Soluble nickel interferes with cellular iron homeostasis

Molecular and Cellular Biochemistry

Volumn 279, Issue 1-2, 2005, Pages 157-162

  Davidson, Todd ^a   Chen, Haobin ^a   Garrick, Michael D ^b   D'Angelo, Gisela ^c   Costa, Max ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c INSERM   (France)

Author keywords

Divalent metal ion transporter 1; HIF 1 ; Iron; Nickel; Prolyl hydroxylase; Von Hippel Lindau

Indexed keywords

CARCINOGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NICKEL; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; VON HIPPEL LINDAU PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CARCINOGENESIS; CELL CULTURE; CELL LINE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; HOMEOSTASIS; HUMAN; HUMAN CELL; IRON TRANSPORT; PROTEIN BINDING; WESTERN BLOTTING;

BINDING, COMPETITIVE; CARCINOGENS; CATION TRANSPORT PROTEINS; CELL LINE; HOMEOSTASIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON; NICKEL; PROCOLLAGEN-PROLINE DIOXYGENASE; SOLUBILITY; TIME FACTORS; TRANSFERRIN; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 30344452292     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-005-8288-y     Document Type: Article

References (32)

1. International Agency for Research on Cancer I: Monographs on the Evaluation of Carcinogenic Risks to Humans: Chromium Nickel and Welding. Lyon, France, 1990
2. Kasprzak KS, Sunderman FW, Jr., Salnikow K: Nickel carcinogenesis. Mutat Res 533: 67-97, 2003 14643413
3. McEwan JC: Cytological monitoring of nickel sinter plant workers. Ann NY Acad Sci 271: 365-369, 1976 1069525
4. Roberts RS, Julian JA, Muir DC, Shannon HS: Cancer mortality associated with the high-temperature oxidation of nickel subsulfide. IARC Sci Publ, Vol. 53: 23-35, 1984
5. Costa M, Sutherland JE, Peng W, Salnikow K, Broday L, Kluz T: Molecular biology of nickel carcinogenesis. Mol Cell Biochem 222: 205-211, 2001 11678603
6. Anttila A, Pukkala E, Aitio A, Rantanen T, Karjalainen S: Update of cancer incidence among workers at a copper/nickel smelter and nickel refinery. Int Arch Occup Environ Health 71: 245-250, 1998 9638480
7. Grimsrud TK, Berge SR, Haldorsen T, Andersen A: Exposure to different forms of nickel and risk of lung cancer. Am J Epidemiol 156: 1123-1132, 2002 10.1093/aje/kwf165
8. Grimsrud TK, Berge SR, Martinsen JI, Andersen A: Lung cancer incidence among Norwegian nickel-refinery workers 1953-2000. J Environ Monit 5: 190-197, 2003 10.1039/b211722n
9. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA: Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388: 482-488, 1997 10.1038/41343
10. Garrick MD, Dolan KG, Horbinski C, Ghio AJ, Higgins D, Porubcin M, Moore EG, Hainsworth LN, Umbreit JN, Conrad ME, Feng L, Lis A, Roth JA, Singleton S, Garrick LM: DMT1: A mammalian transporter for multiple metals. BioMetals 16: 41-54, 2003 10.1023/A:1020702213099
11. Farcich EA, Morgan EH: Uptake of transferrin-bound and nontransferrin-bound iron by reticulocytes from the Belgrade laboratory rat: Comparison with Wistar rat transferrin and reticulocytes. Am J Hematol 39: 9-14, 1992 1536148
12. Garrick LM, Dolan KG, Romano MA, Garrick MD: Non-transferrin-bound iron uptake in Belgrade and normal rat erythroid cells. J Cell Physiol 178: 349-358, 1999 9989781
13. Chen H, Davidson T, Singleton S, Garrick MD, Costa M: Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol Appl Pharmacol, in press.
14. Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ: C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107: 43-54, 2001 10.1016/S0092-8674(01)00507-4
15. 2-regulated prolyl hydroxylation. Science 292: 468-472, 2001 11292861
16. Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML: Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295: 858-861, 2002 10.1126/science.1068592
17. Salnikow K, Davidson T, Costa M: The role of hypoxia-inducible signaling pathway in nickel carcinogenesis. Environ Health Perspect 110: 831-834, 2002 12426141
18. Semenza GL: HIF-1 aOd human disease: one highly involved factor. Genes Dev 14: 1983-1991, 1983
19. Maxwell PH, Ratcliffe PJ: Oxygen sensors and angiogenesis. Semin Cell Dev Biol 13: 29-37, 2002 10.1006/scdb.2001.0287
20. Wiesener MS, MaxweAl PH: HIF and oxygen sensing: as important to life as the air we breathe? Ann Med 35: 183-190, 2003
21. D'Angelo G, Duplan E, Boyer N, Vigne P, Frelin C: Hypoxia up-regulates prolyl hydroxylase activity: A feedback mechanism that limits HIF-1 responses during reoxygenation. J Biol Chem 278: 38183-38187, 2003 10.1074/jbc.M302244200
22. Knopfel M, Zhao L, Garrick MD: Transport of divalent transition-metal ions is lost in small-intestinal tissue of b/b Belgrade rats. Biochemistry 44(9): 3454-3465, 2005 10.1021/bi048768+
23. MAxwell P, Salnikow K: HIF-1: an oxygen and metal responsive transcription factor. Cancer Biol Ther 3: 29-35, 2004 14726713
24. Batie CJ, Ballou DP: Phthalate dioxygenase. Meth Enzymol 188: 61-70, 1990 2280719
25. Batie CJ, LaHaie E, Ballou DP: Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia. J Biol Chem 262: 1510-1518, 1987 3805038
26. Oshiro S, Nozawa K, Hori M, Zhang C, Hashimoto Y, Kitajima S, Kawamura K: Modulation of iron regulatory protein-1 by various metals. Biochem Biophys Res Commun 290: 213-218, 2002 11779155
27. Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS: Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J Biol Chem 279: 40337-40344, 2004 15271983
28. Bridges KR, Hoffman KE: The effects of ascorbic acid on the intracellular metabolism of iron and ferritin. J Biol Chem 261: 14273-14277, 1986 3464594
29. Toth I, Rogers JT, McPhee JA, Elliott SM, Abramson SL, Bridges KR: Ascorbic acid enhances iron-induced ferritin translation in human leukemia and hepatoma cells. J Biol Chem 270: 2846-2852, 1995 10.1074/ jbc.270.6.2846
30. Toth I, Bridges KR: Ascorbic acid enhances ferritin mRNA translation by an IRP/aconitase switch. J Biol Chem 270: 19540-19544, 1995 10.1074/ jbc.270.33.19540
31. Hanahan D, Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364, 1996 10.1016/ S0092-8674(00)80108-7
32. Erez N, Milyavsky M, Eilam R, Shats I, Goldfinger N, Rotter V: Expression of prolyl-hydroxylase-1 (PHD1/EGNL2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth. Cancer Res 63: 8777-8783, 2003