Senescence associated β galactosidase activity in human retinal pigment epithelial cells exposed to mildhyperoxia in vitro

British Journal of Ophthalmology

Volumn 86, Issue 2, 2002, Pages 159-162

  Honda, Shigeru ^a   Hjelmeland, Leonard M ^a   Handa, James T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; BROXURIDINE;

ARTICLE; CELL CULTURE; CELL LABELING; CELL LINE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPEROXIA; IN VITRO STUDY; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA CELL; SENESCENCE;

BETA-GALACTOSIDASE; BIOLOGICAL MARKERS; CELL AGING; CELL CULTURE TECHNIQUES; CELL DIVISION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; OXYGEN; PIGMENT EPITHELIUM OF EYE;

EID: 0036163604     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.86.2.159     Document Type: Article

References (18)

1. Cell culture models for oxidative stress: Superoxide and hydrogenperoxide versus normobaric hyperoxia
2. The use of hyperoxia to induce chronic mild oxidative stress in RPE cells in vitro
3. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
4. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
5. Oxidative stress-induced single-strond breoks in chromosomal telomeres of human retinal pigment epithelial cells in vitro
6. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
7. Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells
8. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
9. Extension of life-span by introduction of telomerase into normal human cells
10. Beta-galactosidase histochemistry and telomere loss in senescent retinal pigment epithelial cells
11. Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events
12. Senescence-associated beta-galactosidase histochemistry for the primate eye
13. Microarray analysis of replicative senescence
14. Induction of telomere shortening and replicative senescence by cryopreservation
15. The mRNA phenotype of a human RPE cell line at replicative senescence
16. Cell aging in vivo and in vitro
17. The biology of replicative senescence
18. Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts