Structural Insights into the Association between BCAR3 and Cas Family Members, an Atypical Complex Implicated in Anti-Oestrogen Resistance

Journal of Molecular Biology

Volumn 386, Issue 1, 2009, Pages 190-203

  Garron, Marie Line ^a,b,c   Arsenieva, Diana ^a,b,c   Zhong, Jessie ^d,e   Bloom, Alexander B ^f   Lerner, Adam ^f   O'Neill, Geraldine M ^d,e   Arold, Stefan T ^a,b,c  

^a INSERM   (France)

^b CENTRE DE BIOCHIMIE STRUCTURALE   (France)

^c UNIV MONTPELLIER   (France)

^d CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^e UNIVERSITY OF SYDNEY   (Australia)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

breast cancer anti oestrogen resistance; focal adhesion; isothermal titration calorimetry; protein protein interaction; signal transduction

Indexed keywords

ANTIESTROGEN; BREAST CANCER ANTIESTROGEN RESISTANCE 3 PROTEIN; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATE; HUMAN ENHANCER OF FILAMENTATION 1 PROTEIN; MEMBRANE PROTEIN; NEUROENDOCRINE SPECIFIC PROTEIN; NUCLEAR PROTEIN; SOS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL FUNCTION; CIRCULAR DICHROISM; ENZYME REGULATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RADIATION SCATTERING; SITE DIRECTED MUTAGENESIS;

EID: 58849146735     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.12.010     Document Type: Article

References (46)

1. van Agthoven T., van Agthoven T.L., Dekker A., van der Spek P.J., Vreede L., and Dorssers L.C. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J. 17 (1998) 2799-2808
2. O'Neill G.M., Fashena S.J., and Golemis E.A. Integrin signalling: a new Cas(t) of characters enters the stage. Trends Cell Biol. 10 (2000) 111-119
3. Defilippi P., Di Stefano P., and Cabodi S. p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol. 16 (2006) 257-263
4. Singh M., Cowell L., Seo S., O'Neill G., and Golemis E. Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle. Cell Biochem. Biophys. 48 (2007) 54-72
5. Brinkman A., van der Flier S., Kok E.M., and Dorssers L.C. BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. J. Natl. Cancer Inst. 92 (2000) 112-120
6. Riggins R.B., Thomas K.S., Ta H.Q., Wen J., Davis R.J., Schuh N.R., et al. Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b. Cancer Res. 66 (2006) 7007-7015
7. Near R.I., Zhang Y., Makkinje A., Vanden Borre P., and Lerner A. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. J. Cell. Physiol. 212 (2007) 655-665
8. Kim M., Gans J.D., Nogueira C., Wang A., Paik J.H., Feng B., et al. Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell 125 (2006) 1269-1281
9. Natarajan M., Stewart J.E., Golemis E.A., Pugacheva E.N., Alexandropoulos K., Cox B.D., et al. HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells. Oncogene 25 (2006) 1721-1732
10. Ji H., Ramsey M.R., Hayes D.N., Fan C., McNamara K., Kozlowski P., et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 448 (2007) 807-810
11. Briknarova K., Nasertorabi F., Havert M.L., Eggleston E., Hoyt D.W., Li C., et al. The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle. J. Biol. Chem. 280 (2005) 21908-21914
12. Burnham M.R., Bruce-Staskal P.J., Harte M.T., Weidow C.L., Ma A., Weed S.A., and Bouton A.H. Regulation of c-SRC activity and function by the adapter protein CAS. Mol. Cell. Biol. 20 (2000) 5865-5878
13. Arold S.T., Hoellerer M.K., and Noble M.E. The structural basis of localization and signaling by the focal adhesion targeting domain. Structure 10 (2002) 319-327
14. Law S.F., Zhang Y.Z., Fashena S.J., Toby G., Estojak J., and Golemis E.A. Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain. Exp. Cell Res. 252 (1999) 224-235
15. Cai D., Felekkis K.N., Near R.I., O'Neill G.M., van Seventer J.M., Golemis E.A., and Lerner A. The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J. Immunol. 170 (2003) 969-978
16. Sakakibara A., and Hattori S. Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways. J. Biol. Chem. 275 (2000) 6404-6410
17. Dail M., Kalo M.S., Seddon J.A., Cote J.F., Vuori K., and Pasquale E.B. SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases. J. Biol. Chem. 279 (2004) 41892-41902
18. Lu Y., Brush J., and Stewart T.A. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. J. Biol. Chem. 274 (1999) 10047-10052
19. Cai D., Clayton L.K., Smolyar A., and Lerner A. AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines. J. Immunol. 163 (1999) 2104-2112
20. Dodelet V.C., Pazzagli C., Zisch A.H., Hauser C.A., and Pasquale E.B. A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. J. Biol. Chem. 274 (1999) 31941-31946
21. Gotoh T., Cai D., Tian X., Feig L.A., and Lerner A. p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor. J. Biol. Chem. 275 (2000) 30118-30123
22. Sakakibara A., Ohba Y., Kurokawa K., Matsuda M., and Hattori S. Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. J. Cell Sci. 115 (2002) 4915-4924
23. Riggins R.B., Quilliam L.A., and Bouton A.H. Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. J. Biol. Chem. 278 (2003) 28264-28273
24. Yu Y., Hao Y., and Feig L.A. The R-Ras GTPase mediates cross talk between estrogen and insulin signaling in breast cancer cells. Mol. Cell. Biol. 26 (2006) 6372-6380
25. Regelmann A.G., Danzl N.M., Wanjalla C., and Alexandropoulos K. The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking. Immunity 25 (2006) 907-918
26. Clamp M., Cuff J., Searle S.M., and Barton G.J. The Jalview Java alignment editor. Bioinformatics 20 (2004) 426-427
27. Gingras A.R., Vogel K.P., Steinhoff H.J., Ziegler W.H., Patel B., Emsley J., et al. Structural and dynamic characterization of a vinculin binding site in the talin rod. Biochemistry 45 (2006) 1805-1817
28. Strelkov S.V., Herrmann H., Geisler N., Wedig T., Zimbelmann R., Aebi U., and Burkhard P. Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly. EMBO J. 21 (2002) 1255-1266
29. Landau M., Mayrose I., Rosenberg Y., Glaser F., Martz E., Pupko T., and Ben-Tal N. ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures. Nucleic Acids Res. 33 (2005) W299-W302
30. O'Neill G.M., and Golemis E.A. Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics. Mol. Cell. Biol. 21 (2001) 5094-5108
31. Boriack-Sjodin P.A., Margarit S.M., Bar-Sagi D., and Kuriyan J. The structural basis of the activation of Ras by Sos. Nature 394 (1998) 337-343
32. Rehmann H., Das J., Knipscheer P., Wittinghofer A., and Bos J.L. Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature 439 (2006) 625-628
33. Catherinot V., and Labesse G. ViTO: tool for refinement of protein sequence-structure alignments. Bioinformatics 20 (2004) 3694-3696
34. Konarev P.V., Vladimir V.V., Sokolova A.V., Koch M.J., and Svergun D.I. PRIMUS: a Windows PC-based system for small-angle scattering data. J. Appl. Crystallogr. 36 (2003) 1277-1282
35. Volkov V.V., and Svergun D.I. J. Appl. Crystallogr 36 (2003) 860-864
36. Petoukhov M.V., and Svergun D.I. Global rigid body modeling of macromolecular complexes against small-angle scattering data. Biophys. J. 89 (2005) 1237-1250
37. Petoukhov M.V., Eady N.A., Brown K.A., and Svergun D.I. Addition of missing loops and domains to protein models by x-ray solution scattering. Biophys. J. 83 (2002) 3113-3125
38. Derunes C., Burgess R., Iraheta E., Kellerer R., Becherer K., Gessner C.R., et al. Molecular determinants for interaction of SHEP1 with Cas localize to a highly solvent-protected region in the complex. FEBS Lett. 580 (2006) 175-178
39. Margarit S.M., Sondermann H., Hall B.E., Nagar B., Hoelz A., Pirruccello M., et al. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell 112 (2003) 685-695
40. Svergun D.I. Determination of the regularization parameter in indirect-transform methods using perceptual criteria. J. Appl. Crystallogr. 25 (1992) 495-503
41. Svergun D.I. Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. Biophys. J. 76 (1999) 2879-2886
42. Svergun D.I., Petoukhov M.V., and Koch M.H. Determination of domain structure of proteins from X-ray solution scattering. Biophys. J. 80 (2001) 2946-2953
43. Svergun D.I., Barberato C., and Koch M.H.J. CRYSOL-a program to evaluate X-ray solution scattering of biological macromolecules from atomic coordinates. J. Appl. Crystallogr. 28 (1995) 768-773
44. Fiser A., and Sali A. Modeller: generation and refinement of homology-based protein structure models. Methods Enzymol. 374 (2003) 461-491
45. Emsley P., and Cowtan K. Coot: model-building tools for molecular graphics. Acta Crystallogr., Sect. D: Biol. Crystallogr. 60 (2004) 2126-2132
46. Murshudov G.N., Vagin A.A., and Dodson E.J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr., Sect. D: Biol. Crystallogr. 53 (1997) 240-255