메뉴 건너뛰기




Volumn 15, Issue 3, 2003, Pages 275-280

Telomerase: What are the Est proteins doing?

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CELL CYCLE PROTEIN; FUNGAL DNA; FUNGAL ENZYME; FUNGAL RNA; GENOMIC DNA; GENOMIC RNA; HOLOENZYME; HYBRID PROTEIN; PROTEIN; PROTEIN CDC13P; PROTEIN EST1; PROTEIN EST2; PROTEIN EST3; REPETITIVE DNA; RNA DIRECTED DNA POLYMERASE; TELOMERASE; UNCLASSIFIED DRUG;

EID: 0038360921     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(03)00040-1     Document Type: Review
Times cited : (41)

References (47)
  • 1
    • 0027298574 scopus 로고
    • 1-3 tails occur sequentially in late S phase on a yeast linear plasmid
    • 1-3 tails occur sequentially in late S phase on a yeast linear plasmid. Mol. Cell Biol. 13:1993;4057-4065.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 4057-4065
    • Wellinger, R.J.1    Wolf, A.J.2    Zakian, V.A.3
  • 3
  • 4
    • 0037047643 scopus 로고    scopus 로고
    • Est1p as a cell cycle-regulated activator of telomere-bound telomerase
    • The authors use chromatin immunoprecipitation to study telomere association of Est1p, Est2p, and Cdc13p in the cell cycle. As expected from the transient recruitment model, Est1p telomere binding is limited to late S phase, and Cdc13p association peaks in late S phase. Surprisingly, however, Est2p shows a strong peak of telomere association in G1 phase as well as late S phase. In a telomerase-null cdc13-2 background, only the late S phase peak of Est2p binding is lost, and Est1p binding is unaffected. These data suggest a role for Est1p in activating telomere-bound Est2p in situ.
    • Taggart A.K.P., Teng S.-C., Zakian V.A. Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science. 297:2002;1023-1026 The authors use chromatin immunoprecipitation to study telomere association of Est1p, Est2p, and Cdc13p in the cell cycle. As expected from the transient recruitment model, Est1p telomere binding is limited to late S phase, and Cdc13p association peaks in late S phase. Surprisingly, however, Est2p shows a strong peak of telomere association in G1 phase as well as late S phase. In a telomerase-null cdc13-2 background, only the late S phase peak of Est2p binding is lost, and Est1p binding is unaffected. These data suggest a role for Est1p in activating telomere-bound Est2p in situ.
    • (2002) Science , vol.297 , pp. 1023-1026
    • Taggart, A.K.P.1    Teng, S.-C.2    Zakian, V.A.3
  • 5
    • 0020583113 scopus 로고
    • Growth of chromosome ends in multiplying trypansomes
    • Bernards A., Michels P.A.M., Lincke C.R., Borst P. Growth of chromosome ends in multiplying trypansomes. Nature. 303:1983;592-597.
    • (1983) Nature , vol.303 , pp. 592-597
    • Bernards, A.1    Michels, P.A.M.2    Lincke, C.R.3    Borst, P.4
  • 6
    • 0020210955 scopus 로고
    • Tandemly repeated hexanucleotide at Tetrahymena rDNA free end is generated from a single copy during development
    • King B.O., Yao M.-C. Tandemly repeated hexanucleotide at Tetrahymena rDNA free end is generated from a single copy during development. Cell. 31:1982;177-182.
    • (1982) Cell , vol.31 , pp. 177-182
    • King, B.O.1    Yao, M.-C.2
  • 7
    • 0020676319 scopus 로고
    • Is there left-handed DNA at the ends of yeast chromosomes?
    • Walmsley R.M., Szostak J.W., Petes T.D. Is there left-handed DNA at the ends of yeast chromosomes? Nature. 302:1983;84-86.
    • (1983) Nature , vol.302 , pp. 84-86
    • Walmsley, R.M.1    Szostak, J.W.2    Petes, T.D.3
  • 8
    • 0021346699 scopus 로고
    • Elaboration of telomeres in yeast: Recognition and modification of termini from Oxytricha macronuclear DNA
    • Pluta A.F., Dani G.M., Spear B.B., Zakian V.A. Elaboration of telomeres in yeast: recognition and modification of termini from Oxytricha macronuclear DNA. Proc. Natl. Acad. Sci. U.S.A. 81:1984;1475-1479.
    • (1984) Proc. Natl. Acad. Sci. U.S.A. , vol.81 , pp. 1475-1479
    • Pluta, A.F.1    Dani, G.M.2    Spear, B.B.3    Zakian, V.A.4
  • 9
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider C.W., Blackburn E.H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell. 43:1985;405-413.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 10
    • 0023663881 scopus 로고
    • The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
    • Greider C.W., Blackburn E.H. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell. 51:1987;887-898.
    • (1987) Cell , vol.51 , pp. 887-898
    • Greider, C.W.1    Blackburn, E.H.2
  • 11
    • 0024978857 scopus 로고
    • A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
    • Greider C.W., Blackburn E.H. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature. 337:1989;331-337.
    • (1989) Nature , vol.337 , pp. 331-337
    • Greider, C.W.1    Blackburn, E.H.2
  • 12
    • 0025279059 scopus 로고
    • In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
    • Yu G.-L., Bradley J.D., Attardi L.D., Blackburn E.H. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature. 344:1990;126-132.
    • (1990) Nature , vol.344 , pp. 126-132
    • Yu, G.-L.1    Bradley, J.D.2    Attardi, L.D.3    Blackburn, E.H.4
  • 13
    • 0024297032 scopus 로고
    • Telomere terminal transferase activity in the hypotrichous ciliate Oxytricha nova and a model for replication of the ends of linear DNA molecules
    • Zahler A.M., Prescott D.M. Telomere terminal transferase activity in the hypotrichous ciliate Oxytricha nova and a model for replication of the ends of linear DNA molecules. Nucleic Acids Res. 16:1988;6953-6985.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 6953-6985
    • Zahler, A.M.1    Prescott, D.M.2
  • 14
    • 0024677875 scopus 로고
    • Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers
    • Shippen-Lentz D., Blackburn E.H. Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers. Mol. Cell Biol. 9:1989;2761-2764.
    • (1989) Mol. Cell Biol. , vol.9 , pp. 2761-2764
    • Shippen-Lentz, D.1    Blackburn, E.H.2
  • 15
    • 0024325562 scopus 로고
    • The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
    • Morin G.B. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell. 59:1989;521-529.
    • (1989) Cell , vol.59 , pp. 521-529
    • Morin, G.B.1
  • 16
    • 0030455861 scopus 로고    scopus 로고
    • Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
    • Lendvay T.S., Morris D.K., Sah J., Balasubramanian B., Lundblad V. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics. 144:1996;1399-1412.
    • (1996) Genetics , vol.144 , pp. 1399-1412
    • Lendvay, T.S.1    Morris, D.K.2    Sah, J.3    Balasubramanian, B.4    Lundblad, V.5
  • 17
    • 0024973811 scopus 로고
    • A mutant with a defect in telomere elongation leads to senescence in yeast
    • Lundblad V., Szostak J.W. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell. 57:1989;633-643.
    • (1989) Cell , vol.57 , pp. 633-643
    • Lundblad, V.1    Szostak, J.W.2
  • 18
    • 0027944347 scopus 로고
    • TLC1, the template RNA component of the Saccharomyces cerevisiae telomerase
    • Singer M.S., Gottschling D.E. TLC1, the template RNA component of the Saccharomyces cerevisiae telomerase. Science. 266:1994;404-409.
    • (1994) Science , vol.266 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 19
    • 0035839132 scopus 로고    scopus 로고
    • Telomere dysfunction increases mutation rate and genomic instability
    • Hackett J.A., Feldser D.M., Greider C.W. Telomere dysfunction increases mutation rate and genomic instability. Cell. 106:2001;275-286.
    • (2001) Cell , vol.106 , pp. 275-286
    • Hackett, J.A.1    Feldser, D.M.2    Greider, C.W.3
  • 21
    • 0030447657 scopus 로고    scopus 로고
    • 1-3 telomeric DNA binding protein in vitro that affects telomere behavior in vivo
    • 1-3 telomeric DNA binding protein in vitro that affects telomere behavior in vivo. Proc. Natl. Acad. Sci. U.S.A. 93:1996;13760-13765.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 13760-13765
    • Lin, J.J.1    Zakian, V.A.2
  • 22
    • 0029845892 scopus 로고    scopus 로고
    • Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
    • Nugent C.I., Hughes T.R., Lue N.F., Lundblad V. Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science. 274:1996;249-252.
    • (1996) Science , vol.274 , pp. 249-252
    • Nugent, C.I.1    Hughes, T.R.2    Lue, N.F.3    Lundblad, V.4
  • 23
    • 0031810967 scopus 로고    scopus 로고
    • Sir proteins, Rif proteins and Cdc13p bind Saccharomyces telomeres in vivo
    • Bourns B.D., Alexander M.K., Smith A.M., Zakian V.A. Sir proteins, Rif proteins and Cdc13p bind Saccharomyces telomeres in vivo. Mol. Cell Biol. 18:1998;5600-5608.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 5600-5608
    • Bourns, B.D.1    Alexander, M.K.2    Smith, A.M.3    Zakian, V.A.4
  • 24
    • 0035806977 scopus 로고    scopus 로고
    • The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres
    • Tsukamoto Y., Taggart A.K.P., Zakian V.A. The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres. Curr. Biol. 11:2001;1328-1335.
    • (2001) Curr. Biol. , vol.11 , pp. 1328-1335
    • Tsukamoto, Y.1    Taggart, A.K.P.2    Zakian, V.A.3
  • 25
    • 0028822203 scopus 로고
    • Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
    • Garvik B., Carson M., Hartwell L. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell Biol. 15:1995;6128-6138.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 6128-6138
    • Garvik, B.1    Carson, M.2    Hartwell, L.3
  • 26
    • 0029033695 scopus 로고
    • An in vitro assay for Saccharomyces telomerase requires EST1
    • Lin J.-J., Zakian V.A. An in vitro assay for Saccharomyces telomerase requires EST1. Cell. 81:1995;1127-1135.
    • (1995) Cell , vol.81 , pp. 1127-1135
    • Lin, J.-J.1    Zakian, V.A.2
  • 27
    • 0036118479 scopus 로고    scopus 로고
    • Essential regions of Saccharomyces cerevisiae telomerase RNA: Separate elements for Est1p and Est2p interaction
    • Livengood A.J., Zaug A.J., Cech T.R. Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol. Cell Biol. 22:2002;2366-2374.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 2366-2374
    • Livengood, A.J.1    Zaug, A.J.2    Cech, T.R.3
  • 28
    • 0033994222 scopus 로고    scopus 로고
    • The Est1 subunit of yeast telomerase binds the TLC1 telomerase RNA
    • Zhou J., Hidaka K., Futcher B. The Est1 subunit of yeast telomerase binds the TLC1 telomerase RNA. Mol. Cell Biol. 20:2000;1947-1955.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 1947-1955
    • Zhou, J.1    Hidaka, K.2    Futcher, B.3
  • 29
    • 0030462146 scopus 로고    scopus 로고
    • Est1 has the properties of a single-stranded telomere end-binding protein
    • Virta-Pearlman V., Morris D.K., Lundblad V. Est1 has the properties of a single-stranded telomere end-binding protein. Genes Dev. 10:1996;3094-3104.
    • (1996) Genes Dev. , vol.10 , pp. 3094-3104
    • Virta-Pearlman, V.1    Morris, D.K.2    Lundblad, V.3
  • 30
    • 0036828725 scopus 로고    scopus 로고
    • A bulged stem tethers Est1p to telomerase RNA in budding yeast
    • This paper (with Lin and Zakian [1995] [26], Livengood et al. [2002] [27], Zhou et al. [2000] [28] and Virta-Pearlman et al. [1996] [29]) provides strong evidence that Est1p binds TLC1 RNA, and that this interaction is necessary for telomerase function in vivo. Est1p binds a stem-loop structure in the RNA that is distinct from the regions bound by Est2p.
    • Seto A.G., Livengood A.J., Tzfati Y., Blackburn E.H., Cech T.R. A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes Dev. 16:2002;2800-2812 This paper (with Lin and Zakian [1995] [26], Livengood et al. [2002] [27], Zhou et al. [2000] [28] and Virta-Pearlman et al. [1996] [29]) provides strong evidence that Est1p binds TLC1 RNA, and that this interaction is necessary for telomerase function in vivo. Est1p binds a stem-loop structure in the RNA that is distinct from the regions bound by Est2p.
    • (2002) Genes Dev. , vol.16 , pp. 2800-2812
    • Seto, A.G.1    Livengood, A.J.2    Tzfati, Y.3    Blackburn, E.H.4    Cech, T.R.5
  • 31
    • 0036861668 scopus 로고    scopus 로고
    • The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance
    • Evans S.K., Lundblad V. The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance. Genetics. 162:2002;1101-1115.
    • (2002) Genetics , vol.162 , pp. 1101-1115
    • Evans, S.K.1    Lundblad, V.2
  • 33
    • 0034661246 scopus 로고    scopus 로고
    • The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase α and the telomerase-associated Est1 protein
    • Qi H., Zakian V.A. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase α and the telomerase-associated Est1 protein. Genes Dev. 14:2000;1777-1788.
    • (2000) Genes Dev. , vol.14 , pp. 1777-1788
    • Qi, H.1    Zakian, V.A.2
  • 34
    • 0035830494 scopus 로고    scopus 로고
    • Cdc13 delivers separate complexes to the telomere for end protection and replication
    • This paper, with Evans and Lundblad (1999) [38] and others, describes the use of fusions between Cdc13p (or its DNA-binding domain) and components of the telomerase pathway to study telomerase regulation. Also, an elegant genetic analysis in this paper demonstrates that the est phenotype of the cdc13-2 allele is caused by disruption of an ionic bond with Est1p.
    • Pennock E., Buckley K., Lundblad V. Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell. 104:2001;387-396 This paper, with Evans and Lundblad (1999) [38] and others, describes the use of fusions between Cdc13p (or its DNA-binding domain) and components of the telomerase pathway to study telomerase regulation. Also, an elegant genetic analysis in this paper demonstrates that the est phenotype of the cdc13-2 allele is caused by disruption of an ionic bond with Est1p.
    • (2001) Cell , vol.104 , pp. 387-396
    • Pennock, E.1    Buckley, K.2    Lundblad, V.3
  • 35
    • 0033598944 scopus 로고    scopus 로고
    • Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta
    • Diede S.J., Gottschling D.E. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta. Cell. 99:1999;723-733.
    • (1999) Cell , vol.99 , pp. 723-733
    • Diede, S.J.1    Gottschling, D.E.2
  • 36
    • 0034175814 scopus 로고    scopus 로고
    • Cell cycle restriction of telomere elongation
    • Marcand S., Brevet V., Mann C., Gilson E. Cell cycle restriction of telomere elongation. Curr. Biol. 10:2000;487-490.
    • (2000) Curr. Biol. , vol.10 , pp. 487-490
    • Marcand, S.1    Brevet, V.2    Mann, C.3    Gilson, E.4
  • 37
    • 0034612253 scopus 로고    scopus 로고
    • Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein
    • Hughes T.R., Weilbaecher R.G., Walterscheid M., Lundblad V. Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein. Proc. Natl. Acad. Sci. U.S.A. 97:2000;6457-6462.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 6457-6462
    • Hughes, T.R.1    Weilbaecher, R.G.2    Walterscheid, M.3    Lundblad, V.4
  • 38
    • 0033214013 scopus 로고    scopus 로고
    • Est1 and Cdc13 as co-mediators of telomerase access
    • Evans S.K., Lundblad V. Est1 and Cdc13 as co-mediators of telomerase access. Science. 286:1999;117-120.
    • (1999) Science , vol.286 , pp. 117-120
    • Evans, S.K.1    Lundblad, V.2
  • 39
    • 0030781067 scopus 로고    scopus 로고
    • Functionally interacting telomerase RNAs in the yeast telomerase complex
    • Prescott J., Blackburn E. Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev. 11:1997;2790-2800.
    • (1997) Genes Dev. , vol.11 , pp. 2790-2800
    • Prescott, J.1    Blackburn, E.2
  • 40
    • 0029155795 scopus 로고
    • Telomerase in yeast
    • Cohn M., Blackburn E.H. Telomerase in yeast. Science. 269:1995;396-400.
    • (1995) Science , vol.269 , pp. 396-400
    • Cohn, M.1    Blackburn, E.H.2
  • 41
    • 0030881688 scopus 로고    scopus 로고
    • Three ever-shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity
    • Lingner J., Cech T.R., Hughes T.R., Lundblad V. Three ever-shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc. Natl. Acad. Sci. U.S.A. 94:1997;11190-11195.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 11190-11195
    • Lingner, J.1    Cech, T.R.2    Hughes, T.R.3    Lundblad, V.4
  • 42
    • 0035115859 scopus 로고    scopus 로고
    • Cdc13 both positively and negatively regulates telomere replication
    • Chandra A., Hughes T.R., Nugent C.I., Lundblad V. Cdc13 both positively and negatively regulates telomere replication. Genes Dev. 15:2001;404-414.
    • (2001) Genes Dev. , vol.15 , pp. 404-414
    • Chandra, A.1    Hughes, T.R.2    Nugent, C.I.3    Lundblad, V.4
  • 43
    • 0032076127 scopus 로고    scopus 로고
    • Yeast Ku as a regulator of chromosomal DNA end structure
    • Gravel S., Larrivee M., Labrecque P., Wellinger R.J. Yeast Ku as a regulator of chromosomal DNA end structure. Science. 280:1998;741-744.
    • (1998) Science , vol.280 , pp. 741-744
    • Gravel, S.1    Larrivee, M.2    Labrecque, P.3    Wellinger, R.J.4
  • 44
    • 0033612287 scopus 로고    scopus 로고
    • Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
    • Martin S.G., Laroche T., Suka N., Grunstein M., Gasser S.M. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell. 97:1999;621-633.
    • (1999) Cell , vol.97 , pp. 621-633
    • Martin, S.G.1    Laroche, T.2    Suka, N.3    Grunstein, M.4    Gasser, S.M.5
  • 45
    • 0035158605 scopus 로고    scopus 로고
    • The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku
    • Before this paper, the yeast Ku heterodimer had been thought to function in a telomere maintenance pathway separate from the telomerase pathway. However, it now appears that Ku has two functions in telomere maintenance - one to promote telomerase action via binding to a stem-loop in TLC1 RNA, and another that has yet to be characterized (possibly protection against telomeric DNA degradation).
    • Peterson S.E., Stellwagen A.E., Diede S.J., Singer M.S., Haimberger Z.W., Johnson C.O., Tzoneva M., Gottschling D.E. The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku. Nat. Genet. 27:2001;64-67 Before this paper, the yeast Ku heterodimer had been thought to function in a telomere maintenance pathway separate from the telomerase pathway. However, it now appears that Ku has two functions in telomere maintenance - one to promote telomerase action via binding to a stem-loop in TLC1 RNA, and another that has yet to be characterized (possibly protection against telomeric DNA degradation).
    • (2001) Nat. Genet. , vol.27 , pp. 64-67
    • Peterson, S.E.1    Stellwagen, A.E.2    Diede, S.J.3    Singer, M.S.4    Haimberger, Z.W.5    Johnson, C.O.6    Tzoneva, M.7    Gottschling, D.E.8
  • 46
    • 0013040064 scopus 로고    scopus 로고
    • Analysis of telomerase in Candida albicans: Potential role in telomere end protection
    • This paper describes orthologues of EST1, EST2, and EST3 in the yeast Candida albicans. Similar to Saccharomyces cerevisiae, disruption of the EST3 homologue leads to an est phenotype (i.e. progressively shortening telomeres). However, disruption of either the EST1 or EST2 homologues leads to rapid shortening and recovery of telomere length, consistent with a defect in telomere 'capping'. These data suggest that telomerase could have a protective role at telomeres distinct from its telomere DNA replication activity.
    • Singh S.M., Steinberg-Neifach O., Mian I.S., Lue N.F. Analysis of telomerase in Candida albicans: potential role in telomere end protection. Eukaryot Cell. 1:2002;967-977 This paper describes orthologues of EST1, EST2, and EST3 in the yeast Candida albicans. Similar to Saccharomyces cerevisiae, disruption of the EST3 homologue leads to an est phenotype (i.e. progressively shortening telomeres). However, disruption of either the EST1 or EST2 homologues leads to rapid shortening and recovery of telomere length, consistent with a defect in telomere 'capping'. These data suggest that telomerase could have a protective role at telomeres distinct from its telomere DNA replication activity.
    • (2002) Eukaryot Cell , vol.1 , pp. 967-977
    • Singh, S.M.1    Steinberg-Neifach, O.2    Mian, I.S.3    Lue, N.F.4
  • 47
    • 0037381155 scopus 로고    scopus 로고
    • A human homolog of yeast Est1 is a telomerase subunit which uncaps chromosome ends upon overexpression
    • in press
    • Reichenbach P, Höss M, Azzalin CM, Nabholz M, Bucher P, Lingner J: A human homolog of yeast Est1 is a telomerase subunit which uncaps chromosome ends upon overexpression. Curr Biol 2003, in press.
    • (2003) Curr Biol
    • Reichenbach, P.1    Höss, M.2    Azzalin, C.M.3    Nabholz, M.4    Bucher, P.5    Lingner, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.