Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma

Carcinogenesis

Volumn 26, Issue 12, 2005, Pages 2050-2057

  Patil, Mohini A ^a   Gütgemann, Ines ^b   Zhang, Ji ^a,c   Ho, Coral ^a   Cheung, Siu Tim ^d   Ginzinger, David ^a   Li, Rui ^c   Dykema, Karl J ^f   So, Samuel ^e   Fan, Sheung Tat ^d   Kakar, Sanjay ^a   Furge, Kyle A ^f   Büttner, Reinhard ^b   Chen, Xin ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BONN   (Germany)

^c PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e STANFORD UNIVERSITY   (United States)

^f VAN ANDEL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GENOMIC DNA; PROTEIN JAB1; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CHROMOSOME 13Q; CHROMOSOME 16Q; CHROMOSOME 17P; CHROMOSOME 1Q; CHROMOSOME 20Q; CHROMOSOME 4Q; CHROMOSOME 6P; CHROMOSOME 8P; CHROMOSOME 8Q; CHROMOSOME ABERRATION; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA MICROARRAY; FEASIBILITY STUDY; GENE EXPRESSION REGULATION; GENE LOCUS; GENE OVEREXPRESSION; GENE TARGETING; GENETIC IDENTIFICATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MICROSATELLITE MARKER; ONCOGENE; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; TUMOR SUPPRESSOR GENE; VALIDATION PROCESS;

CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CHROMOSOME ABERRATIONS; CHROMOSOMES, ARTIFICIAL, BACTERIAL; CHROMOSOMES, HUMAN, PAIR 8; GENE AMPLIFICATION; GENE DOSAGE; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION, FLUORESCENCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KARYOTYPING; LIVER; LIVER NEOPLASMS; MICROARRAY ANALYSIS; MICROSATELLITE REPEATS; NEOPLASM RECURRENCE, LOCAL; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDE HYDROLASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 27944491603     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgi178     Document Type: Article

References (51)

1. Parkin,D.M. (2001) Global cancer statistics in the year 2000. Lancet Oncol., 2, 533-543.
2. Parkin,D.M., Bray,F., Ferlay,J. and Pisani,P. (2001) Estimating the world cancer burden: Globocan 2000. Int. J. Cancer, 94, 153-156.
3. Feitelson,M.A., Sun,B., Satiroglu Tufan,N.L., Liu,J., Pan,J. and Lian,Z. (2002) Genetic mechanisms of hepatocarcinogenesis. Oncogene, 21, 2593-2604.
4. El-Serag,H. (2001) Epidemiology of hepatocellular carcinoma. Clin. Liver Dis., 5, 87-107.
5. El-Serag,H.B. (2002) Hepatocellular carcinoma: An epidemiologic view. J. Clin. Gastroenterol., 35, S72-S78.
6. Buendia,M.A. (2000) Genetics of hepatocellular carcinoma. Semin. Cancer Biol., 10, 185-200.
7. Jallepalli,P.V. and Lengauer,C. (2001) Chromosome segregation and cancer: Cutting through the mystery. Nat. Rev. Cancer, 1, 109-117.
8. Gollin,S.M. (2004) Chromosomal instability. Curr. Opin. Oncol., 16, 25-31.
9. Kallioniemi,A., Kallioniemi,O.P., Sudar,D., Rutovitz,D., Gray,J.W., Waldman,F. and Pinkel,D. (1992) Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science, 258, 818-821.
10. Zimonjic,D.B., Keck,C.L., Thorgeirsson,S.S. and Popescu,N.C. (1999) Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization. Hepatology, 29, 1208-1214.
11. Wong,N., Lai,P., Lee,S.W., Fan,S., Pang,E., Liew,C.T., Sheng,Z., Lau,J.W. and Johnson,P.J. (1999) Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: relationship to disease stage, tumor size, and cirrhosis. Am. J. Pathol., 154, 37-43.
12. Kitay-Cohen,Y., Amiel,A., Ashur,Y., Fejgin,M.D., Herishanu,Y., Afanasyev,F., Bomstein,Y. and Lishner,M. (2001) Analysis of chromosomal aberrations in large hepatocellular carcinomas by comparative genomic hybridization. Cancer Genet. Cytogenet., 131, 60-64.
13. Guan,X.Y., Fu,S.B., Xia,J.C. et al. (2000) Recurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization. Cancer Genet. Cytogenet., 123, 27-34.
14. Hashimoto,K., Mori,N., Tamesa,T., Okada,T., Kawauchi,S., OgaA., Furuya,T., Tangoku,A., Oka,M. and Sasaki,K. (2004) Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH. Mod. Pathol., 17, 617-622.
15. Pollack,J.R., Perou,C.M., Alizadeh,A.A., Eisen,M.B., Pergamenschikov,A., Williams,C.F., Jeffrey,S.S., Botstein,D. and Brown,P.O. (1999) Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat. Genet., 23, 41-46.
16. Pinkel,D., Segraves,R., Sudar,D. et al. (1998) High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat. Genet., 20, 207-211.
17. Albertson,D.G., Ylstra,B., Segraves,R., Collins,C., Dairkee,S.H., Kowbel,D., Kuo,W.L., Gray,J.W. and Pinkel,D. (2000) Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene. Nat. Genet., 25, 144-146.
18. Wilhelm,M., Veltman,J.A., Olshen,A.B., Jain,A.N., Moore,D.H., Presti,J.C.Jr, Kovacs,G. and Waldman,F.M. (2002) Array-based comparative genomic hybridization for the differential diagnosis of renal cell cancer. Cancer Res., 62, 957-960.
19. Weiss,M.M., Kuipers,E.J., Postma,C., Snijders,A.M., Siccama,I., Pinkel,D., Westerga,J., Meuwissen,S.G., Albertson,D.G. and Meijer,G.A. (2003) Genomic profiling of gastric cancer predicts lymph node status and survival. Oncogene, 22, 1872-1879.
20. Veltman,J.A., Fridlyand,J., Pejavar,S. et al. (2003) Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors. Cancer Res., 63, 2872-2880.
21. Chen,X., Cheung,S.T., So,S. et al. (2002) Gene expression patterns in human liver cancers. Mol. Biol. Cell, 13, 1929-1939.
22. Patil,M.A., Chua,M.S., Pan,K.H. et al. (2005) An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma. Oncogene, 24, 3737-3747.
23. Jain,A.N., Tokuyasu,T.A., Snijders,A.M., Segraves,R., Albertson,D.G. and Pinkel,D. (2002) Fully automatic quantification of microarray image data. Genome. Res., 12, 325-332.
24. Tusher,V.G., Tibshirani,R. and Chu,G. (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl Acad. Sci. USA, 98, 5116-5121.
25. Bustin,S.A. (2000) Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J. Mol. Endocrinol., 25, 169-193.
26. Ginzinger,D.G., Godfrey,T.E., Nigro,J., Moore,D.H.,2nd, Suzuki,S., Pallavicini,M.G., Gray,J.W. and Jensen,R.H. (2000) Measurement of DNA copy number at microsatellite loci using quantitative PCR analysis. Cancer Res., 60, 5405-5409.
27. Kallioniemi,O.P., Wagner,U., Kononen,J. and Sauter,G. (2001) Tissue microarray technology for high-throughput molecular profiling of cancer. Hum. Mol. Genet., 10, 657-662.
28. Kim,B.C., Lee,H.J., Park,S.H., Lee,S.R., Karpova,T.S., McNally,J.G., Felici,A., Lee,D.K. and Kim,S.J. (2004) Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation. Mol. Cell. Biol., 24, 2251-2262.
29. Emberley,E.D., Niu,Y., Leygue,E., Tomes,L., Gietz,R.D., Murphy,L.C. and Watson,P.H. (2003) Psoriasin interacts with Jab1 and influences breast cancer progression. Cancer Res., 63, 1954-1961.
30. Zhang,Y.J., Jiang,W., Chen,C.J., Lee,C.S., Kahn,S.M., Santella,R.M. and Weinstein,I.B. (1993) Amplification and over expression of cyclin D1 in human hepatocellular carcinoma. Biochem. Biophys. Res. Commun., 196, 1010-1016.
31. Nishida,N., Fukuda,Y., Komeda,T. et al. (1994) Amplification and over expression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res., 54, 3107-3110.
32. Guan,X.Y., Fang,Y., Sham,J.S., Kwong,D.L., Zhang,Y., Liang,Q., Li,H., Zhou,H. and Trent,J.M. (2000) Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer, 29, 110-116.
33. Kusano,N., Shiraishi,K., Kubo,K., Oga,A., Okita,K. and Sasaki,K. (1999) Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: Their relationship to clinicopathological features. Hepatology, 29, 1858-1862.
34. Suzuki,S., Moore,D.H.II, Ginzinger,D.G. et al. (2000) An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer. Cancer Res., 60, 5382-5385.
35. Nigro,J.M., Takahashi,M.A., Ginzinger,D.G., Law,M., Passe,S., Jenkins,R.B. and Aldape,K. (2001) Detection of 1p and 19q loss in oligodendroglioma by quantitative microsatellite analysis, a real-time quantitative polymerase chain reaction assay. Am. J. Pathol., 158, 1253-1262.
36. Tomoda,K., Kubota,Y., Arata,Y., Mori,S., Maeda,M., Tanaka,T., Yoshida,M., Yoneda-Kato,N. and Kato,J.Y. (2002) The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. J. Biol. Chem., 277, 2302-2310.
37. Tomoda,K., Kubota,Y. and Kato,J. (1999) Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1. Nature, 398, 160-165.
38. Nishida,N., Nishimura,T., Ito,T., Komeda,T., Fukuda,Y. and Nakao,K. (2003) Chromosomal instability and human hepatocarcinogenesis. Histol. Histopathol., 18, 897-909.
39. Deng,X.W., Dubiel,W., Wei,N., Hofmann,K. and Mundt,K. (2000) Unified nomenclature for the COP9 signalosome and its subunits: An essential regulator of development. Trends Genet., 16, 289.
40. Chamovitz,D.A. and Segal,D. (2001) JAB1/CSN5 and the COP9 signalosome. A complex situation. EMBO Rep., 2, 96-101.
41. Claret,F.X., Hibi,M., Dhut,S., Toda,J. and Karin,M. (1996) A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature, 383, 453-457.
42. Wan,M., Cao,X., Wu,Y., Bai,S., Wu,L., Shi,X. and Wang,N. (2002) Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. EMBO Rep., 3, 171-176.
43. Bianchi,E., Denti,S., Granata,A., Bossi,G., Geginat,J., Villa,A., Rogge,L. and Pardi,R. (2000) Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Nature, 404, 617-621.
44. Chauchereau,A., Georgiakaki,M., Perrin-Wolff,M., Milgrom,E. and Loosfelt,H. (2000) JAB1 interacts with both the progesterone receptor and SRC-1. J. Biol. Chem., 275, 8540-8548.
45. Li,S., Liu,X. and Ascoli,M. (2000) p38JAB1 binds to the intracellular precursor of the lutropin/choriogonadotropin receptor and promotes its degradation. J. Biol. Chem., 275, 13386-13393.
46. Dechend,R., Hirano,F., Lehmann,K., Heissmeyer,V., Ansieau,S., Wulczyn,F.G., Scheidereit,C. and Leutz,A. (1999) The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. Oncogene, 18, 3316-3323.
47. Kouvaraki,M.A., Rassidakis,G.Z., Tian,L., Kumar,R., Kittas,C. and Claret,F.X. (2003) Jun activation domain-binding protein 1 expression in breast cancer inversely correlates with the cell cycle inhibitor p27(Kip1). Cancer Res., 63, 2977-2981.
48. Sui,L., Dong,Y., Ohno,M., Watanabe,Y., Sugimoto,K., Tai,Y. and Tokuda,M. (2001) Jab1 expression is associated with inverse expression of p27(kip1) and poor prognosis in epithelial ovarian tumors. Clin. Cancer Res., 7, 4130-4135.
49. Tsuchida,R., Miyauchi,J., Shen,L. et al. (2002) Expression of cyclin-dependent kinase inhibitor p27/Kip1 and AP-1 coactivator p38/Jab1 correlates with differentiation of embryonal rhabdomyosarcoma. Jpn. J. Cancer Res., 93, 1000-1006.
50. Fukumoto,A., Ikeda,N., Sho,M., Tomoda,K., Kanehiro,H., Hisanaga,M., Tsurui,Y., Tsutsumi,M., Kato,J.Y. and Nakajima,Y. (2004) Prognostic significance of localized p27Kip1 and potential role of Jab1/CSN5 in pancreatic cancer. Oncol. Rep., 11, 277-284.
51. Shintani,S., Li,C., Mihara,M., Hino,S., Nakashiro,K. and Hamakawa,H. (2003) Skp2 and Jab1 expression are associated with inverse expression of p27(KIP1) and poor prognosis in oral squamous cell carcinomas. Oncology, 65, 355-362.