Effect of metal ions on radical intensity and cytotoxic activity of ascorbate

Anticancer Research

Volumn 17, Issue 2 A, 1997, Pages 1125-1129

  Satoh, Kazue ^a,b   Sakagami, Hiroshi ^b  

^a Kitasato University   (Japan)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

Ascorbate; Ascorbyl radical; Cytotoxicity; Degradation; Metal ions

Indexed keywords

ALBUMIN; ASCORBIC ACID; CALCIUM ION; COPPER ION; FERRIC ION; FERROUS ION; FREE RADICAL; MAGNESIUM ION; MANGANESE; METAL ION; POTASSIUM ION; SODIUM ION; ZINC;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG DEGRADATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SERUM;

ASCORBIC ACID; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; FERROUS COMPOUNDS; FREE RADICALS; HUMANS; HYDROGEN-ION CONCENTRATION; IRON; METALS; ZINC;

EID: 0030932653     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Iyanagi T, Yamazaki I and Anan KF: One-electron oxidation reduction properties of ascorbic acid. Biochim Biophys Act 806: 255-261, 1985.
2. Sakagami H, Satoh K, Ohata H, Takahashi H, Yoshida H, Iida M, Kuribayashi N, Sakagami T, Momose K and Takeda M: Relationship between ascorbyl radical intensity and apoptosis inducing activity. Anticancer Res 16: 2635-2644, 1996.
3. Satoh K and Sakagami H: Ascorbyl radical scavenging activity of polyphenols. Anticancer Res 16: 2885-2890, 1996.
4. Satoh K, Sakagami H and Nakamura K: Enhancement of radical intensity and cytotoxic activity of ascorbate by PSK and lignins. Anticancer Res 16: 2981-2986, 1996.
5. Satoh K, Sakagami H and Nakamura K: Enhancement of radical intensity and cytotoxic activity of ascorbate by hyperthermia. Anticancer Res 16: 2987-2992, 1996.
6. Sakagami H and Satoh K: The interaction between two antioxidants, sodium ascorbate and gallic acid: Radical intensity and apoptosis induction. Anticancer Res 16: 1231-1234, 1996.
7. Sakagami H, Satoh K, Sugaya K, Iida M, Hirota N, Matsumoto K, Kimura S, Gomi K, Taguchi S, Kato S and Takeda M: Effect of the type of serum in the medium on sodium ascorbate-induced cytotoxicity. Anticancer Res 16: 1937-1942, 1996.
8. Khan MMT and Martell AE: Metal ion and metal chelate catalyzed oxidation of ascorbic acid by molecular oxygen. I. Cupric and ferricion catalyzed oxidation. J Am Chem Soc 89: 4176-4185, 1967.
9. Fujita Y, Komagoe K, Uehara I, Morimoto Y and Hara R: Studies on inhibition mechanism of autoxidation by tannins and flavonoids. IV. Acceleration mechanism of methyl linoleate peroxidation induced by the presence of tannin and Cu(II) ion. (In Japanese). YAKUGAKU ZASSHI 108: 625-634, 1988
10. Halliwell B and Gutteridge JMC: Role of free radicals and catalytic metal ions in human disease. An overview. Method Enzymol 186: 1-85, 1990.
11. Bram S, Froussard P, Guichard M, Jasmin C, Augery Y, SinoussiBarre F and Wray W: Vitamin C preferential toxicity for malignant melanoma cells. Nature 284: 629-631, 1980.
12. Chiou S-H, Chang W-C, Jou Y-S, Chung H-MM and Lo TB: Specific cleavages of DNA by ascorbate in the presence of copper ion or copper chelates. J Biochem 98: 1723-1726, 1985.