How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40

Virology

Volumn 384, Issue 2, 2009, Pages 274-284

  DeCaprio, James A ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Adenovirus; Cell cycle; E1A; Large T antigen; pRb; Rb; Retinoblastoma; SV40; Transformation; Tumor suppressor

Indexed keywords

CELL PROTEIN; E1A PROTEIN; MONOCLONAL ANTIBODY; POLIOMYELITIS VACCINE; PROTEIN P107; PROTEIN P130; PROTEIN P300; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; VIRUS LARGE T ANTIGEN; VIRUS PROTEIN;

ADENOVIRUS; CANCER GENETICS; CELL CYCLE; CELL CYCLE PROGRESSION; CLONING; DNA TUMOR VIRUS; GENE IDENTIFICATION; GENETICS; HUMAN; IMMUNOPRECIPITATION; MUTANT; NONHUMAN; ONCOGENE; PNEUMONIA; POLYOMA VIRUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; RETINOBLASTOMA; SHORT SURVEY; SIMIAN VIRUS 40; VIRUS TRANSFORMATION;

ADENOVIRIDAE; ADENOVIRUS E1A PROTEINS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL TRANSFORMATION, VIRAL; GENES, RETINOBLASTOMA; HUMANS; ONCOGENES; RETINAL NEOPLASMS; RETINOBLASTOMA; RETINOBLASTOMA PROTEIN; SIMIAN VIRUS 40; STRUCTURE-ACTIVITY RELATIONSHIP;

ADENOVIRIDAE; ANIMALIA; POLIOVIRUS;

EID: 59349095716     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2008.12.010     Document Type: Short Survey

References (237)

1. Abrahams P.J., Mulder C., Van De Voorde A., Warnaar S.O., and van der Eb A.J. Transformation of primary rat kidney cells by fragments of simian virus 40 DNA. J. Virol. 16 4 (1975) 818-823
2. Ach R.A., Taranto P., and Gruissem W. A conserved family of WD-40 proteins binds to the retinoblastoma protein in both plants and animals. Plant Cell 9 9 (1997) 1595-1606
3. Arany Z., Sellers W.R., Livingston D.M., and Eckner R. E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell 77 6 (1994) 799-800
4. Bagchi S., Raychaudhuri P., and Nevins J.R. Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation. Cell 62 4 (1990) 659-669
5. Bandara L.R., and La Thangue N.B. Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor. Nature 351 6326 (1991) 494-497
6. Bandara L.R., Adamczewski J.P., Hunt T., and La Thangue N.B. Cyclin A and the retinoblastoma gene product complex with a common transcription factor. Nature 352 6332 (1991) 249-251
7. Bandara L.R., Buck V.M., Zamanian M., Johnston L.H., and La Thangue N.B. Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F. EMBO J. 12 11 (1993) 4317-4324
8. Bandara L.R., Lam E.W., Sorensen T.S., Zamanian M., Girling R., and La Thangue N.B. DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. EMBO J. 13 13 (1994) 3104-3114
9. Barbeau D., Charbonneau R., Whalen S.G., Bayley S.T., and Branton P.E. Functional interactions within adenovirus E1A protein complexes. Oncogene 9 2 (1994) 359-373
10. Benedict W.F., Murphree A.L., Banerjee A., Spina C.A., Sparkes M.C., and Sparkes R.S. Patient with 13 chromosome deletion: evidence that the retinoblastoma gene is a recessive cancer gene. Science 219 4587 (1983) 973-975
11. Berk A.J. Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus. Oncogene 24 52 (2005) 7673-7685
12. Bernat A., Avvakumov N., Mymryk J.S., and Banks L. Interaction between the HPV E7 oncoprotein and the transcriptional coactivator p300. Oncogene 22 39 (2003) 7871-7881
13. Bignon Y.J., Shew J.Y., Rappolee D., Naylor S.L., Lee E.Y., Schnier J., and Lee W.H. A single Cys706 to Phe substitution in the retinoblastoma protein causes the loss of binding to SV40 T antigen. Cell Growth Differ. 1 12 (1990) 647-651
14. Borger D.R., and DeCaprio J.A. Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53. J. Virol. 80 9 (2006) 4292-4303
15. Braithwaite A.W., Cheetham B.F., Li P., Parish C.R., Waldron-Stevens L.K., and Bellett A.J. Adenovirus-induced alterations of the cell growth cycle: a requirement for expression of E1A but not of E1B. J. Virol. 45 1 (1983) 192-199
16. Brugge J.S., and Butel J.S. Role of simian virus 40 gene A function in maintenance of transformation. J. Virol. 15 3 (1975) 619-635
17. Buchkovich K., Duffy L.A., and Harlow E. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58 6 (1989) 1097-1105
18. Campbell K.S., Mullane K.P., Aksoy I.A., Stubdal H., Zalvide J., Pipas J.M., Silver P.A., Roberts T.M., Schaffhausen B.S., and DeCaprio J.A. DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev. 11 9 (1997) 1098-1110
19. Cavenee W.K., Dryja T.P., Phillips R.A., Benedict W.F., Godbout R., Gallie B.L., Murphree A.L., Strong L.C., and White R.L. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 305 5937 (1983) 779-784
20. Cavenee W.K., Hansen M.F., Nordenskjold M., Kock E., Maumenee I., Squire J.A., Phillips R.A., and Gallie B.L. Genetic origin of mutations predisposing to retinoblastoma. Science 228 4698 (1985) 501-503
21. Chakravarti D., Ogryzko V., Kao H.Y., Nash A., Chen H., Nakatani Y., and Evans R.M. A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. Cell 96 3 (1999) 393-403
22. Chan H.M., Narita M., Lowe S.W., and Livingston D.M. The p400 E1A-associated protein is a novel component of the p53 → p21 senescence pathway. Genes Dev. 19 2 (2005) 196-201
23. Chellappan S., Kraus V.B., Kroger B., Munger K., Howley P.M., Phelps W.C., and Nevins J.R. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc. Natl. Acad. Sci. U.S.A. 89 10 (1992) 4549-4553
24. Chellappan S.P., Hiebert S., Mudryj M., Horowitz J.M., and Nevins J.R. The E2F transcription factor is a cellular target for the RB protein. Cell 65 6 (1991) 1053-1061
25. Chen P.L., Scully P., Shew J.Y., Wang J.Y., and Lee W.H. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58 6 (1989) 1193-1198
26. Chen S., and Paucha E. Identification of a region of simian virus 40 large T antigen required for cell transformation. J. Virol. 64 7 (1990) 3350-3357
27. Chittenden T., Livingston D.M., and Kaelin Jr. W.G. The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell 65 6 (1991) 1073-1082
28. Christensen J.B., and Imperiale M.J. Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen. J. Virol. 69 6 (1995) 3945-3948
29. Chrivia J.C., Kwok R.P., Lamb N., Hagiwara M., Montminy M.R., and Goodman R.H. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365 6449 (1993) 855-859
30. Cobrinik D., Whyte P., Peeper D.S., Jacks T., and Weinberg R.A. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev. 7 12A (1993) 2392-2404
31. Comings D.E. A general theory of carcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 70 12 (1973) 3324-3328
32. Courtneidge S.A., and Smith A.E. Polyoma virus transforming protein associates with the product of the c-src cellular gene. Nature 303 5916 (1983) 435-439
33. Crawford L., and Harlow E. Uniform nomenclature for monoclonal antibodies directed against virus-coded proteins of simian virus 40 and polyoma virus. J. Virol. 41 2 (1982) 709
34. DeCaprio J.A., Ludlow J.W., Figge J., Shew J.Y., Huang C.M., Lee W.H., Marsilio E., Paucha E., and Livingston D.M. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54 2 (1988) 275-283
35. DeCaprio J.A., Ludlow J.W., Lynch D., Furukawa Y., Griffin J., Piwnica-Worms H., Huang C.M., and Livingston D.M. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell 58 6 (1989) 1085-1095
36. DeCaprio J.A., Furukawa Y., Ajchenbaum F., Griffin J.D., and Livingston D.M. The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. Proc. Natl. Acad. Sci. U.S.A. 89 5 (1992) 1795-1798
37. Defeo-Jones D., Huang P.S., Jones R.E., Haskell K.M., Vuocolo G.A., Hanobik M.G., Huber H.E., and Oliff A. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. Nature 352 6332 (1991) 251-254
38. Deleu L., Shellard S., Alevizopoulos K., Amati B., and Land H. Recruitment of TRRAP required for oncogenic transformation by E1A. Oncogene 20 57 (2001) 8270-8275
39. Draetta G., and Beach D. Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell 54 1 (1988) 17-26
40. Draetta G., Brizuela L., Potashkin J., and Beach D. Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+. Cell 50 2 (1987) 319-325
41. Draetta G., Luca F., Westendorf J., Brizuela L., Ruderman J., and Beach D. Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell 56 5 (1989) 829-838
42. Drdova B., and Vachtenheim J. Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein. Folia Biol. (Praha) 50 5 (2004) 159-166
43. Du W., Vidal M., Xie J.E., and Dyson N. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10 10 (1996) 1206-1218
44. Dumont D.J., and Branton P.E. Phosphorylation of adenovirus E1A proteins by the p34cdc2 protein kinase. Virology 189 1 (1992) 111-120
45. Durst M., Gissmann L., Ikenberg H., and zur Hausen H. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc. Natl. Acad. Sci. U.S.A. 80 12 (1983) 3812-3815
46. Dyson N., Buchkovich K., Whyte P., and Harlow E. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell 58 2 (1989) 249-255
47. Dyson N., Howley P.M., Munger K., and Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243 4893 (1989) 934-937
48. Dyson N., Bernards R., Friend S.H., Gooding L.R., Hassell J.A., Major E.O., Pipas J.M., Vandyke T., and Harlow E. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J. Virol. 64 3 (1990) 1353-1356
49. Dyson N., Guida P., McCall C., and Harlow E. Adenovirus E1A makes two distinct contacts with the retinoblastoma protein. J. Virol. 66 7 (1992) 4606-4611
50. Eckhart W., Hutchinson M.A., and Hunter T. An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates. Cell 18 4 (1979) 925-933
51. Eckner R., Ewen M.E., Newsome D., Gerdes M., DeCaprio J.A., Lawrence J.B., and Livingston D.M. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8 8 (1994) 869-884
52. Eckner R., Ludlow J.W., Lill N.L., Oldread E., Arany Z., Modjtahedi N., DeCaprio J.A., Livingston D.M., and Morgan J.A. Association of p300 and CBP with simian virus 40 large T antigen. Mol. Cell. Biol. 16 7 (1996) 3454-3464
53. Eddy B.E., Stewart S.E., Young R., and Mider G.B. Neoplasms in hamsters induced by mouse tumor agent passed in tissue culture. J. Natl. Cancer Inst. 20 4 (1958) 747-761
54. Eddy B.E., Borman G.S., Berkeley W.H., and Young R.D. Tumors induced in hamsters by injection of rhesus monkey kidney cell extracts. Proc. Soc. Exp. Biol. Med. 107 (1961) 191-197
55. Eddy B.E., Borman G.S., Grubbs G.E., and Young R.D. Identification of the oncogenic substance in rhesus monkey kidney cell culture as simian virus 40. Virology 17 (1962) 65-75
56. Egan C., Yee S.P., Ferguson B., Rosenberg M., and Branton P.E. Binding of cellular polypeptides to human adenovirus type 5 E1A proteins produced in Escherichia coli. Virology 160 1 (1987) 292-296
57. Egan C., Jelsma T.N., Howe J.A., Bayley S.T., Ferguson B., and Branton P.E. Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5. Mol. Cell. Biol. 8 9 (1988) 3955-3959
58. Ewen M.E., Faha B., Harlow E., and Livingston D.M. Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins. Science 255 5040 (1992) 85-87
59. Ewen M.E., Ludlow J.W., Marsilio E., DeCaprio J.A., Millikan R.C., Cheng S.H., Paucha E., and Livingston D.M. An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120. Cell 58 2 (1989) 257-267
60. Ewen M.E., Xing Y.G., Lawrence J.B., and Livingston D.M. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell 66 6 (1991) 1155-1164
61. Faha B., Ewen M.E., Tsai L.H., Livingston D.M., and Harlow E. Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science 255 5040 (1992) 87-90
62. Fattaey A.R., Harlow E., and Helin K. Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol. Cell. Biol. 13 12 (1993) 7267-7277
63. Feng H., Shuda M., Chang Y., and Moore P.S. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319 5866 (2008) 1096-1100
64. Ferrari R., Pellegrini M., Horwitz G.A., Xie W., Berk A.J., and Kurdistani S.K. Epigenetic reprogramming by adenovirus e1a. Science 321 5892 (2008) 1086-1088
65. Figge J., Webster T., Smith T.F., and Paucha E. Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins. J. Virol. 62 5 (1988) 1814-1818
66. Finlay C.A., Hinds P.W., and Levine A.J. The p53 proto-oncogene can act as a suppressor of transformation. Cell 57 7 (1989) 1083-1093
67. Flint S.J., Gallimore P.H., and Sharp P.A. Comparison of viral RNA sequences in adenovirus 2-transformed and lytically infected cells. J. Mol. Biol. 96 1 (1975) 47-68
68. Friend S.H., Bernards R., Rogelj S., Weinberg R.A., Rapaport J.M., Albert D.M., and Dryja T.P. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323 6089 (1986) 643-646
69. Friend S.H., Horowitz J.M., Gerber M.R., Wang X.F., Bogenmann E., Li F.P., and Weinberg R.A. Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. Proc. Natl. Acad. Sci. U.S.A. 84 24 (1987) 9059-9063
70. Fuchs M., Gerber J., Drapkin R., Sif S., Ikura T., Ogryzko V., Lane W.S., Nakatani Y., and Livingston D.M. The p400 complex is an essential E1A transformation target. Cell 106 3 (2001) 297-307
71. Fung Y.K., Murphree A.L., T'Ang A., Qian J., Hinrichs S.H., and Benedict W.F. Structural evidence for the authenticity of the human retinoblastoma gene. Science 236 4809 (1987) 1657-1661
72. Ghosh M.K., and Harter M.L. A viral mechanism for remodeling chromatin structure in G0 cells. Mol. Cell 12 1 (2003) 255-260
73. Giordano A., Whyte P., Harlow E., Franza Jr. B.R., Beach D., and Draetta G. A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell 58 5 (1989) 981-990
74. Girling R., Partridge J.F., Bandara L.R., Burden N., Totty N.F., Hsuan J.J., and La Thangue N.B. A new component of the transcription factor DRTF1/E2F. Nature 362 6415 (1993) 83-87
75. Godbout R., Dryja T.P., Squire J., Gallie B.L., and Phillips R.A. Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma. Nature 304 5925 (1983) 451-453
76. Goodrich D.W., Wang N.P., Qian Y.W., Lee E.Y., and Lee W.H. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell 67 2 (1991) 293-302
77. Haley K.P., Overhauser J., Babiss L.E., Ginsberg H.S., and Jones N.C. Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products. Proc. Natl. Acad. Sci. U.S.A. 81 18 (1984) 5734-5738
78. Hamamori Y., Sartorelli V., Ogryzko V., Puri P.L., Wu H.Y., Wang J.Y., Nakatani Y., and Kedes L. Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Cell 96 3 (1999) 405-413
79. Hannon G.J., Demetrick D., and Beach D. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev. 7 12A (1993) 2378-2391
80. Harlow E., Franza Jr. B.R., and Schley C. Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products. J. Virol. 55 3 (1985) 533-546
81. Harlow E., Whyte P., Franza Jr. B.R., and Schley C. Association of adenovirus early-region 1A proteins with cellular polypeptides. Mol. Cell. Biol. 6 5 (1986) 1579-1589
82. Harrison M.M., Ceol C.J., Lu X., and Horvitz H.R. Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex. Proc. Natl. Acad. Sci. U.S.A. 103 45 (2006) 16782-16787
83. Helin K., and Harlow E. Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein. J. Virol. 68 8 (1994) 5027-5035
84. Helin K., Lees J.A., Vidal M., Dyson N., Harlow E., and Fattaey A. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70 2 (1992) 337-350
85. Helin K., Wu C.L., Fattaey A.R., Lees J.A., Dynlacht B.D., Ngwu C., and Harlow E. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 7 10 (1993) 1850-1861
86. Herrmann C.H., Su L.K., and Harlow E. Adenovirus E1A is associated with a serine/threonine protein kinase. J. Virol. 65 11 (1991) 5848-5859
87. Hiebert S.W., Chellappan S.P., Horowitz J.M., and Nevins J.R. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev. 6 2 (1992) 177-185
88. Hinds P.W., Mittnacht S., Dulic V., Arnold A., Reed S.I., and Weinberg R.A. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70 6 (1992) 993-1006
89. Horowitz J.M., Yandell D.W., Park S.H., Canning S., Whyte P., Buchkovich K., Harlow E., Weinberg R.A., and Dryja T.P. Point mutational inactivation of the retinoblastoma antioncogene. Science 243 4893 (1989) 937-940
90. Horwitz G.A., Zhang K., McBrian M.A., Grunstein M., Kurdistani S.K., and Berk A.J. Adenovirus small e1a alters global patterns of histone modification. Science 321 5892 (2008) 1084-1085
91. Howard E., Marcus D., O'Brien J., Albert D., and Bernards R. Five DNA tumor viruses undetectable in human retinoblastomas. Invest. Ophthalmol. Vis. Sci. 33 5 (1992) 1564-1567
92. Howe J.A., Mymryk J.S., Egan C., Branton P.E., and Bayley S.T. Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis. Proc. Natl. Acad. Sci. U.S.A. 87 15 (1990) 5883-5887
93. Hu Q.J., Dyson N., and Harlow E. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J. 9 4 (1990) 1147-1155
94. Huang M.M., and Hearing P. The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex. Genes Dev. 3 11 (1989) 1699-1710
95. Huang S., Wang N.P., Tseng B.Y., Lee W.H., and Lee E.H. Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen. EMBO J. 9 6 (1990) 1815-1822
96. Huang S., Lee W.H., and Lee E.Y. A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product. Nature 350 6314 (1991) 160-162
97. Huebner R.J., Rowe W.P., and Lane W.T. Oncogenic effects in hamsters of human adenovirus types 12 and 18. Proc. Natl. Acad. Sci. U.S.A. 48 (1962) 2051-2058
98. Imperiale M.J., Feldman L.T., and Nevins J.R. Activation of gene expression by adenovirus and herpesvirus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element. Cell 35 1 (1983) 127-136
99. Jenkins J.R., Rudge K., and Currie G.A. Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53. Nature 312 5995 (1984) 651-654
100. Johnson D.G., Schwarz J.K., Cress W.D., and Nevins J.R. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365 6444 (1993) 349-352
101. Jones R.E., Wegrzyn R.J., Patrick D.R., Balishin N.L., Vuocolo G.A., Riemen M.W., Defeo-Jones D., Garsky V.M., Heimbrook D.C., and Oliff A. Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein. J. Biol. Chem. 265 22 (1990) 12782-12785
102. Jones R.E., Heimbrook D.C., Huber H.E., Wegrzyn R.J., Rotberg N.S., Stauffer K.J., Lumma P.K., Garsky V.M., and Oliff A. Specific N-methylations of HPV-16 E7 peptides alter binding to the retinoblastoma suppressor protein. J. Biol. Chem. 267 2 (1992) 908-912
103. Jost C.A., Ginsberg D., and Kaelin Jr. W.G. A conserved region of unknown function participates in the recognition of E2F family members by the adenovirus E4 ORF 6/7 protein. Virology 220 1 (1996) 78-90
104. Kaczmarek L., Ferguson B., Rosenberg M., and Baserga R. Induction of cellular DNA synthesis by purified adenovirus E1A proteins. Virology 152 1 (1986) 1-10
105. Kaelin Jr. W.G., Ewen M.E., and Livingston D.M. Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product. Mol. Cell. Biol. 10 7 (1990) 3761-3769
106. Kaelin Jr. W.G., Pallas D.C., DeCaprio J.A., Kaye F.J., and Livingston D.M. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell 64 3 (1991) 521-532
107. Kaelin Jr. W.G., Krek W., Sellers W.R., DeCaprio J.A., Ajchenbaum F., Fuchs C.S., Chittenden T., Li Y., Farnham P.J., Blanar M.A., et al. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70 2 (1992) 351-364
108. Kalderon D., and Smith A.E. In vitro mutagenesis of a putative DNA binding domain of SV40 large-T. Virology 139 1 (1984) 109-137
109. Kaplan D.R., Whitman M., Schaffhausen B., Pallas D.C., White M., Cantley L., and Roberts T.M. Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell 50 7 (1987) 1021-1029
110. Kaye F.J., Kratzke R.A., Gerster J.L., and Horowitz J.M. A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding. Proc. Natl. Acad. Sci. U.S.A. 87 17 (1990) 6922-6926
111. Kierstead T.D., and Tevethia M.J. Association of p53 binding and immortalization of primary C57BL/6 mouse embryo fibroblasts by using simian virus 40 T-antigen mutants bearing internal overlapping deletion mutations. J. Virol. 67 4 (1993) 1817-1829
112. Kim H.Y., and Cho Y. Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box. Nat. Struct. Biol. 4 5 (1997) 390-395
113. Kim H.Y., Ahn B.Y., and Cho Y. Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen. EMBO J. 20 1-2 (2001) 295-304
114. Kimelman D. A novel general approach to eucaryotic mutagenesis functionally identifies conserved regions within the adenovirus 13S E1A polypeptide. Mol. Cell. Biol. 6 5 (1986) 1487-1496
115. Kimelman D., Miller J.S., Porter D., and Roberts B.E. E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related. J. Virol. 53 2 (1985) 399-409
116. Kimura G., and Itagaki A. Initiation and maintenance of cell transformation by simian virus 40: a viral genetic property. Proc. Natl. Acad. Sci. U.S.A. 72 2 (1975) 673-677
117. Kleinberger T., and Shenk T. A protein kinase is present in a complex with adenovirus E1A proteins. Proc. Natl. Acad. Sci. U.S.A. 88 24 (1991) 11143-11147
118. Klose R.J., Yan Q., Tothova Z., Yamane K., Erdjument-Bromage H., Tempst P., Gilliland D.G., Zhang Y., and Kaelin Jr. W.G. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 128 5 (2007) 889-900
119. Knudson Jr. A.G. Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. U.S.A. 68 4 (1971) 820-823
120. Kobayashi S., and Mukai N. Retinoblastoma-like tumors induced in rats by human adenovirus. Invest. Ophthalmol. 12 11 (1973) 853-856
121. Kobayashi M., Mukai N., Solish S.P., and Pomeroy M.E. A highly predictable animal model of retinoblastoma. Acta Neuropathol. 57 2-3 (1982) 203-208
122. Korenjak M., Taylor-Harding B., Binne U.K., Satterlee J.S., Stevaux O., Aasland R., White-Cooper H., Dyson N., and Brehm A. Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell 119 2 (2004) 181-193
123. Kovesdi I., Reichel R., and Nevins J.R. E1A transcription induction: enhanced binding of a factor to upstream promoter sequences. Science 231 4739 (1986) 719-722
124. Kovesdi I., Reichel R., and Nevins J.R. Identification of a cellular transcription factor involved in E1A trans-activation. Cell 45 2 (1986) 219-228
125. Kwok R.P., Lundblad J.R., Chrivia J.C., Richards J.P., Bachinger H.P., Brennan R.G., Roberts S.G., Green M.R., and Goodman R.H. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370 6486 (1994) 223-226
126. La Thangue N.B., and Rigby P.W. An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells. Cell 49 4 (1987) 507-513
127. La Thangue N.B., Thimmappaya B., and Rigby P.W. The embryonal carcinoma stem cell Ela-like activity involves a differentiation-regulated transcription factor. Nucleic Acids Res. 18 10 (1990) 2929-2938
128. Lai A., Lee J.M., Yang W.M., DeCaprio J.A., Kaelin Jr. W.G., Seto E., and Branton P.E. RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. Mol. Cell. Biol. 19 10 (1999) 6632-6641
129. Laiho M., DeCaprio J.A., Ludlow J.W., Livingston D.M., and Massague J. Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell 62 1 (1990) 175-185
130. Lalande M., Dryja T.P., Schreck R.R., Shipley J., Flint A., and Latt S.A. Isolation of human chromosome 13-specific DNA sequences cloned from flow sorted chromosomes and potentially linked to the retinoblastoma locus. Cancer Genet. Cytogenet. 13 4 (1984) 283-295
131. Lane D.P. Cell immortalization and transformation by the p53 gene. Nature 312 5995 (1984) 596-597
132. Lane D.P., and Robbins A.K. An immunochemical investigation of SV40 T antigens. 1. Production properties and specificity of rabbit antibody to purified simian virus 40 large-T antigen. Virology 87 1 (1978) 182-193
133. Lang S.E., and Hearing P. The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex. Oncogene 22 18 (2003) 2836-2841
134. Lassam N.J., Bayley S.T., Graham F.L., and Branton P.E. Immunoprecipitation of protein kinase activity from adenovirus 5-infected cells using antiserum directed against tumour antigens. Nature 277 5693 (1979) 241-243
135. Lee C., Chang J.H., Lee H.S., and Cho Y. Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes Dev. 16 24 (2002) 3199-3212
136. Lee J.O., Russo A.A., and Pavletich N.P. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature 391 6670 (1998) 859-865
137. Lee M.G., and Nurse P. Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. Nature 327 6117 (1987) 31-35
138. Lee W.H., Bookstein R., Hong F., Young L.J., Shew J.Y., and Lee E.Y. Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science 235 4794 (1987) 1394-1399
139. Lee W.H., Shew J.Y., Hong F.D., Sery T.W., Donoso L.A., Young L.J., Bookstein R., and Lee E.Y. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature 329 6140 (1987) 642-645
140. Lees J.A., Buchkovich K.J., Marshak D.R., Anderson C.W., and Harlow E. The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J. 10 13 (1991) 4279-4290
141. Lewis P.W., Beall E.L., Fleischer T.C., Georlette D., Link A.J., and Botchan M.R. Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev. 18 23 (2004) 2929-2940
142. Li Y., Graham C., Lacy S., Duncan A.M., and Whyte P. The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev. 7 12A (1993) 2366-2377
143. Lill N.L., Grossman S.R., Ginsberg D., DeCaprio J., and Livingston D.M. Binding and modulation of p53 by p300/CBP coactivators. Nature 387 6635 (1997) 823-827
144. Lill N.L., Tevethia M.J., Eckner R., Livingston D.M., and Modjtahedi N. p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen. J. Virol. 71 1 (1997) 129-137
145. Lillie J.W., Green M., and Green M.R. An adenovirus E1a protein region required for transformation and transcriptional repression. Cell 46 7 (1986) 1043-1051
146. Lillie J.W., Loewenstein P.M., Green M.R., and Green M. Functional domains of adenovirus type 5 E1a proteins. Cell 50 7 (1987) 1091-1100
147. Lin J.Y., and DeCaprio J.A. SV40 large T antigen promotes dephosphorylation of p130. J. Biol. Chem. 278 47 (2003) 46482-46487
148. Linzer D.I., and Levine A.J. Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17 1 (1979) 43-52
149. Litovchick L., Sadasivam S., Florens L., Zhu X., Swanson S.K., Velmurugan S., Chen R., Washburn M.P., Liu X.S., and DeCaprio J.A. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. Mol. Cell 26 4 (2007) 539-551
150. Liu X., and Marmorstein R. Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor. Genes Dev. 21 21 (2007) 2711-2716
151. Lu X., and Horvitz H.R. lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. Cell 95 7 (1998) 981-991
152. Ludlow J.W., DeCaprio J.A., Huang C.M., Lee W.H., Paucha E., and Livingston D.M. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell 56 1 (1989) 57-65
153. Ludlow J.W., Shon J., Pipas J.M., Livingston D.M., and DeCaprio J.A. The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell 60 3 (1990) 387-396
154. Mak S., Mak I., Gallie B.L., Godbout R., and Phillips R.A. Adenovirus-12 genes undetectable in human retinoblastoma. Int. J. Cancer 30 6 (1982) 697-700
155. Martin R.G., and Chou J.Y. Simian virus 40 functions required for the establishment and maintenance of malignant transformation. J. Virol. 15 3 (1975) 599-612
156. Mayol X., Grana X., Baldi A., Sang N., Hu Q., and Giordano A. Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. Oncogene 8 9 (1993) 2561-2566
157. McMahon S.B., Van Buskirk H.A., Dugan K.A., Copeland T.D., and Cole M.D. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94 3 (1998) 363-374
158. McVey D., Brizuela L., Mohr I., Marshak D.R., Gluzman Y., and Beach D. Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication. Nature 341 6242 (1989) 503-507
159. Mihara K., Cao X.R., Yen A., Chandler S., Driscoll B., Murphree A.L., T'Ang A., and Fung Y.K. Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product. Science 246 4935 (1989) 1300-1303
160. Montell C., Courtois G., Eng C., and Berk A. Complete transformation by adenovirus 2 requires both E1A proteins. Cell 36 4 (1984) 951-961
161. Moran E. A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products. Nature 334 6178 (1988) 168-170
162. Moran E., Grodzicker T., Roberts R.J., Mathews M.B., and Zerler B. Lytic and transforming functions of individual products of the adenovirus E1A gene. J. Virol. 57 3 (1986) 765-775
163. Moran E., Zerler B., Harrison T.M., and Mathews M.B. Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes. Mol. Cell. Biol. 6 10 (1986) 3470-3480
164. Morris E.J., and Dyson N.J. Retinoblastoma protein partners. Adv. Cancer Res. 82 (2001) 1-54
165. Mukai N., Nakajima T., Freddo T., Jacobson M., and Dunn M. Retinoblastoma-like neoplasm induced in C3H/BifB/Ki strain mice by human adenovirus serotype 12. Acta Neuropathol. 39 2 (1977) 147-155
166. Mukai N., Kalter S.S., Cummins L.B., Matthews V.A., Nishida T., and Nakajima T. Retinal tumor induced in the baboon by human adenovirus 12. Science 210 4473 (1980) 1023-1025
167. Munger K., Werness B.A., Dyson N., Phelps W.C., Harlow E., and Howley P.M. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 8 13 (1989) 4099-4105
168. Murzina N.V., Pei X.Y., Zhang W., Sparkes M., Vicente-Garcia J., Pratap J.V., McLaughlin S.H., Ben-Shahar T.R., Verreault A., Luisi B.F., and Laue E.D. Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. Structure 16 7 (2008) 1077-1085
169. Nagl Jr. N.G., Wang X., Patsialou A., Van Scoy M., and Moran E. Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control. EMBO J. 26 3 (2007) 752-763
170. Neill S.D., Hemstrom C., Virtanen A., and Nevins J.R. An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F. Proc. Natl. Acad. Sci. U.S.A. 87 5 (1990) 2008-2012
171. Nevins J.R. Mechanism of activation of early viral transcription by the adenovirus E1A gene product. Cell 26 2 Pt 2 (1981) 213-220
172. Ogryzko V.V., Schiltz R.L., Russanova V., Howard B.H., and Nakatani Y. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87 5 (1996) 953-959
173. Osborn M., and Weber K. Simian virus 40 gene A function and maintenance of transformation. J. Virol. 15 3 (1975) 636-644
174. Osterloh L., von Eyss B., Schmit F., Rein L., Hubner D., Samans B., Hauser S., and Gaubatz S. The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis. EMBO J. 26 1 (2007) 144-157
175. Peden K.W., Pipas J.M., Pearson-White S., and Nathans D. Isolation of mutants of an animal virus in bacteria. Science 209 4463 (1980) 1392-1396
176. Phelps W.C., Bagchi S., Barnes J.A., Raychaudhuri P., Kraus V., Munger K., Howley P.M., and Nevins J.R. Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. J. Virol. 65 12 (1991) 6922-6930
177. Pietenpol J.A., Stein R.W., Moran E., Yaciuk P., Schlegel R., Lyons R.M., Pittelkow M.R., Munger K., Howley P.M., and Moses H.L. TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell 61 5 (1990) 777-785
178. Pines J., and Hunter T. Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell 58 5 (1989) 833-846
179. Poulin D.L., Kung A.L., and DeCaprio J.A. p53 targets simian virus 40 large T antigen for acetylation by CBP. J. Virol. 78 15 (2004) 8245-8253
180. Qian Y.W., Wang Y.C., Hollingsworth Jr. R.E., Jones D., Ling N., and Lee E.Y. A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature 364 6438 (1993) 648-652
181. Rabson A.S., and Kirschstein R.L. Induction of malignancy in vitro in newborn hamster kidney tissue infected with simian vacuolating virus (SV40). Proc. Soc. Exp. Biol. Med. 111 (1962) 323-328
182. Raychaudhuri P., Bagchi S., Devoto S.H., Kraus V.B., Moran E., and Nevins J.R. Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. Genes Dev. 5 7 (1991) 1200-1211
183. Reichel R., Neill S.D., Kovesdi I., Simon M.C., Raychaudhuri P., and Nevins J.R. The adenovirus E4 gene, in addition to the E1A gene, is important for trans-activation of E2 transcription and for E2F activation. J. Virol. 63 9 (1989) 3643-3650
184. Riabowol K., Draetta G., Brizuela L., Vandre D., and Beach D. The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 57 3 (1989) 393-401
185. Rowe D.T., Yee S.P., Otis J., Graham F.L., and Branton P.E. Characterization of human adenovirus type 5 early region 1A polypeptides using antitumor sera and an antiserum specific for the carboxy terminus. Virology 127 2 (1983) 253-271
186. Sachs L., and Winocour E. Formation of different cell-virus relationships in tumour cells induced by polyoma. Nature 184 (1959) 1702-1704
187. Samuelson A.V., Narita M., Chan H.M., Jin J., de Stanchina E., McCurrach M.E., Fuchs M., Livingston D.M., and Lowe S.W. p400 is required for E1A to promote apoptosis. J. Biol. Chem. 280 23 (2005) 21915-21923
188. Schaffhausen B.S., and Benjamin T.L. Phosphorylation of polyoma T antigens. Cell 18 4 (1979) 935-946
189. Sheng Q., Denis D., Ratnofsky M., Roberts T.M., DeCaprio J.A., and Schaffhausen B. The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function. J. Virol. 71 12 (1997) 9410-9416
190. Shew J.Y., Chen P.L., Bookstein R., Lee E.Y., and Lee W.H. Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen. Cell Growth Differ. 1 1 (1990) 17-25
191. Shimazu T., Komatsu Y., Nakayama K.I., Fukazawa H., Horinouchi S., and Yoshida M. Regulation of SV40 large T-antigen stability by reversible acetylation. Oncogene 25 56 (2006) 7391-7400
192. Smith A.E., Smith R., Griffin B., and Fried M. Protein kinase activity associated with polyoma virus middle T antigen in vitro. Cell 18 4 (1979) 915-924
193. Smith A.E., Smith R., and Paucha E. Characterization of different tumor antigens present in cells transformed by simian virus 40. Cell 18 2 (1979) 335-346
194. Smith D.H., and Ziff E.B. The amino-terminal region of the adenovirus serotype 5 E1a protein performs two separate functions when expressed in primary baby rat kidney cells. Mol. Cell. Biol. 8 9 (1988) 3882-3890
195. Sparkes R.S., Murphree A.L., Lingua R.W., Sparkes M.C., Field L.L., Funderburk S.J., and Benedict W.F. Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D. Science 219 4587 (1983) 971-973
196. Srinivasan A., McClellan A.J., Vartikar J., Marks I., Cantalupo P., Li Y., Whyte P., Rundell K., Brodsky J.L., and Pipas J.M. The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain. Mol. Cell. Biol. 17 8 (1997) 4761-4773
197. Stabel S., Argos P., and Philipson L. The release of growth arrest by microinjection of adenovirus E1A DNA. EMBO J. 4 9 (1985) 2329-2336
198. Stein R.W., and Ziff E.B. Repression of insulin gene expression by adenovirus type 5 E1a proteins. Mol. Cell. Biol. 7 3 (1987) 1164-1170
199. Stein G.H., Beeson M., and Gordon L. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249 4969 (1990) 666-669
200. Stein R.W., Corrigan M., Yaciuk P., Whelan J., and Moran E. Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity. J. Virol. 64 9 (1990) 4421-4427
201. Stewart S.E., Eddy B.E., Gochenour A.M., Borgese N.G., and Grubbs G.E. The induction of neoplasms with a substance released from mouse tumors by tissue culture. Virology 3 2 (1957) 380-400
202. Stubdal H., Zalvide J., Campbell K.S., Schweitzer C., Roberts T.M., and DeCaprio J.A. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol. Cell. Biol. 17 9 (1997) 4979-4990
203. Stubdal H., Zalvide J., and DeCaprio J.A. Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107. J. Virol. 70 5 (1996) 2781-2788
204. Sullivan C.S., Baker A.E., and Pipas J.M. Simian virus 40 infection disrupts p130-E2F and p107-E2F complexes but does not perturb pRb-E2F complexes. Virology 320 2 (2004) 218-228
205. Sullivan C.S., Tremblay J.D., Fewell S.W., Lewis J.A., Brodsky J.L., and Pipas J.M. Species-specific elements in the large T-antigen J domain are required for cellular transformation and DNA replication by simian virus 40. Mol. Cell. Biol. 20 15 (2000) 5749-5757
206. Sweet B.H., and Hilleman M.R. The vacuolating virus, S.V. 40. Proc. Soc. Exp. Biol. Med. 105 (1960) 420-427
207. Taya Y., Yasuda H., Kamijo M., Nakaya K., Nakamura Y., Ohba Y., and Nishimura S. In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase. Biochem. Biophys. Res. Commun. 164 1 (1989) 580-586
208. Taylor-Harding B., Binne U.K., Korenjak M., Brehm A., and Dyson N.J. p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-regulated genes. Mol. Cell. Biol. 24 20 (2004) 9124-9136
209. Tegtmeyer P. Function of simian virus 40 gene A in transforming infection. J. Virol. 15 3 (1975) 613-618
210. Templeton D.J., Park S.H., Lanier L., and Weinberg R.A. Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering. Proc. Natl. Acad. Sci. U.S.A. 88 8 (1991) 3033-3037
211. Todaro G.J., and Green H. An assay for cellular transformation by SV40. Virology 23 1 (1964) 117-119
212. Trentin J.J., Yabe Y., and Taylor G. The quest for human cancer viruses. Science 137 (1962) 835-841
213. Tsai L.H., Harlow E., and Meyerson M. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature 353 6340 (1991) 174-177
214. Tworkowski K.A., Chakraborty A.A., Samuelson A.V., Seger Y.R., Narita M., Hannon G.J., Lowe S.W., and Tansey W.P. Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc. Proc. Natl. Acad. Sci. U.S.A. 105 16 (2008) 6103-6108
215. Ueno T., Suzuki N., Kaneko A., and Fujinaga K. Analysis of retinoblastoma for human adenovirus and human JC virus genome integration. Jpn. J. Ophthalmol. 31 2 (1987) 274-283
216. van den Heuvel S., and Dyson N.J. Conserved functions of the pRB and E2F families. Nat. Rev., Mol. Cell Biol. 9 9 (2008) 713-724
217. van Ormondt H., Maat J., and Dijkema R. Comparison of nucleotide sequences of the early E1a regions for subgroups A, B and C of human adenoviruses. Gene 12 1-2 (1980) 63-76
218. Velcich A., and Ziff E. Adenovirus E1a ras cooperation activity is separate from its positive and negative transcription regulatory functions. Mol. Cell. Biol. 8 5 (1988) 2177-2183
219. Velcich A., Kern F.G., Basilico C., and Ziff E.B. Adenovirus E1a proteins repress expression from polyomavirus early and late promoters. Mol. Cell. Biol. 6 11 (1986) 4019-4025
220. Vogt M., and Dulbecco R. Virus-cell interaction with a tumor-producing virus. Proc. Natl. Acad. Sci. U.S.A. 46 3 (1960) 365-370
221. Vousden K.H., and Jat P.S. Functional similarity between HPV16E7, SV40 large T and adenovirus E1a proteins. Oncogene 4 2 (1989) 153-158
222. Wang H.G., Rikitake Y., Carter M.C., Yaciuk P., Abraham S.E., Zerler B., and Moran E. Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth. J. Virol. 67 1 (1993) 476-488
223. Whitman M., Kaplan D.R., Schaffhausen B., Cantley L., and Roberts T.M. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature 315 6016 (1985) 239-242
224. Whyte P., Buchkovich K.J., Horowitz J.M., Friend S.H., Raybuck M., Weinberg R.A., and Harlow E. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334 6178 (1988) 124-129
225. Windle J.J., Albert D.M., O'Brien J.M., Marcus D.M., Disteche C.M., Bernards R., and Mellon P.L. Retinoblastoma in transgenic mice. Nature 343 6259 (1990) 665-669
226. Xiao B., Spencer J., Clements A., Ali-Khan N., Mittnacht S., Broceno C., Burghammer M., Perrakis A., Marmorstein R., and Gamblin S.J. Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation. Proc. Natl. Acad. Sci. U.S.A. 100 5 (2003) 2363-2368
227. Yaciuk P., Carter M.C., Pipas J.M., and Moran E. Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products. Mol. Cell. Biol. 11 4 (1991) 2116-2124
228. Yee A.S., Reichel R., Kovesdi I., and Nevins J.R. Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex. EMBO J. 6 7 (1987) 2061-2068
229. Yee S.P., and Branton P.E. Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides. Virology 147 1 (1985) 142-153
230. Yew P.R., and Berk A.J. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature 357 6373 (1992) 82-85
231. Young A.P., Schlisio S., Minamishima Y.A., Zhang Q., Li L., Grisanzio C., Signoretti S., and Kaelin Jr. W.G. VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. Nat. Cell Biol. 10 3 (2008) 361-369
232. Yunis J.J., and Ramsay N. Retinoblastoma and subband deletion of chromosome 13. Am. J. Dis. Child. 132 2 (1978) 161-163
233. Zalvide J., and DeCaprio J.A. Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation. Mol. Cell. Biol. 15 10 (1995) 5800-5810
234. Zalvide J., Stubdal H., and DeCaprio J.A. The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins. Mol. Cell. Biol. 18 3 (1998) 1408-1415
235. Zhang Q., Yao H., Vo N., and Goodman R.H. Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP. Proc. Natl. Acad. Sci. U.S.A. 97 26 (2000) 14323-14328
236. Zhu J.Y., Abate M., Rice P.W., and Cole C.N. The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53. J. Virol. 65 12 (1991) 6872-6880
237. Zu Rhein G.M. Studies of JC virus-induced nervous system tumors in the Syrian hamster: a review. Prog. Clin. Biol. Res. 105 (1983) 205-221