Species-specific elements in the large T-antigen J domain are required for cellular transformation and DNA replication by simian virus 40

Molecular and Cellular Biology

Volumn 20, Issue 15, 2000, Pages 5749-5757

  Sullivan, Christopher S ^a   Tremblay, James D ^a   Fewell, Sheara W ^a   Lewis, John A ^a   Brodsky, Jeffrey L ^a   Pipas, James M ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS LARGE T ANTIGEN;

ANTIGEN BINDING; ARTICLE; CELL TRANSFORMATION; DNA REPLICATION; ESCHERICHIA COLI; GENE SEQUENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIMIAN VIRUS 40; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, VIRAL, TUMOR; BACTERIAL PROTEINS; BINDING SITES; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL TRANSFORMATION, VIRAL; DNA REPLICATION; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; ESCHERICHIA COLI PROTEINS; FUNGAL PROTEINS; HEAT-SHOCK PROTEINS; HSP40 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; JC VIRUS; MAMMALS; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROTEINS; RECOMBINANT PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P130; SACCHAROMYCES CEREVISIAE PROTEINS; SIMIAN VIRUS 40; SPECIES SPECIFICITY; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; VIRUS REPLICATION;

ANIMALIA; DNA VIRUSES; ESCHERICHIA COLI; JC VIRUS; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

EID: 0033929731     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.15.5749-5757.2000     Document Type: Article

References (45)

1. Barik, S. 1993. Site-directed mutagenesis by double polymerase chain reaction: megaprimer method. Methods Mol. Biol. 15:277-286.
2. Becker, J., W. Walter, W. Yan, and E. A. Craig. 1996. Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydjlp, in protein translocation in vivo. Mol. Cell. Biol. 16:4378-4386.
3. Bimston, J. Song, D. Winchester, S. Takayama, J. C. Reed, and R. I. Morimoto. 1998. BAG-1, a negative regulator of hsc70 chaperone activity, uncouples nucleotide hydrolysis from substrate release. EMBO J. 17:6871-6878.
4. Brodsky, J. L., S. Hamamoto, D. Feldheim, and R. Schekman. 1993. Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic hsc70. J. Cell Biol. 120:95-102.
5. Brodsky, J. L., and J. M. Pipas. 1998. Polyomavirus T antigens: molecular chaperones for multiprotein complexes. J. Virol. 72:5329-5334.
6. Campbell, K. S., K. P. Mullane, I. A. Aksoy, H. Stubdal, J. Zalvide, J. M. Pipas, P. A. Silver, T. M. Roberts, B. S. Schaffhausen, and J. A. DeCaprio. 1997. DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev. 11:1098-1110.
7. Cantalupo, P., M. T. Sáenz-Robles, and J. M. Pipas. 1999. Expression of SV40 large T antigen in Baculovirus systems and purification by immunoaffinity chromatography. Methods Enzymol. 306:297-307.
8. Caplan, A. J., J. Tsai, P. J. Casey, and M. G. Douglas. 1992. Farnesylation of Ydjlp is required for function at elevated growth temperatures in Saccharomyces cerevisiae. J. Biol. Chem. 267:18890-18895.
9. Chuke, W. F., D. L. Walker, L. B. Peitzman, and R. J. Frisque. 1986. Construction and characterization of hybrid polyomavirus genomes. J. Virol. 60:960-971.
10. Cyr, D. M. 1995. Cooperation of the molecular chaperone Ydjlp with specific Hsp70 homologs to suppress protein aggregation. FEBS Lett. 359:129-132.
11. Cyr, D. M., and M. G. Douglas. 1994. Differential regulation of Hsp70 subfamilies by the eukaryotic DnaJ homologue YDJ1. J. Biol. Chem. 269: 9798-9804.
12. DeCaprio, J. A., J. W. Ludlow, J. Figge, J. Y. Shew, C. M. Huang, W. H. Lee, E. Marsilio, E. Paucha, and D. M. Livingston. 1988. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54:275-283.
13. Davis, J. E., C. Voisine, and E. Craig. 1999. Intragenic suppressors of Hsp70 mutants: Interplay between the ATPase-and peptide-binding domains. Proc. Natl. Acad. Sci. USA 16:9269-9276.
14. Dornreiter, I., A. Hoss, A. K. Arthur, and E. Fanning. 1990. SV40 T antigen binds directly to the large subunit of purified DNA polymerase alpha. EMBO J. 9:3329-3336.
15. Dyson, N., K. Buchkovich, P. Whyte, and E. Harlow. 1989. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell 58:249-255.
16. Ewen, M. E., J. W. Ludlow, E. Marsilio, J. A. DeCaprio, R. C. Millikan, S. H. Cheng, E. Paucha, and D. M. Livingston. 1989. An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein p120. Cell 2:405-415.
17. Feldheim, D., J. Rothblatt, and R. Schekman. 1992. Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation. Mol. Cell. Biol. 12:3288-3296.
18. Frisque, R. J., G. L. Bream, and M. T. Cannella. 1984. Human polyomavirus JC virus genome. J. Virol. 51:458-469.
19. Greene, M. K., K. Maskos, and S. J. Landry. 1998. Role of the J-domain in the cooperation of Hsp40 with Hsp70. Proc. Natl. Acad. Sci. USA 95:6108-6113.
20. Harris, K. F., J. B. Christensen, E. H. Radany, and M. J. Imperiale. 1998. Novel mechanisms of E2F induction by BK virus large T antigen: requirement of both the pRB-binding and the J domains. Mol. Cell. Biol. 18:1746-1756.
21. Hartl, F. U. 1996. Molecular chaperones in cellular protein folding. Nature 381:571-580.
22. Höhfeld, J. 1998. Regulation of the heat shock cognate hsc70 in the mammalian cell: the characterization of the anti-apoptotic protein BAG-1 provides novel insights. Biol. Chem. 379:269-274.
23. Kelley, W. L., and C. Georgopoulos. 1997. The T/t common exon of SV40, JCV, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone. Proc. Natl. Acad. Sci. USA 94:3679-3684.
24. King, C., E. Eisenberg, and L. Greene. 1995. Polymerization of 70-kDa heat shock protein by yeast DnaJ in ATP. J. Biol. Chem. 270:22535-22540.
25. Lai, C.-J., and D. Nathans. 1974. Deletion mutants of simian virus 40 generated by enzymatic excision of DNA segments from the viral genome. J. Mol. Biol. 89:179-193.
26. Lane, D. P., and L. V. Crawford. 1979. T antigen is bound to a host protein in SV40-transformed cells. Nature 278:261-263.
27. Levy, E. J., B. Bukau, and W. J. Chirico. 1995. Conserved ATPase and luciferase refolding activities between bacteria and yeast hsp70 chaperones and modulators. FEBS Lett. 368:435-440.
28. Linzer, D. I., and A. J. Levine. 1979. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17:43-52.
29. Lu, Z., and D. M. Cyr. 1998. Protein folding activity of hsp70 is modified differentially by the hsp40 co-chaperones Sis1 and Ydjl. J. Biol. Chem. 273:27824-27830.
30. McClellan, A. J., J. Endres, J. P. Vogel, D. Palazzi, M. D. Rose, and J. L. Brodsky. 1998. Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into yeast ER. Mol. Biol. Cell 9:3533-3545.
31. Peden, K. W. C., and J. M. Pipas. 1992. Simian virus 40 mutants with amino acid substitutions near the amino-terminus of large T antigen. Virus Genes 6:107-118.
32. Peden, K. W. C., J. M. Pipas, S. Pearson-White, and D. Nathans. 1980 Isolation of mutants of an animal virus in bacteria. Science 209:1392-1396.
33. Pipas, J. M. 1992. Common and unique features of T antigens encoded by the polyoma group. J. Virol. 66:979-985.
34. Schlenstedt, G., S. Harris, B. Risse, R. Lill, and P. A. Silver. 1995. A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with hsp70s. J. Cell Biol. 129:979-988.
35. Schumacher, R. J., W. J. Hansen, B. C. Freeman, E. Alnemri, G. Litwack, and D. O. Toft. 1996. Cooperative action of hsp70, hsp90 and DnaJ proteins in protein renaturation. Biochemistry 35:14889-14898.
36. Sock, E., J. Enderich, and M. Wegner. 1999. The J domain of papovaviral large tumor antigen is required for synergistic interaction with the POU-domain protein Tst-1/Oct6/SCIP. Mol. Cell. Biol. 19:2455-2464.
37. Spence, S. L., and J. M. Pipas. 1994. SV40 large T antigen functions at two distinct steps in virion assembly. Virology 204:200-209.
38. Srinivasan, A., A. J. McClellan, J. Vartikar, I. Marks, P. Cantalupo, Y. Li, P. Whyte, K. Rundell, J. L. Brodsky, and J. M. Pipas. 1997. The amino-terminal transforming region of SV40 large and small T antigens function as a J-domain. Mol. Cell. Biol. 17:4761-4773.
39. Stubdal, H., J. Zalvide, K. S. Campbell, C. Schweitzer, T. M. Roberts, and J. A. DeCaprio. 1997. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol. Cell. Biol. 17:4979-4990.
40. Sullivan, C. S., P. Cantalupo, and J. M. Pipas. Mol. Cell. Biol., in press.
41. Tsai, J., and M. G. Douglas. 1996. A conserved HPD sequence of the J domain is necessary for YDJ1 stimulation of Hsp70 ATPase activity at a site distinct from substrate binding. J. Biol. Chem. 271:9347-9354.
42. 2-terminal 108 amino acids of Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for λ replication. J. Biol. Chem. 269:5446-5451.
43. Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
44. Yan, W., and E. A. Craig. 1999. The glycine-phenylalanine-rich region determines the specificity of the yeast hsp40, Sis1. Mol. Cell. Biol. 19:7751-7758.
45. Zalvide, J., H. Stubdal, and J. A. DeCaprio. 1998. The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins. Mol. Cell. Biol. 18:1408-1415.