MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres

Aging Cell

Volumn 8, Issue 1, 2009, Pages 2-17

  Martinez, Paula ^a   Siegl Cachedenier, Irene ^a   Flores, Juana M ^b   Blasco, Maria A ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Aging; Cancer; MMR; Mouse models; Telomeres

Indexed keywords

PROTEIN MSH2; PROTEIN P21; PROTEIN P53;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; GASTROINTESTINAL DISEASE; GENE MUTATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; SHORT TELOMERE; SIGNAL TRANSDUCTION; TELOMERE; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

AGING; ANIMALS; CELL CYCLE; CHROMOSOMAL INSTABILITY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; INTESTINE, SMALL; LIFE EXPECTANCY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; MUTS HOMOLOG 2 PROTEIN; NEOPLASMS, EXPERIMENTAL; RECOMBINATION, GENETIC; TELOMERASE; TELOMERE; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 59049097927     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2008.00441.x     Document Type: Article

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