USP14 inhibits ER-associated degradation via interaction with IRE1α

Biochemical and Biophysical Research Communications

Volumn 379, Issue 4, 2009, Pages 995-1000

  Nagai, Atsushi ^a   Kadowaki, Hisae ^a,b   Maruyama, Takeshi ^a,b   Takeda, Kohsuke ^b   Nishitoh, Hideki ^a,b   Ichijo, Hidenori ^b  

^a Graduate School   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

ER stress; ERAD; IRE1; USP14

Indexed keywords

INOSITOL DERIVATIVE; INOSITOL REQUIRING ENZYME 1 ALPHA; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE; UBIQUITIN SPECICIFC PROTEASE 14; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; EMBRYO; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INTERACTION; UNFOLDED PROTEIN RESPONSE;

ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; HELA CELLS; HUMANS; MEMBRANE PROTEINS; PROTEIN FOLDING; PROTEIN-SERINE-THREONINE KINASES; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITIN THIOLESTERASE;

EUKARYOTA;

EID: 58949093382     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.12.182     Document Type: Article

References (29)

1. Kang S.W., Rane N.S., Kim S.J., Garrison J.L., Taunton J., and Hegde R.S. Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway. Cell 127 (2006) 999-1013
2. Schroder M., and Kaufman R.J. Divergent roles of IRE1alpha and PERK in the unfolded protein response. Curr. Mol. Med. 6 (2006) 5-36
3. Sekine Y., Takeda K., and Ichijo H. The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases. Curr. Mol. Med. 6 (2006) 87-97
4. Nishitoh H., Kadowaki H., Nagai A., Maruyama T., Yokota T., Fukutomi H., Noguchi T., Matsuzawa A., Takeda K., and Ichijo H. ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. Genes Dev. 22 (2008) 1451-1464
5. Bertolotti A., Zhang Y., Hendershot L.M., Harding H.P., and Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2 (2000) 326-332
6. Bertolotti A., Wang X., Novoa I., Jungreis R., Schlessinger K., Cho J.H., West A.B., and Ron D. Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J. Clin. Invest. 107 (2001) 585-593
7. Yoshida H., Matsui T., Yamamoto A., Okada T., and Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107 (2001) 881-891
8. Hosokawa N., Wada I., Hasegawa K., Yorihuzi T., Tremblay L.O., Herscovics A., and Nagata K. A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. EMBO Rep. 2 (2001) 415-422
9. Gardner R.G., Shearer A.G., and Hampton R.Y. In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Mol. Cell Biol. 21 (2001) 4276-4291
10. Lilley B.N., and Ploegh H.L. A membrane protein required for dislocation of misfolded proteins from the ER. Nature 429 (2004) 834-840
11. Ye Y., Shibata Y., Yun C., Ron D., and Rapoport T.A. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature 429 (2004) 841-847
12. Oda Y., Okada T., Yoshida H., Kaufman R.J., Nagata K., and Mori K. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. J. Cell Biol. 172 (2006) 383-393
13. Welihinda A.A., Tirasophon W., Green S.R., and Kaufman R.J. Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase. Mol. Cell Biol. 18 (1998) 1967-1977
14. Oono K., Yoneda T., Manabe T., Yamagishi S., Matsuda S., Hitomi J., Miyata S., Mizuno T., Imaizumi K., Katayama T., and Tohyama M. JAB1 participates in unfolded protein responses by association and dissociation with IRE1. Neurochem. Int. 45 (2004) 765-772
15. Nguyen D.T., Kebache S., Fazel A., Wong H.N., Jenna S., Emadali A., Lee E.H., Bergeron J.J., Kaufman R.J., Larose L., and Chevet E. Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress. Mol. Biol. Cell 15 (2004) 4248-4260
16. Hetz C., Bernasconi P., Fisher J., Lee A.H., Bassik M.C., Antonsson B., Brandt G.S., Iwakoshi N.N., Schinzel A., Glimcher L.H., and Korsmeyer S.J. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312 (2006) 572-576
17. Iwawaki T., Hosoda A., Okuda T., Kamigori Y., Nomura-Furuwatari C., Kimata Y., Tsuru A., and Kohno K. Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. Nat. Cell Biol. 3 (2001) 158-164
18. Urano F., Wang X., Bertolotti A., Zhang Y., Chung P., Harding H.P., and Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287 (2000) 664-666
19. Nishitoh H., Matsuzawa A., Tobiume K., Saegusa K., Takeda K., Inoue K., Hori S., Kakizuka A., and Ichijo H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16 (2002) 1345-1355
20. Guterman A., and Glickman M.H. Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome. J. Biol. Chem. 279 (2004) 1729-1738
21. Crimmins S., Jin Y., Wheeler C., Huffman A.K., Chapman C., Dobrunz L.E., Levey A., Roth K.A., Wilson J.A., and Wilson S.M. Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14. J. Neurosci. 26 (2006) 11423-11431
22. Wilson S.M., Bhattacharyya B., Rachel R.A., Coppola V., Tessarollo L., Householder D.B., Fletcher C.F., Miller R.J., Copeland N.G., and Jenkins N.A. Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat. Genet. 32 (2002) 420-425
23. Borodovsky A., Kessler B.M., Casagrande R., Overkleeft H.S., Wilkinson K.D., and Ploegh H.L. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. EMBO J. 20 (2001) 5187-5196
24. Hu M., Li P., Song L., Jeffrey P.D., Chenova T.A., Wilkinson K.D., Cohen R.E., and Shi Y. Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J. 24 (2005) 3747-3756
25. Leggett D.S., Hanna J., Borodovsky A., Crosas B., Schmidt M., Baker R.T., Walz T., Ploegh H., and Finley D. Multiple associated proteins regulate proteasome structure and function. Mol. Cell 10 (2002) 495-507
26. Hanna J., Hathaway N.A., Tone Y., Crosas B., Elsasser S., Kirkpatrick D.S., Leggett D.S., Gygi S.P., King R.W., and Finley D. Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell 127 (2006) 99-111
27. Kopito R.R. ER quality control: the cytoplasmic connection. Cell 88 (1997) 427-430
28. Tsai B., Ye Y., and Rapoport T.A. Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat. Rev. Mol. Cell Biol. 3 (2002) 246-255
29. Meusser B., Hirsch C., Jarosch E., and Sommer T. ERAD: the long road to destruction. Nat. Cell Biol. 7 (2005) 766-772