메뉴 건너뛰기




Volumn 44, Issue 2, 2009, Pages 115-123

Atorvastatin decreases stearoyl-CoA desaturase gene expression in THP-1 macrophages incubated with oxidized LDL

Author keywords

Atorvastatin; Cholesterol; Fatty acids; Gene expression; Stearoyl CoA desaturase; THP 1

Indexed keywords

ACYL COENZYME A DESATURASE; ATORVASTATIN; FATTY ACID; MEVALONIC ACID; OLEIC ACID; OXIDIZED LOW DENSITY LIPOPROTEIN; PALMITOLEIC ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 59449101274     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-008-3255-5     Document Type: Article
Times cited : (8)

References (43)
  • 1
  • 2
    • 0033984125 scopus 로고    scopus 로고
    • The evolving role of statins in the management of atherosclerosis
    • C Vaughan AJ Gotto C Basson 2000 The evolving role of statins in the management of atherosclerosis J Am Coll Cardiol 35 1 10
    • (2000) J Am Coll Cardiol , vol.35 , pp. 1-10
    • Vaughan, C.1    Gotto, A.J.2    Basson, C.3
  • 3
    • 33746428470 scopus 로고    scopus 로고
    • Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes: The treating to new targets (TNT) study
    • J Shepherd P Barter R Carmena P Deedwania J Fruchart S Haffner J Hsia A Breazna J LaRosa S Grundy D Waters 2006 Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes: the treating to new targets (TNT) study Diabetes Care 29 1220 1226
    • (2006) Diabetes Care , vol.29 , pp. 1220-1226
    • Shepherd, J.1    Barter, P.2    Carmena, R.3    Deedwania, P.4    Fruchart, J.5    Haffner, S.6    Hsia, J.7    Breazna, A.8    Larosa, J.9    Grundy, S.10    Waters, D.11
  • 4
    • 4444272739 scopus 로고    scopus 로고
    • Non-lipid effects of statins: Emerging new indications
    • A Yildirir H Müderrisoglu 2004 Non-lipid effects of statins: emerging new indications Curr Vasc Pharmacol 2 309 318
    • (2004) Curr Vasc Pharmacol , vol.2 , pp. 309-318
    • Yildirir, A.1    Müderrisoglu, H.2
  • 5
    • 33751180331 scopus 로고    scopus 로고
    • Beyond lipid lowering: What have we learned about the benefits of statins from the acute coronary syndromes trials?
    • K Ray C Cannon P Ganz 2006 Beyond lipid lowering: what have we learned about the benefits of statins from the acute coronary syndromes trials? Am J Cardiol 98 18P 25P
    • (2006) Am J Cardiol , vol.98
    • Ray, K.1    Cannon, C.2    Ganz, P.3
  • 6
    • 2942720515 scopus 로고    scopus 로고
    • Beneficial cardiovascular pleiotropic effects of statins
    • J Davignon 2004 Beneficial cardiovascular pleiotropic effects of statins Circulation 109 III39 III43
    • (2004) Circulation , vol.109
    • Davignon, J.1
  • 7
    • 33646740966 scopus 로고    scopus 로고
    • Differential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: Clinical evidence for 'pleiotropic' functions of statin therapy
    • S Fichtlscherer C Schmidt-Lucke S Bojunga L Rössig C Heeschen S Dimmeler A Zeiher 2006 Differential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: clinical evidence for 'pleiotropic' functions of statin therapy Eur Heart J 27 1182 1190
    • (2006) Eur Heart J , vol.27 , pp. 1182-1190
    • Fichtlscherer, S.1    Schmidt-Lucke, C.2    Bojunga, S.3    Rössig, L.4    Heeschen, C.5    Dimmeler, S.6    Zeiher, A.7
  • 9
    • 0029966304 scopus 로고    scopus 로고
    • Protein prenyltransferases
    • P Casey M Seabra 1996 Protein prenyltransferases J Biol Chem 271 5289 5292
    • (1996) J Biol Chem , vol.271 , pp. 5289-5292
    • Casey, P.1    Seabra, M.2
  • 10
    • 9144236957 scopus 로고    scopus 로고
    • Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia
    • X Bi M Baudry J Liu Y Yao L Fu F Brucher G Lynch 2004 Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia J Biol Chem 279 48238 48245
    • (2004) J Biol Chem , vol.279 , pp. 48238-48245
    • Bi, X.1    Baudry, M.2    Liu, J.3    Yao, Y.4    Fu, L.5    Brucher, F.6    Lynch, G.7
  • 11
    • 23644443991 scopus 로고    scopus 로고
    • Tendon xanthomas in familial hypercholesterolemia are associated with a differential inflammatory response of macrophages to oxidized LDL
    • M Artieda A Cenarro C Junquera P Lasierra M Martínez-Lorenzo M Pocoví C Civeira 2005 Tendon xanthomas in familial hypercholesterolemia are associated with a differential inflammatory response of macrophages to oxidized LDL FEBS Lett 579 4503 4512
    • (2005) FEBS Lett , vol.579 , pp. 4503-4512
    • Artieda, M.1    Cenarro, A.2    Junquera, C.3    Lasierra, P.4    Martínez-Lorenzo, M.5    Pocoví, M.6    Civeira, C.7
  • 12
    • 0032871502 scopus 로고    scopus 로고
    • Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol
    • J Ntambi 1999 Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol J Lipid Res 40 1549 1558
    • (1999) J Lipid Res , vol.40 , pp. 1549-1558
    • Ntambi, J.1
  • 13
    • 0017181438 scopus 로고
    • Mechanism of rat liver microsomal stearyl-CoA desaturase: Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid
    • H Enoch A Catalá P Strittmatter 1976 Mechanism of rat liver microsomal stearyl-CoA desaturase: studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid J Biol Chem 251 5095 5103
    • (1976) J Biol Chem , vol.251 , pp. 5095-5103
    • Enoch, H.1    Catalá, A.2    Strittmatter, P.3
  • 14
    • 0029077405 scopus 로고
    • The regulation of stearoyl-CoA desaturase (SCD)
    • J Ntambi 1995 The regulation of stearoyl-CoA desaturase (SCD) Prog Lipid Res 34 139 150
    • (1995) Prog Lipid Res , vol.34 , pp. 139-150
    • Ntambi, J.1
  • 15
    • 0034958783 scopus 로고    scopus 로고
    • A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis
    • M Miyazaki Y Kim J Ntambi 2001 A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis J Lipid Res 42 1018 1024
    • (2001) J Lipid Res , vol.42 , pp. 1018-1024
    • Miyazaki, M.1    Kim, Y.2    Ntambi, J.3
  • 16
    • 0032846064 scopus 로고    scopus 로고
    • The preventive effects of incomplete Freund's adjuvant and other vehicles on the development of adjuvant-induced arthritis in Lewis rats
    • L Zhang M Mia C Zheng M Hossain F Yamasaki O Tokunaga O Kohashi 1999 The preventive effects of incomplete Freund's adjuvant and other vehicles on the development of adjuvant-induced arthritis in Lewis rats Immunology 98 267 272
    • (1999) Immunology , vol.98 , pp. 267-272
    • Zhang, L.1    Mia, M.2    Zheng, C.3    Hossain, M.4    Yamasaki, F.5    Tokunaga, O.6    Kohashi, O.7
  • 17
    • 0032567445 scopus 로고    scopus 로고
    • Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver
    • I Shimomura H Shimano B Korn Y Bashmakov J Horton 1998 Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver J Biol Chem 273 35299 35306
    • (1998) J Biol Chem , vol.273 , pp. 35299-35306
    • Shimomura, I.1    Shimano, H.2    Korn, B.3    Bashmakov, Y.4    Horton, J.5
  • 18
    • 0037088683 scopus 로고    scopus 로고
    • Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
    • G Liang J Yang J Horton R Hammer J Goldstein M Brown 2002 Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c J Biol Chem 277 9520 9528
    • (2002) J Biol Chem , vol.277 , pp. 9520-9528
    • Liang, G.1    Yang, J.2    Horton, J.3    Hammer, R.4    Goldstein, J.5    Brown, M.6
  • 19
    • 21344471138 scopus 로고    scopus 로고
    • Real-time RT-PCR normalisation; Strategies and considerations
    • J Huggett K Dheda S Bustin A Zumla 2005 Real-time RT-PCR normalisation; strategies and considerations Genes Immun 6 279 284
    • (2005) Genes Immun , vol.6 , pp. 279-284
    • Huggett, J.1    Dheda, K.2    Bustin, S.3    Zumla, A.4
  • 20
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • J Vandesompele K De Preter F Pattyn B Poppe N Van Roy A De Paepe F Speleman 2002 Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Genome Biol 3 1 12
    • (2002) Genome Biol , vol.3 , pp. 1-12
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 21
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • J Folch M Lees GH Sloane Stanley 1957 A simple method for the isolation and purification of total lipides from animal tissues J Biol Chem 226 497 509
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 22
    • 0022803343 scopus 로고
    • A comparison of pyrrolidide and picolinyl ester derivatives for the identification of fatty acids in natural samples by gas chromatography-mass spectrometry
    • W Christie E Brechany S Johnson R Holman 1986 A comparison of pyrrolidide and picolinyl ester derivatives for the identification of fatty acids in natural samples by gas chromatography-mass spectrometry Lipids 21 657 661
    • (1986) Lipids , vol.21 , pp. 657-661
    • Christie, W.1    Brechany, E.2    Johnson, S.3    Holman, R.4
  • 24
    • 0030753142 scopus 로고    scopus 로고
    • Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells
    • P Risé C Colombo C Galli 1997 Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells J Lipid Res 38 1299 1307
    • (1997) J Lipid Res , vol.38 , pp. 1299-1307
    • Risé, P.1    Colombo, C.2    Galli, C.3
  • 25
    • 0038474035 scopus 로고    scopus 로고
    • Relation between the fatty acid composition of peripheral blood mononuclear cells and measures of immune cell function in healthy, free-living subjects aged 25-72 y
    • S Kew T Banerjee AM Minihane YE Finnegan CM Williams PC Calder 2003 Relation between the fatty acid composition of peripheral blood mononuclear cells and measures of immune cell function in healthy, free-living subjects aged 25-72 y Am J Clin Nutr 77 1278 1286
    • (2003) Am J Clin Nutr , vol.77 , pp. 1278-1286
    • Kew, S.1    Banerjee, T.2    Minihane, A.M.3    Finnegan, Y.E.4    Williams, C.M.5    Calder, P.C.6
  • 26
    • 14844320042 scopus 로고    scopus 로고
    • Differential modulation by simvastatin of the metabolic pathways in the n-9, n-6 and n-3 fatty acid series, in human monocytic and hepatocytic cell lines
    • P Risé S Ghezzi I Priori C Galli 2005 Differential modulation by simvastatin of the metabolic pathways in the n-9, n-6 and n-3 fatty acid series, in human monocytic and hepatocytic cell lines Biochem Pharmacol 69 1095 1100
    • (2005) Biochem Pharmacol , vol.69 , pp. 1095-1100
    • Risé, P.1    Ghezzi, S.2    Priori, I.3    Galli, C.4
  • 27
    • 0036864411 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins: Transcriptional activators of lipid synthesis
    • J Horton 2002 Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis Biochem Soc Trans 30 1091 1095
    • (2002) Biochem Soc Trans , vol.30 , pp. 1091-1095
    • Horton, J.1
  • 28
    • 0032555479 scopus 로고    scopus 로고
    • Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1
    • D Tabor J Kim B Spiegelman P Edwards 1998 Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1 J Biol Chem 273 22052 22058
    • (1998) J Biol Chem , vol.273 , pp. 22052-22058
    • Tabor, D.1    Kim, J.2    Spiegelman, B.3    Edwards, P.4
  • 29
    • 0040799893 scopus 로고    scopus 로고
    • Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2
    • D Tabor J Kim B Spiegelman P Edwards 1999 Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2 J Biol Chem 274 20603 20610
    • (1999) J Biol Chem , vol.274 , pp. 20603-20610
    • Tabor, D.1    Kim, J.2    Spiegelman, B.3    Edwards, P.4
  • 30
    • 0033570119 scopus 로고    scopus 로고
    • Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
    • I Shimomura Y Bashmakov J Horton 1999 Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus J Biol Chem 274 30028 30032
    • (1999) J Biol Chem , vol.274 , pp. 30028-30032
    • Shimomura, I.1    Bashmakov, Y.2    Horton, J.3
  • 33
    • 0034815771 scopus 로고    scopus 로고
    • Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: Transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol
    • H Bené D Lasky JM Ntambi 2001 Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol Biochem Biophys Res Commun 284 1194 1198
    • (2001) Biochem Biophys Res Commun , vol.284 , pp. 1194-1198
    • Bené, H.1    Lasky, D.2    Ntambi, J.M.3
  • 34
    • 0034804783 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins (SREBPs): Transcriptional regulators of lipid synthetic genes
    • H Shimano 2001 Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes Prog Lipid Res 40 439 452
    • (2001) Prog Lipid Res , vol.40 , pp. 439-452
    • Shimano, H.1
  • 35
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • M Brown J Goldstein 1997 The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 89 331 340
    • (1997) Cell , vol.89 , pp. 331-340
    • Brown, M.1    Goldstein, J.2
  • 36
    • 0028225462 scopus 로고
    • SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
    • X Wang R Sato M Brown X Hua J Goldstein 1994 SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis Cell 77 53 62
    • (1994) Cell , vol.77 , pp. 53-62
    • Wang, X.1    Sato, R.2    Brown, M.3    Hua, X.4    Goldstein, J.5
  • 37
    • 0028839010 scopus 로고
    • Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver
    • Z Sheng H Otani M Brown J Goldstein 1995 Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver Proc Natl Acad Sci USA 92 935 938
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 935-938
    • Sheng, Z.1    Otani, H.2    Brown, M.3    Goldstein, J.4
  • 39
    • 0035996597 scopus 로고    scopus 로고
    • Atorvastatin therapy in hypercholesterolemic patients suppresses cellular uptake of oxidized-LDL by differentiating monocytes
    • B Fuhrman L Koren N Volkova S Keidar T Hayek M Aviram 2002 Atorvastatin therapy in hypercholesterolemic patients suppresses cellular uptake of oxidized-LDL by differentiating monocytes Atherosclerosis 164 179 185
    • (2002) Atherosclerosis , vol.164 , pp. 179-185
    • Fuhrman, B.1    Koren, L.2    Volkova, N.3    Keidar, S.4    Hayek, T.5    Aviram, M.6
  • 40
    • 0034839396 scopus 로고    scopus 로고
    • Statins inhibit oxidized-LDL-mediated LOX-1 expression, uptake of oxidized-LDL and reduction in PKB phosphorylation
    • DY Li HJ Chen JL Mehta 2001 Statins inhibit oxidized-LDL-mediated LOX-1 expression, uptake of oxidized-LDL and reduction in PKB phosphorylation Cardiovasc Res 52 130 135
    • (2001) Cardiovasc Res , vol.52 , pp. 130-135
    • Li, D.Y.1    Chen, H.J.2    Mehta, J.L.3
  • 42
    • 24144450280 scopus 로고    scopus 로고
    • Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: A randomized controlled trial
    • A Jula J Marniemi T Rönnemaa A Virtanen R Huupponen 2005 Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: a randomized controlled trial Arterioscler Thromb Vasc Biol 25 1952 1959
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1952-1959
    • Jula, A.1    Marniemi, J.2    Rönnemaa, T.3    Virtanen, A.4    Huupponen, R.5
  • 43
    • 0036445650 scopus 로고    scopus 로고
    • Modulation of inflammatory mediators and PPARgamma and NFkappaB expression by pravastatin in response to lipoproteins in human monocytes in vitro
    • I Zelvyte R Dominaitiene M Crisby S Janciauskiene 2002 Modulation of inflammatory mediators and PPARgamma and NFkappaB expression by pravastatin in response to lipoproteins in human monocytes in vitro Pharmacol Res 45 147 154
    • (2002) Pharmacol Res , vol.45 , pp. 147-154
    • Zelvyte, I.1    Dominaitiene, R.2    Crisby, M.3    Janciauskiene, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.