The telomeric transcriptome and SMG proteins at the crossroads

Cytogenetic and Genome Research

Volumn 122, Issue 3-4, 2009, Pages 194-201

  Chawla, R ^a   Azzalin, C M ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL KINASE; PROTEIN HEST1A; PROTEIN KINASE; PROTEIN SMG; PROTEIN SMG1; PROTEIN UPF1; TRANSCRIPTOME; UNCLASSIFIED DRUG;

CELL DEATH; DNA DAMAGE; GENOMIC INSTABILITY; HELA CELL; HUMAN; NONHUMAN; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; RNA METABOLISM; RNA TRANSCRIPTION; TELOMERE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; GENE EXPRESSION PROFILING; HUMANS; MAMMALS; REPRESSOR PROTEINS; RNA; RNA-BINDING PROTEINS; TELOMERASE; TELOMERE; TRANS-ACTIVATORS;

EUKARYOTA; MAMMALIA;

EID: 59649089120     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000167804     Document Type: Review

References (54)

1. Ajamian L, Abrahamyan L, Milev M, Ivanov PV, Kulozik AE, Gehring NH, Mouland AJ: Unexpected roles for UPF1 in HIV-1 RNA metabolism and translation. RNA 14:914-927 (2008).
2. Arneric M, Lingner J: Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast. EMBO Rep 8:1080-1085 (2007).
3. Azzalin CM, Lingner J: The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. Curr Biol 16:433-439 (2006).
4. Azzalin CM, Lingner J: Telomeres: the silence is broken. Cell Cycle 7:1161-1165 (2008).
5. Azzalin CM, Reichenbach P, Khoriauli L, Giulotto E, Lingner J: Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science 318:798-801 (2007).
6. Baur JA, Zou Y, Shay JW, Wright WE: Telomere position effect in human cells. Science 292:2075-2077 (2001).
7. Behm-Ansmant I, Kashima I, Rehwinkel J, Sauliere J, Wittkopp N, Izaurralde E: mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett 581:2845-2853 (2007).
8. Benetti R, Garcia-Cao M, Blasco MA: Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat Genet 39:243-250 (2007).
9. Bhattacharya A, Czaplinski K, Trifillis P, He F, Jacobson A, Peltz SW: Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. RNA 6:1226-1235 (2000).
10. Blasco MA: The epigenetic regulation of mammalian telomeres. Nat Rev Genet 8:299-309 (2007).
11. Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, et al: The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell 14:585-598 (2004).
12. Carastro LM, Tan CK, Selg M, Jack HM, So AG, Downey KM: Identification of delta helicase as the bovine homolog of HUPF1: Demonstration of an interaction with the third subunit of DNA polymerase delta. Nucleic Acids Res 30:2232-2243 (2002).
13. Chang M, Arneric M, Lingner J: Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae. Genes Dev 21:2485-2494 (2007).
14. Chiu SY, Serin G, Ohara O, Maquat LE: Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. RNA 9:77-87 (2003).
15. Clissold PM, Ponting CP: PIN domains in non-sense-mediated mRNA decay and RNAi. Curr Biol 10:R888-890 (2000).
16. Evans SK, Lundblad V: Positive and negative regulation of telomerase access to the telomere. J Cell Sci 113 Pt 19:3357-3364 (2000).
17. Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E: SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell 17:537-547 (2005).
18. Gao Q, Reynolds GE, Innes L, Pedram M, Jones E, et al: Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts, but are expressed in embryonic stem cells. Stem Cells 25:3085-3092 (2007).
19. Garcia-Cao M, O'Sullivan R, Peters AH, Jenuwein T, Blasco MA: Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet 36:94-99 (2004).
20. Gatfield D, Unterholzner L, Ciccarelli FD, Bork P, Izaurralde E: Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J 22:3960-3970 (2003).
21. Glavan F, Behm-Ansmant I, Izaurralde E, Conti E: Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J 25:5117-5125 (2006).
22. Gonzalo S, Jaco I, Fraga MF, Chen T, Li E, Esteller M, Blasco MA: DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol 8:416-424 (2006).
23. Grimson A, O'Connor S, Newman CL, Anderson P: SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA decay in Caenorhabditis elegans. Mol Cell Biol 24:7483-7490 (2004).
24. Ho CY, Murnane JP, Yeung AK, Ng HK, Lo AW: Telomeres acquire distinct heterochromatin characteristics during siRNA-induced RNA interference in mouse cells. Curr Biol 18:183-187 (2008).
25. Hockemeyer D, Daniels JP, Takai H, de Lange T: Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell 126:63-77 (2006).
26. Hug N, Lingner J: Telomere length homeostasis. Chromosoma 115:413-425 (2006).
27. Kadlec J, Guilligay D, Ravelli RB, Cusack S: Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1. RNA 12:1817-1824 (2006).
28. Kaygun H, Marzluff WF: Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat Struct Mol Biol 12:794-800 (2005).
29. Kim YK, Furic L, Desgroseillers L, Maquat LE: Mammalian Staufen1 recruits Upf1 to specific mRNA 3′UTRs so as to elicit mRNA decay. Cell 120:195-208 (2005).
30. Lundblad V, Szostak JW: A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57:633-643 (1989).
31. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, et al: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316:1160-1166 (2007).
32. Mhawech P: 14-3-3 proteins - an update. Cell Res 15:228-236 (2005).
33. Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S: Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay. J Biol Chem 282:7799-7808 (2007).
34. Muller B, Blackburn J, Feijoo C, Zhao X, Smythe C: DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication. J Cell Biol 179:1385-1398 (2007).
35. Ogawa Y, Sun BK, Lee JT: Intersection of the RNA interference and X-inactivation pathways. Science 320:1336-1341 (2008).
36. Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, et al: Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell 12:1187-1200 (2003).
37. Oliveira V, Romanow WJ, Geisen C, Otterness DM, Mercurio F, et al: A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis. J Biol Chem 283:13174-13184 (2008).
38. Palm W, de Lange T: How shelterin protects mammalian telomeres. Annu Rev Genet 42:16.1-16.34 (2008).
39. Pedram M, Sprung CN, Gao Q, Lo AW, Reynolds GE, Murnane JP: Telomere position effect and silencing of transgenes near telomeres in the mouse. Mol Cell Biol 26:1865-1878 (2006).
40. Redon S, Reichenbach P, Lingner J: Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. Nucleic Acids Res 35:7011-7022 (2007).
41. Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J: A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed. Curr Biol 13:568-574 (2003).
42. Schoeftner S, Blasco MA: Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat Cell Biol 10:228-236 (2008).
43. Singh G, Jakob S, Kleedehn MG, Lykke-Andersen J: Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm. Mol Cell 27:780-792 (2007).
44. Smogorzewska A, de Lange T: Regulation of telomerase by telomeric proteins. Annu Rev Biochem 73:177-208 (2004).
45. Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L: Functional conservation of the telomerase protein Est1p in humans. Curr Biol 13:698-704 (2003).
46. Taggart AK, Zakian VA: Telomerase: what are the Est proteins doing? Curr Opin Cell Biol 15:275-280 (2003).
47. Takeshita D, Zenno S, Lee WC, Saigo K, Tanokura M: Crystal structure of the PIN domain of human telomerase-associated protein EST1A. Proteins 68:980-989 (2007).
48. Teixeira MT, Arneric M, Sperisen P, Lingner J: Telomere length homeostasis is achieved via a switch between telomerase-extendible and -nonextendible states. Cell 117:323-335 (2004).
49. Verdun RE, Karlseder J: The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell 127:709-720 (2006).
50. Verdun RE, Crabbe L, Haggblom C, Karlseder J: Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol Cell 20:551-561 (2005).
51. Wittmann J, Hol EM, Jack HM: hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay. Mol Cell Biol 26:1272-1287 (2006).
52. Wu L, Multani AS, He H, Cosme-Blanco W, Deng Y, et al: Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell 126:49-62 (2006).
53. Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S: Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of non-sense-mediated mRNA decay. Genes Dev 15:2215-2228 (2001).
54. Yehezkel S, Segev Y, Viegas-Pequignot E, Skorecki K, Selig S: Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions. Hum Mol Genet 17:2776-2789 (2008).