-1551
-
(2001)
J Neurochem
, vol.76
, pp. 1540-1551
-
-
Bilderback, T.R.1
Gazula, V.R.2
Dobrowsky, R.T.3
-
33
-
-
0037203320
-
Ceramide and cell death receptor clustering
-
Gulbins E, Grassme H (2002) Ceramide and cell death receptor clustering. Biochim Biophys Acta 1585:139-145
-
(2002)
Biochim Biophys Acta
, vol.1585
, pp. 139-145
-
-
Gulbins, E.1
Grassme, H.2
-
34
-
-
0042335762
-
Ceramide-mediated clustering is required for CD95-DISC formation
-
Grassme H, Cremesti A, Kolesnick R, Gulbins E (2003) Ceramide-mediated clustering is required for CD95-DISC formation. Oncogene 22:5457-5470
-
(2003)
Oncogene
, vol.22
, pp. 5457-5470
-
-
Grassme, H.1
Cremesti, A.2
Kolesnick, R.3
Gulbins, E.4
-
35
-
-
0141757451
-
Radiation and ceramide-induced apoptosis
-
Kolesnick R, Fuks Z (2003) Radiation and ceramide-induced apoptosis. Oncogene 22:5897-5906
-
(2003)
Oncogene
, vol.22
, pp. 5897-5906
-
-
Kolesnick, R.1
Fuks, Z.2
-
36
-
-
0033658372
-
Regulation of TNFRSF6 (Fas) expression in ataxia telangiectasia cells by ionizing radiation
-
Albanese J, Dainiak N (2000) Regulation of TNFRSF6 (Fas) expression in ataxia telangiectasia cells by ionizing radiation. Radiat Res 154:616-624
-
(2000)
Radiat Res
, vol.154
, pp. 616-624
-
-
Albanese, J.1
Dainiak, N.2
-
37
-
-
0035832358
-
Radiation induced apoptosis in ataxia telangiectasia homozygote, heterozygote and normal cells
-
Bebb DG, Warrington PJ, de Jong G et al (2001) Radiation induced apoptosis in ataxia telangiectasia homozygote, heterozygote and normal cells. Mutat Res 476:13-20
-
(2001)
Mutat Res
, vol.476
, pp. 13-20
-
-
Bebb, D.G.1
Warrington, P.J.2
de Jong, G.3
-
38
-
-
0034697333
-
Protective roles for ATM in cellular response to oxidative stress
-
Takao N, Li Y, Yamamoto K (2000) Protective roles for ATM in cellular response to oxidative stress. FEBS Lett 472:133-136
-
(2000)
FEBS Lett
, vol.472
, pp. 133-136
-
-
Takao, N.1
Li, Y.2
Yamamoto, K.3
-
39
-
-
0033604444
-
Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation
-
Takao N, Kato H, Mori R et al (1999) Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation. Oncogene 18:7002-7009
-
(1999)
Oncogene
, vol.18
, pp. 7002-7009
-
-
Takao, N.1
Kato, H.2
Mori, R.3
-
40
-
-
1842431822
-
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
-
Lee JH, Paull TT (2004) Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 304:93-96
-
(2004)
Science
, vol.304
, pp. 93-96
-
-
Lee, J.H.1
Paull, T.T.2
-
41
-
-
0142136826
-
Requirement of the MRN complex for ATM activation by DNA damage
-
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y (2003) Requirement of the MRN complex for ATM activation by DNA damage. Embo J 22:5612-5621
-
(2003)
Embo J
, vol.22
, pp. 5612-5621
-
-
Uziel, T.1
Lerenthal, Y.2
Moyal, L.3
Andegeko, Y.4
Mittelman, L.5
Shiloh, Y.6
-
42
-
-
0033572746
-
Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
-
Dumaz N, Meek DW (1999) Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. Embo J 18:7002-7010
-
(1999)
Embo J
, vol.18
, pp. 7002-7010
-
-
Dumaz, N.1
Meek, D.W.2
-
43
-
-
0032484128
-
Phosphorylation of p53 serine 15 increases interaction with CBP
-
Lambert PF, Kashanchi F, Radonovich MF, Shiekhattar R, Brady JN (1998) Phosphorylation of p53 serine 15 increases interaction with CBP. J Biol Chem 273:33048-33053
-
(1998)
J Biol Chem
, vol.273
, pp. 33048-33053
-
-
Lambert, P.F.1
Kashanchi, F.2
Radonovich, M.F.3
Shiekhattar, R.4
Brady, J.N.5
-
44
-
-
22144462810
-
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
-
Difilippantonio S, Celeste A, Fernandez-Capetillo O et al (2005) Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol 7:675-685
-
(2005)
Nat Cell Biol
, vol.7
, pp. 675-685
-
-
Difilippantonio, S.1
Celeste, A.2
Fernandez-Capetillo, O.3
-
46
-
-
0031835210
-
Radiation-induced apoptosis in human lymphocytes and lymphoma cells critically relies on the up-regulation of CD95/Fas/APO-1 ligand
-
Belka C, Marini P, Budach W et al (1998) Radiation-induced apoptosis in human lymphocytes and lymphoma cells critically relies on the up-regulation of CD95/Fas/APO-1 ligand. Radiat Res 149:588-595
-
(1998)
Radiat Res
, vol.149
, pp. 588-595
-
-
Belka, C.1
Marini, P.2
Budach, W.3
-
47
-
-
0035921189
-
Ionizing radiation as a response-enhancing agent for CD95-mediated apoptosis
-
Sheard MA (2001) Ionizing radiation as a response-enhancing agent for CD95-mediated apoptosis. Int J Cancer 96:213-220
-
(2001)
Int J Cancer
, vol.96
, pp. 213-220
-
-
Sheard, M.A.1
-
48
-
-
18044369285
-
Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X rays and death receptor agonists
-
Hamasu T, Inanami O, Asanuma T, Kuwabara M (2005) Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X rays and death receptor agonists. J Radiat Res (Tokyo) 46:103-110
-
(2005)
J Radiat Res (Tokyo)
, vol.46
, pp. 103-110
-
-
Hamasu, T.1
Inanami, O.2
Asanuma, T.3
Kuwabara, M.4
-
49
-
-
1542441608
-
Induction of apoptosis through the activation of SAPK/JNK followed by the expression of death receptor Fas in X-irradiated cells
-
Kuwabara M, Takahashi K, Inanami O (2003) Induction of apoptosis through the activation of SAPK/JNK followed by the expression of death receptor Fas in X-irradiated cells. J Radiat Res (Tokyo) 44:203-209
-
(2003)
J Radiat Res (Tokyo)
, vol.44
, pp. 203-209
-
-
Kuwabara, M.1
Takahashi, K.2
Inanami, O.3
-
50
-
-
0029978202
-
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
-
Damen JE, Liu L, Rosten P et al (1996) The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci USA 93:1689-1693
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 1689-1693
-
-
Damen, J.E.1
Liu, L.2
Rosten, P.3
-
51
-
-
0029665083
-
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity
-
Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold A, Rohrschneider LR (1996) p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes Dev 10:1084-1095
-
(1996)
Genes Dev
, vol.10
, pp. 1084-1095
-
-
Lioubin, M.N.1
Algate, P.A.2
Tsai, S.3
Carlberg, K.4
Aebersold, A.5
Rohrschneider, L.R.6
-
52
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375-13378
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
53
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
-
Myers MP, Pass I, Batty IH et al (1998) The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci USA 95:13513-13518
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13513-13518
-
-
Myers, M.P.1
Pass, I.2
Batty, I.H.3
-
54
-
-
0742269398
-
Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45
-
Osaki M, Kase S, Adachi K, Takeda A, Hashimoto K, Ito H (2004) Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45. J Cancer Res Clin Oncol 130:8-14
-
(2004)
J Cancer Res Clin Oncol
, vol.130
, pp. 8-14
-
-
Osaki, M.1
Kase, S.2
Adachi, K.3
Takeda, A.4
Hashimoto, K.5
Ito, H.6
-
55
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh Y (2003) ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3:155-168
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
|