Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling

Journal of Clinical Investigation

Volumn 108, Issue 1, 2001, Pages 131-141

  Apasov, S G ^a   Blackburn, M R ^a   Kellems, R E ^a   Smith, P T ^a   Sitkovsky, M V ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE DEAMINASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; ENZYME DEFICIENCY; FLOW CYTOMETRY; IMMUNE DEFICIENCY; LYMPH NODE; LYMPHOCYTOTOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PURINE METABOLISM; SCID MOUSE; SIGNAL TRANSDUCTION; SPLEEN; T LYMPHOCYTE; THYMOCYTE; THYMUS;

ADENOSINE; ADENOSINE DEAMINASE; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; APOPTOSIS; B-LYMPHOCYTES; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELLS, CULTURED; DEOXYADENINE NUCLEOTIDES; DEOXYADENOSINES; GENE EXPRESSION REGULATION; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MICE, SCID; ORGAN SPECIFICITY; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN-2; SEVERE COMBINED IMMUNODEFICIENCY; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0034942561     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200110360     Document Type: Article

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