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Volumn 69, Issue 7, 2005, Pages 1095-1100

Differential modulation by simvastatin of the metabolic pathways in the n-9, n-6 and n-3 fatty acid series, in human monocytic and hepatocytic cell lines

Author keywords

Cultured cells; Fatty acid metabolism; Linoleic acid; Simvastatin; Stearic acid; Linolenic acid

Indexed keywords

FATTY ACID; LINOLEIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; OMEGA 9 FATTY ACID; SIMVASTATIN; STEARIC ACID; UNCLASSIFIED DRUG;

EID: 14844320042     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.01.006     Document Type: Article
Times cited : (20)

References (29)
  • 2
    • 0031025656 scopus 로고    scopus 로고
    • Vastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosis
    • S. Colli, S. Eligini, M. Lalli, M. Camera, R. Paoletti, and E. Tremoli Vastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosis Arterioscler Thromb Vasc Biol 17 1997 265 272
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 265-272
    • Colli, S.1    Eligini, S.2    Lalli, M.3    Camera, M.4    Paoletti, R.5    Tremoli, E.6
  • 3
    • 0026071965 scopus 로고
    • Treatment with hydroxymethylglutaryl-coenzyme a reductase inhibitors in hypercholesterolemia induces changes in the components of the extrinsic coagulation system
    • P.M. Sandset, H. Lund, J. Norseth, U. Abildgaard, and L. Ose Treatment with hydroxymethylglutaryl-coenzyme A reductase inhibitors in hypercholesterolemia induces changes in the components of the extrinsic coagulation system Arterioscler Thromb 11 1991 138 145
    • (1991) Arterioscler Thromb , vol.11 , pp. 138-145
    • Sandset, P.M.1    Lund, H.2    Norseth, J.3    Abildgaard, U.4    Ose, L.5
  • 4
    • 0026589912 scopus 로고
    • Lovastatin inhibits low-density lipoprotein oxidation and alters its fluidity and uptake by macrophages: In vitro and in vivo studies
    • M. Aviram, G. Dankner, U. Cogan, E. Hochgraf, and J.G. Brook Lovastatin inhibits low-density lipoprotein oxidation and alters its fluidity and uptake by macrophages: in vitro and in vivo studies Metabolism 41 1992 229 235
    • (1992) Metabolism , vol.41 , pp. 229-235
    • Aviram, M.1    Dankner, G.2    Cogan, U.3    Hochgraf, E.4    Brook, J.G.5
  • 7
    • 0029938301 scopus 로고    scopus 로고
    • Lovastatin induces apoptosis in a metastatic ovarian tumor-cell line
    • Z.Y. Han, and J.H. Wyche Lovastatin induces apoptosis in a metastatic ovarian tumor-cell line Cell Death Differ 3 1996 223 228
    • (1996) Cell Death Differ , vol.3 , pp. 223-228
    • Han, Z.Y.1    Wyche, J.H.2
  • 8
    • 0030753142 scopus 로고    scopus 로고
    • Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipids, cholesterol, and de novo lipid synthesis in THP-1 cells
    • P. Risé, C. Colombo, and C. Galli Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipids, cholesterol, and de novo lipid synthesis in THP-1 cells J Lipid Res 38 1997 1299 1307
    • (1997) J Lipid Res , vol.38 , pp. 1299-1307
    • Risé, P.1    Colombo, C.2    Galli, C.3
  • 9
    • 0027954994 scopus 로고
    • Lovastatin increases arachidonic acid levels and stimulates tromboxane synthesis in human liver and monocytic cell lines
    • N. Hrboticky, L. Tang, B. Zimmer, I. Lux, and P.C. Weber Lovastatin increases arachidonic acid levels and stimulates tromboxane synthesis in human liver and monocytic cell lines J Clin Invest 93 1994 195 203
    • (1994) J Clin Invest , vol.93 , pp. 195-203
    • Hrboticky, N.1    Tang, L.2    Zimmer, B.3    Lux, I.4    Weber, P.C.5
  • 10
    • 0035319257 scopus 로고    scopus 로고
    • Statins enhance arachidonic acid synthesis in hypercholesterolemic patients
    • P. Risé, F. Pazzucconi, C.R. Sirtori, and C. Galli Statins enhance arachidonic acid synthesis in hypercholesterolemic patients Nutr Metab Cardiovasc Dis 11 2001 88 94
    • (2001) Nutr Metab Cardiovasc Dis , vol.11 , pp. 88-94
    • Risé, P.1    Pazzucconi, F.2    Sirtori, C.R.3    Galli, C.4
  • 11
    • 0242584758 scopus 로고    scopus 로고
    • Statins stimulate arachidonic acid release and prostaglandin I2 production in rat liver cells
    • L. Levine Statins stimulate arachidonic acid release and prostaglandin I2 production in rat liver cells Lipids Health Dis 2 2003 1 9
    • (2003) Lipids Health Dis , vol.2 , pp. 1-9
    • Levine, L.1
  • 13
    • 0037184418 scopus 로고    scopus 로고
    • Optimal diets for prevention of coronary heart disease
    • F.B. Hu, and W.C. Willett Optimal diets for prevention of coronary heart disease J Am Med Assoc 288 2002 2569 2578
    • (2002) J Am Med Assoc , vol.288 , pp. 2569-2578
    • Hu, F.B.1    Willett, W.C.2
  • 14
    • 0344329878 scopus 로고    scopus 로고
    • Health benefits of docosahexaenoic acid (DHA)
    • L.A. Horrocks, and Y.K. Yeo Health benefits of docosahexaenoic acid (DHA) Pharmacol Res 40 1999 211 225
    • (1999) Pharmacol Res , vol.40 , pp. 211-225
    • Horrocks, L.A.1    Yeo, Y.K.2
  • 15
    • 0242383315 scopus 로고    scopus 로고
    • Effect of simvastatin on the uptake and metabolic conversion of palmitic, dihomo-γ-linoleic and α-linolenic acids in A549 cells
    • M.J. Bellini, M.P. Polo, M.J.T. de Alaniz, and M.G. de Bravo Effect of simvastatin on the uptake and metabolic conversion of palmitic, dihomo-γ-linoleic and α-linolenic acids in A549 cells Prost Leuk Essent Fatty Acids 69 2003 351 357
    • (2003) Prost Leuk Essent Fatty Acids , vol.69 , pp. 351-357
    • Bellini, M.J.1    Polo, M.P.2    De Alaniz, M.J.T.3    De Bravo, M.G.4
  • 16
    • 0035725016 scopus 로고    scopus 로고
    • Uptake and metabolic conversion of saturated and unsaturated fatty acids in Hep2 human larynx tumor cells
    • L. Albino, M.P. Polo, M.G. de Bravo, and M.J.T. de Alaniz Uptake and metabolic conversion of saturated and unsaturated fatty acids in Hep2 human larynx tumor cells Prost Leuk Essent Fatty Acids 65 2001 295 300
    • (2001) Prost Leuk Essent Fatty Acids , vol.65 , pp. 295-300
    • Albino, L.1    Polo, M.P.2    De Bravo, M.G.3    De Alaniz, M.J.T.4
  • 17
    • 70449158340 scopus 로고
    • A sample method for the isolation and purification of total lipids from animal tissue
    • J. Folch, M. Lees, and G.H. Sloane Stanley A sample method for the isolation and purification of total lipids from animal tissue J Biol Chem 226 1957 497 509
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 18
    • 0030217997 scopus 로고    scopus 로고
    • α-Linolenic acid reduces the lovastatin-induced rise in arachidonic acid and elevates cellular and lipoprotein eicosapentaenoic and docosahexaenoic acid levels in HepG2 cells
    • N. Hrboticky, B. Zimmer, and P.C. Weber α-Linolenic acid reduces the lovastatin-induced rise in arachidonic acid and elevates cellular and lipoprotein eicosapentaenoic and docosahexaenoic acid levels in HepG2 cells Nutr Biochem 7 1996 465 471
    • (1996) Nutr Biochem , vol.7 , pp. 465-471
    • Hrboticky, N.1    Zimmer, B.2    Weber, P.C.3
  • 19
    • 0031693109 scopus 로고    scopus 로고
    • Effect of HMG-CoA reductase inhibitors on plasma polyunsaturated fatty acid concentrations in patients with hyperlipidemia
    • N. Nakamura, T. Hamazaki, H. Jokaji, S. Minami, and M. Kobayashi Effect of HMG-CoA reductase inhibitors on plasma polyunsaturated fatty acid concentrations in patients with hyperlipidemia Int J Clin Lab Res 28 1998 192 195
    • (1998) Int J Clin Lab Res , vol.28 , pp. 192-195
    • Nakamura, N.1    Hamazaki, T.2    Jokaji, H.3    Minami, S.4    Kobayashi, M.5
  • 20
    • 0034686664 scopus 로고    scopus 로고
    • Metabolism of highly unsaturated n-3 and n-6 fatty acids
    • H. Sprecher Metabolism of highly unsaturated n-3 and n-6 fatty acids Biochim Biophys Acta 1486 2000 219 231
    • (2000) Biochim Biophys Acta , vol.1486 , pp. 219-231
    • Sprecher, H.1
  • 21
    • 0035976311 scopus 로고    scopus 로고
    • Activity of human Δ5 and Δ6 desaturases on multiple n-3 and n-6 polyunsaturated fatty acids
    • R.J. de Antueno, L.C. Knickle, H. Smith, M.L. Elliot, S.J. Allen, and S. Nwaka Activity of human Δ5 and Δ6 desaturases on multiple n-3 and n-6 polyunsaturated fatty acids FEBS Lett 509 2001 77 80
    • (2001) FEBS Lett , vol.509 , pp. 77-80
    • De Antueno, R.J.1    Knickle, L.C.2    Smith, H.3    Elliot, M.L.4    Allen, S.J.5    Nwaka, S.6
  • 22
    • 0014028072 scopus 로고
    • Effect of saturated and unsaturated fatty acids on the desaturation in vitro of palmitic, stearic, oleic, linoleic and linolenic acids
    • R.R. Brenner, and R.O. Peluffo Effect of saturated and unsaturated fatty acids on the desaturation in vitro of palmitic, stearic, oleic, linoleic and linolenic acids J Biol Chem 241 1966 5213 5219
    • (1966) J Biol Chem , vol.241 , pp. 5213-5219
    • Brenner, R.R.1    Peluffo, R.O.2
  • 23
    • 0027377094 scopus 로고
    • Studies to determine if rat liver contains chain-length-specific acyl-CoA 6-desaturases
    • M. Geiger, B.S. Mohammed, S. Sankarappa, and H. Sprecher Studies to determine if rat liver contains chain-length-specific acyl-CoA 6-desaturases Biochim Biophys Acta 1170 1993 137 142
    • (1993) Biochim Biophys Acta , vol.1170 , pp. 137-142
    • Geiger, M.1    Mohammed, B.S.2    Sankarappa, S.3    Sprecher, H.4
  • 24
    • 0002634872 scopus 로고
    • Essential fatty acids, lipid peroxidation and cancer
    • D.F. Horrobin Alan R. Liss Inc. New York
    • D.F. Horrobin Essential fatty acids, lipid peroxidation and cancer D.F. Horrobin Omega-6, essential fatty acids 1990 Alan R. Liss Inc. New York 351 377
    • (1990) Omega-6, Essential Fatty Acids , pp. 351-377
    • Horrobin, D.F.1
  • 25
    • 0035793964 scopus 로고    scopus 로고
    • Activity and mRNA abundance of Δ5 and Δ6 fatty acid desaturases in two human cell lines
    • R.J. de Antueno, S.J. Allen, A. Ponton, and M.D. Winther Activity and mRNA abundance of Δ5 and Δ6 fatty acid desaturases in two human cell lines FEBS Lett 491 2001 247 251
    • (2001) FEBS Lett , vol.491 , pp. 247-251
    • De Antueno, R.J.1    Allen, S.J.2    Ponton, A.3    Winther, M.D.4
  • 26
    • 0027101989 scopus 로고
    • Incorporation and metabolic conversion of saturated and unsaturated fatty acids in SK-Hep1 human hepatoma cells in culture
    • C.A. Marra, and M.J. de Alaniz Incorporation and metabolic conversion of saturated and unsaturated fatty acids in SK-Hep1 human hepatoma cells in culture Mol Cell Biochem 18 1992 107 118
    • (1992) Mol Cell Biochem , vol.18 , pp. 107-118
    • Marra, C.A.1    De Alaniz, M.J.2
  • 27
    • 0025156849 scopus 로고
    • Linoleate and linolenate desaturation by rat hepatoma cells
    • M. Iturralde, B. Gonzalez, and A. Pineiro Linoleate and linolenate desaturation by rat hepatoma cells Biochem Int 20 1990 37 43
    • (1990) Biochem Int , vol.20 , pp. 37-43
    • Iturralde, M.1    Gonzalez, B.2    Pineiro, A.3
  • 28
    • 0029828647 scopus 로고    scopus 로고
    • Metabolic fate of oleic acid, palmitic acid and stearic acid in cultured hamster hepatocytes
    • J.S. Bruce, and A.M. Salter Metabolic fate of oleic acid, palmitic acid and stearic acid in cultured hamster hepatocytes Biochem J 316 1996 847 852
    • (1996) Biochem J , vol.316 , pp. 847-852
    • Bruce, J.S.1    Salter, A.M.2
  • 29
    • 0034674746 scopus 로고    scopus 로고
    • Effects of carnitine palmitoyltransferase I inhibitors on hepatic hypertrophy
    • T. Yotsumoto, T. Naitoh, M. Kitahara, and N. Tsuruzoe Effects of carnitine palmitoyltransferase I inhibitors on hepatic hypertrophy Eur J Pharm 398 2000 297 302
    • (2000) Eur J Pharm , vol.398 , pp. 297-302
    • Yotsumoto, T.1    Naitoh, T.2    Kitahara, M.3    Tsuruzoe, N.4


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