Integrin signalling: A new Cas(t) of characters enters the stage

Trends in Cell Biology

Volumn 10, Issue 3, 2000, Pages 111-119

  O’Neill, Geraldine M ^a   Fashena, Sarah J ^a   Golemis, Erica A ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; INTEGRIN; PROTEIN P130; UNCLASSIFIED DRUG;

APOPTOSIS; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CYTOSKELETON; EXTRACELLULAR MATRIX; MORPHOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; REVIEW; SIGNAL TRANSDUCTION;

ACTINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL DEATH; CELL MOVEMENT; CELL SIZE; CELL TRANSFORMATION, NEOPLASTIC; CRK-ASSOCIATED SUBSTRATE PROTEIN; CYTOSKELETON; HUMANS; INTEGRINS; PHOSPHOPROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P130; SIGNAL TRANSDUCTION;

EID: 0034160011     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(99)01714-6     Document Type: Review

References (69)

1. Dulbecco, R. (1970) Topoinhibition and serum requirement of transformed and untransformed cells. Nature 227, 802-806
2. Folkman, J. and Moscona, A. (1978) Role of cell shape in growth control. Nature 273, 345-349
3. Burridge, K. et al. (1988) Focal adhesions: Transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu. Rev. Cell Biol. 4, 487-525
4. Schoenwaelder, S.M. and Burridge, K. (1999) Bidirectional signaling between the cytoskeleton and integrins. Curr. Opin. Cell Biol. 11, 274-286
5. Giancotti, F.G. and Ruoslahti, E. (1999) Integrin signaling. Science 285, 1028-1032
6. Reynolds, A.B. et al. (1989) Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins. Mol. Cell. Biol. 9, 3951-3958
7. Sakai, R. et al. (1994) A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 13, 3748-3756
8. Law, S.F. et al. (1996) Human enhancer of filamentation 1 (HEF1), a novel p130Cas-like docking protein, associates with FAK, and induces pseudohyphal growth in yeast. Mol. Cell. Biol. 16, 3327-3337
9. Minegishi, M. et al. (1996) Structure and function of Cas-l, a 105-kD Crk-associated substrate-related protein that is involved in beta-1 integrin-mediated signaling in lymphocytes. J. Exp. Med. 184, 1365-1375
10. Alexandropoulos, K. and Baltimore, D. (1996) Coordinate activation of c-Src by SH3-and SH2-binding sites on a novel, p130Cas-related protein, sin. Genes Dev. 10, 1341-1355
11. Ishino, M. et al. (1995) Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn. Oncogene 11, 2331-2338
12. Zhang, Z. et al. (1999) Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase. J. Biol. Chem. 274, 25093-25098
13. Kanda, H. et al. (1997) Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas-related docking protein family, and its subsequent binding to the Src homology 2 domain of c-CrK. Eur. J. Immunol. 27, 2113-2117
14. Ohashi, Y. et al. (1998) T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G. J. Biol. Chem. 273, 6446-6451
15. Harte, M.T. et al. (1996) P130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. J. Biol. Chem. 271, 13649-13655
16. Polte, T.R. and Hanks, S.K. (1995) Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc. Natl. Acad. Sci. U. S. A. 92, 10678-10682
17. Nakamoto, T. et al. (1997) Requirements for localization of p130Cas to focal adhesions. Mol. Cell. Biol. 17, 3884-3897
18. Ohba, T. et al. (1998) Dot far-western blot analysis of relative binding affinities of the src homology 3 domains of efs and its related proteins. Anal. Biochem. 262, 185-192
19. Kanner, S.B. et al. (1990) Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc. Natl. Acad. Sci. U. S. A. 87, 3328-3332
20. Manie, S.N. et al. (1997) Involvement of p130Cas and p105HEF1, a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells. J. Biol. Chem. 272, 4230-4236
21. Nojima, Y. et al. (1995) Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J. Biol. Chem. 270, 15398-15402
22. Petch, L.A. et al. (1995) Adhesion-induced tyrosine phosphorylation of the p130src substrate. J. Cell Sci. 108, 1371-1379
23. Vuori, K. and Ruoslahti, E. (1995) Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix. J. Biol. Chem. 270, 22259-22262
24. Hunter, A.J. and Shimizu, Y. (1997) Alpha 4 beta 1 integrin-mediated tyrosine phosphorylation in human T cells: Characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn1. J. Immunol. 159, 4806-4814
25. Sattler, M. et al. (1997) Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120CBL and p110HEF1. J. Biol. Chem. 272, 14320-14326
26. Law, S.F. et al. (1998) Cell-cycle regulated processing of HEF1 to multiple protein forms differentially targeted to multiple compartments. Mol. Cell. Biol. 18, 3540-3551
27. Yamakita, Y. et al. (1999) Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: Role of mitosis-specific serine phosphorylation of FAK. J. Cell Biol. 144, 315-324
28. Polte, T.R. and Hanks, S.K. (1997) Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130Cas) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. J. Biol. Chem. 272, 5501-5509
29. Liu, F. et al. (1996) Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130Cas. J. Biol. Chem. 271, 31290-31295
30. Cary, L.A. and Guan, J.L. (1999) Focal adhesion kinase in integrin-mediated signaling. Front Biosci. 4, D102-113
31. Schlaepfer, D.D. et al. (1999) Signaling through focal adhesion kinase. Prog. Biophys. Mol. Biol. 71, 435-478
32. Astier, A. et al. (1997) The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1. J. Biol. Chem. 272, 19719-19730
33. Tachibana, K. et al. (1997) Tyrosine phosphorylation of crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of crk-associated substrates. J. Biol. Chem. 272, 29083-29090
34. Schlaepfer, D.D. et al (1997) Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: Involvement of the Grb2, p130Cas, and Nck adaptor proteins. Mol. Cell. Biol. 17, 1702-1713
35. Vuori, K. et al. (1996) Induction of p130Cas signaling complex formation upon integrin-mediated cell adhesion: A role for Src family kinases. Mol. Cell. Biol. 16, 2606-2613
36. Mayer, B.J. et al. (1995) Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases. Curr. Biol. 5, 296-305
37. Manie, S.N. et al. (1997) Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2. J. Biol. Chem. 272, 15636-15641
38. Garton, A.J. et al. (1997) Association of PTP-PEST with the SH3 domain of p130Cas; a novel mechanism of protein tyrosine phosphatase substrate recognition. Oncogene 15, 877-885
39. Rock, M.T. et al. (1997) Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events. J. Biol. Chem. 272, 33377-33383
40. Hakak, Y. and Martin, G. S. (1999) Cas mediates transcriptional activation of the serum response element by Src. Mol. Cell. Biol. 19, 6953-6962
41. Blaukat, A. et al. (1999) Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades. J. Biol. Chem. 274, 14893-14901
42. Tanaka, S. et al. (1997) Downstream of Crk adaptor signaling pathway: Activation of jun kinase by v-Crk through the guanine nucleotide exchange protein C3G. Proc. Natl. Acad. Sci. U. S. A. 94, 2356-2361
43. Dolfi, F. et al. (1998) The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc. Natl. Acad. Sci. U. S. A. 95, 15394-15399
44. Cary, L.A. et al. (1996) Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J. Cell Sci. 109, 1787-1794
45. Cary, L.A. et al. (1998) Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J. Cell Biol. 140, 211-221
46. Klemke, R.L. et al. (1998) Cas/Crk coupling serves as a 'molecular switch' for induction of cell migration. J. Cell Biol. 140, 961-972
47. Cheresh, D.A. et al. (1999) Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells. J. Cell Biol. 146, 1107-1116
48. Honda, H. et al. (1998) Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat. Genet. 19, 361-365
49. Ilic, D. et al. (1995) Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-544
50. Angers-Loustau, A. et al. (1999) Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J. Cell Biol. 144, 1019-1031
51. Ueki, K. et al. (1998) Integrin-mediated signal transduction in cells lacking focal adhesion kinase p125FAK. FEBS Lett. 432, 197-201
52. Gu, J. et al. (1999) Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J. Cell Biol. 146, 389-403
53. Auvinen, M. et al. (1995) Ornithine decarboxylase and ras-induced cell transformations: Reversal by protein tyrosine kinase inhibitors and role of pp130Cas. Mol. Cell. Biol. 15, 6513-6525
54. Nakamura, I. et al. (1998) Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts. J. Biol. Chem. 273, 11144-11149
55. Ojaniemi, M. and Vuori, K. (1997) Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3′-kinase and actin cytoskeleton. J. Biol. Chem. 272, 25993-25998
56. Thornberry, N.A. and Lazebnik, Y. (1998) Caspases: Enemies within. Science 281, 1312-1316
57. Ghayur, T. et al. (1997) Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 386, 619-623
58. Ishizaki, Y. et al. (1998) A role for caspases in lens fiber differentiation. J. Cell Biol. 140, 153-158
59. Watanabe, Y. and Akaike, T. (1999) Possible involvement of caspase-like family in maintenance of cytoskeleton integrity. J. Cell. Physiol. 179, 45-51
60. Oktay, M. et al. (1999) Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J. Cell Biol. 145, 1461-1469
61. Bannerman, D.D. et al. (1998) Bacterial lipopolysaccharide disrupts endothelial monolayer integrity and survival signaling events through caspase cleavage of adherens junction proteins. J. Biol. Chem. 273, 35371-35380
62. Weng, L.P. et al. (1999) Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas. Genes Cells 4, 185-196
63. Crouch, D.H. et al. (1996) Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling. Oncogene 12, 2689-2696
64. Frisch, S.M. et al. (1996) Control of adhesion-dependent cell survival by focal adhesion kinase. J. Cell Biol. 134, 793-799
65. Hungerford, J.E. et al. (1996) Inhibition of pp125FAK in cultured fibroblasts results in apoptosis. J. Cell Biol. 135, 1383-1390
66. Xu, L.H. et al. (1996) Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Differ. 7, 413-418
67. Frisch, S.M. and Francis, H. (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626
68. Burnham, M.R. et al. (1999) The role of SRC-CAS interactions in cellular transformation: Ectopic expression of the carboxy-terminus of CAS inhibits SRC-CAS interaction but has no effect on cellular transformation. Mol. Carcinog. 26, 20-31
69. Liu, F. et al. (1998) Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand. Mol. Cell. Biol. 18, 250-259