Immunohistochemically detected expression of p27Kip1 and Skp2 predicts survival in patients with intrahepatic cholangiocarcinomas

Annals of Surgical Oncology

Volumn 16, Issue 2, 2009, Pages 395-403

  Hashimoto, Nozomi ^a   Yachida, Shinichi ^a   Okano, Keiichi ^a   Wakabayashi, Hisao ^a   Imaida, Katsumi ^a   Kurokohchi, Kazutaka ^b   Masaki, Tsutomu ^b   Kinoshita, Hisoka ^c   Tominaga, Masahiro ^c   Ajiki, Tetsuo ^c   Ku, Yonson ^c   Okabayashi, Takehiro ^d   Hanazaki, Kazuhiro ^d   Hiroi, Makoto ^d   Izumi, Sadanobu ^e   Mano, Shohei ^e   Okada, Setsuo ^f   Karasawa, Yukihiko ^g   Maeba, Takashi ^g   Suzuki, Yasuyuki ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

^c KOBE UNIVERSITY   (Japan)

^d KOCHI MEDICAL SCHOOL   (Japan)

^e KAGAWA PREFECTURAL CENTRAL HOSPITAL   (Japan)

^f Sakaide Municipal General Hospital   (Japan)

^g Ritsurin Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; ONCOPROTEIN; PROTEIN JAB1; S PHASE KINASE ASSOCIATED PROTEIN 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CANCER SURGERY; CANCER SURVIVAL; CLINICAL FEATURE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME DEGRADATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; PROTEIN EXPRESSION;

AGED; AGED, 80 AND OVER; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CHOLANGIOCARCINOMA; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; HEPATOCYTES; HUMANS; IMMUNOENZYME TECHNIQUES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PEPTIDE HYDROLASES; PROGNOSIS; S-PHASE KINASE-ASSOCIATED PROTEINS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 59449086081     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-008-0236-0     Document Type: Article

References (57)

1. Y Nakanuma B Sripa V Vatanasapt 2000
2. Liver Cancer Study Group of Japan 1990 Primary liver cancer in Japan: clinicopathologic features and results of surgical treatment Ann Surg 211 277 87
3. T Sano K Shimada Y Sakamoto 2008 Prognosis of perihilar cholangiocarcinoma: hilar bile duct cancer versus intrahepatic cholangiocarcinoma involving the hepatic hilus Ann Surg Oncol 15 590 9
4. K Shimada T Sano Y Sakamoto 2007 Clinical impact of the surgical margin status in hepatectomy for solitary mass-forming type intrahepatic cholangiocarcinoma without lymph node metastases J Surg Oncol 96 160 5
5. S Miwa S Miyagawa A Kobayashi 2006 Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery J Gastroenterol 41 893 900
6. K Hanazaki S Kajikawa N Shimozawa 2002 Prognostic factors of intrahepatic cholangiocarcinoma after hepatic resection: univariate and multivariate analysis Hepatogastroenterology 49 311 6
7. K Taguchi S Aishima Y Asayama 2001 The role of p27kip1 protein expression on the biological behavior of intrahepatic cholangiocarcinoma Hepatology 33 1118 23
8. M Fiorentino A Altimari A D'Errico 2001 Low p27 expression is an independent predictor of survival for patients with either hilar or peripheral intrahepatic cholangiocarcinoma Clin Cancer Res 7 3994 9
9. H Shibahara S Tamada M Higashi 2004 MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming type Hepatology 39 220 9
10. Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals Cell 78 59 66
11. CJ Sherr JM Roberts 1995 Inhibitors of mammalian G1 cyclin-dependent kinases Genes Dev 9 1149 63
12. SI Reed E Bailly V Dulic 1994 G1 control in mammalian cells J Cell Sci Suppl 18 69 73
13. Kip1 is haplo-insufficient for tumor suppression Nature 396 177 80
14. KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution Genes Dev 9 639 49
15. T Nozoe T Oyama M Takenoyama 2006 Significance of immunohistochemical expression of p27 and involucrin as the marker of cellular differentiation of squamous cell carcinoma of the esophagus Oncology 71 402 10
16. G Galizia E Lieto F Ferraraccio 2006 Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery Ann Surg Oncol 13 823 35
17. Kip1 is overexpressed in very early stages of hepatocarcinogenesis. Cancer Sci. 2008 (in press).
18. kip1 in hepatocarcinogenesis World J Gastroenterol 29 4587 91
19. KIP1 and poor prognosis in oral squamous cell carcinomas Oncology 65 355 62
20. A Goto T Niki S Moriyama 2004 Immunohistochemical study of Skp2 and Jab1, two key molecules in the degradation of P27, in lung adenocarcinoma Pathol Int 54 675 81
21. AC Carrano E Eytan A Hershko 1999 SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 Nat Cell Biol 1 193 9
22. Kip1 degradation and induces S phase in quiescent cells Nat Cell Biol 1 207 14
23. K Tomoda Y Kubota J Kato 1999 Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1 Nature 398 160 5
24. Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex J Biol Chem 277 2302 10
25. M Gstaiger R Jordan M Lim 2001 Skp2 is oncogenic and overexpressed in human cancers Proc Natl Acad Sci USA 98 5043 8
26. T Masuda H Inoue H Sonoda 2002 Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis Cancer Res 62 3819 25
27. H Sonoda H Inoue K Ogawa 2006 Significance of Skp2 expression in primary breast cancer Clin Cancer Res 12 1215 20
28. R Seki T Okamura H Koga 2003 Prognostic significance of the F-box protein Skp2 expression in diffuse large B-cell lymphoma Am J Hematol 73 230 5
29. A Osoegawa I Yoshino T Kometani 2006 Overexpression of Jun activation domain-binding protein 1 in nonsmall cell lung cancer and its significance in p27 expression and clinical features Cancer 107 154 61
30. Kip1: influence on proliferation in hepatocellular carcinoma Hum Pathol 38 1621 7
31. MA Patil I Gütgemann J Zhang 2005 Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma Carcinogenesis 26 2050 7
32. kip1 in pancreatic adenocarcinoma Cancer Res 66 8581 9
33. Liver Cancer Study Group of Japan. General rules for the clinical and pathological study of primary liver cancer. Tokyo: Kanehara; 2003.
34. S Yamasaki 2003 Intrahepatic cholangiocarcinoma: macroscopic type and stage classification J Hepatobiliary Pancreat Surg 10 288 91
35. K Shimada T Sano Y Sakamoto 2007 Surgical outcomes of the mass-forming plus periductal infiltration types of intrahepatic cholangiocarcinoma: a comparative study with the typical mass-forming type of intrahepatic cholangiocarcinoma World J Surg 31 2016 22
36. Y Morimoto Y Tanaka T Ito 2003 Long-term survival and prognostic factors in the surgical treatment for intrahepatic cholangiocarcinoma J Hepatobiliary Pancreat Surg 10 432 40
37. K Ohashi Y Nakajima H Kanehiro 1995 Ki-ras mutations and p53 protein expressions in intrahepatic cholangiocarcinomas: relation to gross tumor morphology Gastroenterology 109 1612 7
38. KS Suh SH Chang HJ Lee 2002 Clinical outcomes and apomucin expression of intrahepatic cholangiocarcinoma according to gross morphology J Am Coll Surg 195 782 9
39. M Ohtsuka H Ito F Kimura 2002 Results of surgical treatment for intrahepatic cholangiocarcinoma and clinicopathological factors influencing survival Br J Surg 89 1525 31
40. M Yamamoto K Takasaki T Yoshikawa 1998 Does gross appearance indicate prognosis in intrahepatic cholangiocarcinoma? J Surg Oncol 69 162 7
41. TS Yeh TC Chen MF Chen 2000 Dedifferentiation of human hepatocellular carcinoma up-regulates telomerase and Ki-67 expression Arch Surg 135 1334 9
42. T Okabayashi J Yamamoto T Kosuge 2001 A new staging system for mass-forming intrahepatic cholangiocarcinoma: analysis of preoperative and postoperative variables Cancer 92 2374 83
43. Kip1 in estrogen-related endometrial adenocarcinomas Clin Cancer Res 9 5332 8
44. V Rodolico D Cabibi G Pizzolanti 2007 BRAFV600E mutation and p27 kip1 expression in papillary carcinomas of the thyroid < or = 1 cm and their paired lymph node metastases Cancer 110 1218 26
45. Kip1 enhances carcinoma cell invasiveness and metastasis Cancer Res 66 11623 31
46. kip1 gene in hepatocellular carcinoma Cancer Lett 153 169 73
47. skp2 pathway in murine models of lung and colon cancer Proc Natl Acad Sci USA 103 14009 14
48. Kip1-interacting cell cycle regulators: an immunohistochemical study of 62 cases by tissue microarray Mod Pathol 20 497 507
49. Kip1, polyploidy and centrosome overduplication EMBO J 19 2069 81
50. G Chiappetta C De Marco A Quintiero 2007 Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer Endocr Relat Cancer 14 405 20
51. DA Chamovitz D Segal 2001 JAB1/CSN5 and the COP9 signalosome. A complex situation EMBO Rep 2 96 101
52. E Bianchi S Denti A Granata 2000 Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity Nature 404 617 21
53. R Kleemann A Hausser G Geiger 2000 Intracelluar action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1 Nature 408 211 6
54. GA Cope GS Suh L Aravind 2002 Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1 Science 298 608 11
55. D Bech-Otschir R Kraft X Huang 2001 COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system EMBO J 20 1630 9
56. T Hara T Kamura K Nakayama 2001 Degradation of p27Kip1 at the G0-G1 transition mediated by a Skp2-independent ubiquitination pathway J Biol Chem 276 48937 43
57. 1 phase J Biol Chem 280 17694 700